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The map label for this gene is nadC

Identifier: 88608448

GI number: 88608448

Start: 100662

End: 101522

Strand: Direct

Name: nadC

Synonym: NSE_0122

Alternate gene names: 88608448

Gene position: 100662-101522 (Clockwise)

Preceding gene: 88608043

Following gene: 88608585

Centisome position: 11.72

GC content: 42.16

Gene sequence:

>861_bases
TTGCTAACCGTTATTTCTATGGATTACGAAGCTTTGGAAAAAATAATCACACTCGCGCTTAATGAGGATCTAGGTCTTGG
TTGTGATATAACAACTGAGAATACACTTCCCTGTGATTTAGTTACGTCTTTCGATGTAAATGCACGCAAGGAAACAGTAG
TGTGTGTAGAACCCTTGGCAAAAGTGATTTTTGGCCAATCTGGGATAGAATACTTTCTAAATAAGCAAGATGGCGATCGC
GTTCTTCCTGGAGAGTGCATTATCCGGGGATGCGGTAGTGCACATGTACTACTTAGGATAGAACGTGTGTTTCTGAATTT
TATTCAAAGGAGTTGTGCAGTTGCAGCTGCCACAAGGCGGTTTGTCGACGCAGTGTCTCACACGAAGGCAAAAATACGTG
ATACGCGGAAAACGACTCCAGGCATGCGCTGTGTGGAAAGATACGCTGTTAAGGTCGGTGGAGGAGGAAGCTATCGTAAC
TCTCTAAACGACAGGGTCTTGTTAAAAGATAATCATATAGCGATTTGTGGTGGCATAACTGCGGCTGTACACAAATTGAA
AAAGTCTTTTGAAGGTATTTATATCACCGTCGAGTGTGACACGTTTGATCAGGTAAAAGAATCATTATCCGTCGATGTTG
ACTCAGTCCTTTTAGATAACATGTCGGTTAGAGAAATTATTGATTGTGTCACATATATAAGAAATGCCTCATCGCGTGTG
AAAATTGATGCTTCCGGTGGTATCACGCTTGCCACGGTAAAGGAAATTGCTGAAACAGGCGTAGATTTTATCTCGGTGGG
AATGCTAACGCATTCTATTGTCAGCGCAGATATTGGTATCGATGTAAGAACAAAGCTCTGA

Upstream 100 bases:

>100_bases
AAGTTTCTAACGCAAATAGTTTTTTTAATACTTTGAGTGCTCTAGATGGGTTAATAAAATAGCACTATGCCTAGAAACCA
TTGTATACTCTTCGACTCTA

Downstream 100 bases:

>100_bases
TATCCACTGAATGTCTCTTGGAGTGTACCAAAGGATTTTTTGGGTGACCTTACTTCAAATTATGAAATCATGAAATTCTG
GAGCTGGAAGCTCCCTCTTT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MLTVISMDYEALEKIITLALNEDLGLGCDITTENTLPCDLVTSFDVNARKETVVCVEPLAKVIFGQSGIEYFLNKQDGDR
VLPGECIIRGCGSAHVLLRIERVFLNFIQRSCAVAAATRRFVDAVSHTKAKIRDTRKTTPGMRCVERYAVKVGGGGSYRN
SLNDRVLLKDNHIAICGGITAAVHKLKKSFEGIYITVECDTFDQVKESLSVDVDSVLLDNMSVREIIDCVTYIRNASSRV
KIDASGGITLATVKEIAETGVDFISVGMLTHSIVSADIGIDVRTKL

Sequences:

>Translated_286_residues
MLTVISMDYEALEKIITLALNEDLGLGCDITTENTLPCDLVTSFDVNARKETVVCVEPLAKVIFGQSGIEYFLNKQDGDR
VLPGECIIRGCGSAHVLLRIERVFLNFIQRSCAVAAATRRFVDAVSHTKAKIRDTRKTTPGMRCVERYAVKVGGGGSYRN
SLNDRVLLKDNHIAICGGITAAVHKLKKSFEGIYITVECDTFDQVKESLSVDVDSVLLDNMSVREIIDCVTYIRNASSRV
KIDASGGITLATVKEIAETGVDFISVGMLTHSIVSADIGIDVRTKL
>Mature_286_residues
MLTVISMDYEALEKIITLALNEDLGLGCDITTENTLPCDLVTSFDVNARKETVVCVEPLAKVIFGQSGIEYFLNKQDGDR
VLPGECIIRGCGSAHVLLRIERVFLNFIQRSCAVAAATRRFVDAVSHTKAKIRDTRKTTPGMRCVERYAVKVGGGGSYRN
SLNDRVLLKDNHIAICGGITAAVHKLKKSFEGIYITVECDTFDQVKESLSVDVDSVLLDNMSVREIIDCVTYIRNASSRV
KIDASGGITLATVKEIAETGVDFISVGMLTHSIVSADIGIDVRTKL

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=243, Percent_Identity=32.5102880658436, Blast_Score=124, Evalue=8e-29,
Organism=Escherichia coli, GI1786299, Length=287, Percent_Identity=32.404181184669, Blast_Score=133, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6321162, Length=251, Percent_Identity=30.2788844621514, Blast_Score=105, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31210; Mature: 31210

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTVISMDYEALEKIITLALNEDLGLGCDITTENTLPCDLVTSFDVNARKETVVCVEPLA
CEEEEECCHHHHHHHHHHHCCCCCCCCCEECCCCCCCEEEEECCCCCCCCCEEEEHHHHH
KVIFGQSGIEYFLNKQDGDRVLPGECIIRGCGSAHVLLRIERVFLNFIQRSCAVAAATRR
HHHHCCCCHHHHCCCCCCCEECCHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVDAVSHTKAKIRDTRKTTPGMRCVERYAVKVGGGGSYRNSLNDRVLLKDNHIAICGGIT
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHEEECCCCCCCCCCCCEEEEECCCEEEECHHH
AAVHKLKKSFEGIYITVECDTFDQVKESLSVDVDSVLLDNMSVREIIDCVTYIRNASSRV
HHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCCEE
KIDASGGITLATVKEIAETGVDFISVGMLTHSIVSADIGIDVRTKL
EEECCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEECC
>Mature Secondary Structure
MLTVISMDYEALEKIITLALNEDLGLGCDITTENTLPCDLVTSFDVNARKETVVCVEPLA
CEEEEECCHHHHHHHHHHHCCCCCCCCCEECCCCCCCEEEEECCCCCCCCCEEEEHHHHH
KVIFGQSGIEYFLNKQDGDRVLPGECIIRGCGSAHVLLRIERVFLNFIQRSCAVAAATRR
HHHHCCCCHHHHCCCCCCCEECCHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVDAVSHTKAKIRDTRKTTPGMRCVERYAVKVGGGGSYRNSLNDRVLLKDNHIAICGGIT
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHEEECCCCCCCCCCCCEEEEECCCEEEECHHH
AAVHKLKKSFEGIYITVECDTFDQVKESLSVDVDSVLLDNMSVREIIDCVTYIRNASSRV
HHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCCEE
KIDASGGITLATVKEIAETGVDFISVGMLTHSIVSADIGIDVRTKL
EEECCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]