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The map label for this gene is fabF

Identifier: 88608089

GI number: 88608089

Start: 369192

End: 370439

Strand: Direct

Name: fabF

Synonym: NSE_0453

Alternate gene names: 88608089

Gene position: 369192-370439 (Clockwise)

Preceding gene: 88608705

Following gene: 88608200

Centisome position: 42.98

GC content: 46.39

Gene sequence:

>1248_bases
ATGTCGAAGAGAGTTGTAGTAACCGGATTGGGGTTGCTTACTTGTCTATCCAGTACTAGGGAAAGATCTTGGGCGCTGAT
CCTTGAGTCGAGGTCTGGGGTGCGGGCACTTTCTACTATAGAAACGGAAGGACTTCCTGTTACTATAGGCGGGGAGGTGT
TAGAGAACGGGGAAGATGGCTTTGACTGTAAAAAGTTTAGTGATCCACGAAAACATGATCGCTATATATCGTATGGTATA
GCCGCGTCTAGAGAGGCAGTACAACATTCGCAATTGCTGGAATATCCTTCTTTGGATAAGAGAAGGGTCGGCGTATCAAT
AGGTTCTGGTATAGGAGGGTTACCACTTATCGAGAAAAACTCGATTCTTCTCCGTGAAGAGGGTATACGGAAGGTGAGTC
CGTTTTTTATTCCGGCAAGTTTGATCAATCTTACTTCAGGGAATGTTGCCATTGAAAACGGATTTACTGGGCCAAATGAT
GCTTTGGTCACTGCATGTGCAACGGGTGCTCACGCAATAGTGAATTCTTGGCGCATAATTGCTAACGATGAAGCTGATGT
GATGATAGCTGGTGCTTCTGAAGGGGCTTTATGTCGAGTCGGTATAGCTGGGTTTGCAAATATGAAAGCCCTTTCGAGGC
GTAATGATGAGCCGGAGAAGGCTTCTAGGCCATGGGATGTTGATAGGGACGGTTTCGTAATGAGTGATGGTGCCGGGGTT
ATGGTGCTCGAAGAGTATGGCCATGCGAAAAGACGTGGAGCGCGAATTTACGCTGAGTTAGTAGGTTTTGGTGTCTCTGG
AGATGCATATCATGTCGCTGCTCCTAATCCGAATGGAGATGGCGCGCTTGCTGCAATGGCTTCTGCAATAAAAATGGCGG
GGATTGGGTTGGACGAGATTGATTATATCAATGCACACGGAACGTCCACTCCAAATGGCGACGCTGCTGAGTTGAATGCT
CTACGGCGTTTGTTTGGCAGCTCCTTAGGAATGGGTGTGTCTTCAACGAAGTCATCTATAGGGCATGCTTTGGGTGCTGC
TGGCGGTATAGAAGCGGTTCTTTGTGTACTCGCTATGCGTGATTCGGTAATGCCTCCAACGCTTAATTTGGATAAACCTG
ATGATTGTGCTAGTGGATTTAATTTAGTACCACACACATCTCAAGAGAAGAATTTGCGGTATGTACTCTCGAATTCTTTT
GGGTTTGGGGGAACCAATGTATCATTACTGTTTGGGCAATATTCATAA

Upstream 100 bases:

>100_bases
TAGTGTTGCCGTGTCGTTTAATTGCGAGCTTGCCAACCTTGAGGCTGTTTCCAGCATGAGTGATTTGGTCTCTGTGCTTA
TTTCCGCTTCAGCAAAGTAA

Downstream 100 bases:

>100_bases
TTGTGAGGTCCGTGTGTTAAGTGAGAAAAAAGAAACAGCAGCTGCCTGGTTTAGGGAGTTAAGAGATTGTATCAGGGATG
AGTTTGTCGCTATAGAAAAA

Product: 3-oxoacyl-(acyl-carrier-protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MSKRVVVTGLGLLTCLSSTRERSWALILESRSGVRALSTIETEGLPVTIGGEVLENGEDGFDCKKFSDPRKHDRYISYGI
AASREAVQHSQLLEYPSLDKRRVGVSIGSGIGGLPLIEKNSILLREEGIRKVSPFFIPASLINLTSGNVAIENGFTGPND
ALVTACATGAHAIVNSWRIIANDEADVMIAGASEGALCRVGIAGFANMKALSRRNDEPEKASRPWDVDRDGFVMSDGAGV
MVLEEYGHAKRRGARIYAELVGFGVSGDAYHVAAPNPNGDGALAAMASAIKMAGIGLDEIDYINAHGTSTPNGDAAELNA
LRRLFGSSLGMGVSSTKSSIGHALGAAGGIEAVLCVLAMRDSVMPPTLNLDKPDDCASGFNLVPHTSQEKNLRYVLSNSF
GFGGTNVSLLFGQYS

Sequences:

>Translated_415_residues
MSKRVVVTGLGLLTCLSSTRERSWALILESRSGVRALSTIETEGLPVTIGGEVLENGEDGFDCKKFSDPRKHDRYISYGI
AASREAVQHSQLLEYPSLDKRRVGVSIGSGIGGLPLIEKNSILLREEGIRKVSPFFIPASLINLTSGNVAIENGFTGPND
ALVTACATGAHAIVNSWRIIANDEADVMIAGASEGALCRVGIAGFANMKALSRRNDEPEKASRPWDVDRDGFVMSDGAGV
MVLEEYGHAKRRGARIYAELVGFGVSGDAYHVAAPNPNGDGALAAMASAIKMAGIGLDEIDYINAHGTSTPNGDAAELNA
LRRLFGSSLGMGVSSTKSSIGHALGAAGGIEAVLCVLAMRDSVMPPTLNLDKPDDCASGFNLVPHTSQEKNLRYVLSNSF
GFGGTNVSLLFGQYS
>Mature_414_residues
SKRVVVTGLGLLTCLSSTRERSWALILESRSGVRALSTIETEGLPVTIGGEVLENGEDGFDCKKFSDPRKHDRYISYGIA
ASREAVQHSQLLEYPSLDKRRVGVSIGSGIGGLPLIEKNSILLREEGIRKVSPFFIPASLINLTSGNVAIENGFTGPNDA
LVTACATGAHAIVNSWRIIANDEADVMIAGASEGALCRVGIAGFANMKALSRRNDEPEKASRPWDVDRDGFVMSDGAGVM
VLEEYGHAKRRGARIYAELVGFGVSGDAYHVAAPNPNGDGALAAMASAIKMAGIGLDEIDYINAHGTSTPNGDAAELNAL
RRLFGSSLGMGVSSTKSSIGHALGAAGGIEAVLCVLAMRDSVMPPTLNLDKPDDCASGFNLVPHTSQEKNLRYVLSNSFG
FGGTNVSLLFGQYS

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=43.1654676258993, Blast_Score=321, Evalue=9e-88,
Organism=Homo sapiens, GI223972627, Length=161, Percent_Identity=49.0683229813665, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI41872631, Length=264, Percent_Identity=27.6515151515151, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1787337, Length=417, Percent_Identity=49.400479616307, Blast_Score=348, Evalue=3e-97,
Organism=Escherichia coli, GI1788663, Length=417, Percent_Identity=37.1702637889688, Blast_Score=233, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71983541, Length=416, Percent_Identity=37.9807692307692, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI71983535, Length=256, Percent_Identity=44.921875, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17550940, Length=255, Percent_Identity=27.4509803921569, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI212642053, Length=294, Percent_Identity=22.7891156462585, Blast_Score=81, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=445, Percent_Identity=34.3820224719101, Blast_Score=248, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24644341, Length=417, Percent_Identity=40.5275779376499, Blast_Score=285, Evalue=4e-77,
Organism=Drosophila melanogaster, GI221330659, Length=266, Percent_Identity=25.5639097744361, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19920632, Length=266, Percent_Identity=25.5639097744361, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24581345, Length=269, Percent_Identity=24.1635687732342, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43719; Mature: 43588

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRVVVTGLGLLTCLSSTRERSWALILESRSGVRALSTIETEGLPVTIGGEVLENGEDG
CCCCEEEECHHHHHHHHHHCCCEEEEEEECCCCCEEEHEEECCCEEEEECHHHHCCCCCC
FDCKKFSDPRKHDRYISYGIAASREAVQHSQLLEYPSLDKRRVGVSIGSGIGGLPLIEKN
CCCCCCCCCHHHCCEEEECCHHHHHHHHHHHHHCCCCCCCCEECEEECCCCCCCCEEECC
SILLREEGIRKVSPFFIPASLINLTSGNVAIENGFTGPNDALVTACATGAHAIVNSWRII
CEEEECCCCCCCCCEEECHHHEEECCCCEEEECCCCCCCHHEEEEHHCCHHHHHHCCEEE
ANDEADVMIAGASEGALCRVGIAGFANMKALSRRNDEPEKASRPWDVDRDGFVMSDGAGV
ECCCCCEEEEECCCCCEEEEECCCHHHHHHHHHCCCCHHHCCCCCCCCCCCEEEECCCCE
MVLEEYGHAKRRGARIYAELVGFGVSGDAYHVAAPNPNGDGALAAMASAIKMAGIGLDEI
EEECCCCCHHHHHHHEEEHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCC
DYINAHGTSTPNGDAAELNALRRLFGSSLGMGVSSTKSSIGHALGAAGGIEAVLCVLAMR
EEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
DSVMPPTLNLDKPDDCASGFNLVPHTSQEKNLRYVLSNSFGFGGTNVSLLFGQYS
CCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
SKRVVVTGLGLLTCLSSTRERSWALILESRSGVRALSTIETEGLPVTIGGEVLENGEDG
CCCEEEECHHHHHHHHHHCCCEEEEEEECCCCCEEEHEEECCCEEEEECHHHHCCCCCC
FDCKKFSDPRKHDRYISYGIAASREAVQHSQLLEYPSLDKRRVGVSIGSGIGGLPLIEKN
CCCCCCCCCHHHCCEEEECCHHHHHHHHHHHHHCCCCCCCCEECEEECCCCCCCCEEECC
SILLREEGIRKVSPFFIPASLINLTSGNVAIENGFTGPNDALVTACATGAHAIVNSWRII
CEEEECCCCCCCCCEEECHHHEEECCCCEEEECCCCCCCHHEEEEHHCCHHHHHHCCEEE
ANDEADVMIAGASEGALCRVGIAGFANMKALSRRNDEPEKASRPWDVDRDGFVMSDGAGV
ECCCCCEEEEECCCCCEEEEECCCHHHHHHHHHCCCCHHHCCCCCCCCCCCEEEECCCCE
MVLEEYGHAKRRGARIYAELVGFGVSGDAYHVAAPNPNGDGALAAMASAIKMAGIGLDEI
EEECCCCCHHHHHHHEEEHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCC
DYINAHGTSTPNGDAAELNALRRLFGSSLGMGVSSTKSSIGHALGAAGGIEAVLCVLAMR
EEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
DSVMPPTLNLDKPDDCASGFNLVPHTSQEKNLRYVLSNSFGFGGTNVSLLFGQYS
CCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]