| Definition | Neorickettsia sennetsu str. Miyayama chromosome, complete genome. |
|---|---|
| Accession | NC_007798 |
| Length | 859,006 |
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The map label for this gene is virB4-2
Identifier: 88608419
GI number: 88608419
Start: 770926
End: 773337
Strand: Reverse
Name: virB4-2
Synonym: NSE_0863
Alternate gene names: 88608419
Gene position: 773337-770926 (Counterclockwise)
Preceding gene: 88608247
Following gene: 88607976
Centisome position: 90.03
GC content: 42.37
Gene sequence:
>2412_bases ATGTTCGATTTTGCCGTTTTTAAGAACTATAAAGCTAAAGTTGCTTCCTCGGAGTATCACGCCAGAAATTTTGTACCCTA TAAGGATCACTTAGATTCCAGTACCATTCTTCTGAAGGATAACTCCATGCTTAAGGTTATAAGGCTGGTCGGTTACCCCT TCGAAACTGCCGATGATGAGGACGTAGACATTCACAAGGCATTAAGAAATCAGCTTTTTAAAAGTGTCTCTTCTGGTCAT TTTGCTCTTAGTTTCCACTTAATCCGCAGAAGAGAAGGAAGTCAGGCTCGTGCTCTCTTTTCTAACAAAATACCCAATTA CTTTGCTGACTATGTCAGAAAGAGATGGCGCCAGAAACATGGGAATAAAAGCTCTTTTGTGAATGAGCTATACATAACAG TCGTGAGGCGTAATGACAAAAAAGTCGAGCTCTTCAACGATCTTTATAGAAAAGTAACTCGTAAGGACACGAAAGAGGGT CGTATTGCCGATTTGAAAATTGCCCACGAAGAATTAGAGGAAATGACAAACAAGCTTTTGGTAAGCTTGAGGAACAATAC GCCCCATCTTCTTGGGTTGAAAAAAGTTGGCAATGTTACATACTCCGAAGTTCTAGCTTTTCTCTCTGGGATTGCCAATT GTGGTGTGGCGCAATCAGATTTTGTTCTTCCTTACGGACCACTTGATGAGGCTCTCTGTGGTTGCAGGATGTATTTTGGA AGGAAATCGATAGAGATAGTTACACCATCCAGAAGTGAGTATGCTGGGATTATAAGTCTGAAGGAATATGGTCAGAATAC TTCAGCTGGAATGCTCGACAATTTTCTGCAAGTCCCATATGAACTTGTTATCACGCAGACATTTCAGTTTGTGCACAGAC AGGTTGCAATCAGTAAGATGCAGGTTCAGCAGAGCCGAATGTTACAAACTCAGGATAAAGCTATTTCGCAGGTTGCTGAA ATAACTAGAGCTCTCGATGATGCTATGAGCGGTCGAATTGCGTTTGGGCTGCACCATTTGACCATACTCTGTCGTGAAAA AACTGAAAAAGGACTTGAGAATGCACTGTCGCTAGTCGAATCTGAGCTAACAAATGCTGGTGTGTATGCTGTCCGCGAAA AGATCAATCTTGAACCTGCTTTTTGGGCCCAGTTACCCGGAAATTTTGATTATATAGTTAGAAAAGCTACGATAAGTACA CTAAATCTGGCGGGCTTTGCATCACAGCACAATTACCCATTTGGGAAGATGGAGGGTAATCACTGGGGGGATGCAATCAC TGTTTTTGATACTACTTCGGGTACGCCATTTTACTTCAATTTCCACTGTAAAGATGTTGGGCACACGCTAATAATTGGCC CGACTGGGGCAGGTAAAACTGTCTTACTCAACTTTTTATGTGCACAGAGTATGAAGTTCAGGCCACGGATGTTTTTTTTT GATAAGGATAGGGGTGCTGAGATTTTTATTCGTGCGCTAGGTGGTATTTACACAGTGATAGAACCAAGGAGCAAGAGTTA CTTTAACCCTCTTCAGCTTGATGATACACCGGAGAATAGAACCTTCTTGACAGAGTGGTTGAAGATTCTAGCCTCTGTCA ATGGAGATAAGTTCACTGCGGCGGATATTGCGACACTGAATGATGCGGTGGCAGGTAATTTTAAGCTCGACAAAGCAGAT AGAACTCTGAGCAATCTTTCTGCGTTTTTTGGGTTGGAAGGTGACAATAGTTTGGCTACTCGCCTATTAATGTGGTATGG GAATGGTTCGCATGCAACGCTTTTTGATAATCAGGAAGATTGTCTCGATTTTTCAAAGGCTAGTGTATTTGGTTTTGAAA TGGGACACCTCCTTAGAGACAGTGCGGCGCTTGCGCCTGTTTTGCAATATTTGTTCCATAGAATAAGCATCTCGTTGGAT GGGTCCCCTTCCATGATTGTGTTAGATGAGGCTTGGGCCCTTATAGATAATCCAGTTTTTGCGCCCACAATTAAGGATTG GCTCAAGGTTCTAAGGAAGCTAAATACGTTTGTTATATTCGCTACCCAGAGTGTAGAGGATGCAAGTAAGAGTGCGATAA GTGATACTTTAGTTCAGCAGACAGCGACGCAGATTTTTTTGCCAAACCTTAAAGCAACAGATGTTTACAGATCCGTGTTT ATGCTTAGCGAGCGGGAGTACATGCTTATCAAACACACAGATCCAGCTACACGGTTTTTCTTGATAAAACAGGCTATGAG TGCTGTTATAGCGCGGATCAATCTCAGTGGAATGGAAGATATTATCTCAGTCTTATCTGGACGCGCGGATACGGTACTAC TCCTGCACCGGATTATGGAAGAGTATGGTGAAGAACCAGTAAAGTGGCTTCCAGTTTTTTATGAAAAAGTGAAGGAGTTG GATCAGCAATGA
Upstream 100 bases:
>100_bases AGCCGCTCTTTTTGGAGCTTTTTCTAGTAAGGAATCAGAAATGCATGAGATGTAAGAATCGTGCTTACCATGATGCTAAC TCTTACGATGTGTTCTAGGG
Downstream 100 bases:
>100_bases AGCTTTTTCTCAGAGGAATACTTTTACTCTTAGCACTCAACCTTTTAGACAATAATATACTGCTTCTTAAGAGCGGGTTC TTCTTTTCTCACGCGTATGC
Product: type IV secretion system ATPase VirB4
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 803; Mature: 803
Protein sequence:
>803_residues MFDFAVFKNYKAKVASSEYHARNFVPYKDHLDSSTILLKDNSMLKVIRLVGYPFETADDEDVDIHKALRNQLFKSVSSGH FALSFHLIRRREGSQARALFSNKIPNYFADYVRKRWRQKHGNKSSFVNELYITVVRRNDKKVELFNDLYRKVTRKDTKEG RIADLKIAHEELEEMTNKLLVSLRNNTPHLLGLKKVGNVTYSEVLAFLSGIANCGVAQSDFVLPYGPLDEALCGCRMYFG RKSIEIVTPSRSEYAGIISLKEYGQNTSAGMLDNFLQVPYELVITQTFQFVHRQVAISKMQVQQSRMLQTQDKAISQVAE ITRALDDAMSGRIAFGLHHLTILCREKTEKGLENALSLVESELTNAGVYAVREKINLEPAFWAQLPGNFDYIVRKATIST LNLAGFASQHNYPFGKMEGNHWGDAITVFDTTSGTPFYFNFHCKDVGHTLIIGPTGAGKTVLLNFLCAQSMKFRPRMFFF DKDRGAEIFIRALGGIYTVIEPRSKSYFNPLQLDDTPENRTFLTEWLKILASVNGDKFTAADIATLNDAVAGNFKLDKAD RTLSNLSAFFGLEGDNSLATRLLMWYGNGSHATLFDNQEDCLDFSKASVFGFEMGHLLRDSAALAPVLQYLFHRISISLD GSPSMIVLDEAWALIDNPVFAPTIKDWLKVLRKLNTFVIFATQSVEDASKSAISDTLVQQTATQIFLPNLKATDVYRSVF MLSEREYMLIKHTDPATRFFLIKQAMSAVIARINLSGMEDIISVLSGRADTVLLLHRIMEEYGEEPVKWLPVFYEKVKEL DQQ
Sequences:
>Translated_803_residues MFDFAVFKNYKAKVASSEYHARNFVPYKDHLDSSTILLKDNSMLKVIRLVGYPFETADDEDVDIHKALRNQLFKSVSSGH FALSFHLIRRREGSQARALFSNKIPNYFADYVRKRWRQKHGNKSSFVNELYITVVRRNDKKVELFNDLYRKVTRKDTKEG RIADLKIAHEELEEMTNKLLVSLRNNTPHLLGLKKVGNVTYSEVLAFLSGIANCGVAQSDFVLPYGPLDEALCGCRMYFG RKSIEIVTPSRSEYAGIISLKEYGQNTSAGMLDNFLQVPYELVITQTFQFVHRQVAISKMQVQQSRMLQTQDKAISQVAE ITRALDDAMSGRIAFGLHHLTILCREKTEKGLENALSLVESELTNAGVYAVREKINLEPAFWAQLPGNFDYIVRKATIST LNLAGFASQHNYPFGKMEGNHWGDAITVFDTTSGTPFYFNFHCKDVGHTLIIGPTGAGKTVLLNFLCAQSMKFRPRMFFF DKDRGAEIFIRALGGIYTVIEPRSKSYFNPLQLDDTPENRTFLTEWLKILASVNGDKFTAADIATLNDAVAGNFKLDKAD RTLSNLSAFFGLEGDNSLATRLLMWYGNGSHATLFDNQEDCLDFSKASVFGFEMGHLLRDSAALAPVLQYLFHRISISLD GSPSMIVLDEAWALIDNPVFAPTIKDWLKVLRKLNTFVIFATQSVEDASKSAISDTLVQQTATQIFLPNLKATDVYRSVF MLSEREYMLIKHTDPATRFFLIKQAMSAVIARINLSGMEDIISVLSGRADTVLLLHRIMEEYGEEPVKWLPVFYEKVKEL DQQ >Mature_803_residues MFDFAVFKNYKAKVASSEYHARNFVPYKDHLDSSTILLKDNSMLKVIRLVGYPFETADDEDVDIHKALRNQLFKSVSSGH FALSFHLIRRREGSQARALFSNKIPNYFADYVRKRWRQKHGNKSSFVNELYITVVRRNDKKVELFNDLYRKVTRKDTKEG RIADLKIAHEELEEMTNKLLVSLRNNTPHLLGLKKVGNVTYSEVLAFLSGIANCGVAQSDFVLPYGPLDEALCGCRMYFG RKSIEIVTPSRSEYAGIISLKEYGQNTSAGMLDNFLQVPYELVITQTFQFVHRQVAISKMQVQQSRMLQTQDKAISQVAE ITRALDDAMSGRIAFGLHHLTILCREKTEKGLENALSLVESELTNAGVYAVREKINLEPAFWAQLPGNFDYIVRKATIST LNLAGFASQHNYPFGKMEGNHWGDAITVFDTTSGTPFYFNFHCKDVGHTLIIGPTGAGKTVLLNFLCAQSMKFRPRMFFF DKDRGAEIFIRALGGIYTVIEPRSKSYFNPLQLDDTPENRTFLTEWLKILASVNGDKFTAADIATLNDAVAGNFKLDKAD RTLSNLSAFFGLEGDNSLATRLLMWYGNGSHATLFDNQEDCLDFSKASVFGFEMGHLLRDSAALAPVLQYLFHRISISLD GSPSMIVLDEAWALIDNPVFAPTIKDWLKVLRKLNTFVIFATQSVEDASKSAISDTLVQQTATQIFLPNLKATDVYRSVF MLSEREYMLIKHTDPATRFFLIKQAMSAVIARINLSGMEDIISVLSGRADTVLLLHRIMEEYGEEPVKWLPVFYEKVKEL DQQ
Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-
COG id: COG3451
COG function: function code U; Type IV secretory pathway, VirB4 components
Gene ontology:
Cell location: Cell inner membrane (Potential) [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the trbE/virB4 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR004346 - InterPro: IPR018145 [H]
Pfam domain/function: PF03135 CagE_TrbE_VirB [H]
EC number: NA
Molecular weight: Translated: 90848; Mature: 90848
Theoretical pI: Translated: 7.90; Mature: 7.90
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MFDFAVFKNYKAKVASSEYHARNFVPYKDHLDSSTILLKDNSMLKVIRLVGYPFETADDE CCCHHHHHCCHHHHCCCCHHHCCCCCHHHCCCCCEEEEECCCHHHHHHHHCCCCCCCCCC DVDIHKALRNQLFKSVSSGHFALSFHLIRRREGSQARALFSNKIPNYFADYVRKRWRQKH CCHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHC GNKSSFVNELYITVVRRNDKKVELFNDLYRKVTRKDTKEGRIADLKIAHEELEEMTNKLL CCHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHH VSLRNNTPHLLGLKKVGNVTYSEVLAFLSGIANCGVAQSDFVLPYGPLDEALCGCRMYFG HHHCCCCCCEEEHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHC RKSIEIVTPSRSEYAGIISLKEYGQNTSAGMLDNFLQVPYELVITQTFQFVHRQVAISKM CCEEEEECCCCCCHHEEEEHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH QVQQSRMLQTQDKAISQVAEITRALDDAMSGRIAFGLHHLTILCREKTEKGLENALSLVE HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH SELTNAGVYAVREKINLEPAFWAQLPGNFDYIVRKATISTLNLAGFASQHNYPFGKMEGN HHHHCCCHHHHHHHCCCCCHHHHCCCCCHHHEEEEHHHHHEEHHHCCCCCCCCCCCCCCC HWGDAITVFDTTSGTPFYFNFHCKDVGHTLIIGPTGAGKTVLLNFLCAQSMKFRPRMFFF CCCCEEEEEECCCCCEEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEE DKDRGAEIFIRALGGIYTVIEPRSKSYFNPLQLDDTPENRTFLTEWLKILASVNGDKFTA ECCCCHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEH ADIATLNDAVAGNFKLDKADRTLSNLSAFFGLEGDNSLATRLLMWYGNGSHATLFDNQED HHHHHHHHHHCCCEEECHHHHHHHHHHHHHCCCCCCHHHEEEEEEECCCCEEEEECCHHH CLDFSKASVFGFEMGHLLRDSAALAPVLQYLFHRISISLDGSPSMIVLDEAWALIDNPVF HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCHHHHCCCCC APTIKDWLKVLRKLNTFVIFATQSVEDASKSAISDTLVQQTATQIFLPNLKATDVYRSVF CCCHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH MLSEREYMLIKHTDPATRFFLIKQAMSAVIARINLSGMEDIISVLSGRADTVLLLHRIME HHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHH EYGEEPVKWLPVFYEKVKELDQQ HHCCCCHHHHHHHHHHHHHHCCC >Mature Secondary Structure MFDFAVFKNYKAKVASSEYHARNFVPYKDHLDSSTILLKDNSMLKVIRLVGYPFETADDE CCCHHHHHCCHHHHCCCCHHHCCCCCHHHCCCCCEEEEECCCHHHHHHHHCCCCCCCCCC DVDIHKALRNQLFKSVSSGHFALSFHLIRRREGSQARALFSNKIPNYFADYVRKRWRQKH CCHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHC GNKSSFVNELYITVVRRNDKKVELFNDLYRKVTRKDTKEGRIADLKIAHEELEEMTNKLL CCHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHH VSLRNNTPHLLGLKKVGNVTYSEVLAFLSGIANCGVAQSDFVLPYGPLDEALCGCRMYFG HHHCCCCCCEEEHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHC RKSIEIVTPSRSEYAGIISLKEYGQNTSAGMLDNFLQVPYELVITQTFQFVHRQVAISKM CCEEEEECCCCCCHHEEEEHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH QVQQSRMLQTQDKAISQVAEITRALDDAMSGRIAFGLHHLTILCREKTEKGLENALSLVE HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH SELTNAGVYAVREKINLEPAFWAQLPGNFDYIVRKATISTLNLAGFASQHNYPFGKMEGN HHHHCCCHHHHHHHCCCCCHHHHCCCCCHHHEEEEHHHHHEEHHHCCCCCCCCCCCCCCC HWGDAITVFDTTSGTPFYFNFHCKDVGHTLIIGPTGAGKTVLLNFLCAQSMKFRPRMFFF CCCCEEEEEECCCCCEEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEE DKDRGAEIFIRALGGIYTVIEPRSKSYFNPLQLDDTPENRTFLTEWLKILASVNGDKFTA ECCCCHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEH ADIATLNDAVAGNFKLDKADRTLSNLSAFFGLEGDNSLATRLLMWYGNGSHATLFDNQED HHHHHHHHHHCCCEEECHHHHHHHHHHHHHCCCCCCHHHEEEEEEECCCCEEEEECCHHH CLDFSKASVFGFEMGHLLRDSAALAPVLQYLFHRISISLDGSPSMIVLDEAWALIDNPVF HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCHHHHCCCCC APTIKDWLKVLRKLNTFVIFATQSVEDASKSAISDTLVQQTATQIFLPNLKATDVYRSVF CCCHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH MLSEREYMLIKHTDPATRFFLIKQAMSAVIARINLSGMEDIISVLSGRADTVLLLHRIME HHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHH EYGEEPVKWLPVFYEKVKELDQQ HHCCCCHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10749166; 10882236; 7494028 [H]