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The map label for this gene is adk

Identifier: 88608637

GI number: 88608637

Start: 234113

End: 234742

Strand: Direct

Name: adk

Synonym: NSE_0286

Alternate gene names: 88608637

Gene position: 234113-234742 (Clockwise)

Preceding gene: 88608542

Following gene: 88608326

Centisome position: 27.25

GC content: 41.59

Gene sequence:

>630_bases
ATGAATTTAGTAATGTTTGGTCCACCTGGCTCTGGTAAGGGTACGCAGTCCTCACGGATTTGTTCTTATGTTTCGGCCTC
CGTGGTTGACTGTGGTAAGCTTTTGAGGGTAGCCGCTCTTACTATGAGGCAGTCTGAGGATCTTAAAGCTGGAAAACTCC
TTCCAGATGAGTTGGTAATAGGTGTTGTAAGAGAGAAATTGAGAGAGCTGATAAAAGTCGGGGATAATTTTATTCTTGAT
GGTTTTCCACGAAGTGTGGTTCAGTGTCATGCGCTATTTGAAATGTCTTCTGAACTAGAGTTCGAGATTTCGTGTCTTGT
AAAATTTGAAGTTTCTGAAAGGGAAATTTTTGCGAGGCTTTTGGATAGGCTTGTTTGTAGTGCGTGTGGTGCTCTCCATG
ATGTTGTTTTGGGTAGGTGTGTTTCCTGTGGTAGCGTTGAATGTGAAAGACGTAGTGATGATCTCAAAGTTGAGATAATA
AAAAAGAGGTTGATGCTATATGGTGCTGTTGAGCGGGATATTGTAAACTTGTTCAGGTCTAGATCTATAAAGGTGTTGAG
CATAGATGCAGGCCGTTCAGTAGATGAGGTTGCAGCTGATCTTAGAACGCAACTTTTGATGTTTATATGA

Upstream 100 bases:

>100_bases
TAAATGTTATAACAGATCTGCTCTCTCAGATTCAGGTGCTTCTTTTCAGTTCTCATTATTCTTCTTTTTTGAAAAAGGGA
GGAATGGTTTTTAATAAGCG

Downstream 100 bases:

>100_bases
TATATTTGAGCGTATGAGGTTTTTAGGGGTAAACTTGCCGGATAATAAGGCGGTTGTCGTTGCTTTGACGTATTTATATG
GGATAGGCCTACCTACCGCG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MNLVMFGPPGSGKGTQSSRICSYVSASVVDCGKLLRVAALTMRQSEDLKAGKLLPDELVIGVVREKLRELIKVGDNFILD
GFPRSVVQCHALFEMSSELEFEISCLVKFEVSEREIFARLLDRLVCSACGALHDVVLGRCVSCGSVECERRSDDLKVEII
KKRLMLYGAVERDIVNLFRSRSIKVLSIDAGRSVDEVAADLRTQLLMFI

Sequences:

>Translated_209_residues
MNLVMFGPPGSGKGTQSSRICSYVSASVVDCGKLLRVAALTMRQSEDLKAGKLLPDELVIGVVREKLRELIKVGDNFILD
GFPRSVVQCHALFEMSSELEFEISCLVKFEVSEREIFARLLDRLVCSACGALHDVVLGRCVSCGSVECERRSDDLKVEII
KKRLMLYGAVERDIVNLFRSRSIKVLSIDAGRSVDEVAADLRTQLLMFI
>Mature_209_residues
MNLVMFGPPGSGKGTQSSRICSYVSASVVDCGKLLRVAALTMRQSEDLKAGKLLPDELVIGVVREKLRELIKVGDNFILD
GFPRSVVQCHALFEMSSELEFEISCLVKFEVSEREIFARLLDRLVCSACGALHDVVLGRCVSCGSVECERRSDDLKVEII
KKRLMLYGAVERDIVNLFRSRSIKVLSIDAGRSVDEVAADLRTQLLMFI

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=215, Percent_Identity=27.4418604651163, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI7524346, Length=215, Percent_Identity=27.4418604651163, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI19923437, Length=192, Percent_Identity=29.6875, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=30.8755760368664, Blast_Score=91, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17552384, Length=208, Percent_Identity=29.8076923076923, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17567503, Length=201, Percent_Identity=29.8507462686567, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=213, Percent_Identity=27.6995305164319, Blast_Score=89, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6321018, Length=190, Percent_Identity=28.9473684210526, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322828, Length=207, Percent_Identity=26.5700483091787, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI22026816, Length=207, Percent_Identity=28.5024154589372, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17737899, Length=192, Percent_Identity=27.6041666666667, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24645822, Length=192, Percent_Identity=27.6041666666667, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_NEOSM (Q2GEB9)

Other databases:

- EMBL:   CP000237
- RefSeq:   YP_506177.1
- HSSP:   P16304
- ProteinModelPortal:   Q2GEB9
- SMR:   Q2GEB9
- STRING:   Q2GEB9
- GeneID:   3931914
- GenomeReviews:   CP000237_GR
- KEGG:   nse:NSE_0286
- TIGR:   NSE_0286
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   GILYQRK
- ProtClustDB:   CLSK2528051
- BioCyc:   NSEN222891:NSE_0286-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 23175; Mature: 23175

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLVMFGPPGSGKGTQSSRICSYVSASVVDCGKLLRVAALTMRQSEDLKAGKLLPDELVI
CCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
GVVREKLRELIKVGDNFILDGFPRSVVQCHALFEMSSELEFEISCLVKFEVSEREIFARL
HHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCEEEEEEEEEECHHHHHHHHH
LDRLVCSACGALHDVVLGRCVSCGSVECERRSDDLKVEIIKKRLMLYGAVERDIVNLFRS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RSIKVLSIDAGRSVDEVAADLRTQLLMFI
CCEEEEEECCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLVMFGPPGSGKGTQSSRICSYVSASVVDCGKLLRVAALTMRQSEDLKAGKLLPDELVI
CCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
GVVREKLRELIKVGDNFILDGFPRSVVQCHALFEMSSELEFEISCLVKFEVSEREIFARL
HHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCEEEEEEEEEECHHHHHHHHH
LDRLVCSACGALHDVVLGRCVSCGSVECERRSDDLKVEIIKKRLMLYGAVERDIVNLFRS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RSIKVLSIDAGRSVDEVAADLRTQLLMFI
CCEEEEEECCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA