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The map label for this gene is icd [H]

Identifier: 88607979

GI number: 88607979

Start: 141195

End: 142610

Strand: Reverse

Name: icd [H]

Synonym: NSE_0172

Alternate gene names: 88607979

Gene position: 142610-141195 (Counterclockwise)

Preceding gene: 88608195

Following gene: 88608112

Centisome position: 16.6

GC content: 41.24

Gene sequence:

>1416_bases
ATGCCCAAGTTGACAGTAGCGTACGGTGACGGAGTCGGACCAGAAATAATGACATCGGTGCTCGAAATTATTTTTGAGGC
TGGTGCAGAAATACAGATTGATACAATTGAAATTGGACAGAAGATTTATGAAAAAGGCTGGCATTCTGGGATTTCTGACT
CCGGATGGGAAACCCTCAAGAGAAATAAAGTACTCCTAAAAGCACCGATAACAACTCCTCGCGGAGGGGGTGTAAGAAGT
CTTAACGTAACGCTCAGAAAGAAGCTAGGACTGTTCGCCAATATTAGACCCTGCAAATCGCACTTAGAATGGCAAAGCCC
TAAAATGGATATCGTCATTATCCGAGAAAATGAGGAAGACCTCTACTCAGGGACAGAATACAGACAGACCCTCGATACAT
ACAACTGCACTAAGGTTATTACAGAAAGTACATCTGAGCGGATTTGTAGATATGCTTTCGAATACGCACGCAAAAACGGC
AGAAAAAAAGTCACCGTAATGGTGAAAGATAATATCATGAAACTGACTGATGGAATCTTTCACAAACTGTTTAAGAAGGT
CGCGCTTGAGTATCCAGATATCGAGAGTGAAAACTACATTATAGATATAGGGGCAGCAAGAATAGCAAAAAACCCTGAAA
AATTTGATGTGATCGTCACGCTTAACCTATATGGAGACATTATTTCGGACATTGCAGCAGAAATTTCAGGATCAGTGGGT
CTTGGAGGTAGTATCAATATAGGCGAAGAATACGCAATGTTCGAGGCTGTACATGGTTCTGCACCTGACATAGCAGACCA
AGACATTGCAAATCCTTCCGGACTTTTGAACGCCGCAATGTATATGCTCAGTTATATAGGACAGAAGGAAATTGCACAAA
AGGTCTATTCTGCATGGTTGAAGACACTAAAATCAGGTGTACATACCGCGGACATTTTTAATCCTTTGCACAGCAAGCTC
AAGGTTGGCACTAAAAAGTTTACAGAACACATAATTCACAACATCGACAGAAAAAGTTTGGTAGCTTTCTCATGTAACAG
TCTGGTCGAAGGTGTACTTCTTAAACCCCGATACCAGAGTAAGAAGGAAAAAGTTCTAATCGGTGTGGATCTCTTTATTA
GCTGGGATAGTACAAATTTAGCAGCCCTTTTGGCTGCTTTAGAAAAAATAAAAGTAGACGATGTGATAATCCTGGGTAGC
ATAAGCGTCAAAGGCGTCTTGATTTGGCCAGAAGAAACAGCCGTCATGCCCTACAGTGACACTCTTTGTTGTAGATTCTT
GGCAGAACCCAATAAGAGTCTAGCCACAACAGTTATCTGCGGTCTAATAAGTGAACTAGAAAATTCAGCAATAGAGGTCA
CCAAAATGGAGAAACTTTACTCCTTTGGCGATGAAGCGGGGTTTTCAAATATTTAA

Upstream 100 bases:

>100_bases
AACCACGAAGAACACCTACTTTTGCTAACAGGACAACTCTAAACTATAATAGCGACAATTTTCTATAAAATGAAAGAAGT
ACAGTATACAGAAGATTAAT

Downstream 100 bases:

>100_bases
GAGATAGTGATACCTCGCGTTCATGACTTCTGCTCAGCGAACTTATGCAGAATCTTACCCTTAAGTAAAAAGGAACCAGA
TACCCAACTTAGAACAACAG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MPKLTVAYGDGVGPEIMTSVLEIIFEAGAEIQIDTIEIGQKIYEKGWHSGISDSGWETLKRNKVLLKAPITTPRGGGVRS
LNVTLRKKLGLFANIRPCKSHLEWQSPKMDIVIIRENEEDLYSGTEYRQTLDTYNCTKVITESTSERICRYAFEYARKNG
RKKVTVMVKDNIMKLTDGIFHKLFKKVALEYPDIESENYIIDIGAARIAKNPEKFDVIVTLNLYGDIISDIAAEISGSVG
LGGSINIGEEYAMFEAVHGSAPDIADQDIANPSGLLNAAMYMLSYIGQKEIAQKVYSAWLKTLKSGVHTADIFNPLHSKL
KVGTKKFTEHIIHNIDRKSLVAFSCNSLVEGVLLKPRYQSKKEKVLIGVDLFISWDSTNLAALLAALEKIKVDDVIILGS
ISVKGVLIWPEETAVMPYSDTLCCRFLAEPNKSLATTVICGLISELENSAIEVTKMEKLYSFGDEAGFSNI

Sequences:

>Translated_471_residues
MPKLTVAYGDGVGPEIMTSVLEIIFEAGAEIQIDTIEIGQKIYEKGWHSGISDSGWETLKRNKVLLKAPITTPRGGGVRS
LNVTLRKKLGLFANIRPCKSHLEWQSPKMDIVIIRENEEDLYSGTEYRQTLDTYNCTKVITESTSERICRYAFEYARKNG
RKKVTVMVKDNIMKLTDGIFHKLFKKVALEYPDIESENYIIDIGAARIAKNPEKFDVIVTLNLYGDIISDIAAEISGSVG
LGGSINIGEEYAMFEAVHGSAPDIADQDIANPSGLLNAAMYMLSYIGQKEIAQKVYSAWLKTLKSGVHTADIFNPLHSKL
KVGTKKFTEHIIHNIDRKSLVAFSCNSLVEGVLLKPRYQSKKEKVLIGVDLFISWDSTNLAALLAALEKIKVDDVIILGS
ISVKGVLIWPEETAVMPYSDTLCCRFLAEPNKSLATTVICGLISELENSAIEVTKMEKLYSFGDEAGFSNI
>Mature_470_residues
PKLTVAYGDGVGPEIMTSVLEIIFEAGAEIQIDTIEIGQKIYEKGWHSGISDSGWETLKRNKVLLKAPITTPRGGGVRSL
NVTLRKKLGLFANIRPCKSHLEWQSPKMDIVIIRENEEDLYSGTEYRQTLDTYNCTKVITESTSERICRYAFEYARKNGR
KKVTVMVKDNIMKLTDGIFHKLFKKVALEYPDIESENYIIDIGAARIAKNPEKFDVIVTLNLYGDIISDIAAEISGSVGL
GGSINIGEEYAMFEAVHGSAPDIADQDIANPSGLLNAAMYMLSYIGQKEIAQKVYSAWLKTLKSGVHTADIFNPLHSKLK
VGTKKFTEHIIHNIDRKSLVAFSCNSLVEGVLLKPRYQSKKEKVLIGVDLFISWDSTNLAALLAALEKIKVDDVIILGSI
SVKGVLIWPEETAVMPYSDTLCCRFLAEPNKSLATTVICGLISELENSAIEVTKMEKLYSFGDEAGFSNI

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=306, Percent_Identity=41.1764705882353, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI4758582, Length=315, Percent_Identity=35.5555555555556, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI28178838, Length=305, Percent_Identity=35.4098360655738, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI28178816, Length=292, Percent_Identity=37.6712328767123, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI28178821, Length=292, Percent_Identity=37.6712328767123, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI28178819, Length=153, Percent_Identity=43.1372549019608, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI1787381, Length=392, Percent_Identity=30.8673469387755, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI87081683, Length=352, Percent_Identity=30.1136363636364, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI1788101, Length=329, Percent_Identity=28.8753799392097, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71986051, Length=307, Percent_Identity=41.6938110749186, Blast_Score=232, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17505779, Length=309, Percent_Identity=37.2168284789644, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI25144293, Length=319, Percent_Identity=36.9905956112853, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17550882, Length=319, Percent_Identity=34.4827586206897, Blast_Score=175, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6324709, Length=342, Percent_Identity=42.1052631578947, Blast_Score=241, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6324291, Length=315, Percent_Identity=39.3650793650794, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6322097, Length=274, Percent_Identity=36.8613138686131, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6319830, Length=339, Percent_Identity=27.1386430678466, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24643270, Length=313, Percent_Identity=40.8945686900958, Blast_Score=244, Evalue=7e-65,
Organism=Drosophila melanogaster, GI24643268, Length=313, Percent_Identity=40.8945686900958, Blast_Score=244, Evalue=9e-65,
Organism=Drosophila melanogaster, GI24661184, Length=341, Percent_Identity=37.8299120234604, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI161078635, Length=316, Percent_Identity=36.3924050632911, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI161078633, Length=316, Percent_Identity=36.3924050632911, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI24650122, Length=316, Percent_Identity=36.3924050632911, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI161078637, Length=316, Percent_Identity=36.3924050632911, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI161078639, Length=311, Percent_Identity=36.6559485530547, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI281362242, Length=339, Percent_Identity=33.0383480825959, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24648872, Length=339, Percent_Identity=33.0383480825959, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI20130355, Length=315, Percent_Identity=31.4285714285714, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI45550436, Length=290, Percent_Identity=20.3448275862069, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR014273 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 52191; Mature: 52060

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLTVAYGDGVGPEIMTSVLEIIFEAGAEIQIDTIEIGQKIYEKGWHSGISDSGWETLK
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCCCHHHHH
RNKVLLKAPITTPRGGGVRSLNVTLRKKLGLFANIRPCKSHLEWQSPKMDIVIIRENEED
CCCEEEEECCCCCCCCCEEEEEHHHHHHCCCCCCCHHHHHCCCCCCCCEEEEEEECCCHH
LYSGTEYRQTLDTYNCTKVITESTSERICRYAFEYARKNGRKKVTVMVKDNIMKLTDGIF
HHCCHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHH
HKLFKKVALEYPDIESENYIIDIGAARIAKNPEKFDVIVTLNLYGDIISDIAAEISGSVG
HHHHHHHHCCCCCCCCCCEEEEECHHHHHCCCCCEEEEEEEEHHHHHHHHHHHHHCCCCC
LGGSINIGEEYAMFEAVHGSAPDIADQDIANPSGLLNAAMYMLSYIGQKEIAQKVYSAWL
CCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
KTLKSGVHTADIFNPLHSKLKVGTKKFTEHIIHNIDRKSLVAFSCNSLVEGVLLKPRYQS
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEHHHHHHHHCCCCCCCC
KKEKVLIGVDLFISWDSTNLAALLAALEKIKVDDVIILGSISVKGVLIWPEETAVMPYSD
CCCEEEEEEEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCEECCCCH
TLCCRFLAEPNKSLATTVICGLISELENSAIEVTKMEKLYSFGDEAGFSNI
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PKLTVAYGDGVGPEIMTSVLEIIFEAGAEIQIDTIEIGQKIYEKGWHSGISDSGWETLK
CCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCCCHHHHH
RNKVLLKAPITTPRGGGVRSLNVTLRKKLGLFANIRPCKSHLEWQSPKMDIVIIRENEED
CCCEEEEECCCCCCCCCEEEEEHHHHHHCCCCCCCHHHHHCCCCCCCCEEEEEEECCCHH
LYSGTEYRQTLDTYNCTKVITESTSERICRYAFEYARKNGRKKVTVMVKDNIMKLTDGIF
HHCCHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHH
HKLFKKVALEYPDIESENYIIDIGAARIAKNPEKFDVIVTLNLYGDIISDIAAEISGSVG
HHHHHHHHCCCCCCCCCCEEEEECHHHHHCCCCCEEEEEEEEHHHHHHHHHHHHHCCCCC
LGGSINIGEEYAMFEAVHGSAPDIADQDIANPSGLLNAAMYMLSYIGQKEIAQKVYSAWL
CCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
KTLKSGVHTADIFNPLHSKLKVGTKKFTEHIIHNIDRKSLVAFSCNSLVEGVLLKPRYQS
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEHHHHHHHHCCCCCCCC
KKEKVLIGVDLFISWDSTNLAALLAALEKIKVDDVIILGSISVKGVLIWPEETAVMPYSD
CCCEEEEEEEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCEECCCCH
TLCCRFLAEPNKSLATTVICGLISELENSAIEVTKMEKLYSFGDEAGFSNI
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA