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The map label for this gene is bioF [C]

Identifier: 88607209

GI number: 88607209

Start: 1074237

End: 1075373

Strand: Direct

Name: bioF [C]

Synonym: APH_1016

Alternate gene names: 88607209

Gene position: 1074237-1075373 (Clockwise)

Preceding gene: 88607377

Following gene: 88607254

Centisome position: 73.01

GC content: 41.69

Gene sequence:

>1137_bases
ATGTTAAAAGATATATTAAGAGAGAGGTTAGAGGTAATAGAGAGCAATGGATTACTTAGAAAGTTAAAGCAAAGCACAAT
ACAGTCGTCAATAGCGGGACGTAAAATACAAAATGATGCAGGAAATGAGCTCACTTCTTTCTCATGCAATGATTACATGG
GGCTTTCAACACATGATGTAGTAAAGCAAGCCGCAATAGATGCTATCAATTTGTATGGCATGGGTGCACGCGCCTCTAGA
TTGACCACAGGAAACCATCCATTGTACGCAGAAATAGAAGCAAAACTTGCATCACTATACGGAACAGAAGCTGCGTTGGT
ATTTAGCAGCGGATATACAACAAATATAGGAAGCATCTCAGCATTGGTAGGTCGCCATGATATGATCTTGGCAGATAAGT
TCATACACGCTTCTTCTCTTGATGGAGCAAGATTATCTGGAGCTACAATATACAGGTTTACGCACAATAACGTAGATCAC
TGCATGCAACTAATTAGTAAGTATAGGGAACTACACGATAACTGCCTAATTCTGCTAGAAAACATATACGGGGTAGATGG
TGACTTAGCTCCCGTAGACGAGTTTATCCAACTAGCAAAAGAGTGGAATGCTTGGGTCATTGTAGATACTGCTCATGGCT
TTGGTATGCTCAGTTCCTTACAAGCAGACATATATGTGGGTACACTTTCCAAGGCAATGGGAGCACTGGGTGGATTTGTG
TGCTCATCAAAAATTACGATTGAGTACTTATTAAATAAGTCACGCAGTTTTATTTATACAACTGCTTTACCACCGGCAAT
TATAGCAGCTGCAAGTGCGTCTATAGACCTTTTCAAATCTTACGCAGAAGTTCCGATGCGTCTTGCAAAAGAATTTTGCA
AAATTATGGAACTACCTGAACCGCAAAGTCACATAGTGCCTTTGATTATGGAAGATGTCAGAAGCGTGATACTTGCTGAG
CAAGCCCTAGCTGAACGGGGCATTTTAGTATCAGCAATTCGTCCTCCGACAGCCCCAACTCCGAGACTGAGGTTAACATT
TACTGCTGCACACAAGCTAATAGACGTACATAGACTGTGTAATGCATTGAAAGCGTGCGTTGTACTTACAGAGGCAGGAA
ACTGGCGGGTCCTATAG

Upstream 100 bases:

>100_bases
TTACATGCTGACTCATAACTGGTATAAAACTTTACAATCTGTATAATCGATCTGTTGTTACGTGACGCTAATCCAGGCTG
TAGTTGAATAAGGTAGCCCC

Downstream 100 bases:

>100_bases
TAGCTTCACTCTTACACATCTCTACCCCCATTCGGGAATAGAAACAGGGCACAAGAGAAGTTACCCTGCTCCACCTCAAA
AAGCGAACCTAACGCCAAAC

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MLKDILRERLEVIESNGLLRKLKQSTIQSSIAGRKIQNDAGNELTSFSCNDYMGLSTHDVVKQAAIDAINLYGMGARASR
LTTGNHPLYAEIEAKLASLYGTEAALVFSSGYTTNIGSISALVGRHDMILADKFIHASSLDGARLSGATIYRFTHNNVDH
CMQLISKYRELHDNCLILLENIYGVDGDLAPVDEFIQLAKEWNAWVIVDTAHGFGMLSSLQADIYVGTLSKAMGALGGFV
CSSKITIEYLLNKSRSFIYTTALPPAIIAAASASIDLFKSYAEVPMRLAKEFCKIMELPEPQSHIVPLIMEDVRSVILAE
QALAERGILVSAIRPPTAPTPRLRLTFTAAHKLIDVHRLCNALKACVVLTEAGNWRVL

Sequences:

>Translated_378_residues
MLKDILRERLEVIESNGLLRKLKQSTIQSSIAGRKIQNDAGNELTSFSCNDYMGLSTHDVVKQAAIDAINLYGMGARASR
LTTGNHPLYAEIEAKLASLYGTEAALVFSSGYTTNIGSISALVGRHDMILADKFIHASSLDGARLSGATIYRFTHNNVDH
CMQLISKYRELHDNCLILLENIYGVDGDLAPVDEFIQLAKEWNAWVIVDTAHGFGMLSSLQADIYVGTLSKAMGALGGFV
CSSKITIEYLLNKSRSFIYTTALPPAIIAAASASIDLFKSYAEVPMRLAKEFCKIMELPEPQSHIVPLIMEDVRSVILAE
QALAERGILVSAIRPPTAPTPRLRLTFTAAHKLIDVHRLCNALKACVVLTEAGNWRVL
>Mature_378_residues
MLKDILRERLEVIESNGLLRKLKQSTIQSSIAGRKIQNDAGNELTSFSCNDYMGLSTHDVVKQAAIDAINLYGMGARASR
LTTGNHPLYAEIEAKLASLYGTEAALVFSSGYTTNIGSISALVGRHDMILADKFIHASSLDGARLSGATIYRFTHNNVDH
CMQLISKYRELHDNCLILLENIYGVDGDLAPVDEFIQLAKEWNAWVIVDTAHGFGMLSSLQADIYVGTLSKAMGALGGFV
CSSKITIEYLLNKSRSFIYTTALPPAIIAAASASIDLFKSYAEVPMRLAKEFCKIMELPEPQSHIVPLIMEDVRSVILAE
QALAERGILVSAIRPPTAPTPRLRLTFTAAHKLIDVHRLCNALKACVVLTEAGNWRVL

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=388, Percent_Identity=29.639175257732, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI284448556, Length=345, Percent_Identity=29.8550724637681, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI83977440, Length=340, Percent_Identity=30, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI83977444, Length=340, Percent_Identity=30, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI83977442, Length=340, Percent_Identity=30, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4502025, Length=337, Percent_Identity=29.673590504451, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI40316939, Length=337, Percent_Identity=29.673590504451, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI4758668, Length=341, Percent_Identity=30.2052785923754, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI119220554, Length=342, Percent_Identity=28.9473684210526, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI5454084, Length=248, Percent_Identity=23.7903225806452, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI1786993, Length=355, Percent_Identity=34.6478873239437, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1790046, Length=382, Percent_Identity=28.7958115183246, Blast_Score=157, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI71994529, Length=343, Percent_Identity=27.9883381924198, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI32566772, Length=349, Percent_Identity=26.9340974212034, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17560912, Length=250, Percent_Identity=28, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17560914, Length=240, Percent_Identity=28.75, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71982625, Length=287, Percent_Identity=23.6933797909408, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71982617, Length=287, Percent_Identity=23.6933797909408, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320438, Length=361, Percent_Identity=30.4709141274238, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320267, Length=345, Percent_Identity=22.3188405797101, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323954, Length=267, Percent_Identity=24.7191011235955, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24662918, Length=387, Percent_Identity=26.3565891472868, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI17137420, Length=351, Percent_Identity=29.3447293447293, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI17136286, Length=217, Percent_Identity=30.8755760368664, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24653280, Length=285, Percent_Identity=23.5087719298246, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24653276, Length=285, Percent_Identity=23.5087719298246, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24653278, Length=285, Percent_Identity=23.5087719298246, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 41367; Mature: 41367

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKDILRERLEVIESNGLLRKLKQSTIQSSIAGRKIQNDAGNELTSFSCNDYMGLSTHDV
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
VKQAAIDAINLYGMGARASRLTTGNHPLYAEIEAKLASLYGTEAALVFSSGYTTNIGSIS
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCEEEEEECCCCCCCCHHH
ALVGRHDMILADKFIHASSLDGARLSGATIYRFTHNNVDHCMQLISKYRELHDNCLILLE
HHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCHHEEEEH
NIYGVDGDLAPVDEFIQLAKEWNAWVIVDTAHGFGMLSSLQADIYVGTLSKAMGALGGFV
HHCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHEEHHHHHHHHHHHHHH
CSSKITIEYLLNKSRSFIYTTALPPAIIAAASASIDLFKSYAEVPMRLAKEFCKIMELPE
HCCCEEEEEHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PQSHIVPLIMEDVRSVILAEQALAERGILVSAIRPPTAPTPRLRLTFTAAHKLIDVHRLC
CHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHH
NALKACVVLTEAGNWRVL
HHHHHHEEEECCCCEEEC
>Mature Secondary Structure
MLKDILRERLEVIESNGLLRKLKQSTIQSSIAGRKIQNDAGNELTSFSCNDYMGLSTHDV
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
VKQAAIDAINLYGMGARASRLTTGNHPLYAEIEAKLASLYGTEAALVFSSGYTTNIGSIS
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCEEEEEECCCCCCCCHHH
ALVGRHDMILADKFIHASSLDGARLSGATIYRFTHNNVDHCMQLISKYRELHDNCLILLE
HHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCHHEEEEH
NIYGVDGDLAPVDEFIQLAKEWNAWVIVDTAHGFGMLSSLQADIYVGTLSKAMGALGGFV
HHCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHEEHHHHHHHHHHHHHH
CSSKITIEYLLNKSRSFIYTTALPPAIIAAASASIDLFKSYAEVPMRLAKEFCKIMELPE
HCCCEEEEEHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PQSHIVPLIMEDVRSVILAEQALAERGILVSAIRPPTAPTPRLRLTFTAAHKLIDVHRLC
CHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHH
NALKACVVLTEAGNWRVL
HHHHHHEEEECCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA