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The map label for this gene is pyrH

Identifier: 88608491

GI number: 88608491

Start: 833729

End: 834430

Strand: Reverse

Name: pyrH

Synonym: NSE_0946

Alternate gene names: 88608491

Gene position: 834430-833729 (Counterclockwise)

Preceding gene: 88608372

Following gene: 88608154

Centisome position: 97.14

GC content: 44.02

Gene sequence:

>702_bases
ATGCGGAGAGTTCTGCTGAAAATCTCAGGGGAAAGATTGGCTGCACGTGGGGTCTCTGTTCACGATGCTGAGGTCATCGG
TATGCTTGCTAGGGGCATAAAGAGAGTTCATGAAATGGGTATACAAGTATGCCTTGTTATTGGTGGTGGGAATATTTACA
GGGGAAGTAGTGGTATTCCAAACATAGACAGAGCTACTGGCGACTATATGGGGATGCTTGCAACTGTTATTAATGCCCTT
GCTCTGCAAGGTGCTATAAACAATTTGGGTGTGGTTTCGAGGGTGCAGTCTGCTATTCCTATGAGATCTATATGTGAGCC
TTATGTGCGTCAGAAAGCGATTAGTCACATGGAGAAAAACCGGATCGTAATATTTGCGGCGGGAACGGGCAATCCATTTT
TCACGACCGATACAGCTGCAGTGCTTCGTTCTGTTGAAATGGGATGCGATGTGATGCTTAAGGGTACACTTGTAGACGGG
ATATATTCTGATGATCCCAGAACAAATATTAATGCAGAAAGAATAACTAAGCTCTCCTATACAGATGTGCTTTCTAAAAA
GCTTAGGGTGTTGGATTCTTCTGCTGTTTCAATAGCACGGGATAATGGTATGCCCGTGGTAATCTTTTCATTGGACAGTG
AAATGGCGTTTTACGAGGTGATCAATAAACAGGGCAACTATAGCACCATAGAGGGTGAATGA

Upstream 100 bases:

>100_bases
CGTAAAGCAATATATTTCTGACAAGGAAATGGAATCTTCAGCTAAGATTGATGTAGTTTGGTATGAGGTGTTTGTTCTAG
GAGAAGCTAGTTGAGTCTCT

Downstream 100 bases:

>100_bases
GTTTTTTTAGGTATGCTAGAAGATGTAATTAAGGAAACAAATGATAAACTCCGTTCGTCGTACGAGGTGTTTCTCTCTGA
CTTGAAGGGTATTAGGTCAG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MRRVLLKISGERLAARGVSVHDAEVIGMLARGIKRVHEMGIQVCLVIGGGNIYRGSSGIPNIDRATGDYMGMLATVINAL
ALQGAINNLGVVSRVQSAIPMRSICEPYVRQKAISHMEKNRIVIFAAGTGNPFFTTDTAAVLRSVEMGCDVMLKGTLVDG
IYSDDPRTNINAERITKLSYTDVLSKKLRVLDSSAVSIARDNGMPVVIFSLDSEMAFYEVINKQGNYSTIEGE

Sequences:

>Translated_233_residues
MRRVLLKISGERLAARGVSVHDAEVIGMLARGIKRVHEMGIQVCLVIGGGNIYRGSSGIPNIDRATGDYMGMLATVINAL
ALQGAINNLGVVSRVQSAIPMRSICEPYVRQKAISHMEKNRIVIFAAGTGNPFFTTDTAAVLRSVEMGCDVMLKGTLVDG
IYSDDPRTNINAERITKLSYTDVLSKKLRVLDSSAVSIARDNGMPVVIFSLDSEMAFYEVINKQGNYSTIEGE
>Mature_233_residues
MRRVLLKISGERLAARGVSVHDAEVIGMLARGIKRVHEMGIQVCLVIGGGNIYRGSSGIPNIDRATGDYMGMLATVINAL
ALQGAINNLGVVSRVQSAIPMRSICEPYVRQKAISHMEKNRIVIFAAGTGNPFFTTDTAAVLRSVEMGCDVMLKGTLVDG
IYSDDPRTNINAERITKLSYTDVLSKKLRVLDSSAVSIARDNGMPVVIFSLDSEMAFYEVINKQGNYSTIEGE

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=232, Percent_Identity=43.9655172413793, Blast_Score=200, Evalue=6e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_NEOSM (Q2GCI6)

Other databases:

- EMBL:   CP000237
- RefSeq:   YP_506810.1
- ProteinModelPortal:   Q2GCI6
- SMR:   Q2GCI6
- STRING:   Q2GCI6
- GeneID:   3931337
- GenomeReviews:   CP000237_GR
- KEGG:   nse:NSE_0946
- TIGR:   NSE_0946
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   CLSK2527950
- BioCyc:   NSEN222891:NSE_0946-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25242; Mature: 25242

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: BINDING 49-49 BINDING 50-50 BINDING 54-54 BINDING 68-68 BINDING 156-156 BINDING 162-162 BINDING 165-165

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVLLKISGERLAARGVSVHDAEVIGMLARGIKRVHEMGIQVCLVIGGGNIYRGSSGIP
CCEEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCEECCCCCCC
NIDRATGDYMGMLATVINALALQGAINNLGVVSRVQSAIPMRSICEPYVRQKAISHMEKN
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
RIVIFAAGTGNPFFTTDTAAVLRSVEMGCDVMLKGTLVDGIYSDDPRTNINAERITKLSY
CEEEEEECCCCCCEECHHHHHHHHHHCCCCEEEECEEECCEECCCCCCCCCHHHHHHHHH
TDVLSKKLRVLDSSAVSIARDNGMPVVIFSLDSEMAFYEVINKQGNYSTIEGE
HHHHHHHHHHHHHHHHEEEECCCCEEEEEECCCCHHHHHHHHCCCCEEECCCC
>Mature Secondary Structure
MRRVLLKISGERLAARGVSVHDAEVIGMLARGIKRVHEMGIQVCLVIGGGNIYRGSSGIP
CCEEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCEECCCCCCC
NIDRATGDYMGMLATVINALALQGAINNLGVVSRVQSAIPMRSICEPYVRQKAISHMEKN
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
RIVIFAAGTGNPFFTTDTAAVLRSVEMGCDVMLKGTLVDGIYSDDPRTNINAERITKLSY
CEEEEEECCCCCCEECHHHHHHHHHHCCCCEEEECEEECCEECCCCCCCCCHHHHHHHHH
TDVLSKKLRVLDSSAVSIARDNGMPVVIFSLDSEMAFYEVINKQGNYSTIEGE
HHHHHHHHHHHHHHHHEEEECCCCEEEEEECCCCHHHHHHHHCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA