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The map label for this gene is nuoE

Identifier: 88608494

GI number: 88608494

Start: 557420

End: 557965

Strand: Reverse

Name: nuoE

Synonym: NSE_0636

Alternate gene names: 88608494

Gene position: 557965-557420 (Counterclockwise)

Preceding gene: 88608734

Following gene: 88608615

Centisome position: 64.95

GC content: 42.86

Gene sequence:

>546_bases
TTGCAGGTTTTTTTAGTTTTGCTTTTCATGAAAAAACGTATTGCTCATGCATCAATTCAACCGGACAAATTCTGCTTTAG
TGAAGAGAATTCACGAGAGGTAGCTAGAATCCTTGCTAAATATCCCGCTTCCCGTAAGAGGAGTGCTGTCCTTCCGTTGC
TACACCTTGTCCAAAGACAGCATGAAAACTGGATTCCTATCGCTGCAATGGATCATGTTGCACAGTTACTTGGACTACCG
GTTATTAAAGTGTATGAAGTGGCGTCTTTCTACAGTATGTTTAATACTGCCCCGGTGGGGAAGCATACCATACGTGTCTG
CAGAACCACGCCATGTTGGTTGAGAGGTTCCGATTGTCTAATTGAAGCTGCGAAACGAGAATTAGGGATCAAAGTGGGCC
ATAAAACCGAAGACAACAAATTTTCTTTAGATGAAGTAGAGTGTCTTGGGGCCTGTGTTAGCGCGCCAGTCGTACAGATT
AACGACGACTATTTTGAAAATTTGGACGAAAGGTCTTTTCTCGAGCTTTTATCCAGGCTTAAGTAA

Upstream 100 bases:

>100_bases
ACAATAAGGAGAGTAAGTATCGTGCGGTTACTGCGTCACGATGTGAGGTGTTTTTCTGGATCTGTCTTGCCTCAATTATC
AATTTCCTTGCCATACTTGC

Downstream 100 bases:

>100_bases
CTGACTATTTTTGAGTCCTAGCGATATTTTAATTACTTAATGTTACAATGAAAGCATGAGGGGGTCCCTCTAGGAGGAGG
TTCCTTTTGGTTTTTAAAAT

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MQVFLVLLFMKKRIAHASIQPDKFCFSEENSREVARILAKYPASRKRSAVLPLLHLVQRQHENWIPIAAMDHVAQLLGLP
VIKVYEVASFYSMFNTAPVGKHTIRVCRTTPCWLRGSDCLIEAAKRELGIKVGHKTEDNKFSLDEVECLGACVSAPVVQI
NDDYFENLDERSFLELLSRLK

Sequences:

>Translated_181_residues
MQVFLVLLFMKKRIAHASIQPDKFCFSEENSREVARILAKYPASRKRSAVLPLLHLVQRQHENWIPIAAMDHVAQLLGLP
VIKVYEVASFYSMFNTAPVGKHTIRVCRTTPCWLRGSDCLIEAAKRELGIKVGHKTEDNKFSLDEVECLGACVSAPVVQI
NDDYFENLDERSFLELLSRLK
>Mature_181_residues
MQVFLVLLFMKKRIAHASIQPDKFCFSEENSREVARILAKYPASRKRSAVLPLLHLVQRQHENWIPIAAMDHVAQLLGLP
VIKVYEVASFYSMFNTAPVGKHTIRVCRTTPCWLRGSDCLIEAAKRELGIKVGHKTEDNKFSLDEVECLGACVSAPVVQI
NDDYFENLDERSFLELLSRLK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=163, Percent_Identity=52.760736196319, Blast_Score=183, Evalue=7e-47,
Organism=Escherichia coli, GI1788621, Length=135, Percent_Identity=37.037037037037, Blast_Score=96, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17561328, Length=159, Percent_Identity=51.5723270440252, Blast_Score=181, Evalue=1e-46,
Organism=Drosophila melanogaster, GI18859877, Length=158, Percent_Identity=55.0632911392405, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI21355353, Length=159, Percent_Identity=44.0251572327044, Blast_Score=150, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 20629; Mature: 20629

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVFLVLLFMKKRIAHASIQPDKFCFSEENSREVARILAKYPASRKRSAVLPLLHLVQRQ
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
HENWIPIAAMDHVAQLLGLPVIKVYEVASFYSMFNTAPVGKHTIRVCRTTPCWLRGSDCL
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEECCCHHH
IEAAKRELGIKVGHKTEDNKFSLDEVECLGACVSAPVVQINDDYFENLDERSFLELLSRL
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCHHHHCCCHHHHHHHHHHC
K
C
>Mature Secondary Structure
MQVFLVLLFMKKRIAHASIQPDKFCFSEENSREVARILAKYPASRKRSAVLPLLHLVQRQ
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
HENWIPIAAMDHVAQLLGLPVIKVYEVASFYSMFNTAPVGKHTIRVCRTTPCWLRGSDCL
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEECCCHHH
IEAAKRELGIKVGHKTEDNKFSLDEVECLGACVSAPVVQINDDYFENLDERSFLELLSRL
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCHHHHCCCHHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]