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The map label for this gene is mutL

Identifier: 88608179

GI number: 88608179

Start: 532652

End: 534610

Strand: Direct

Name: mutL

Synonym: NSE_0609

Alternate gene names: 88608179

Gene position: 532652-534610 (Clockwise)

Preceding gene: 88608047

Following gene: 88608683

Centisome position: 62.01

GC content: 40.38

Gene sequence:

>1959_bases
GTGAAGATACATATACTTCCAATAGAGATAATAAATAAGATCGCTGCGGGTGAAATCCTTGAGAAGCCTGCCAATGCTGT
TAAGGAACTCGTTGAAAATGCTATAGATGCAGGCTCGACCAGCATCAAAGTCGAGCTGGAGGAGGTAGGCAGAAATCTTA
TTCGTGTCACTGATAATGGCGTAGGAATTTCAAGAGAGGACTTACCTTTAGCAATAGAGAAACATGCAACATCAAAACTG
AATACAAAGGATCTTTACGATATCAGTTACCTAGGTTTTCGGGGAGAAGCCTTACATTCAATTGCTATCACTTCCGAAAT
GAAGATCGCCTCCTGTTTCAATGGAGAGGGATACGTAATTGATGCTCAGACGAAAGAAGTAAAGCCTCACCATATAAAGT
GCGGTACGCTAGTTGAAGTAAGGAAACTTTTTCACAACATACCAAATAAACTCCGTTTCTTGAGAAGCGAAAAGACAGAA
CTCTCATCCATAATTGAACTCTTAAATAGGCTGGCTCTAGTAAACCCTAATATTGCGTTTGAACTCATCTCAAATGGTAG
GCAGGTATTCGATTACCAGACTGCAACCCAACTAAAACGGATGGAACAGCTGAAAGTCTTGGGCAAGGAATTTGTCGAGA
ATATGATACATGTGAAGCACACAAACGACGGTATCTTCGGTGAACTATTTTTAGGGCTACCCACTCTCACTCAAAAGAGG
AACAACTGTCTTATTTTCGTAAACGGGAGACCAGTAAAAGACAGCGTTATTTCGTCGGTAATGAGGCATGCATATAATGA
CTACATCCCCAAAAATACATATCCGATTGCTGTTATTTTCATTAGGGTTCATAACAACGAAGTGGATGTCAATATTCATC
CCAATAAGTCTGAAGTAAAGTTCCGTGACCCTCAAGTAATTAGAAGATTTCTCCTTTCAGTGAGCAGTAGGAGCCTCTTA
CAATGTGGCCGTAGTACCTCTACAACTGTTGCAGATCGTGCGGTTGAACAATTCAATCAATTACTCAAAAAGCAAACTGC
CTTTCGCAAGGAAACCGTTTCAAAAACAACAGAAAGTGGTTTTTTTCAGTCACCTAAAGCAAAAAAAGCGATAGATCAAT
CGCAAGAATATGCGAAACAATTTGAGGGCAAAAGAAATCTGGATTTTGATCAGATGCAAAACAACAACGGCCCGTTTCAC
TTTTCAACAGACCAATCTGAAGAAGCACTCCCCTTGATGAGTCACAAAAAAACTTCTGAGGATTACTCAAACAAACTTCC
ACTAGAAAAGCAACAGAGCCCTTCAATTTTTCTACATGACAATCGAGACACCTCGTTCTTGCAGCAACAACTGAGGAAGA
TAAACCATTGCGAACACCTGCAAAATGAGAAACACTTCGAGACTTTTGGAAAGTTCAAGTGCCAGGTACACGGAACTTTT
ATAATCACAGAAACGGAGAACGAAATGATTATAATAGATCAGCACGCAGCACACGAACGTATACTGTATGAACAGATGAA
AAAGAGCATTACTTCACCTGGACAAAACTTATTAACAGCAGAGTTCGTACCACTTAGCGAAAAAGCTGTCGAGATACTTT
CTTTCAACGTAGAAAAGCTCAAGGAAATCGGTTTGGTAGTAGAGCGTGTTAGTCATTGTGCCGTCATGGTGAATTCGCTA
CCAGAAGCATTTAAAAATGTACCTACGAACGAACTAATAGAAGACATAGCTTCCCTGCTGGAAGAAGAAATCGAACCAAA
AACACTCCTCGAAAGAATACACGCAAATATAGCATGCAAAAGAGCTATAAAGGCAAACCATAATCTCACAAGAGAAGAGA
TAGAGGAGCTATTAACACTGATGGAGGATATTCCACACACAGGTCAGTGTAATCACGGCCGCCCCACTCACATTCGTCTA
CCTAGAAAAGAGATTGAAAAGTTATTCCTCCGTTCTTGA

Upstream 100 bases:

>100_bases
AGCAGTAGAAAAACTATTTCTGTACTAGTATGAATAATAACGTTTAAAATAAGGGTACGGTTATTCCCTCGAAATTATAA
AACGCACTTTCATAAATGCA

Downstream 100 bases:

>100_bases
ACACCCAAAAAAACTTAGCAGACGATCATCTGCTATAGTGACGCAAGCGCAGAAGAATCCGAAATTATACTTAACCAAAA
TTGGATGTGTACTATAAGAT

Product: MutL/HexB family DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 652; Mature: 652

Protein sequence:

>652_residues
MKIHILPIEIINKIAAGEILEKPANAVKELVENAIDAGSTSIKVELEEVGRNLIRVTDNGVGISREDLPLAIEKHATSKL
NTKDLYDISYLGFRGEALHSIAITSEMKIASCFNGEGYVIDAQTKEVKPHHIKCGTLVEVRKLFHNIPNKLRFLRSEKTE
LSSIIELLNRLALVNPNIAFELISNGRQVFDYQTATQLKRMEQLKVLGKEFVENMIHVKHTNDGIFGELFLGLPTLTQKR
NNCLIFVNGRPVKDSVISSVMRHAYNDYIPKNTYPIAVIFIRVHNNEVDVNIHPNKSEVKFRDPQVIRRFLLSVSSRSLL
QCGRSTSTTVADRAVEQFNQLLKKQTAFRKETVSKTTESGFFQSPKAKKAIDQSQEYAKQFEGKRNLDFDQMQNNNGPFH
FSTDQSEEALPLMSHKKTSEDYSNKLPLEKQQSPSIFLHDNRDTSFLQQQLRKINHCEHLQNEKHFETFGKFKCQVHGTF
IITETENEMIIIDQHAAHERILYEQMKKSITSPGQNLLTAEFVPLSEKAVEILSFNVEKLKEIGLVVERVSHCAVMVNSL
PEAFKNVPTNELIEDIASLLEEEIEPKTLLERIHANIACKRAIKANHNLTREEIEELLTLMEDIPHTGQCNHGRPTHIRL
PRKEIEKLFLRS

Sequences:

>Translated_652_residues
MKIHILPIEIINKIAAGEILEKPANAVKELVENAIDAGSTSIKVELEEVGRNLIRVTDNGVGISREDLPLAIEKHATSKL
NTKDLYDISYLGFRGEALHSIAITSEMKIASCFNGEGYVIDAQTKEVKPHHIKCGTLVEVRKLFHNIPNKLRFLRSEKTE
LSSIIELLNRLALVNPNIAFELISNGRQVFDYQTATQLKRMEQLKVLGKEFVENMIHVKHTNDGIFGELFLGLPTLTQKR
NNCLIFVNGRPVKDSVISSVMRHAYNDYIPKNTYPIAVIFIRVHNNEVDVNIHPNKSEVKFRDPQVIRRFLLSVSSRSLL
QCGRSTSTTVADRAVEQFNQLLKKQTAFRKETVSKTTESGFFQSPKAKKAIDQSQEYAKQFEGKRNLDFDQMQNNNGPFH
FSTDQSEEALPLMSHKKTSEDYSNKLPLEKQQSPSIFLHDNRDTSFLQQQLRKINHCEHLQNEKHFETFGKFKCQVHGTF
IITETENEMIIIDQHAAHERILYEQMKKSITSPGQNLLTAEFVPLSEKAVEILSFNVEKLKEIGLVVERVSHCAVMVNSL
PEAFKNVPTNELIEDIASLLEEEIEPKTLLERIHANIACKRAIKANHNLTREEIEELLTLMEDIPHTGQCNHGRPTHIRL
PRKEIEKLFLRS
>Mature_652_residues
MKIHILPIEIINKIAAGEILEKPANAVKELVENAIDAGSTSIKVELEEVGRNLIRVTDNGVGISREDLPLAIEKHATSKL
NTKDLYDISYLGFRGEALHSIAITSEMKIASCFNGEGYVIDAQTKEVKPHHIKCGTLVEVRKLFHNIPNKLRFLRSEKTE
LSSIIELLNRLALVNPNIAFELISNGRQVFDYQTATQLKRMEQLKVLGKEFVENMIHVKHTNDGIFGELFLGLPTLTQKR
NNCLIFVNGRPVKDSVISSVMRHAYNDYIPKNTYPIAVIFIRVHNNEVDVNIHPNKSEVKFRDPQVIRRFLLSVSSRSLL
QCGRSTSTTVADRAVEQFNQLLKKQTAFRKETVSKTTESGFFQSPKAKKAIDQSQEYAKQFEGKRNLDFDQMQNNNGPFH
FSTDQSEEALPLMSHKKTSEDYSNKLPLEKQQSPSIFLHDNRDTSFLQQQLRKINHCEHLQNEKHFETFGKFKCQVHGTF
IITETENEMIIIDQHAAHERILYEQMKKSITSPGQNLLTAEFVPLSEKAVEILSFNVEKLKEIGLVVERVSHCAVMVNSL
PEAFKNVPTNELIEDIASLLEEEIEPKTLLERIHANIACKRAIKANHNLTREEIEELLTLMEDIPHTGQCNHGRPTHIRL
PRKEIEKLFLRS

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=302, Percent_Identity=33.4437086092715, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI4505911, Length=325, Percent_Identity=31.0769230769231, Blast_Score=143, Evalue=6e-34,
Organism=Homo sapiens, GI189458898, Length=328, Percent_Identity=32.0121951219512, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI189458896, Length=315, Percent_Identity=31.1111111111111, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI310128478, Length=353, Percent_Identity=27.4787535410765, Blast_Score=117, Evalue=5e-26,
Organism=Homo sapiens, GI4505913, Length=353, Percent_Identity=27.4787535410765, Blast_Score=117, Evalue=5e-26,
Organism=Homo sapiens, GI310128480, Length=315, Percent_Identity=25.3968253968254, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI263191589, Length=215, Percent_Identity=25.5813953488372, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI91992160, Length=344, Percent_Identity=25.5813953488372, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI91992162, Length=344, Percent_Identity=25.5813953488372, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790612, Length=324, Percent_Identity=36.1111111111111, Blast_Score=206, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI71991825, Length=321, Percent_Identity=31.4641744548287, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17562796, Length=370, Percent_Identity=25.9459459459459, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323819, Length=315, Percent_Identity=33.968253968254, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324247, Length=328, Percent_Identity=24.390243902439, Blast_Score=91, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6323063, Length=351, Percent_Identity=27.6353276353276, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6325093, Length=393, Percent_Identity=23.4096692111959, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17136968, Length=303, Percent_Identity=33.003300330033, Blast_Score=175, Evalue=8e-44,
Organism=Drosophila melanogaster, GI17136970, Length=353, Percent_Identity=25.2124645892351, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_NEOSM (Q2GDF7)

Other databases:

- EMBL:   CP000237
- RefSeq:   YP_506489.1
- ProteinModelPortal:   Q2GDF7
- SMR:   Q2GDF7
- STRING:   Q2GDF7
- GeneID:   3931746
- GenomeReviews:   CP000237_GR
- KEGG:   nse:NSE_0609
- TIGR:   NSE_0609
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- PhylomeDB:   Q2GDF7
- ProtClustDB:   CLSK2527761
- BioCyc:   NSEN222891:NSE_0609-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 74401; Mature: 74401

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHILPIEIINKIAAGEILEKPANAVKELVENAIDAGSTSIKVELEEVGRNLIRVTDNG
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCCCEEEEECCC
VGISREDLPLAIEKHATSKLNTKDLYDISYLGFRGEALHSIAITSEMKIASCFNGEGYVI
CCCCCCCCCCHHHHHCCCCCCCCCCCEEHEECCCCCHHHHEEEECCCEEEEEECCCCEEE
DAQTKEVKPHHIKCGTLVEVRKLFHNIPNKLRFLRSEKTELSSIIELLNRLALVNPNIAF
ECCCCCCCCCEECCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
ELISNGRQVFDYQTATQLKRMEQLKVLGKEFVENMIHVKHTNDGIFGELFLGLPTLTQKR
HHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHCCCHHHCCC
NNCLIFVNGRPVKDSVISSVMRHAYNDYIPKNTYPIAVIFIRVHNNEVDVNIHPNKSEVK
CCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCEEEEEECCCCCCCC
FRDPQVIRRFLLSVSSRSLLQCGRSTSTTVADRAVEQFNQLLKKQTAFRKETVSKTTESG
CCCHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FFQSPKAKKAIDQSQEYAKQFEGKRNLDFDQMQNNNGPFHFSTDQSEEALPLMSHKKTSE
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCEEECCCCCCCCCCHHHCCCCCH
DYSNKLPLEKQQSPSIFLHDNRDTSFLQQQLRKINHCEHLQNEKHFETFGKFKCQVHGTF
HHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCEEEEEEEEE
IITETENEMIIIDQHAAHERILYEQMKKSITSPGQNLLTAEFVPLSEKAVEILSFNVEKL
EEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHCCHHHH
KEIGLVVERVSHCAVMVNSLPEAFKNVPTNELIEDIASLLEEEIEPKTLLERIHANIACK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RAIKANHNLTREEIEELLTLMEDIPHTGQCNHGRPTHIRLPRKEIEKLFLRS
HHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHCCC
>Mature Secondary Structure
MKIHILPIEIINKIAAGEILEKPANAVKELVENAIDAGSTSIKVELEEVGRNLIRVTDNG
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCCCEEEEECCC
VGISREDLPLAIEKHATSKLNTKDLYDISYLGFRGEALHSIAITSEMKIASCFNGEGYVI
CCCCCCCCCCHHHHHCCCCCCCCCCCEEHEECCCCCHHHHEEEECCCEEEEEECCCCEEE
DAQTKEVKPHHIKCGTLVEVRKLFHNIPNKLRFLRSEKTELSSIIELLNRLALVNPNIAF
ECCCCCCCCCEECCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
ELISNGRQVFDYQTATQLKRMEQLKVLGKEFVENMIHVKHTNDGIFGELFLGLPTLTQKR
HHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHCCCHHHCCC
NNCLIFVNGRPVKDSVISSVMRHAYNDYIPKNTYPIAVIFIRVHNNEVDVNIHPNKSEVK
CCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCEEEEEECCCCCCCC
FRDPQVIRRFLLSVSSRSLLQCGRSTSTTVADRAVEQFNQLLKKQTAFRKETVSKTTESG
CCCHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FFQSPKAKKAIDQSQEYAKQFEGKRNLDFDQMQNNNGPFHFSTDQSEEALPLMSHKKTSE
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCEEECCCCCCCCCCHHHCCCCCH
DYSNKLPLEKQQSPSIFLHDNRDTSFLQQQLRKINHCEHLQNEKHFETFGKFKCQVHGTF
HHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCEEEEEEEEE
IITETENEMIIIDQHAAHERILYEQMKKSITSPGQNLLTAEFVPLSEKAVEILSFNVEKL
EEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHCCHHHH
KEIGLVVERVSHCAVMVNSLPEAFKNVPTNELIEDIASLLEEEIEPKTLLERIHANIACK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RAIKANHNLTREEIEELLTLMEDIPHTGQCNHGRPTHIRLPRKEIEKLFLRS
HHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA