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The map label for this gene is ccmE

Identifier: 88607810

GI number: 88607810

Start: 545395

End: 545820

Strand: Direct

Name: ccmE

Synonym: APH_0526

Alternate gene names: 88607810

Gene position: 545395-545820 (Clockwise)

Preceding gene: 88607277

Following gene: 88607572

Centisome position: 37.07

GC content: 40.85

Gene sequence:

>426_bases
ATGCAAAGAAAACATAAACGTATTCTTTTTGTAGCTGTTTCATTTATAGCTTTAGGGTGCGTATCTGCTTTTGTGTTGTT
TGAGCTCAGCAAAAGTATATCCTTTTTCTGCACTCCTACCGAACTTGTAGCTGATCCCATAAAGTCGTCTCGCTATCCTA
TCCGTGTAGGGGGAATGATAGTGAAGGGTAGTATTGTGCGGCATGGTGATTCAGTAACTTTTTCTATAACGGATTTAGGG
ACTGAACTTGAGGTTACGTATAGAGGGGTATTACCCCCTATGTTTGGTGAGGATGTTGGTGCTATAGCAAAGGGGCGATT
TGTAGATGGGGTATTTATAGCGGAGGAACTCTTAGCCAAACACGATGAGAAATATATGCCTAAAAAGTATTCATCATCAG
ATGCCGCTGTTATTGGTAGTAGTTAG

Upstream 100 bases:

>100_bases
CTGGCTTATGCTCTGGGCTTCAGCATCTTGGCATTGTTTGGTGTGTATGTTGTGAGGAGCTTTCTGAAGAGTAAGCGGGT
GCTTAGAGAAGTAGTCAATA

Downstream 100 bases:

>100_bases
TCTATTATTGGGAGATCTACAGCGAAATTGCGTGGAAGCCATGTGAATCACTGCTATGTAATCGTGCATTAGGTGTTTTG
TATCGCTATTCTCTTCTCAA

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MQRKHKRILFVAVSFIALGCVSAFVLFELSKSISFFCTPTELVADPIKSSRYPIRVGGMIVKGSIVRHGDSVTFSITDLG
TELEVTYRGVLPPMFGEDVGAIAKGRFVDGVFIAEELLAKHDEKYMPKKYSSSDAAVIGSS

Sequences:

>Translated_141_residues
MQRKHKRILFVAVSFIALGCVSAFVLFELSKSISFFCTPTELVADPIKSSRYPIRVGGMIVKGSIVRHGDSVTFSITDLG
TELEVTYRGVLPPMFGEDVGAIAKGRFVDGVFIAEELLAKHDEKYMPKKYSSSDAAVIGSS
>Mature_141_residues
MQRKHKRILFVAVSFIALGCVSAFVLFELSKSISFFCTPTELVADPIKSSRYPIRVGGMIVKGSIVRHGDSVTFSITDLG
TELEVTYRGVLPPMFGEDVGAIAKGRFVDGVFIAEELLAKHDEKYMPKKYSSSDAAVIGSS

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=136, Percent_Identity=36.7647058823529, Blast_Score=86, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_ANAPZ (Q2GKI0)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_505121.1
- ProteinModelPortal:   Q2GKI0
- SMR:   Q2GKI0
- STRING:   Q2GKI0
- GeneID:   3930854
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_0526
- NMPDR:   fig|212042.5.peg.515
- TIGR:   APH_0526
- eggNOG:   COG2332
- HOGENOM:   HBG296631
- OMA:   HVEFAVH
- PhylomeDB:   Q2GKI0
- ProtClustDB:   PRK13254
- BioCyc:   APHA212042:APH_0526-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 15381; Mature: 15381

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: BINDING 121-121

Signals:

None

Transmembrane regions:

HASH(0x18b824ac)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRKHKRILFVAVSFIALGCVSAFVLFELSKSISFFCTPTELVADPIKSSRYPIRVGGMI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCCEEECCEE
VKGSIVRHGDSVTFSITDLGTELEVTYRGVLPPMFGEDVGAIAKGRFVDGVFIAEELLAK
EECEEEECCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHH
HDEKYMPKKYSSSDAAVIGSS
CCCCCCCCCCCCCCCEEEECH
>Mature Secondary Structure
MQRKHKRILFVAVSFIALGCVSAFVLFELSKSISFFCTPTELVADPIKSSRYPIRVGGMI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCCEEECCEE
VKGSIVRHGDSVTFSITDLGTELEVTYRGVLPPMFGEDVGAIAKGRFVDGVFIAEELLAK
EECEEEECCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHH
HDEKYMPKKYSSSDAAVIGSS
CCCCCCCCCCCCCCCEEEECH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA