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The map label for this gene is prtE [H]

Identifier: 88608033

GI number: 88608033

Start: 828564

End: 830048

Strand: Direct

Name: prtE [H]

Synonym: NSE_0939

Alternate gene names: 88608033

Gene position: 828564-830048 (Clockwise)

Preceding gene: 88607967

Following gene: 88608582

Centisome position: 96.46

GC content: 39.19

Gene sequence:

>1485_bases
ATGATAAAAAAAATTACTGATTCTGCAAAATCTGGAAAACTAAAAATATTAGACTTTCTTACCTCCGGATTCAAAAGGAC
ACTTCACAGCAGCGTGAAAATTGTTGATCAAAGTATTTCATTTTTTCAAAACAAGAAAACTAACGAACTTAAAGCACTCA
CAAAAAACGCACGAATTACTGGAACAGTCGTTCTTATAGGTTTCTTTGGAATTTTTGGAATGTGGGCAGTCTTTGCCCCA
ATTGACGGTGCGAGTCTTGCAATGGGTGAAATTGTTATCAGCTCTGATAAGAAATCCGTCCAACATCTTGAAGGTGGAAT
AATAGAGGAGATCTTCGTCCATGAAGGAGATCATGTTACTGAAGGACAGGTACTCATGACTCTCAAAAACGTCGGTAATA
AGGCACAGCTTTCAATACTCGAGGAGAATCAAATCTCGCTTCTAGCAACCGAACAGAGGCTCCTCGCACATATAGGCAGA
AAAGCAAATATGGAGCTCCCTAATATAGAAAAATTAGAGTATGTGACTGAAGAAAAGAAAAGCGATACTATCAAAAATCA
GGTGCTACTATTTGAATCCAATAAAGAATCTTTTGCTAATAAGGTCAGAATCATAGACAAGAAAATCGGCCAGATACAGA
ATGAGGTCCTCGCATTGAAGGCACAGTTGGAATCAGCCGAAAAAAATATCCAGCTTCTCGAAGAGGAACTTGAAGCAAAG
AGGTCTCTATATGATGAACACGTCATAGACAAAACCAAGATCGTATCTCTAGAAAGGGAAAGAATCTCTTGGAATGGCAA
AATTGCCGAATATAAAGCTCTGATAGCTAGAGGGGAACAACACGTTACAGAAGCTGAACTGGAGAAAATTCAGGTGGAGA
ATAGTTTCAATAGTGAGCTTGCAGCACAACTCAAAGAGGTTTCGCATGCCATTCATGAAAATATGCAGAAACTCACCGCA
GCGTATGACTTAATGTTAAGGACAATCATAAGAGCTCCACAATCAGGTATTGTGACCGGTTTGCGCTCGCTAAGCATCGG
TGGCGTGATACCTCCAGCTATATCGTTAATGGAAATCGTCCCTGAAAACGAAGATATGTTCATAGAAGCAAAGGTTGCAC
CAAATAATATTGAGGCGATAGTATCTGCGAGACTCGTTAAGAAAAATCTTAGCGAAGTTGAAGGTTACATAGGGGTAAGG
ACAAGAGTCAAGATAACAGCATTTAATTCAAAGAAAGTAGGAATATTAAAAGGTGTAATGACGTACATTTCTGCAAACAC
GATTTTAGACCCACGAACAGGAATGCATTATTATCTAGCGCATATAAGGATCCCAAAATCAGAAATAGCTATGATAAATG
CCAGAACCAAGCTCTATCCAGGAATGCCCGCCATTGTTTTCATTACAACTGAGTCTAGAAGTTTTCTTTCATACCTACTT
GCACCTATCATAGGAACCTTCGATACAGCCTTCAGAGAACGTTGA

Upstream 100 bases:

>100_bases
AAGAAAAAGAAATTAAAATAATTTAAGCTCACTAACCTACAAAGTAGAGTGATTGTGTAATAGGATTAGCCGACCAAGGC
AGCATTCGTGTGTCAGAGAA

Downstream 100 bases:

>100_bases
AAAACAGAAAGTTTTGTTTGGTAAGAGTTTCTACTTAAAAGATTTCCCGAAAAACTCCATTATTAAGGGACCCTGTTCGA
AAATTTGCATGCGACAGCCA

Product: HlyD family type I secretion membrane fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MIKKITDSAKSGKLKILDFLTSGFKRTLHSSVKIVDQSISFFQNKKTNELKALTKNARITGTVVLIGFFGIFGMWAVFAP
IDGASLAMGEIVISSDKKSVQHLEGGIIEEIFVHEGDHVTEGQVLMTLKNVGNKAQLSILEENQISLLATEQRLLAHIGR
KANMELPNIEKLEYVTEEKKSDTIKNQVLLFESNKESFANKVRIIDKKIGQIQNEVLALKAQLESAEKNIQLLEEELEAK
RSLYDEHVIDKTKIVSLERERISWNGKIAEYKALIARGEQHVTEAELEKIQVENSFNSELAAQLKEVSHAIHENMQKLTA
AYDLMLRTIIRAPQSGIVTGLRSLSIGGVIPPAISLMEIVPENEDMFIEAKVAPNNIEAIVSARLVKKNLSEVEGYIGVR
TRVKITAFNSKKVGILKGVMTYISANTILDPRTGMHYYLAHIRIPKSEIAMINARTKLYPGMPAIVFITTESRSFLSYLL
APIIGTFDTAFRER

Sequences:

>Translated_494_residues
MIKKITDSAKSGKLKILDFLTSGFKRTLHSSVKIVDQSISFFQNKKTNELKALTKNARITGTVVLIGFFGIFGMWAVFAP
IDGASLAMGEIVISSDKKSVQHLEGGIIEEIFVHEGDHVTEGQVLMTLKNVGNKAQLSILEENQISLLATEQRLLAHIGR
KANMELPNIEKLEYVTEEKKSDTIKNQVLLFESNKESFANKVRIIDKKIGQIQNEVLALKAQLESAEKNIQLLEEELEAK
RSLYDEHVIDKTKIVSLERERISWNGKIAEYKALIARGEQHVTEAELEKIQVENSFNSELAAQLKEVSHAIHENMQKLTA
AYDLMLRTIIRAPQSGIVTGLRSLSIGGVIPPAISLMEIVPENEDMFIEAKVAPNNIEAIVSARLVKKNLSEVEGYIGVR
TRVKITAFNSKKVGILKGVMTYISANTILDPRTGMHYYLAHIRIPKSEIAMINARTKLYPGMPAIVFITTESRSFLSYLL
APIIGTFDTAFRER
>Mature_494_residues
MIKKITDSAKSGKLKILDFLTSGFKRTLHSSVKIVDQSISFFQNKKTNELKALTKNARITGTVVLIGFFGIFGMWAVFAP
IDGASLAMGEIVISSDKKSVQHLEGGIIEEIFVHEGDHVTEGQVLMTLKNVGNKAQLSILEENQISLLATEQRLLAHIGR
KANMELPNIEKLEYVTEEKKSDTIKNQVLLFESNKESFANKVRIIDKKIGQIQNEVLALKAQLESAEKNIQLLEEELEAK
RSLYDEHVIDKTKIVSLERERISWNGKIAEYKALIARGEQHVTEAELEKIQVENSFNSELAAQLKEVSHAIHENMQKLTA
AYDLMLRTIIRAPQSGIVTGLRSLSIGGVIPPAISLMEIVPENEDMFIEAKVAPNNIEAIVSARLVKKNLSEVEGYIGVR
TRVKITAFNSKKVGILKGVMTYISANTILDPRTGMHYYLAHIRIPKSEIAMINARTKLYPGMPAIVFITTESRSFLSYLL
APIIGTFDTAFRER

Specific function: Involved in the secretion of proteases A, B, C and G [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003997
- InterPro:   IPR006143
- InterPro:   IPR006144
- InterPro:   IPR010129 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 55172; Mature: 55172

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS00543 HLYD_FAMILY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKITDSAKSGKLKILDFLTSGFKRTLHSSVKIVDQSISFFQNKKTNELKALTKNARIT
CCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEE
GTVVLIGFFGIFGMWAVFAPIDGASLAMGEIVISSDKKSVQHLEGGIIEEIFVHEGDHVT
HHHHHHHHHHHHHHHHHHCCCCCCCEECCEEEEECCHHHHHHHCCCHHHHHHHCCCCCCC
EGQVLMTLKNVGNKAQLSILEENQISLLATEQRLLAHIGRKANMELPNIEKLEYVTEEKK
CCCEEEEEHHCCCCEEEEEEECCCEEEEEHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
SDTIKNQVLLFESNKESFANKVRIIDKKIGQIQNEVLALKAQLESAEKNIQLLEEELEAK
HHHHHCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSLYDEHVIDKTKIVSLERERISWNGKIAEYKALIARGEQHVTEAELEKIQVENSFNSEL
HHHHHHHHCCCHHEEEEEHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHEECCCCCCHHH
AAQLKEVSHAIHENMQKLTAAYDLMLRTIIRAPQSGIVTGLRSLSIGGVIPPAISLMEIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHC
PENEDMFIEAKVAPNNIEAIVSARLVKKNLSEVEGYIGVRTRVKITAFNSKKVGILKGVM
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCHHHHHHHH
TYISANTILDPRTGMHYYLAHIRIPKSEIAMINARTKLYPGMPAIVFITTESRSFLSYLL
HHHHHCCCCCCCCCCEEEEEEEECCHHHEEEEECCCEECCCCCEEEEEEECCHHHHHHHH
APIIGTFDTAFRER
HHHHHHHHHHHCCC
>Mature Secondary Structure
MIKKITDSAKSGKLKILDFLTSGFKRTLHSSVKIVDQSISFFQNKKTNELKALTKNARIT
CCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEE
GTVVLIGFFGIFGMWAVFAPIDGASLAMGEIVISSDKKSVQHLEGGIIEEIFVHEGDHVT
HHHHHHHHHHHHHHHHHHCCCCCCCEECCEEEEECCHHHHHHHCCCHHHHHHHCCCCCCC
EGQVLMTLKNVGNKAQLSILEENQISLLATEQRLLAHIGRKANMELPNIEKLEYVTEEKK
CCCEEEEEHHCCCCEEEEEEECCCEEEEEHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
SDTIKNQVLLFESNKESFANKVRIIDKKIGQIQNEVLALKAQLESAEKNIQLLEEELEAK
HHHHHCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSLYDEHVIDKTKIVSLERERISWNGKIAEYKALIARGEQHVTEAELEKIQVENSFNSEL
HHHHHHHHCCCHHEEEEEHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHEECCCCCCHHH
AAQLKEVSHAIHENMQKLTAAYDLMLRTIIRAPQSGIVTGLRSLSIGGVIPPAISLMEIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHC
PENEDMFIEAKVAPNNIEAIVSARLVKKNLSEVEGYIGVRTRVKITAFNSKKVGILKGVM
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCHHHHHHHH
TYISANTILDPRTGMHYYLAHIRIPKSEIAMINARTKLYPGMPAIVFITTESRSFLSYLL
HHHHHCCCCCCCCCCEEEEEEEECCHHHEEEEECCCEECCCCCEEEEEEECCHHHHHHHH
APIIGTFDTAFRER
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2184029 [H]