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The map label for this gene is kefC [H]

Identifier: 88608068

GI number: 88608068

Start: 789029

End: 790765

Strand: Direct

Name: kefC [H]

Synonym: NSE_0885

Alternate gene names: 88608068

Gene position: 789029-790765 (Clockwise)

Preceding gene: 88608840

Following gene: 88608032

Centisome position: 91.85

GC content: 43.29

Gene sequence:

>1737_bases
ATGTTTGATGATGGCATCACTTTGTTCCAGGTAATAGCGCTGCTTTCAACCGCTGTTTTAGTGGTAGCGTTGTTCTTGAA
GTTAAATATAAGTCCAATTTTGGGTTATTTTGTCGCCGGAGCAGTACTTGGTACACATGGGTTCAAGATAGTCACGTTTT
CCTCACCCATGGAGACCTTCGCTGAATTTGGTATCGTCTTTTTACTTTTCCTGATCGGGCTGGAGCTTACGCTAGATCGA
ATCATGTCCATGCGGCTGCATGTTTTCGGCTTAGGAACATTACAGGTCATAATAACTGCGCTTCTGATCATATTAATCTG
TCGAATATTTGGTAATAGTTCGAGTGCATCAATCATAATAGGGTGTGCGTTTGCCCTTTCTTCAACAGCTATAGTACTTC
AAGTGCTGCAAGAAACCGGAATGGAATCAAACCAAGTAGGAAGGCTTTCAATAGCTGTCTTGCTAATGCAGGATTTTACG
GTTGTGCCACTGTTAGTACTCGTTGCACTTTTGGGAAATAACGCACCACAGAATCTTCTCCTTCCTATTGCCATGTCACT
AATCAGGGCTGGTTTAGTGTTGTTGCTAATTTTTGTTGCTGGTAGGTTGTTGCTAAGGCCTTTCTTTAAGATTATTGCTT
CCACTAAGAGTAGTGAACTATTCATAGCCACGACGCTACTCATAGTACTCGGAGCAGCTTATATAACCGAGAAACTTGAA
TTATCAATGGCGATGGGCGCATTCGTGGCCGGTCTTTTGCTTGCAGAAACGGAATACCGTCACGAAGTCGAGCAAGTAAT
ATTCCCATTCAAGAGTTTGCTCCTGGGCCTGTTTTTTATGACAGTTGGTATGTCGATAGACCTCAGGATGCTCGTCGAAA
ACATAGGATTAATTACCGGTATAGCTTTAGCTTTAATGACACTCAAAGCATCAATTGTAATAGGGTTAGCAAAATTGTTT
GGGTTTAAAACTGGTCCTGCAATAAATGCTGGTTTGCTGTTAGCACAGGGCAGTGAATTTGCACTCATCCTGTTTAAACT
GGACAGCAGCACTACAATCCTTGATGCTTCAATGGTTAACATACTGGTCTCCTCGGTTACGATGAGCATGGCATTTACAC
CACTTTTCTCCAGCATTGGAACCATGGTTGCAAATAAACTTGAGGCACCTGATAGAATAGTCGAGGAAGACGAACTCATT
CAACTAATGCGTGCTAGTGTCGCTGATATTGATAACCATGTCGTCATAGCGGGTTTTGGCCGGGTGGGTAGAATGGTTGC
GCGAATGCTAGCTGAGGAAAGAATCAACTACATTGCCATTGATGTGGATTCTAAGATTGTGGAAAAGGCACAGGATGAAG
GTTTCCCTATTTTTAAAGGGAACATCAACAAGCGTGCCACTTTAGATGCAATCGCCGCAGACAGAGCTTCCACTATAGTG
CTTTCAATGCAAAACGGGGTTACTAGTAAAAAGGCGGTCGCCCTTATAGGGCAAAGTTTCCCTCATGCTACTATTGTCGC
ACGCGTGGCAGATTTCTCCGATATCAAGACTTATAGAAAGTTAGGCGCACATAAGCTTGTACCAGAAACCTACGAAACTG
GTCTGCAAATAGGAGCAGAAGTGTTACAGTCAGTCGGCCTAGGATCTTTTGCAATTGCCTCACTCAAAGAACGCTTCAGA
GCGTGTGATTATGCAATTCCAAAAAGCATCGCCAAAGAAGAGGAACCACCTTCTTAG

Upstream 100 bases:

>100_bases
GATGCTTGAGATCGCTGGCGGTAGAAAAGTTTCGAGAAAACAGAAGCCCAGTATTGGTTGTTCAATAAAGTGGAAATAAT
TTTGACGGTACCACCTTTGC

Downstream 100 bases:

>100_bases
AGACCACACGCACAAGTACCGAGAGCTTAGCCCGTATGCACAAAGCGCTGTGATATCAAGGTTTATTCCCACTCAACTGT
GGCTGGCGGTTTGGATGTAA

Product: glutathione-regulated potassium-efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MFDDGITLFQVIALLSTAVLVVALFLKLNISPILGYFVAGAVLGTHGFKIVTFSSPMETFAEFGIVFLLFLIGLELTLDR
IMSMRLHVFGLGTLQVIITALLIILICRIFGNSSSASIIIGCAFALSSTAIVLQVLQETGMESNQVGRLSIAVLLMQDFT
VVPLLVLVALLGNNAPQNLLLPIAMSLIRAGLVLLLIFVAGRLLLRPFFKIIASTKSSELFIATTLLIVLGAAYITEKLE
LSMAMGAFVAGLLLAETEYRHEVEQVIFPFKSLLLGLFFMTVGMSIDLRMLVENIGLITGIALALMTLKASIVIGLAKLF
GFKTGPAINAGLLLAQGSEFALILFKLDSSTTILDASMVNILVSSVTMSMAFTPLFSSIGTMVANKLEAPDRIVEEDELI
QLMRASVADIDNHVVIAGFGRVGRMVARMLAEERINYIAIDVDSKIVEKAQDEGFPIFKGNINKRATLDAIAADRASTIV
LSMQNGVTSKKAVALIGQSFPHATIVARVADFSDIKTYRKLGAHKLVPETYETGLQIGAEVLQSVGLGSFAIASLKERFR
ACDYAIPKSIAKEEEPPS

Sequences:

>Translated_578_residues
MFDDGITLFQVIALLSTAVLVVALFLKLNISPILGYFVAGAVLGTHGFKIVTFSSPMETFAEFGIVFLLFLIGLELTLDR
IMSMRLHVFGLGTLQVIITALLIILICRIFGNSSSASIIIGCAFALSSTAIVLQVLQETGMESNQVGRLSIAVLLMQDFT
VVPLLVLVALLGNNAPQNLLLPIAMSLIRAGLVLLLIFVAGRLLLRPFFKIIASTKSSELFIATTLLIVLGAAYITEKLE
LSMAMGAFVAGLLLAETEYRHEVEQVIFPFKSLLLGLFFMTVGMSIDLRMLVENIGLITGIALALMTLKASIVIGLAKLF
GFKTGPAINAGLLLAQGSEFALILFKLDSSTTILDASMVNILVSSVTMSMAFTPLFSSIGTMVANKLEAPDRIVEEDELI
QLMRASVADIDNHVVIAGFGRVGRMVARMLAEERINYIAIDVDSKIVEKAQDEGFPIFKGNINKRATLDAIAADRASTIV
LSMQNGVTSKKAVALIGQSFPHATIVARVADFSDIKTYRKLGAHKLVPETYETGLQIGAEVLQSVGLGSFAIASLKERFR
ACDYAIPKSIAKEEEPPS
>Mature_578_residues
MFDDGITLFQVIALLSTAVLVVALFLKLNISPILGYFVAGAVLGTHGFKIVTFSSPMETFAEFGIVFLLFLIGLELTLDR
IMSMRLHVFGLGTLQVIITALLIILICRIFGNSSSASIIIGCAFALSSTAIVLQVLQETGMESNQVGRLSIAVLLMQDFT
VVPLLVLVALLGNNAPQNLLLPIAMSLIRAGLVLLLIFVAGRLLLRPFFKIIASTKSSELFIATTLLIVLGAAYITEKLE
LSMAMGAFVAGLLLAETEYRHEVEQVIFPFKSLLLGLFFMTVGMSIDLRMLVENIGLITGIALALMTLKASIVIGLAKLF
GFKTGPAINAGLLLAQGSEFALILFKLDSSTTILDASMVNILVSSVTMSMAFTPLFSSIGTMVANKLEAPDRIVEEDELI
QLMRASVADIDNHVVIAGFGRVGRMVARMLAEERINYIAIDVDSKIVEKAQDEGFPIFKGNINKRATLDAIAADRASTIV
LSMQNGVTSKKAVALIGQSFPHATIVARVADFSDIKTYRKLGAHKLVPETYETGLQIGAEVLQSVGLGSFAIASLKERFR
ACDYAIPKSIAKEEEPPS

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=345, Percent_Identity=24.9275362318841, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786232, Length=573, Percent_Identity=33.5078534031414, Blast_Score=320, Evalue=2e-88,
Organism=Escherichia coli, GI1789749, Length=554, Percent_Identity=33.3935018050542, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1786685, Length=522, Percent_Identity=26.0536398467433, Blast_Score=154, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 62215; Mature: 62215

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDDGITLFQVIALLSTAVLVVALFLKLNISPILGYFVAGAVLGTHGFKIVTFSSPMETF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHH
AEFGIVFLLFLIGLELTLDRIMSMRLHVFGLGTLQVIITALLIILICRIFGNSSSASIII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
GCAFALSSTAIVLQVLQETGMESNQVGRLSIAVLLMQDFTVVPLLVLVALLGNNAPQNLL
EHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHH
LPIAMSLIRAGLVLLLIFVAGRLLLRPFFKIIASTKSSELFIATTLLIVLGAAYITEKLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LSMAMGAFVAGLLLAETEYRHEVEQVIFPFKSLLLGLFFMTVGMSIDLRMLVENIGLITG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IALALMTLKASIVIGLAKLFGFKTGPAINAGLLLAQGSEFALILFKLDSSTTILDASMVN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEEECCCCEEHHHHHHH
ILVSSVTMSMAFTPLFSSIGTMVANKLEAPDRIVEEDELIQLMRASVADIDNHVVIAGFG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHCCCCCEEEEECH
RVGRMVARMLAEERINYIAIDVDSKIVEKAQDEGFPIFKGNINKRATLDAIAADRASTIV
HHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCCEEECCCCCCHHHHHHHHCCCCEEE
LSMQNGVTSKKAVALIGQSFPHATIVARVADFSDIKTYRKLGAHKLVPETYETGLQIGAE
EEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
VLQSVGLGSFAIASLKERFRACDYAIPKSIAKEEEPPS
HHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFDDGITLFQVIALLSTAVLVVALFLKLNISPILGYFVAGAVLGTHGFKIVTFSSPMETF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHH
AEFGIVFLLFLIGLELTLDRIMSMRLHVFGLGTLQVIITALLIILICRIFGNSSSASIII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
GCAFALSSTAIVLQVLQETGMESNQVGRLSIAVLLMQDFTVVPLLVLVALLGNNAPQNLL
EHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHH
LPIAMSLIRAGLVLLLIFVAGRLLLRPFFKIIASTKSSELFIATTLLIVLGAAYITEKLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LSMAMGAFVAGLLLAETEYRHEVEQVIFPFKSLLLGLFFMTVGMSIDLRMLVENIGLITG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IALALMTLKASIVIGLAKLFGFKTGPAINAGLLLAQGSEFALILFKLDSSTTILDASMVN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEEECCCCEEHHHHHHH
ILVSSVTMSMAFTPLFSSIGTMVANKLEAPDRIVEEDELIQLMRASVADIDNHVVIAGFG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHCCCCCEEEEECH
RVGRMVARMLAEERINYIAIDVDSKIVEKAQDEGFPIFKGNINKRATLDAIAADRASTIV
HHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCCEEECCCCCCHHHHHHHHCCCCEEE
LSMQNGVTSKKAVALIGQSFPHATIVARVADFSDIKTYRKLGAHKLVPETYETGLQIGAE
EEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
VLQSVGLGSFAIASLKERFRACDYAIPKSIAKEEEPPS
HHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA