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The map label for this gene is xseA

Identifier: 88607196

GI number: 88607196

Start: 1389045

End: 1390241

Strand: Reverse

Name: xseA

Synonym: APH_1322

Alternate gene names: 88607196

Gene position: 1390241-1389045 (Counterclockwise)

Preceding gene: 88607368

Following gene: 88606710

Centisome position: 94.49

GC content: 42.27

Gene sequence:

>1197_bases
GTGCAGGTAACGCTTTTGAGATCTTTTTCTAACGATATACCGGAGTTTACCGTAACAGAAATTACGGGTGTGCTGCAAAG
ATTCATGCAGGAAACGTTCTATAGCATAAAAGTTAGAGGGGAAATTAGTGGCTTATCTAGACCCAATTCGGGACACGTAT
ACTTTACGCTAAAGGACAGCAACTCTGTAATCAACGCCGTATGTTGGAACGGCACAAGGCTCAAGGTACAGTTTTGCGAT
GGATTGGAAGTAGTGTGTACCGGTTATTTAAGCGTGTACCAATCAAAGTATCAGTTGATTGTAACCGATATGACATTGGC
AGGTTATGGGAAATTGGCTGCCATGCTTGCAGAACTGAAGAAAAAGCTGGAACTCGAAGGGCTTTTTAGCCCTGCACGGA
AGAAAAAGCTTCCGTTTTTACCGACAAAGATAGGAGTGATAACTTCTCCTACAGGTGCCGTTATTAGCGATATTATAAGT
CGAGTAAAGCAAAGATTCCCGAGCAATGTTGTTGTATGGCCTGTACAAGTGCAAGGAGATAGAGCCAGCGCCATGGTTAT
TGAGGCCATTAAGGGATTTAATAGCTTTGCAGACCCTCCCCATGTGATAATTGTGGCGAGAGGTGGAGGAAGCTTCGAAG
ACTTATGGCCGTTTAATGATGAAGAACTAGCTAGAACTGTTGCGGCATCCAAAATCCCTATTGTCTCAGCCATAGGGCAT
GAAACAGATTTTACAATAATAGACTACGCAGCAGACTTGCGTGCTTCGACTCCAACAGCTGCTGTGGAGCTGGTGTTGCC
GGAAAAAAGTAAACTAGTTGCTAGCATAAACGAAAAATTTGTTCGCACTAAAATCTCCTTTGAGCGAATAGTGAAAATGC
AAGAATATCGCCTGTTGAGGCTACACGGTATTCTAACAGAGAAGAAAAATAGTCTACTACAAAAAAGTAGAGTTGCTTTG
GAATATCAGCAAAAAATCCGATACCTTCTGCAGGTTTCCTTACTAAGGAAAAGACAATACCTAGAAAGTTTGATGCAGAG
ACTTTCCTACTATGACAGCAAACATATCTTGAGTGTTGGTTATGCTATAGTACGCGATGAACACGAAAAGCAGATAAGCT
CCGTAGAAGCTCTTTCGACTAATGACACAATAACCATAGAGCTCAAGGATGGTAAACGCCGCGCTATCATCATATGA

Upstream 100 bases:

>100_bases
ATAGAAGTAGATAAGTACAATGTGATAAAAAGCAAGACAGGTATGCATTTCGAAAGGGTCATTGAGGGAGTGCCCAGTTC
AGCAAATACAGTTCAGGTTC

Downstream 100 bases:

>100_bases
ACCAACTTTTCTTCGTTCTCTCCGGTCTCGATTCCCTTTACGTAGTGCTAAAAATACGTGTACTACCTCTACAATGCAAG
GAAGTGCAGAAGTGCTCCTC

Product: exodeoxyribonuclease VII, large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MQVTLLRSFSNDIPEFTVTEITGVLQRFMQETFYSIKVRGEISGLSRPNSGHVYFTLKDSNSVINAVCWNGTRLKVQFCD
GLEVVCTGYLSVYQSKYQLIVTDMTLAGYGKLAAMLAELKKKLELEGLFSPARKKKLPFLPTKIGVITSPTGAVISDIIS
RVKQRFPSNVVVWPVQVQGDRASAMVIEAIKGFNSFADPPHVIIVARGGGSFEDLWPFNDEELARTVAASKIPIVSAIGH
ETDFTIIDYAADLRASTPTAAVELVLPEKSKLVASINEKFVRTKISFERIVKMQEYRLLRLHGILTEKKNSLLQKSRVAL
EYQQKIRYLLQVSLLRKRQYLESLMQRLSYYDSKHILSVGYAIVRDEHEKQISSVEALSTNDTITIELKDGKRRAIII

Sequences:

>Translated_398_residues
MQVTLLRSFSNDIPEFTVTEITGVLQRFMQETFYSIKVRGEISGLSRPNSGHVYFTLKDSNSVINAVCWNGTRLKVQFCD
GLEVVCTGYLSVYQSKYQLIVTDMTLAGYGKLAAMLAELKKKLELEGLFSPARKKKLPFLPTKIGVITSPTGAVISDIIS
RVKQRFPSNVVVWPVQVQGDRASAMVIEAIKGFNSFADPPHVIIVARGGGSFEDLWPFNDEELARTVAASKIPIVSAIGH
ETDFTIIDYAADLRASTPTAAVELVLPEKSKLVASINEKFVRTKISFERIVKMQEYRLLRLHGILTEKKNSLLQKSRVAL
EYQQKIRYLLQVSLLRKRQYLESLMQRLSYYDSKHILSVGYAIVRDEHEKQISSVEALSTNDTITIELKDGKRRAIII
>Mature_398_residues
MQVTLLRSFSNDIPEFTVTEITGVLQRFMQETFYSIKVRGEISGLSRPNSGHVYFTLKDSNSVINAVCWNGTRLKVQFCD
GLEVVCTGYLSVYQSKYQLIVTDMTLAGYGKLAAMLAELKKKLELEGLFSPARKKKLPFLPTKIGVITSPTGAVISDIIS
RVKQRFPSNVVVWPVQVQGDRASAMVIEAIKGFNSFADPPHVIIVARGGGSFEDLWPFNDEELARTVAASKIPIVSAIGH
ETDFTIIDYAADLRASTPTAAVELVLPEKSKLVASINEKFVRTKISFERIVKMQEYRLLRLHGILTEKKNSLLQKSRVAL
EYQQKIRYLLQVSLLRKRQYLESLMQRLSYYDSKHILSVGYAIVRDEHEKQISSVEALSTNDTITIELKDGKRRAIII

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=328, Percent_Identity=37.5, Blast_Score=216, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_ANAPZ (Q2GIH0)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_505831.1
- STRING:   Q2GIH0
- GeneID:   3931050
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_1322
- NMPDR:   fig|212042.5.peg.1269
- TIGR:   APH_1322
- eggNOG:   COG1570
- HOGENOM:   HBG634411
- OMA:   LINWANE
- PhylomeDB:   Q2GIH0
- ProtClustDB:   CLSK749410
- BioCyc:   APHA212042:APH_1322-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 44771; Mature: 44771

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVTLLRSFSNDIPEFTVTEITGVLQRFMQETFYSIKVRGEISGLSRPNSGHVYFTLKDS
CEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCEEEEEEECC
NSVINAVCWNGTRLKVQFCDGLEVVCTGYLSVYQSKYQLIVTDMTLAGYGKLAAMLAELK
CCEEEEEEECCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEEEEHHCHHHHHHHHHHHH
KKLELEGLFSPARKKKLPFLPTKIGVITSPTGAVISDIISRVKQRFPSNVVVWPVQVQGD
HHHHHHHCCCCHHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCEEEEEEEECCC
RASAMVIEAIKGFNSFADPPHVIIVARGGGSFEDLWPFNDEELARTVAASKIPIVSAIGH
CHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCC
ETDFTIIDYAADLRASTPTAAVELVLPEKSKLVASINEKFVRTKISFERIVKMQEYRLLR
CCCEEEEEEHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHGILTEKKNSLLQKSRVALEYQQKIRYLLQVSLLRKRQYLESLMQRLSYYDSKHILSVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
YAIVRDEHEKQISSVEALSTNDTITIELKDGKRRAIII
HHHHHCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEC
>Mature Secondary Structure
MQVTLLRSFSNDIPEFTVTEITGVLQRFMQETFYSIKVRGEISGLSRPNSGHVYFTLKDS
CEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCEEEEEEECC
NSVINAVCWNGTRLKVQFCDGLEVVCTGYLSVYQSKYQLIVTDMTLAGYGKLAAMLAELK
CCEEEEEEECCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEEEEHHCHHHHHHHHHHHH
KKLELEGLFSPARKKKLPFLPTKIGVITSPTGAVISDIISRVKQRFPSNVVVWPVQVQGD
HHHHHHHCCCCHHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCEEEEEEEECCC
RASAMVIEAIKGFNSFADPPHVIIVARGGGSFEDLWPFNDEELARTVAASKIPIVSAIGH
CHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCC
ETDFTIIDYAADLRASTPTAAVELVLPEKSKLVASINEKFVRTKISFERIVKMQEYRLLR
CCCEEEEEEHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHGILTEKKNSLLQKSRVALEYQQKIRYLLQVSLLRKRQYLESLMQRLSYYDSKHILSVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
YAIVRDEHEKQISSVEALSTNDTITIELKDGKRRAIII
HHHHHCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA