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The map label for this gene is nuoN [H]

Identifier: 88608077

GI number: 88608077

Start: 488998

End: 490425

Strand: Direct

Name: nuoN [H]

Synonym: NSE_0563

Alternate gene names: 88608077

Gene position: 488998-490425 (Clockwise)

Preceding gene: 88608527

Following gene: 88608642

Centisome position: 56.93

GC content: 40.13

Gene sequence:

>1428_bases
ATGAGCGAATCAGGTTTTTTATGGGTCACTGAGCTAGCACACTTGTTCGCATTTTTGCTGTACTACACAGCAGGACGGTG
CAAGCCCGTTTTTTACTATACAATTAGCACCTTCACTGCAACATTAAGTTTTATTGCTGCAGCAGTGCTAGCAATAAAAG
GTGAGCCGCTTGCGATTGAAGTATTTCAAATCACACATCATATAGGAATCGCATTCGGGTTGGATAGAATCACACTGACA
TTTGCCTTGTTATGCTCGCTACTTGGCATACCAGCGACAATATATGCAATCAGCTATATGTATGCAATAAATGGAAAAAG
AAAAGCCATATTTTTCGCACGGATCCATCTTTCGCTTGCTATTACTATGCTTTTAGCATTCTCAGGAAATTTGGTAACGA
TGTTTATCTTCTATGAGCTACTCACCCTCGCGACCTATGCACTCGTAAATCACGACAAGACAGAAAATAGTCTCAGAGCT
GTACGGACCTACCTAGCATATCTAGTTCTTCCGTCAGTCGGATTACTATTACCTGCAATCCTCATTACATACAAGATTAC
TGGCACCTTCACCTTTGATAAAAGCTTACATATAAGCATCGTCGGACTTCCAAGGTTGGCCCTATTCTTGATGTTCGCGT
ACGGAATCGCAAAAGCTGCTATCTTTCCTTTACATGGTTGGTTACCAAGAGCCATGGTTGCACCAACCCCTGTAAGCGCA
TTGTTACACGCCGTTGCAGTTGTCAAAGCAGGAGTATTTTGCATGCTGAAGATTGTGAAATACGTTTTTACAATATCTGA
TCCGGCCAATGTAGTTCTCATGACACCAATGACTTGTATTTATGCCTTTACAATCATCTTCGCATCTGTCGTTGCACTGA
AAAAACACTCCCTCAAGGAAATCTTAGCCTATTCTACTATTAGTCAACTTTCCTATATTGGAATTACGTTAAGTATATTC
ACTGAAAACTCATTCCACTATGCAACTCTGTATATGATCCTACATGCCTTTGCGAAAATAACACTTTTTTTTACTGCAGG
AGCTATATATGCAAGAACCGGAAAGACAAGCATAAAGCAACTCCACGGAATAGGAAGGGACATGCCTATAGCAATGTCCT
CCTTTATAATAGGAGCACTTACAATGATAGGACTCCCACCTACTGCAACCCTTCTATGCAAGGCTGACATTCTATCAGAG
GCATTGGGACAAGGTAACTATATACTTATTATCACTTTAGTTATAAGCACCGCTCTTAATTGCGGATACTTTTTACCAAT
TATTTTCAATGCATTTTTCTGTGAACCTACAGTAGCCACTTCTATTGCAAAGACTCCGACTAGATATACGGTATGCCATC
CGCTCACACTGTCATATCTCTTTACTGGAAGCATCTGTATCGTTCTTTTTGTATACAAACTTTTTTAA

Upstream 100 bases:

>100_bases
ACCACATGACTTACTTACTCTTCGCACAAATCCTACCTTACAGTATGCAACTAAGAAAATTTCCATATGCTTAAACAAAT
AGATGAGTTACAAGTGAGAA

Downstream 100 bases:

>100_bases
ACAGCAGTGTTTATACAACAACAGCTTGAACACAAATGCCCTCTCCTATTATCTGTAAATACTCATTTAACCAGGTAGCT
ATATGATTTCGATTACTTAA

Product: NADH-ubiquinone/plastoquinone oxidoreductase family protein

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MSESGFLWVTELAHLFAFLLYYTAGRCKPVFYYTISTFTATLSFIAAAVLAIKGEPLAIEVFQITHHIGIAFGLDRITLT
FALLCSLLGIPATIYAISYMYAINGKRKAIFFARIHLSLAITMLLAFSGNLVTMFIFYELLTLATYALVNHDKTENSLRA
VRTYLAYLVLPSVGLLLPAILITYKITGTFTFDKSLHISIVGLPRLALFLMFAYGIAKAAIFPLHGWLPRAMVAPTPVSA
LLHAVAVVKAGVFCMLKIVKYVFTISDPANVVLMTPMTCIYAFTIIFASVVALKKHSLKEILAYSTISQLSYIGITLSIF
TENSFHYATLYMILHAFAKITLFFTAGAIYARTGKTSIKQLHGIGRDMPIAMSSFIIGALTMIGLPPTATLLCKADILSE
ALGQGNYILIITLVISTALNCGYFLPIIFNAFFCEPTVATSIAKTPTRYTVCHPLTLSYLFTGSICIVLFVYKLF

Sequences:

>Translated_475_residues
MSESGFLWVTELAHLFAFLLYYTAGRCKPVFYYTISTFTATLSFIAAAVLAIKGEPLAIEVFQITHHIGIAFGLDRITLT
FALLCSLLGIPATIYAISYMYAINGKRKAIFFARIHLSLAITMLLAFSGNLVTMFIFYELLTLATYALVNHDKTENSLRA
VRTYLAYLVLPSVGLLLPAILITYKITGTFTFDKSLHISIVGLPRLALFLMFAYGIAKAAIFPLHGWLPRAMVAPTPVSA
LLHAVAVVKAGVFCMLKIVKYVFTISDPANVVLMTPMTCIYAFTIIFASVVALKKHSLKEILAYSTISQLSYIGITLSIF
TENSFHYATLYMILHAFAKITLFFTAGAIYARTGKTSIKQLHGIGRDMPIAMSSFIIGALTMIGLPPTATLLCKADILSE
ALGQGNYILIITLVISTALNCGYFLPIIFNAFFCEPTVATSIAKTPTRYTVCHPLTLSYLFTGSICIVLFVYKLF
>Mature_474_residues
SESGFLWVTELAHLFAFLLYYTAGRCKPVFYYTISTFTATLSFIAAAVLAIKGEPLAIEVFQITHHIGIAFGLDRITLTF
ALLCSLLGIPATIYAISYMYAINGKRKAIFFARIHLSLAITMLLAFSGNLVTMFIFYELLTLATYALVNHDKTENSLRAV
RTYLAYLVLPSVGLLLPAILITYKITGTFTFDKSLHISIVGLPRLALFLMFAYGIAKAAIFPLHGWLPRAMVAPTPVSAL
LHAVAVVKAGVFCMLKIVKYVFTISDPANVVLMTPMTCIYAFTIIFASVVALKKHSLKEILAYSTISQLSYIGITLSIFT
ENSFHYATLYMILHAFAKITLFFTAGAIYARTGKTSIKQLHGIGRDMPIAMSSFIIGALTMIGLPPTATLLCKADILSEA
LGQGNYILIITLVISTALNCGYFLPIIFNAFFCEPTVATSIAKTPTRYTVCHPLTLSYLFTGSICIVLFVYKLF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=397, Percent_Identity=27.7078085642317, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI251831116, Length=319, Percent_Identity=26.0188087774295, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1788614, Length=411, Percent_Identity=27.7372262773723, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788829, Length=334, Percent_Identity=29.940119760479, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788827, Length=314, Percent_Identity=27.3885350318471, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788831, Length=338, Percent_Identity=26.3313609467456, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788613, Length=378, Percent_Identity=24.6031746031746, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI2367154, Length=311, Percent_Identity=27.6527331189711, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI145693160, Length=342, Percent_Identity=23.3918128654971, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 52202; Mature: 52071

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESGFLWVTELAHLFAFLLYYTAGRCKPVFYYTISTFTATLSFIAAAVLAIKGEPLAIE
CCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEE
VFQITHHIGIAFGLDRITLTFALLCSLLGIPATIYAISYMYAINGKRKAIFFARIHLSLA
EEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEECCCCEEEEEEHHHHHHH
ITMLLAFSGNLVTMFIFYELLTLATYALVNHDKTENSLRAVRTYLAYLVLPSVGLLLPAI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LITYKITGTFTFDKSLHISIVGLPRLALFLMFAYGIAKAAIFPLHGWLPRAMVAPTPVSA
HHHEEEEEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
LLHAVAVVKAGVFCMLKIVKYVFTISDPANVVLMTPMTCIYAFTIIFASVVALKKHSLKE
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
ILAYSTISQLSYIGITLSIFTENSFHYATLYMILHAFAKITLFFTAGAIYARTGKTSIKQ
HHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHH
LHGIGRDMPIAMSSFIIGALTMIGLPPTATLLCKADILSEALGQGNYILIITLVISTALN
HHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHC
CGYFLPIIFNAFFCEPTVATSIAKTPTRYTVCHPLTLSYLFTGSICIVLFVYKLF
CCHHHHHHHHHHHCCCHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SESGFLWVTELAHLFAFLLYYTAGRCKPVFYYTISTFTATLSFIAAAVLAIKGEPLAIE
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEE
VFQITHHIGIAFGLDRITLTFALLCSLLGIPATIYAISYMYAINGKRKAIFFARIHLSLA
EEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEECCCCEEEEEEHHHHHHH
ITMLLAFSGNLVTMFIFYELLTLATYALVNHDKTENSLRAVRTYLAYLVLPSVGLLLPAI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LITYKITGTFTFDKSLHISIVGLPRLALFLMFAYGIAKAAIFPLHGWLPRAMVAPTPVSA
HHHEEEEEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
LLHAVAVVKAGVFCMLKIVKYVFTISDPANVVLMTPMTCIYAFTIIFASVVALKKHSLKE
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
ILAYSTISQLSYIGITLSIFTENSFHYATLYMILHAFAKITLFFTAGAIYARTGKTSIKQ
HHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHH
LHGIGRDMPIAMSSFIIGALTMIGLPPTATLLCKADILSEALGQGNYILIITLVISTALN
HHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHC
CGYFLPIIFNAFFCEPTVATSIAKTPTRYTVCHPLTLSYLFTGSICIVLFVYKLF
CCHHHHHHHHHHHCCCHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA