Click here to switch to the map view.

The map label for this gene is aatA [H]

Identifier: 88608084

GI number: 88608084

Start: 675374

End: 676567

Strand: Reverse

Name: aatA [H]

Synonym: NSE_0758

Alternate gene names: 88608084

Gene position: 676567-675374 (Counterclockwise)

Preceding gene: 88608524

Following gene: 88608155

Centisome position: 78.76

GC content: 44.3

Gene sequence:

>1194_bases
ATGTTGTCAAAAAAGATTGAGAGTATTAAACCTTCTGCGACGGCTGCAGCTACACGTAGGGTATGTGAGTTGAGGGCGCG
TGGAAAAGATGTAATATCCTTGTGTATAGGGGAGCCTGACTTTTCTACACCTTTCCTAGGTCAGGAGATGGCCATACAGG
CCATAAAAGATTGTGATGATAATTACTCTCCTGTTGCTGGAACAATGGTGCTTCGCGAGGAGATCGCTGCGAAGTTTGTC
CGCGATAATGCATTGCATTATTCACCGCACGAGATTGTTGTGGGTAATGGAGCAAAGCAAGTGTTGTATAACGTTCTTGG
TGCGATTCTTAATCCAGAGGATGAGGTAGTGCTTATTGCTCCTTATTGGGTCTCTTATTGTGAAATAGTGCGTATCTTTT
CAGGTAAGCCTGTTGTCGTGCCAAGTACAAAAAAGTTTAGGATAGATATTACGGCAATACGGGAGGCACTTAACACAAAA
ACCAAAGCAATACTGATTAACTCTCCTAATAATCCATCCGGAGTGTGTTATGAAGAAAGTGAACTCAGGGATTTGGCTAG
TGCCTTGAGAGCGCATCCGCAGGTCCATATCATATCCGATGACATATACGAGCATATCACTTATGCGGAGTCTAGCTTTC
TCAATATCGCGAATGTTGCACCAGAATTGGGGGAGCGCATAATTTTAGTAAACGGTGTTTCTAAGTGTTATGCTATGACC
GGTTGGCGAGTAGGTTATGCAGCTATTCCAAATAAAGCAGTCATTTCTCTGGTGTGTAGATTACAGGAGCACAGTACGTT
TGGTGTATGTACAATAGCTCAGGCTGCTGCTTTAGGGGCCCTGCGTTCAGGAGCAGATGTTCTTTCTGAAAGGCTTGCTG
TCTTTGCAAGGAAGAGAAACAAGGCTGTCGAAGTGCTTTCTATGTTGCCTGAGTTGTGTTGTTATAAGCCAGATGGTGGG
TTTTACCTCTTTCTCTCTTGTTCTGCCTTCTTCGGGAAGAAAAGTCCCAGTGGCTTCGAAGTGAAAACGGATTCCGATGT
TGCAGACTATCTTCTTGAGGAGCACGCTGTTGCGGTTGTGCCTGGGGAAGAGTTTGGAGTACCAGGGTATTTTAGGATTT
CTTATGCTTTGTCAATGGATCTGCTAGAGCAAGCTTGTATGCGTATAGTGAAGGCATTTAAAGCGCTTAGATGA

Upstream 100 bases:

>100_bases
TTGTTATTGTTGCTTACTTCGTGTGCTGTCAAACATGACAAGGGACTTAGGAGCCCGTGTTTTGTGGAAGGAGCGGGCTT
GTTTGATTGAATTTTGATTT

Downstream 100 bases:

>100_bases
AGATCATCCACTGTCGATTTCCAAAAGTAAGATAATTGAATGTCTCCTTACCTTTGGTTTATACTGATCTCTTGGTACTT
GGGCTTGTGATGTCCATAAG

Product: aspartate aminotransferase

Products: NA

Alternate protein names: AspAT; Transaminase A [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MLSKKIESIKPSATAAATRRVCELRARGKDVISLCIGEPDFSTPFLGQEMAIQAIKDCDDNYSPVAGTMVLREEIAAKFV
RDNALHYSPHEIVVGNGAKQVLYNVLGAILNPEDEVVLIAPYWVSYCEIVRIFSGKPVVVPSTKKFRIDITAIREALNTK
TKAILINSPNNPSGVCYEESELRDLASALRAHPQVHIISDDIYEHITYAESSFLNIANVAPELGERIILVNGVSKCYAMT
GWRVGYAAIPNKAVISLVCRLQEHSTFGVCTIAQAAALGALRSGADVLSERLAVFARKRNKAVEVLSMLPELCCYKPDGG
FYLFLSCSAFFGKKSPSGFEVKTDSDVADYLLEEHAVAVVPGEEFGVPGYFRISYALSMDLLEQACMRIVKAFKALR

Sequences:

>Translated_397_residues
MLSKKIESIKPSATAAATRRVCELRARGKDVISLCIGEPDFSTPFLGQEMAIQAIKDCDDNYSPVAGTMVLREEIAAKFV
RDNALHYSPHEIVVGNGAKQVLYNVLGAILNPEDEVVLIAPYWVSYCEIVRIFSGKPVVVPSTKKFRIDITAIREALNTK
TKAILINSPNNPSGVCYEESELRDLASALRAHPQVHIISDDIYEHITYAESSFLNIANVAPELGERIILVNGVSKCYAMT
GWRVGYAAIPNKAVISLVCRLQEHSTFGVCTIAQAAALGALRSGADVLSERLAVFARKRNKAVEVLSMLPELCCYKPDGG
FYLFLSCSAFFGKKSPSGFEVKTDSDVADYLLEEHAVAVVPGEEFGVPGYFRISYALSMDLLEQACMRIVKAFKALR
>Mature_397_residues
MLSKKIESIKPSATAAATRRVCELRARGKDVISLCIGEPDFSTPFLGQEMAIQAIKDCDDNYSPVAGTMVLREEIAAKFV
RDNALHYSPHEIVVGNGAKQVLYNVLGAILNPEDEVVLIAPYWVSYCEIVRIFSGKPVVVPSTKKFRIDITAIREALNTK
TKAILINSPNNPSGVCYEESELRDLASALRAHPQVHIISDDIYEHITYAESSFLNIANVAPELGERIILVNGVSKCYAMT
GWRVGYAAIPNKAVISLVCRLQEHSTFGVCTIAQAAALGALRSGADVLSERLAVFARKRNKAVEVLSMLPELCCYKPDGG
FYLFLSCSAFFGKKSPSGFEVKTDSDVADYLLEEHAVAVVPGEEFGVPGYFRISYALSMDLLEQACMRIVKAFKALR

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=324, Percent_Identity=28.0864197530864, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI56713254, Length=324, Percent_Identity=28.0864197530864, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI95147551, Length=361, Percent_Identity=23.8227146814404, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI169881279, Length=361, Percent_Identity=23.8227146814404, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI4507369, Length=380, Percent_Identity=23.4210526315789, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI169881281, Length=267, Percent_Identity=22.8464419475655, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1786816, Length=344, Percent_Identity=29.0697674418605, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788627, Length=406, Percent_Identity=27.3399014778325, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1788722, Length=381, Percent_Identity=26.7716535433071, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1790797, Length=306, Percent_Identity=25.1633986928105, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787710, Length=346, Percent_Identity=25.1445086705202, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17567663, Length=380, Percent_Identity=25.2631578947368, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71994472, Length=298, Percent_Identity=27.1812080536913, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71994476, Length=298, Percent_Identity=27.1812080536913, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17567369, Length=330, Percent_Identity=24.5454545454545, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322401, Length=362, Percent_Identity=26.5193370165746, Blast_Score=119, Evalue=6e-28,
Organism=Drosophila melanogaster, GI18859735, Length=390, Percent_Identity=25.3846153846154, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28573069, Length=263, Percent_Identity=25.0950570342205, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24646114, Length=263, Percent_Identity=25.0950570342205, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI28573067, Length=263, Percent_Identity=25.0950570342205, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI28573065, Length=263, Percent_Identity=25.0950570342205, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.1 [H]

Molecular weight: Translated: 43498; Mature: 43498

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSKKIESIKPSATAAATRRVCELRARGKDVISLCIGEPDFSTPFLGQEMAIQAIKDCDD
CCCCHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCC
NYSPVAGTMVLREEIAAKFVRDNALHYSPHEIVVGNGAKQVLYNVLGAILNPEDEVVLIA
CCCCHHHHHHHHHHHHHHHHHCCCCEECCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEC
PYWVSYCEIVRIFSGKPVVVPSTKKFRIDITAIREALNTKTKAILINSPNNPSGVCYEES
HHHHHHHHHHHHHCCCEEEECCCCEEEEEHHHHHHHHCCCCEEEEEECCCCCCCCEECHH
ELRDLASALRAHPQVHIISDDIYEHITYAESSFLNIANVAPELGERIILVNGVSKCYAMT
HHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHCHHHCCEEEEEECCHHHHHHC
GWRVGYAAIPNKAVISLVCRLQEHSTFGVCTIAQAAALGALRSGADVLSERLAVFARKRN
CCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KAVEVLSMLPELCCYKPDGGFYLFLSCSAFFGKKSPSGFEVKTDSDVADYLLEEHAVAVV
HHHHHHHHHHHHHEECCCCCEEEEEEEEHHHCCCCCCCCEEECCCHHHHHHHHCCCEEEE
PGEEFGVPGYFRISYALSMDLLEQACMRIVKAFKALR
CCHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLSKKIESIKPSATAAATRRVCELRARGKDVISLCIGEPDFSTPFLGQEMAIQAIKDCDD
CCCCHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCC
NYSPVAGTMVLREEIAAKFVRDNALHYSPHEIVVGNGAKQVLYNVLGAILNPEDEVVLIA
CCCCHHHHHHHHHHHHHHHHHCCCCEECCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEC
PYWVSYCEIVRIFSGKPVVVPSTKKFRIDITAIREALNTKTKAILINSPNNPSGVCYEES
HHHHHHHHHHHHHCCCEEEECCCCEEEEEHHHHHHHHCCCCEEEEEECCCCCCCCEECHH
ELRDLASALRAHPQVHIISDDIYEHITYAESSFLNIANVAPELGERIILVNGVSKCYAMT
HHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHCHHHCCEEEEEECCHHHHHHC
GWRVGYAAIPNKAVISLVCRLQEHSTFGVCTIAQAAALGALRSGADVLSERLAVFARKRN
CCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KAVEVLSMLPELCCYKPDGGFYLFLSCSAFFGKKSPSGFEVKTDSDVADYLLEEHAVAVV
HHHHHHHHHHHHHEECCCCCEEEEEEEEHHHCCCCCCCCEEECCCHHHHHHHHCCCEEEE
PGEEFGVPGYFRISYALSMDLLEQACMRIVKAFKALR
CCHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA