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The map label for this gene is pqqL [C]

Identifier: 88607993

GI number: 88607993

Start: 143960

End: 145231

Strand: Direct

Name: pqqL [C]

Synonym: NSE_0175

Alternate gene names: 88607993

Gene position: 143960-145231 (Clockwise)

Preceding gene: 88608532

Following gene: 88608110

Centisome position: 16.76

GC content: 43.0

Gene sequence:

>1272_bases
GTGCAAAACCTAGTTCAGAGACGTCTTGGAAATAATCTACCAGTTTTTGTGGATAGTATATCAGGGCATTATTCCGTTTC
AATAAAGGTTTGGGTCAGAGCTGGTAGTGAATGTGAAACTCAAGAAAATGGTGGATTGGCACACTTTCTTGAACATATGA
TTTTCAAGGGCACAAGCACACGAAATGCAGCACAAATAGCTGAAGATTTTGATCGACTTGGAGGTTATTTCAATGCCTGT
ACTAGTAGGGGTTATACGGTTTACTATGTAAGGCTGTTGGAAGAGCACCTAGATAAGGGGATGGAGATTCTTTCCGACGT
GATCAACAACTCGATCTTTCCAGAGGAAGAGCTTGAGCGTGAAAAATTGGTTGTCCTAGAGGAGATTTCTCAAACTGAGG
ATGCACCCGACGATATTATCTTCGACCGTTTTTTTGAGAGCATATATCCGAATCAAGCTTACGGACGGCCTATTCTTGGT
TCTAGGGAGAATGTTAAACGCTTTACAAGAAATGACATCGCTTCTTTCATATCTCAGCACTACTACTCTGAGAATATGAT
GCTCATTGCGTCCGGCAAAGTGGATGCTGAGAGATTTATCTCACTGGCGGAGAAGTATTTTGGAGGTATAAAATCAATCA
GCAGACGCGCCGCAAATAGGTTACCGGCAAAGTATGTTCCTGTTGAATATAGAGAAGAGCGCAAGTTAGAGCAGACCCAT
ATCATTCTAGGATTGCCATGTGTTTCTTACTCAGATGGTATCTCTCAGGTATATTCTGCTAAGGTTCTTGCTATACTCTT
TGGCGGTGGTATGTCTTCTAGATTGTTTCAAGAGGTGCGAGAAAAACGTGGTCTAGCTTACTCTATAAGCGCTTTTCATG
CACCGAGTGAGACCTCAGCAATTATGGGTGTTTACTCTTCTACGGATCCAAAGAGACTAAAAGAGCTGGTTGCAGTGGTC
CTTGGTGAATTGGCTAAGCTTCGGAATACTCTTACGATCGAGGAGGTTGAAAGCGCAAAACAGCAAATTAAGTCGTCGAT
TTTGATGAGTCTGGAAAGTAATGAGTCTCGTGCGTCTCATATAGGTAGGTCGATTCATTACTTTGGCAGGTACATAGATG
GAGCCGAGCTGATCGAAGTTATTGATGCTGTTGAAGTTGATGATGTTGCCTCAATTACAGAGTTTATGTTGCGGGGTAAG
CGCTTGAGCCTTGCGTTGATTGGTGCAAAAGATGTATTGGATGAGCGCGGAGTGTTAGCAGAAGCGCTGTAG

Upstream 100 bases:

>100_bases
TGTGGTGTGCCTTTTCTCCGGCTAAGAATGCATTTGTTCTCGAGTTGATTTCCCCGACTTCAAGTGCTAGAATCGGCCCC
TGAAGCTTTCCACCAGAGAA

Downstream 100 bases:

>100_bases
CATTCATTCGTGTAACCAATTTAGTTTAGCTTTTGGAGATATAAAATGGGTACTGGGTTTCATGGGACTACTATTCTTTC
GATCAGAAAGGATGACAAGG

Product: M16 family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MQNLVQRRLGNNLPVFVDSISGHYSVSIKVWVRAGSECETQENGGLAHFLEHMIFKGTSTRNAAQIAEDFDRLGGYFNAC
TSRGYTVYYVRLLEEHLDKGMEILSDVINNSIFPEEELEREKLVVLEEISQTEDAPDDIIFDRFFESIYPNQAYGRPILG
SRENVKRFTRNDIASFISQHYYSENMMLIASGKVDAERFISLAEKYFGGIKSISRRAANRLPAKYVPVEYREERKLEQTH
IILGLPCVSYSDGISQVYSAKVLAILFGGGMSSRLFQEVREKRGLAYSISAFHAPSETSAIMGVYSSTDPKRLKELVAVV
LGELAKLRNTLTIEEVESAKQQIKSSILMSLESNESRASHIGRSIHYFGRYIDGAELIEVIDAVEVDDVASITEFMLRGK
RLSLALIGAKDVLDERGVLAEAL

Sequences:

>Translated_423_residues
MQNLVQRRLGNNLPVFVDSISGHYSVSIKVWVRAGSECETQENGGLAHFLEHMIFKGTSTRNAAQIAEDFDRLGGYFNAC
TSRGYTVYYVRLLEEHLDKGMEILSDVINNSIFPEEELEREKLVVLEEISQTEDAPDDIIFDRFFESIYPNQAYGRPILG
SRENVKRFTRNDIASFISQHYYSENMMLIASGKVDAERFISLAEKYFGGIKSISRRAANRLPAKYVPVEYREERKLEQTH
IILGLPCVSYSDGISQVYSAKVLAILFGGGMSSRLFQEVREKRGLAYSISAFHAPSETSAIMGVYSSTDPKRLKELVAVV
LGELAKLRNTLTIEEVESAKQQIKSSILMSLESNESRASHIGRSIHYFGRYIDGAELIEVIDAVEVDDVASITEFMLRGK
RLSLALIGAKDVLDERGVLAEAL
>Mature_423_residues
MQNLVQRRLGNNLPVFVDSISGHYSVSIKVWVRAGSECETQENGGLAHFLEHMIFKGTSTRNAAQIAEDFDRLGGYFNAC
TSRGYTVYYVRLLEEHLDKGMEILSDVINNSIFPEEELEREKLVVLEEISQTEDAPDDIIFDRFFESIYPNQAYGRPILG
SRENVKRFTRNDIASFISQHYYSENMMLIASGKVDAERFISLAEKYFGGIKSISRRAANRLPAKYVPVEYREERKLEQTH
IILGLPCVSYSDGISQVYSAKVLAILFGGGMSSRLFQEVREKRGLAYSISAFHAPSETSAIMGVYSSTDPKRLKELVAVV
LGELAKLRNTLTIEEVESAKQQIKSSILMSLESNESRASHIGRSIHYFGRYIDGAELIEVIDAVEVDDVASITEFMLRGK
RLSLALIGAKDVLDERGVLAEAL

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=397, Percent_Identity=30.7304785894207, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI46593007, Length=384, Percent_Identity=27.0833333333333, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI24308013, Length=434, Percent_Identity=26.2672811059908, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI50592988, Length=424, Percent_Identity=23.1132075471698, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1787770, Length=271, Percent_Identity=25.830258302583, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71999683, Length=396, Percent_Identity=27.5252525252525, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17553678, Length=386, Percent_Identity=24.6113989637306, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17510601, Length=443, Percent_Identity=22.7990970654628, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17569737, Length=344, Percent_Identity=22.9651162790698, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17555260, Length=412, Percent_Identity=22.0873786407767, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323192, Length=431, Percent_Identity=30.6264501160093, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6321813, Length=415, Percent_Identity=26.5060240963855, Blast_Score=129, Evalue=9e-31,
Organism=Drosophila melanogaster, GI21357875, Length=413, Percent_Identity=28.8135593220339, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24646943, Length=413, Percent_Identity=28.8135593220339, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI19921772, Length=421, Percent_Identity=23.5154394299287, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24641429, Length=191, Percent_Identity=26.1780104712042, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24667786, Length=174, Percent_Identity=29.8850574712644, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 47499; Mature: 47499

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNLVQRRLGNNLPVFVDSISGHYSVSIKVWVRAGSECETQENGGLAHFLEHMIFKGTST
CHHHHHHHHCCCCCEEEECCCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCC
RNAAQIAEDFDRLGGYFNACTSRGYTVYYVRLLEEHLDKGMEILSDVINNSIFPEEELER
CHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
EKLVVLEEISQTEDAPDDIIFDRFFESIYPNQAYGRPILGSRENVKRFTRNDIASFISQH
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
YYSENMMLIASGKVDAERFISLAEKYFGGIKSISRRAANRLPAKYVPVEYREERKLEQTH
HHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHE
IILGLPCVSYSDGISQVYSAKVLAILFGGGMSSRLFQEVREKRGLAYSISAFHAPSETSA
EEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEHHHCCCCCCHH
IMGVYSSTDPKRLKELVAVVLGELAKLRNTLTIEEVESAKQQIKSSILMSLESNESRASH
HEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
IGRSIHYFGRYIDGAELIEVIDAVEVDDVASITEFMLRGKRLSLALIGAKDVLDERGVLA
HHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEEEECHHHHHHHCCCHH
EAL
HCC
>Mature Secondary Structure
MQNLVQRRLGNNLPVFVDSISGHYSVSIKVWVRAGSECETQENGGLAHFLEHMIFKGTST
CHHHHHHHHCCCCCEEEECCCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCC
RNAAQIAEDFDRLGGYFNACTSRGYTVYYVRLLEEHLDKGMEILSDVINNSIFPEEELER
CHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
EKLVVLEEISQTEDAPDDIIFDRFFESIYPNQAYGRPILGSRENVKRFTRNDIASFISQH
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
YYSENMMLIASGKVDAERFISLAEKYFGGIKSISRRAANRLPAKYVPVEYREERKLEQTH
HHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHE
IILGLPCVSYSDGISQVYSAKVLAILFGGGMSSRLFQEVREKRGLAYSISAFHAPSETSA
EEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEHHHCCCCCCHH
IMGVYSSTDPKRLKELVAVVLGELAKLRNTLTIEEVESAKQQIKSSILMSLESNESRASH
HEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
IGRSIHYFGRYIDGAELIEVIDAVEVDDVASITEFMLRGKRLSLALIGAKDVLDERGVLA
HHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEEEECHHHHHHHCCCHH
EAL
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA