| Definition | Anaplasma phagocytophilum HZ, complete genome. |
|---|---|
| Accession | NC_007797 |
| Length | 1,471,282 |
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The map label for this gene is virB4-2 [H]
Identifier: 88607351
GI number: 88607351
Start: 1191845
End: 1194178
Strand: Reverse
Name: virB4-2 [H]
Synonym: APH_1129
Alternate gene names: 88607351
Gene position: 1194178-1191845 (Counterclockwise)
Preceding gene: 88606826
Following gene: 88607850
Centisome position: 81.17
GC content: 43.7
Gene sequence:
>2334_bases GTGGAAGCGGAAAAGAGTGGTGGTGCTGAGAGGGCTAAATCCTCTTATGCGGAGTATGTTACTCCGGCCTGCCACTATGA TGATAATACGCTTCTGAATAAGGGTGGGGAGCTTGTCCAGATCATAGAGGTTGTGGATAGTGCGTGTGCTGATGGTGTGC AGTCTCTTAGAGATGGAATAAGAAAATGCATTTCCAGTGTTAAGGATCCTGATGTTGCATTTTGGGTGTACACAGTACGT GAGAAGAAGAAGTTTGATCTAGAATGGAGAAGCACTGGGGATTTTTCGGATACTCTGCACGATGTGTATAAGTCTTACAT TGATGAGAAGTATGAGACTTATGACAATAAAGTATACGTAGCTGTGGTAGTGAAGCATCTAGCAGAAGGTCTAGATGGTA TGGTAAATGCATTGTTGTTTAGCCGAGTGATGAGCAAGCACAAGAGTTATTTGGCGAAGCGTGCATCATACCTGACAACA GTGACAGATAAAATAATGGGGGACTTATCGGATTTTTCTACTAAGAAGCTTGGACTTATAGATTGTGGAGATGGACGATG GAGGTCGGAGTTACTGGAGTTTCTTAGCTATCTGGTAACATTCAGACACAGGGAGTGCTATCTGGAGACATGCGATAACG CGCATACTGTTTCCGCGGGTTGTGACCTGCACATGGGTTTTAATGCTTTTAAAGTGATAGACAACGAGAAAGTTAGGTAT GGTGCAATACTAGGGGTCAAGGTTCATGCTAGTGAGAATTTAGATGCCGTGGACGCGTGTTTGCAGCAGGAATGTGAGTT CATAATTGTTGAAATAATAAAGTTTACAGAGGGTAGGGAGCTAAAGAAGCTGTATGGTAGGCAGGCAGCATTGCTTGAGA TTAGTGGAGATGAAGATTTGGCAAAGCTAGGGCATTTGCCTACCATCATGCAGCTTGAAGACAGTGCGTATGGAGACTGC TGTGAAAGACAGGTAAATTGTGTTGTAATAGCAGATGGTCTGCGGTCATTAAGGAGTGGAATCAACGGAATGGTTTCGGC GTTTTCTACGATAGGGGCGCTGGCAGTGAGGTTGGACTTAGCTATGGAGGACAGCTTTTGGGCGTTGATGCCTGGGAACT TCCGGTATGTTATTTACATGAAAGCTGCGTTGATGAAGAAGGCTTGTACTTTTATTGTTTTGCACAGTTATCTATCTTTT TCCGCTAGCAGTACTAAGTGGCCTGATTCTATTACTGTCTTTTTCTCTAATCGTGGGTTGCCGTACTTCTTTAATTTTCA GTGCACAGGTAAAGGGCATACGGTGTGTTTAGGGCCGCATGACTCGTCTATGACCACGCTCTCTAATTTCTTACTTTCTG AGGCAAGACGGTTGCAGATCAGGTCTGTTGTTTTTGACTATAGTGGAAAGTCGATAATATACGCAAATGCAATTGGAGGT AGCTATCACCGGATAGATGATAGGCCAGAGTATGTGAGTGCTACGTTTAATCCATTCAATGTTGAAGATACAGCAGTAAA TCGTGATATAGCTGCGGGAGTATTGTACAGGATGGCTAGGCCCACAGCTGATACTTGTGATGCAGTAAGGCAGGCAGTAT TGGGGGTAGTGGATGCGATCTTTGCGATCCCGATGCAAGAACGCACTAAAGAGAAAATTGGTGAGTGCGTTAAAGTTTTG GGTGGGGGAATAAACAGTTGGTTTGGCAGTGGAAGATTTGCACATTTACTGACGGATTCTACGAGCATACAGTGGCATGC GGAGTTTTTGGGCATCAACGCTGCTATGCTTGTCAGTAAGACGGAATGTCTATCGGTGGTGCTATACTATATAGTACGCA GTATGGAAAATCATCTCGACGGTAAGCCACTGATTTTGGTGATGTATGAGGCTTGGCTTCTTGACTTTGTATTTGAGACG GAGCGTGAGTTTGATAATTGGGTCAACGGTCTTAGCAAGCTTAATGTTGTGGTAGTTTTCGCTTCTGAAAATATTAAAGC GATATCTTCTAGCAGGGTTATTAAGTACGTCAGTAAGCATGCTGATACAAGGATATTTATGCCAAACTTCATGATGGGTA GCAAACAGCATGGACGTATGTTTGGCCTCACACAAGAGGAGCAGGACGTTATGTTGCAGATTTCACAGGCTGAAGGGCAT TTCTTTTTAAAGCAAGGGAATGCATCGGTGGTATTATCTTTGAAGTTGCCAACACGAGAGAGCCGTATTCTAACAGCAAA TAGGACCAGCATACGGATGATGTATGAGGCTATTGCGGAAAAGGGTAAGGATTGGATAGAGGCTTTTCATGATAAATGTG ATGCTGCTAAGTAA
Upstream 100 bases:
>100_bases TCGATGCGGAGTTGCATGAATTTTTACAGGGGCTTTGCCAGTGTCTTTTGTGGATAATTTGGTCTTGAGATTCAGATCTA AAAGAGGAGATAATTGCTCT
Downstream 100 bases:
>100_bases GTTGGTGGTAATGCTGTGAGAAATATATCTGCGCGTATGCAAGGAAGCATATGTAGTGATTATTTGTCTTGAGGTGTTTG TAGCTGCTTCGTTATTAGCT
Product: type IV secretion system protein VirB4
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 777; Mature: 777
Protein sequence:
>777_residues MEAEKSGGAERAKSSYAEYVTPACHYDDNTLLNKGGELVQIIEVVDSACADGVQSLRDGIRKCISSVKDPDVAFWVYTVR EKKKFDLEWRSTGDFSDTLHDVYKSYIDEKYETYDNKVYVAVVVKHLAEGLDGMVNALLFSRVMSKHKSYLAKRASYLTT VTDKIMGDLSDFSTKKLGLIDCGDGRWRSELLEFLSYLVTFRHRECYLETCDNAHTVSAGCDLHMGFNAFKVIDNEKVRY GAILGVKVHASENLDAVDACLQQECEFIIVEIIKFTEGRELKKLYGRQAALLEISGDEDLAKLGHLPTIMQLEDSAYGDC CERQVNCVVIADGLRSLRSGINGMVSAFSTIGALAVRLDLAMEDSFWALMPGNFRYVIYMKAALMKKACTFIVLHSYLSF SASSTKWPDSITVFFSNRGLPYFFNFQCTGKGHTVCLGPHDSSMTTLSNFLLSEARRLQIRSVVFDYSGKSIIYANAIGG SYHRIDDRPEYVSATFNPFNVEDTAVNRDIAAGVLYRMARPTADTCDAVRQAVLGVVDAIFAIPMQERTKEKIGECVKVL GGGINSWFGSGRFAHLLTDSTSIQWHAEFLGINAAMLVSKTECLSVVLYYIVRSMENHLDGKPLILVMYEAWLLDFVFET EREFDNWVNGLSKLNVVVVFASENIKAISSSRVIKYVSKHADTRIFMPNFMMGSKQHGRMFGLTQEEQDVMLQISQAEGH FFLKQGNASVVLSLKLPTRESRILTANRTSIRMMYEAIAEKGKDWIEAFHDKCDAAK
Sequences:
>Translated_777_residues MEAEKSGGAERAKSSYAEYVTPACHYDDNTLLNKGGELVQIIEVVDSACADGVQSLRDGIRKCISSVKDPDVAFWVYTVR EKKKFDLEWRSTGDFSDTLHDVYKSYIDEKYETYDNKVYVAVVVKHLAEGLDGMVNALLFSRVMSKHKSYLAKRASYLTT VTDKIMGDLSDFSTKKLGLIDCGDGRWRSELLEFLSYLVTFRHRECYLETCDNAHTVSAGCDLHMGFNAFKVIDNEKVRY GAILGVKVHASENLDAVDACLQQECEFIIVEIIKFTEGRELKKLYGRQAALLEISGDEDLAKLGHLPTIMQLEDSAYGDC CERQVNCVVIADGLRSLRSGINGMVSAFSTIGALAVRLDLAMEDSFWALMPGNFRYVIYMKAALMKKACTFIVLHSYLSF SASSTKWPDSITVFFSNRGLPYFFNFQCTGKGHTVCLGPHDSSMTTLSNFLLSEARRLQIRSVVFDYSGKSIIYANAIGG SYHRIDDRPEYVSATFNPFNVEDTAVNRDIAAGVLYRMARPTADTCDAVRQAVLGVVDAIFAIPMQERTKEKIGECVKVL GGGINSWFGSGRFAHLLTDSTSIQWHAEFLGINAAMLVSKTECLSVVLYYIVRSMENHLDGKPLILVMYEAWLLDFVFET EREFDNWVNGLSKLNVVVVFASENIKAISSSRVIKYVSKHADTRIFMPNFMMGSKQHGRMFGLTQEEQDVMLQISQAEGH FFLKQGNASVVLSLKLPTRESRILTANRTSIRMMYEAIAEKGKDWIEAFHDKCDAAK >Mature_777_residues MEAEKSGGAERAKSSYAEYVTPACHYDDNTLLNKGGELVQIIEVVDSACADGVQSLRDGIRKCISSVKDPDVAFWVYTVR EKKKFDLEWRSTGDFSDTLHDVYKSYIDEKYETYDNKVYVAVVVKHLAEGLDGMVNALLFSRVMSKHKSYLAKRASYLTT VTDKIMGDLSDFSTKKLGLIDCGDGRWRSELLEFLSYLVTFRHRECYLETCDNAHTVSAGCDLHMGFNAFKVIDNEKVRY GAILGVKVHASENLDAVDACLQQECEFIIVEIIKFTEGRELKKLYGRQAALLEISGDEDLAKLGHLPTIMQLEDSAYGDC CERQVNCVVIADGLRSLRSGINGMVSAFSTIGALAVRLDLAMEDSFWALMPGNFRYVIYMKAALMKKACTFIVLHSYLSF SASSTKWPDSITVFFSNRGLPYFFNFQCTGKGHTVCLGPHDSSMTTLSNFLLSEARRLQIRSVVFDYSGKSIIYANAIGG SYHRIDDRPEYVSATFNPFNVEDTAVNRDIAAGVLYRMARPTADTCDAVRQAVLGVVDAIFAIPMQERTKEKIGECVKVL GGGINSWFGSGRFAHLLTDSTSIQWHAEFLGINAAMLVSKTECLSVVLYYIVRSMENHLDGKPLILVMYEAWLLDFVFET EREFDNWVNGLSKLNVVVVFASENIKAISSSRVIKYVSKHADTRIFMPNFMMGSKQHGRMFGLTQEEQDVMLQISQAEGH FFLKQGNASVVLSLKLPTRESRILTANRTSIRMMYEAIAEKGKDWIEAFHDKCDAAK
Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-
COG id: COG3451
COG function: function code U; Type IV secretory pathway, VirB4 components
Gene ontology:
Cell location: Cell inner membrane (Potential) [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the trbE/virB4 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR004346 - InterPro: IPR018145 [H]
Pfam domain/function: PF03135 CagE_TrbE_VirB [H]
EC number: NA
Molecular weight: Translated: 87125; Mature: 87125
Theoretical pI: Translated: 6.43; Mature: 6.43
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.4 %Cys (Translated Protein) 3.1 %Met (Translated Protein) 5.5 %Cys+Met (Translated Protein) 2.4 %Cys (Mature Protein) 3.1 %Met (Mature Protein) 5.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEAEKSGGAERAKSSYAEYVTPACHYDDNTLLNKGGELVQIIEVVDSACADGVQSLRDGI CCCCCCCCHHHHHHHHHHHCCCCEECCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH RKCISSVKDPDVAFWVYTVREKKKFDLEWRSTGDFSDTLHDVYKSYIDEKYETYDNKVYV HHHHHHCCCCCEEEEEEEECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEH AVVVKHLAEGLDGMVNALLFSRVMSKHKSYLAKRASYLTTVTDKIMGDLSDFSTKKLGLI HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE DCGDGRWRSELLEFLSYLVTFRHRECYLETCDNAHTVSAGCDLHMGFNAFKVIDNEKVRY ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCEEEEECCCCEEE GAILGVKVHASENLDAVDACLQQECEFIIVEIIKFTEGRELKKLYGRQAALLEISGDEDL EEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEEEECCCHHH AKLGHLPTIMQLEDSAYGDCCERQVNCVVIADGLRSLRSGINGMVSAFSTIGALAVRLDL HHHCCCCEEEEECCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE AMEDSFWALMPGNFRYVIYMKAALMKKACTFIVLHSYLSFSASSTKWPDSITVFFSNRGL EECCCEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCC PYFFNFQCTGKGHTVCLGPHDSSMTTLSNFLLSEARRLQIRSVVFDYSGKSIIYANAIGG CEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCC SYHRIDDRPEYVSATFNPFNVEDTAVNRDIAAGVLYRMARPTADTCDAVRQAVLGVVDAI CCCCCCCCCCEEEEECCCCCCCHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH FAIPMQERTKEKIGECVKVLGGGINSWFGSGRFAHLLTDSTSIQWHAEFLGINAAMLVSK HHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCEEEEEECCCCCEEEEHHHCCCHHHHHHH TECLSVVLYYIVRSMENHLDGKPLILVMYEAWLLDFVFETEREFDNWVNGLSKLNVVVVF HHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE ASENIKAISSSRVIKYVSKHADTRIFMPNFMMGSKQHGRMFGLTQEEQDVMLQISQAEGH ECCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEECCCCCCCCEEEEEECCCCE FFLKQGNASVVLSLKLPTRESRILTANRTSIRMMYEAIAEKGKDWIEAFHDKCDAAK EEEEECCCEEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHCHHHHHHHHHHCCCCC >Mature Secondary Structure MEAEKSGGAERAKSSYAEYVTPACHYDDNTLLNKGGELVQIIEVVDSACADGVQSLRDGI CCCCCCCCHHHHHHHHHHHCCCCEECCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH RKCISSVKDPDVAFWVYTVREKKKFDLEWRSTGDFSDTLHDVYKSYIDEKYETYDNKVYV HHHHHHCCCCCEEEEEEEECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEH AVVVKHLAEGLDGMVNALLFSRVMSKHKSYLAKRASYLTTVTDKIMGDLSDFSTKKLGLI HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE DCGDGRWRSELLEFLSYLVTFRHRECYLETCDNAHTVSAGCDLHMGFNAFKVIDNEKVRY ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCEEEEECCCCEEE GAILGVKVHASENLDAVDACLQQECEFIIVEIIKFTEGRELKKLYGRQAALLEISGDEDL EEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEEEECCCHHH AKLGHLPTIMQLEDSAYGDCCERQVNCVVIADGLRSLRSGINGMVSAFSTIGALAVRLDL HHHCCCCEEEEECCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE AMEDSFWALMPGNFRYVIYMKAALMKKACTFIVLHSYLSFSASSTKWPDSITVFFSNRGL EECCCEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCC PYFFNFQCTGKGHTVCLGPHDSSMTTLSNFLLSEARRLQIRSVVFDYSGKSIIYANAIGG CEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCC SYHRIDDRPEYVSATFNPFNVEDTAVNRDIAAGVLYRMARPTADTCDAVRQAVLGVVDAI CCCCCCCCCCEEEEECCCCCCCHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH FAIPMQERTKEKIGECVKVLGGGINSWFGSGRFAHLLTDSTSIQWHAEFLGINAAMLVSK HHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCEEEEEECCCCCEEEEHHHCCCHHHHHHH TECLSVVLYYIVRSMENHLDGKPLILVMYEAWLLDFVFETEREFDNWVNGLSKLNVVVVF HHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE ASENIKAISSSRVIKYVSKHADTRIFMPNFMMGSKQHGRMFGLTQEEQDVMLQISQAEGH ECCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEECCCCCCCCEEEEEECCCCE FFLKQGNASVVLSLKLPTRESRILTANRTSIRMMYEAIAEKGKDWIEAFHDKCDAAK EEEEECCCEEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHCHHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10749166; 10882236; 7494028 [H]