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The map label for this gene is moeB

Identifier: 88608145

GI number: 88608145

Start: 691163

End: 691900

Strand: Reverse

Name: moeB

Synonym: NSE_0777

Alternate gene names: 88608145

Gene position: 691900-691163 (Counterclockwise)

Preceding gene: 88607978

Following gene: 88608718

Centisome position: 80.55

GC content: 41.87

Gene sequence:

>738_bases
GTGAATCGTAGATACTTACGACACTTTGGTCTTTTCGGGAAAGAGGGTCAGTATACACTTCTTGACGCGAAAGTTGCAGT
CATTGGGTCAGGAGGCCTTGGATGTTCAGTCTTGTACAATTTTGCTGCTGCTGGGTTGGGTGAAATTGTTATTGTGGATT
TCGATAGGGTCTCTGAGTCTGATCTGAATAGGCAGTTTCTCTTCGAGAATTCTTCGGTGCAGCAGCTTAAAGTATATGCG
GCTAAAAGGAGGCTTAATGCATTTAATCCGGATTGTAAGATCTTCTGCTATCCAATGCGAATACAGGACTGCCCGGAAGT
GATTGAAGGATGTGAAGTAGTTGTTGATTGTACGGACAATTTCAAGACTAGGTTCTATCTCAATGAGTTGTGCTTTTTTC
AAAAAAAAGCTTTGATTTCTGCTGGTGTTACAGGCTATTCCGGGTATGTTATTGTGCTCAAACCTTTTATCTCTGAGGAC
TCACCCTGTTACAGGTGTTTCTGTCCAGGAGAGCCGGAAGCTTGTTTTAAAGGTTCATGTGAGGACGGTGGAGTGATTGG
TGCTGCAGTCAATACAATAGGAAGCATTCAGGCAATGAAAGTAATTCAGGAAATTTTGCATATTAACCCAGAAAAAGCAG
GTAAACTTATTTTCTGTGACATTCTTAATAATCGTTTCAGAAGTGCAGTTATCATGCGGGATCCGTATTGTAGTGTATGT
GGGCAAAGGTGTGTCTGA

Upstream 100 bases:

>100_bases
GTCCTGTTCCGCGGTTTCTTCTTGGATCAATGCGAGGAGCAATTGATTTCCTGGTGTTCGGAGTGAGAGAATGATGCACT
CATAATTGGAGGACTATTTC

Downstream 100 bases:

>100_bases
GCGGTAATGCAGCTAAATGGTAGTACTAACTGCTATGGTTTTCTGTGACAAAGCAAACGACAGCTCTGCCAGATTTTTAT
GCACTCAGATGTATTCAAAT

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MNRRYLRHFGLFGKEGQYTLLDAKVAVIGSGGLGCSVLYNFAAAGLGEIVIVDFDRVSESDLNRQFLFENSSVQQLKVYA
AKRRLNAFNPDCKIFCYPMRIQDCPEVIEGCEVVVDCTDNFKTRFYLNELCFFQKKALISAGVTGYSGYVIVLKPFISED
SPCYRCFCPGEPEACFKGSCEDGGVIGAAVNTIGSIQAMKVIQEILHINPEKAGKLIFCDILNNRFRSAVIMRDPYCSVC
GQRCV

Sequences:

>Translated_245_residues
MNRRYLRHFGLFGKEGQYTLLDAKVAVIGSGGLGCSVLYNFAAAGLGEIVIVDFDRVSESDLNRQFLFENSSVQQLKVYA
AKRRLNAFNPDCKIFCYPMRIQDCPEVIEGCEVVVDCTDNFKTRFYLNELCFFQKKALISAGVTGYSGYVIVLKPFISED
SPCYRCFCPGEPEACFKGSCEDGGVIGAAVNTIGSIQAMKVIQEILHINPEKAGKLIFCDILNNRFRSAVIMRDPYCSVC
GQRCV
>Mature_245_residues
MNRRYLRHFGLFGKEGQYTLLDAKVAVIGSGGLGCSVLYNFAAAGLGEIVIVDFDRVSESDLNRQFLFENSSVQQLKVYA
AKRRLNAFNPDCKIFCYPMRIQDCPEVIEGCEVVVDCTDNFKTRFYLNELCFFQKKALISAGVTGYSGYVIVLKPFISED
SPCYRCFCPGEPEACFKGSCEDGGVIGAAVNTIGSIQAMKVIQEILHINPEKAGKLIFCDILNNRFRSAVIMRDPYCSVC
GQRCV

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=245, Percent_Identity=33.0612244897959, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI23510338, Length=167, Percent_Identity=32.9341317365269, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI23510340, Length=167, Percent_Identity=32.9341317365269, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI4885649, Length=158, Percent_Identity=32.9113924050633, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI150417996, Length=169, Percent_Identity=29.585798816568, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI38045948, Length=167, Percent_Identity=29.940119760479, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI38045944, Length=152, Percent_Identity=31.5789473684211, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI38045942, Length=152, Percent_Identity=31.5789473684211, Blast_Score=71, Evalue=7e-13,
Organism=Escherichia coli, GI1787048, Length=244, Percent_Identity=36.0655737704918, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI87082356, Length=244, Percent_Identity=34.8360655737705, Blast_Score=129, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17540406, Length=243, Percent_Identity=33.3333333333333, Blast_Score=141, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI193203301, Length=156, Percent_Identity=31.4102564102564, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI86565433, Length=167, Percent_Identity=31.7365269461078, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI86565431, Length=167, Percent_Identity=31.7365269461078, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71984476, Length=157, Percent_Identity=29.9363057324841, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321903, Length=198, Percent_Identity=35.8585858585859, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322639, Length=178, Percent_Identity=32.5842696629214, Blast_Score=92, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320598, Length=168, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6325438, Length=159, Percent_Identity=29.559748427673, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24582879, Length=242, Percent_Identity=35.5371900826446, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI28573937, Length=166, Percent_Identity=33.1325301204819, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24660640, Length=172, Percent_Identity=33.1395348837209, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI20129973, Length=175, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 27255; Mature: 27255

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

6.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
6.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRYLRHFGLFGKEGQYTLLDAKVAVIGSGGLGCSVLYNFAAAGLGEIVIVDFDRVSES
CCCCHHHHHCCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCC
DLNRQFLFENSSVQQLKVYAAKRRLNAFNPDCKIFCYPMRIQDCPEVIEGCEVVVDCTDN
CCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHCCCEEEEECCCC
FKTRFYLNELCFFQKKALISAGVTGYSGYVIVLKPFISEDSPCYRCFCPGEPEACFKGSC
CCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCHHHCCCC
EDGGVIGAAVNTIGSIQAMKVIQEILHINPEKAGKLIFCDILNNRFRSAVIMRDPYCSVC
CCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHCCHHHEEEEEECCHHHHC
GQRCV
CCCCC
>Mature Secondary Structure
MNRRYLRHFGLFGKEGQYTLLDAKVAVIGSGGLGCSVLYNFAAAGLGEIVIVDFDRVSES
CCCCHHHHHCCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCC
DLNRQFLFENSSVQQLKVYAAKRRLNAFNPDCKIFCYPMRIQDCPEVIEGCEVVVDCTDN
CCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHCCCEEEEECCCC
FKTRFYLNELCFFQKKALISAGVTGYSGYVIVLKPFISEDSPCYRCFCPGEPEACFKGSC
CCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCHHHCCCC
EDGGVIGAAVNTIGSIQAMKVIQEILHINPEKAGKLIFCDILNNRFRSAVIMRDPYCSVC
CCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHCCHHHEEEEEECCHHHHC
GQRCV
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]