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The map label for this gene is typA

Identifier: 88608424

GI number: 88608424

Start: 588599

End: 590389

Strand: Reverse

Name: typA

Synonym: NSE_0673

Alternate gene names: 88608424

Gene position: 590389-588599 (Counterclockwise)

Preceding gene: 88608375

Following gene: 88608087

Centisome position: 68.73

GC content: 41.32

Gene sequence:

>1791_bases
ATGAATAACAAGACTCTAAACATAGCCGTAATTGCTCACGTGGATCACGGAAAAACAACGTTAACTAATAATCTGCTTAG
GCAGGCCAATGTTTTGGATGAGGTCGGCATGGACAGAAATCCATTGGAACAGAAACGTGGTATTACAATGTTCTCGAAGG
TTGCTTCTGTATCTTATGGGAATGTGAAAATCAATCTTATAGATACACCAGGACACTCGGATTTTGGAGGTGAGGTAGAG
CGCATCCTGTCAATGGTAGACTCTGTTATGTTACTTGTTGATAGTGCAGAAGGTGTTATGCCGCAAACAAAATTTGTCCT
CTCAAAGGCGCTTAAGGTAGGATTGAGGCCTATAGTGATAATAAACAAAGTTGATCGTCCAGATAGGAGAATTGAAGAGG
TCATCAATGAAATATCTGACCTTTTTCTTGCTCTGGAAGCGAATGATGAGCAACTAGATTTTCCTGTTCTGTATGCCTCC
GGTAGAGATGGTTGGTGTGTCCGTGATCTCAATGATCAGCGAGAAAGCCTCGTACCACTGTTGGAAACAATAATAGGGTA
CACTCCTGTCCGGAAATATGATAGAGAAGCACCTTTTTCAATGCTCGTTACGATGCTCGAAAATGACAATTTCCTTGGAA
GAATTTTAATTGGAAAGATAGAGCAGGGTTCTATTTCAGTGAATGCACACGTAAAGGCAATAAATTTAAGTGGGGAATTG
TTAGAGAATTCCCGCATAACTAAGTTGCAAATTTTTGACGGTATGGTGAAGAAGGTTGTTGAGAATGCAGAAGCAGGCGA
AATAATTGCTATCGCTGGTTTAGCAGATACATCGGTCACTGATACTGTATGCGATCCATCGGTGAATACACCAATTGATG
CTATTCCAATTGATCCCGCTACTATCTCTATCAACATTTCCGTTAATACTTCCCCTTTCACTGGTAAAGAGGGGAATAAA
CTAACTTCTCGTATGATTTTGGCGCGCCTCCTACAAGAGGTGAAGACAAATGTTTCCATAAAAATGGAAGAAAGAGGAGA
AGGACAATTTGAAGTGATGGGACGTGGAGAATTACAGCTCGGTGTTCTGATCGAGAACATGAGAAAAGAGGGCTTTGAAT
TATCTGTTTCACGGCCAAAGGTAGTGATAAAAATCGACGAGAATGGTCAAAAAATGGAGCCGATCGAAGAGCTTACAATC
GATATGGATGAAGAATACGCAGGGATAGTAATGGAGACCCTAAACACAAGGAAAGGGATCATGCAATCTATGGAAAACTA
CCCGGGAGGAAGGGTAAGGTTGGTATATCATATTCCTGCACGTTCGTTGATTGGATATCATGGGAAGTTCTACTCAGATA
CCAGAGGAAGTGGTATACTGAATAAAGTATTTTATGGCTACGCACCATACTCTGGGAAGATAGATAGTAGATCGAATGGT
GTTTTGGTATCGAATGGACAAGGGGAAGCTGTTGCTTATGCACTCTTCAATTTACAGGATAGAGGCATAATGTTTGTAAA
GCCACAGGATCCGGTCTACTGTGGAATGATAGTAGGTGAACACAGCAGGGGTAATGACCTTGATGTAAATGTCCTCAAGG
GTAAGCAGCTCACAAATATTCGTGCTGCTGGTAGTGATGAGGCAGTCAGGCTTAGTCCACCCTTGCTAATGACGTTAGAA
GAAATGATGGCTTATATTAATGATGATGAACTTGTTGAAGTGACACCGTTGTCTTTGAGGTTGCGTAAAAAGGTATTGGA
TTCCAACATGAGGAAAAAACAGAACGTCTAA

Upstream 100 bases:

>100_bases
TTACTGCATTTTTTTATAAAAAAAATAGCATCTTTATATGAAACCTCGATGTTCTCAAGATTATTTGATGCTATAATTCC
GCGAGTAGCCCTGGGTTTAT

Downstream 100 bases:

>100_bases
AAATGAAGTGTACAAAGGGCAAGAAAAACGTACGGACTAAGTATTGTGGAGTGTTCGTAGAAGTCCTACTTATAGCAATA
TTGAGGGGCGCAGCCATGGC

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 596; Mature: 596

Protein sequence:

>596_residues
MNNKTLNIAVIAHVDHGKTTLTNNLLRQANVLDEVGMDRNPLEQKRGITMFSKVASVSYGNVKINLIDTPGHSDFGGEVE
RILSMVDSVMLLVDSAEGVMPQTKFVLSKALKVGLRPIVIINKVDRPDRRIEEVINEISDLFLALEANDEQLDFPVLYAS
GRDGWCVRDLNDQRESLVPLLETIIGYTPVRKYDREAPFSMLVTMLENDNFLGRILIGKIEQGSISVNAHVKAINLSGEL
LENSRITKLQIFDGMVKKVVENAEAGEIIAIAGLADTSVTDTVCDPSVNTPIDAIPIDPATISINISVNTSPFTGKEGNK
LTSRMILARLLQEVKTNVSIKMEERGEGQFEVMGRGELQLGVLIENMRKEGFELSVSRPKVVIKIDENGQKMEPIEELTI
DMDEEYAGIVMETLNTRKGIMQSMENYPGGRVRLVYHIPARSLIGYHGKFYSDTRGSGILNKVFYGYAPYSGKIDSRSNG
VLVSNGQGEAVAYALFNLQDRGIMFVKPQDPVYCGMIVGEHSRGNDLDVNVLKGKQLTNIRAAGSDEAVRLSPPLLMTLE
EMMAYINDDELVEVTPLSLRLRKKVLDSNMRKKQNV

Sequences:

>Translated_596_residues
MNNKTLNIAVIAHVDHGKTTLTNNLLRQANVLDEVGMDRNPLEQKRGITMFSKVASVSYGNVKINLIDTPGHSDFGGEVE
RILSMVDSVMLLVDSAEGVMPQTKFVLSKALKVGLRPIVIINKVDRPDRRIEEVINEISDLFLALEANDEQLDFPVLYAS
GRDGWCVRDLNDQRESLVPLLETIIGYTPVRKYDREAPFSMLVTMLENDNFLGRILIGKIEQGSISVNAHVKAINLSGEL
LENSRITKLQIFDGMVKKVVENAEAGEIIAIAGLADTSVTDTVCDPSVNTPIDAIPIDPATISINISVNTSPFTGKEGNK
LTSRMILARLLQEVKTNVSIKMEERGEGQFEVMGRGELQLGVLIENMRKEGFELSVSRPKVVIKIDENGQKMEPIEELTI
DMDEEYAGIVMETLNTRKGIMQSMENYPGGRVRLVYHIPARSLIGYHGKFYSDTRGSGILNKVFYGYAPYSGKIDSRSNG
VLVSNGQGEAVAYALFNLQDRGIMFVKPQDPVYCGMIVGEHSRGNDLDVNVLKGKQLTNIRAAGSDEAVRLSPPLLMTLE
EMMAYINDDELVEVTPLSLRLRKKVLDSNMRKKQNV
>Mature_596_residues
MNNKTLNIAVIAHVDHGKTTLTNNLLRQANVLDEVGMDRNPLEQKRGITMFSKVASVSYGNVKINLIDTPGHSDFGGEVE
RILSMVDSVMLLVDSAEGVMPQTKFVLSKALKVGLRPIVIINKVDRPDRRIEEVINEISDLFLALEANDEQLDFPVLYAS
GRDGWCVRDLNDQRESLVPLLETIIGYTPVRKYDREAPFSMLVTMLENDNFLGRILIGKIEQGSISVNAHVKAINLSGEL
LENSRITKLQIFDGMVKKVVENAEAGEIIAIAGLADTSVTDTVCDPSVNTPIDAIPIDPATISINISVNTSPFTGKEGNK
LTSRMILARLLQEVKTNVSIKMEERGEGQFEVMGRGELQLGVLIENMRKEGFELSVSRPKVVIKIDENGQKMEPIEELTI
DMDEEYAGIVMETLNTRKGIMQSMENYPGGRVRLVYHIPARSLIGYHGKFYSDTRGSGILNKVFYGYAPYSGKIDSRSNG
VLVSNGQGEAVAYALFNLQDRGIMFVKPQDPVYCGMIVGEHSRGNDLDVNVLKGKQLTNIRAAGSDEAVRLSPPLLMTLE
EMMAYINDDELVEVTPLSLRLRKKVLDSNMRKKQNV

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=487, Percent_Identity=25.6673511293634, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI94966754, Length=130, Percent_Identity=46.1538461538462, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI4503483, Length=142, Percent_Identity=36.6197183098592, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI34147630, Length=274, Percent_Identity=28.4671532846715, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI18390331, Length=153, Percent_Identity=36.6013071895425, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI25306283, Length=161, Percent_Identity=32.2981366459627, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI19923640, Length=161, Percent_Identity=32.2981366459627, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI25306287, Length=161, Percent_Identity=32.2981366459627, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI310132016, Length=108, Percent_Identity=43.5185185185185, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI310110807, Length=108, Percent_Identity=43.5185185185185, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI310123363, Length=108, Percent_Identity=43.5185185185185, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI94966752, Length=75, Percent_Identity=46.6666666666667, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI217272892, Length=140, Percent_Identity=33.5714285714286, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI217272894, Length=140, Percent_Identity=33.5714285714286, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI4503471, Length=299, Percent_Identity=23.4113712374582, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI48994988, Length=603, Percent_Identity=48.7562189054726, Blast_Score=572, Evalue=1e-164,
Organism=Escherichia coli, GI1788922, Length=499, Percent_Identity=25.6513026052104, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789738, Length=147, Percent_Identity=35.3741496598639, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790835, Length=150, Percent_Identity=31.3333333333333, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790412, Length=278, Percent_Identity=25.1798561151079, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789737, Length=278, Percent_Identity=25.1798561151079, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789559, Length=165, Percent_Identity=29.6969696969697, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17557151, Length=226, Percent_Identity=33.1858407079646, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17556745, Length=144, Percent_Identity=38.1944444444444, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71988811, Length=126, Percent_Identity=41.2698412698413, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71988819, Length=126, Percent_Identity=41.2698412698413, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17533571, Length=131, Percent_Identity=39.6946564885496, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17506493, Length=154, Percent_Identity=34.4155844155844, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI25141371, Length=278, Percent_Identity=28.7769784172662, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17552882, Length=187, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17556456, Length=282, Percent_Identity=26.9503546099291, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17506081, Length=292, Percent_Identity=24.6575342465753, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=504, Percent_Identity=25.5952380952381, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6324707, Length=142, Percent_Identity=42.2535211267606, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320593, Length=142, Percent_Identity=42.2535211267606, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324761, Length=276, Percent_Identity=28.9855072463768, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322359, Length=151, Percent_Identity=37.0860927152318, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323098, Length=169, Percent_Identity=36.094674556213, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324166, Length=178, Percent_Identity=34.8314606741573, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324550, Length=139, Percent_Identity=31.6546762589928, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI78706572, Length=523, Percent_Identity=25.8126195028681, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI19921738, Length=278, Percent_Identity=32.3741007194245, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI221458488, Length=163, Percent_Identity=38.0368098159509, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281363316, Length=326, Percent_Identity=26.3803680981595, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17864358, Length=326, Percent_Identity=26.3803680981595, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28574573, Length=135, Percent_Identity=39.2592592592593, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24585709, Length=146, Percent_Identity=35.6164383561644, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24585711, Length=146, Percent_Identity=35.6164383561644, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24585713, Length=146, Percent_Identity=35.6164383561644, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24582462, Length=131, Percent_Identity=38.9312977099237, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21357743, Length=188, Percent_Identity=30.8510638297872, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28572034, Length=143, Percent_Identity=35.6643356643357, Blast_Score=77, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 66045; Mature: 66045

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKTLNIAVIAHVDHGKTTLTNNLLRQANVLDEVGMDRNPLEQKRGITMFSKVASVSYG
CCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHCEEC
NVKINLIDTPGHSDFGGEVERILSMVDSVMLLVDSAEGVMPQTKFVLSKALKVGLRPIVI
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHCCCEEEE
INKVDRPDRRIEEVINEISDLFLALEANDEQLDFPVLYASGRDGWCVRDLNDQRESLVPL
EECCCCCHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEECCCCCEEEECCCHHHHHHHHH
LETIIGYTPVRKYDREAPFSMLVTMLENDNFLGRILIGKIEQGSISVNAHVKAINLSGEL
HHHHHCCCCHHHHCCCCCHHHHHHHHCCCCCEEEEEEEEECCCEEEEEEEEEEEECCHHH
LENSRITKLQIFDGMVKKVVENAEAGEIIAIAGLADTSVTDTVCDPSVNTPIDAIPIDPA
HCCCCCEEEEHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEECCCCE
TISINISVNTSPFTGKEGNKLTSRMILARLLQEVKTNVSIKMEERGEGQFEVMGRGELQL
EEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCEEE
GVLIENMRKEGFELSVSRPKVVIKIDENGQKMEPIEELTIDMDEEYAGIVMETLNTRKGI
HHHHHHHHCCCCEEEECCCEEEEEECCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHH
MQSMENYPGGRVRLVYHIPARSLIGYHGKFYSDTRGSGILNKVFYGYAPYSGKIDSRSNG
HHHHHHCCCCEEEEEEECCCHHHHCCCCCEECCCCCCCCHHHHHCCCCCCCCCCCCCCCC
VLVSNGQGEAVAYALFNLQDRGIMFVKPQDPVYCGMIVGEHSRGNDLDVNVLKGKQLTNI
EEEECCCCCEEEEEEEEECCCCEEEECCCCCEEEEEEEECCCCCCCEEEEEECCCEEEEE
RAAGSDEAVRLSPPLLMTLEEMMAYINDDELVEVTPLSLRLRKKVLDSNMRKKQNV
EECCCCCEEEECCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNKTLNIAVIAHVDHGKTTLTNNLLRQANVLDEVGMDRNPLEQKRGITMFSKVASVSYG
CCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHCEEC
NVKINLIDTPGHSDFGGEVERILSMVDSVMLLVDSAEGVMPQTKFVLSKALKVGLRPIVI
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHCCCEEEE
INKVDRPDRRIEEVINEISDLFLALEANDEQLDFPVLYASGRDGWCVRDLNDQRESLVPL
EECCCCCHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEECCCCCEEEECCCHHHHHHHHH
LETIIGYTPVRKYDREAPFSMLVTMLENDNFLGRILIGKIEQGSISVNAHVKAINLSGEL
HHHHHCCCCHHHHCCCCCHHHHHHHHCCCCCEEEEEEEEECCCEEEEEEEEEEEECCHHH
LENSRITKLQIFDGMVKKVVENAEAGEIIAIAGLADTSVTDTVCDPSVNTPIDAIPIDPA
HCCCCCEEEEHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEECCCCE
TISINISVNTSPFTGKEGNKLTSRMILARLLQEVKTNVSIKMEERGEGQFEVMGRGELQL
EEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCEEE
GVLIENMRKEGFELSVSRPKVVIKIDENGQKMEPIEELTIDMDEEYAGIVMETLNTRKGI
HHHHHHHHCCCCEEEECCCEEEEEECCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHH
MQSMENYPGGRVRLVYHIPARSLIGYHGKFYSDTRGSGILNKVFYGYAPYSGKIDSRSNG
HHHHHHCCCCEEEEEEECCCHHHHCCCCCEECCCCCCCCHHHHHCCCCCCCCCCCCCCCC
VLVSNGQGEAVAYALFNLQDRGIMFVKPQDPVYCGMIVGEHSRGNDLDVNVLKGKQLTNI
EEEECCCCCEEEEEEEEECCCCEEEECCCCCEEEEEEEECCCCCCCEEEEEECCCEEEEE
RAAGSDEAVRLSPPLLMTLEEMMAYINDDELVEVTPLSLRLRKKVLDSNMRKKQNV
EECCCCCEEEECCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]