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The map label for this gene is ubiB [H]

Identifier: 88608734

GI number: 88608734

Start: 557950

End: 559326

Strand: Reverse

Name: ubiB [H]

Synonym: NSE_0637

Alternate gene names: 88608734

Gene position: 559326-557950 (Counterclockwise)

Preceding gene: 88608250

Following gene: 88608494

Centisome position: 65.11

GC content: 40.38

Gene sequence:

>1377_bases
ATGTATTTGTTCTTTAGGGTATTCAGAATAGCGTATTTTGTCTTTTACGCGTATTTTGAGCTCCTGTACAGGAAAAATTA
TTCTGTTCTGGTTTCTGAAGTGGAGAAGATGGGTCCAGCATTCATCAAATTTGGACAGTTTTTCTCCAGTATGGGTGATT
TTATCTGCTCCGATTTATCTACCGAATTAAGGAAGCTGTGTGATAACGTGAAGCCCGTTTCTTACGTAGAGGTAAAGGCA
TCTATTGAAAAGGAATTTTCAAAAGGAATAGACAGGCTCTTCAAGTGGATAGATGAGAGGCCAACGGCTTCTGCATCGAT
TGCGCAAGTGCATAAGGCAATTACGCTATCAGGTGAAGTTGTGGCTGTAAAGATTCTGAAACCAGGAGTAAAAAAGATCT
TTAAGCGAGATATCAAAATCGCCTTTTCGATCGTGTACATTTTATCGTTTTTTCTCCCGAAACGCTTTAACCTAATCACG
ATTTTGAAGAAATTTTCTGCTTCCACAAAAAACGAGCTGGACCTCAAAATGGAGGCAGCTGCATTGTCAGAGATGAAGGA
CAAGCTTCTTACCAATAAAACAGTTGTGATACCTGAAGTTTATTGGGGCCTAACGACTAATGAAATTCTCACTATGTCTT
GGCTTGAAGGGGTGCCACTGACACACTGCAAGTTATGTGATCCACAGTTTGCACGAAGACTTGTTGAGACATTTTTCGTG
CAAGTCTATGTAAATGGCTTTTTTCATGGGGATATGCATCTGGGAAATATATTTCTCATTTCTGGACACAAAGTTGGATT
AGTAGACTTTGGAATAATTGGAAGGATTGATGAGCAAACAAAGGTTTACGTTTTGGAACTGATTAAGGGGTTCTTAGAAA
GAGACTACGACCGCGTGGCAGAATTACATTATTCAGCTGGATACGTAGAAAGGTCCCGAACAGATTTTGCTTCTGCGTGT
CGTGCTCTCGCTGAGCCTATAGTAGACAAACCGCTGAAGGAGGTCTCACTATCTCGTCTTCTGGGTGATTTCTTTAAGCT
TTCTAGGGATTTCCGTATCGAGATTAACCCAAATCTTATTTTGATGCAAAAGAATTTAATTTTTCTCGAGGCAAACTGTG
CGAAACTTGATCCAGAGATAAACGTATGGCGAATAATAGAACCAATGATAAGGAGGTGGTATAAAGACAGGATGTGTCCA
ACAGTGCTAGTGAGGGAGAAAATCCATAAGATAGCGGTTGTTTTAAAAGAGGCCTTCGAGGACAATAAGGAGAGTAAGTA
TCGTGCGGTTACTGCGTCACGATGTGAGGTGTTTTTCTGGATCTGTCTTGCCTCAATTATCAATTTCCTTGCCATACTTG
CTTGCAGGTTTTTTTAG

Upstream 100 bases:

>100_bases
AGGGGTGGACTGTGTTACCGGCCTGAGTTTAGTACCTAAGTTGCTTTGAATTGCACCTATTTCCTTTCGCTCTTGTACTT
AGTAGAAAAATTGTTTGTGC

Downstream 100 bases:

>100_bases
TTTTGCTTTTCATGAAAAAACGTATTGCTCATGCATCAATTCAACCGGACAAATTCTGCTTTAGTGAAGAGAATTCACGA
GAGGTAGCTAGAATCCTTGC

Product: putative ubiquinone biosynthesis protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MYLFFRVFRIAYFVFYAYFELLYRKNYSVLVSEVEKMGPAFIKFGQFFSSMGDFICSDLSTELRKLCDNVKPVSYVEVKA
SIEKEFSKGIDRLFKWIDERPTASASIAQVHKAITLSGEVVAVKILKPGVKKIFKRDIKIAFSIVYILSFFLPKRFNLIT
ILKKFSASTKNELDLKMEAAALSEMKDKLLTNKTVVIPEVYWGLTTNEILTMSWLEGVPLTHCKLCDPQFARRLVETFFV
QVYVNGFFHGDMHLGNIFLISGHKVGLVDFGIIGRIDEQTKVYVLELIKGFLERDYDRVAELHYSAGYVERSRTDFASAC
RALAEPIVDKPLKEVSLSRLLGDFFKLSRDFRIEINPNLILMQKNLIFLEANCAKLDPEINVWRIIEPMIRRWYKDRMCP
TVLVREKIHKIAVVLKEAFEDNKESKYRAVTASRCEVFFWICLASIINFLAILACRFF

Sequences:

>Translated_458_residues
MYLFFRVFRIAYFVFYAYFELLYRKNYSVLVSEVEKMGPAFIKFGQFFSSMGDFICSDLSTELRKLCDNVKPVSYVEVKA
SIEKEFSKGIDRLFKWIDERPTASASIAQVHKAITLSGEVVAVKILKPGVKKIFKRDIKIAFSIVYILSFFLPKRFNLIT
ILKKFSASTKNELDLKMEAAALSEMKDKLLTNKTVVIPEVYWGLTTNEILTMSWLEGVPLTHCKLCDPQFARRLVETFFV
QVYVNGFFHGDMHLGNIFLISGHKVGLVDFGIIGRIDEQTKVYVLELIKGFLERDYDRVAELHYSAGYVERSRTDFASAC
RALAEPIVDKPLKEVSLSRLLGDFFKLSRDFRIEINPNLILMQKNLIFLEANCAKLDPEINVWRIIEPMIRRWYKDRMCP
TVLVREKIHKIAVVLKEAFEDNKESKYRAVTASRCEVFFWICLASIINFLAILACRFF
>Mature_458_residues
MYLFFRVFRIAYFVFYAYFELLYRKNYSVLVSEVEKMGPAFIKFGQFFSSMGDFICSDLSTELRKLCDNVKPVSYVEVKA
SIEKEFSKGIDRLFKWIDERPTASASIAQVHKAITLSGEVVAVKILKPGVKKIFKRDIKIAFSIVYILSFFLPKRFNLIT
ILKKFSASTKNELDLKMEAAALSEMKDKLLTNKTVVIPEVYWGLTTNEILTMSWLEGVPLTHCKLCDPQFARRLVETFFV
QVYVNGFFHGDMHLGNIFLISGHKVGLVDFGIIGRIDEQTKVYVLELIKGFLERDYDRVAELHYSAGYVERSRTDFASAC
RALAEPIVDKPLKEVSLSRLLGDFFKLSRDFRIEINPNLILMQKNLIFLEANCAKLDPEINVWRIIEPMIRRWYKDRMCP
TVLVREKIHKIAVVLKEAFEDNKESKYRAVTASRCEVFFWICLASIINFLAILACRFF

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=279, Percent_Identity=25.4480286738351, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI41393593, Length=292, Percent_Identity=24.6575342465753, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI217035081, Length=234, Percent_Identity=25.6410256410256, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI34147522, Length=300, Percent_Identity=25, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI27363457, Length=320, Percent_Identity=23.4375, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI217416386, Length=259, Percent_Identity=24.7104247104247, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI2367309, Length=391, Percent_Identity=31.7135549872123, Blast_Score=216, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17559152, Length=284, Percent_Identity=27.4647887323944, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI32565180, Length=226, Percent_Identity=27.8761061946903, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6325148, Length=450, Percent_Identity=23.7777777777778, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321319, Length=325, Percent_Identity=25.5384615384615, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24662575, Length=291, Percent_Identity=27.1477663230241, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI22024280, Length=225, Percent_Identity=24.4444444444444, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI18859849, Length=307, Percent_Identity=25.4071661237785, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 53074; Mature: 53074

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLFFRVFRIAYFVFYAYFELLYRKNYSVLVSEVEKMGPAFIKFGQFFSSMGDFICSDLS
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
TELRKLCDNVKPVSYVEVKASIEKEFSKGIDRLFKWIDERPTASASIAQVHKAITLSGEV
HHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEECCCE
VAVKILKPGVKKIFKRDIKIAFSIVYILSFFLPKRFNLITILKKFSASTKNELDLKMEAA
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHH
ALSEMKDKLLTNKTVVIPEVYWGLTTNEILTMSWLEGVPLTHCKLCDPQFARRLVETFFV
HHHHHHHHHHCCCEEEECHHHHCCCCCCEEEHHHHCCCCCCCEECCCHHHHHHHHHHHHH
QVYVNGFFHGDMHLGNIFLISGHKVGLVDFGIIGRIDEQTKVYVLELIKGFLERDYDRVA
HHHHHHEEECCEEECCEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ELHYSAGYVERSRTDFASACRALAEPIVDKPLKEVSLSRLLGDFFKLSRDFRIEINPNLI
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCCEE
LMQKNLIFLEANCAKLDPEINVWRIIEPMIRRWYKDRMCPTVLVREKIHKIAVVLKEAFE
EEECCEEEEECCCHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
DNKESKYRAVTASRCEVFFWICLASIINFLAILACRFF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYLFFRVFRIAYFVFYAYFELLYRKNYSVLVSEVEKMGPAFIKFGQFFSSMGDFICSDLS
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
TELRKLCDNVKPVSYVEVKASIEKEFSKGIDRLFKWIDERPTASASIAQVHKAITLSGEV
HHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEECCCE
VAVKILKPGVKKIFKRDIKIAFSIVYILSFFLPKRFNLITILKKFSASTKNELDLKMEAA
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHH
ALSEMKDKLLTNKTVVIPEVYWGLTTNEILTMSWLEGVPLTHCKLCDPQFARRLVETFFV
HHHHHHHHHHCCCEEEECHHHHCCCCCCEEEHHHHCCCCCCCEECCCHHHHHHHHHHHHH
QVYVNGFFHGDMHLGNIFLISGHKVGLVDFGIIGRIDEQTKVYVLELIKGFLERDYDRVA
HHHHHHEEECCEEECCEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ELHYSAGYVERSRTDFASACRALAEPIVDKPLKEVSLSRLLGDFFKLSRDFRIEINPNLI
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCCEE
LMQKNLIFLEANCAKLDPEINVWRIIEPMIRRWYKDRMCPTVLVREKIHKIAVVLKEAFE
EEECCEEEEECCCHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
DNKESKYRAVTASRCEVFFWICLASIINFLAILACRFF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA