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The map label for this gene is atpB

Identifier: 88606873

GI number: 88606873

Start: 1260922

End: 1261650

Strand: Reverse

Name: atpB

Synonym: APH_1192

Alternate gene names: 88606873

Gene position: 1261650-1260922 (Counterclockwise)

Preceding gene: 88607426

Following gene: 88607588

Centisome position: 85.75

GC content: 44.58

Gene sequence:

>729_bases
TTGAGTCCGCTAGAGCAGTTTAAAGTGGTTAGGTTGCTTGAGATTCCAATGCCGTTCGGAATGGATATAAGCTTTACTAA
TTGCGCGCTTTTCATGATTCTGGCATCGCTGGTTTCTGCGGTGCTGCTGTGTTGTGCACTACGCAAGAGGACTGATGGGT
CTTCGAGTATGTCGCATACTGCAGTTGAGTTGATTTACAACTTCGTTGTGGGTGCTATAGAGAGTAATGCAGGGGTTGGT
GGTCTCCGGTATATACCTTTCGTTCTTAGCATATTCCTATTTGTGTTGGCGTGTAATATTATAGGTATTCTGCCGCTTGG
TTTTACCGCAACAAGTCATGTCTCTGTTACGTTGGCTTTGTCTGTGGTTGTTTGCGCAAGCGTGACGGTACTTGGGTTTA
ATCACCAAGGGTTGCATTTTTTGAGGATTTTTCTTCCAGAGGGTACTCCCCTGTGGTTGGCGCCTATGATGGTATTTATA
AAGCTGTTTGCGTATTTGGCTAGGCCTGTGAGTTTGGCGATACGGTTAGCTGCTAACATGATCGCTGGTCACACTATCAT
TGCAGTTATTGCAGAATTTGTTCTGAAAATGCATCCAGTATTAGCGCCGTTGCCGTTCGCGTTCATAATGGTGCTAATAG
CGTTTGAGATTTTTGTTGCGATTTTGCAAGCGTATATATTTACGGTCTTGACTACTGTATACCTTTCTGATGCAGTTGCA
GGGCACTAG

Upstream 100 bases:

>100_bases
GCATATCTTTCTTAATGATGCTATGAAAACACTCACAACCTGATTGACTACAAATTTGTTCTGCACGATACTGTAGCATA
TAACAAATTTTGGATATAGC

Downstream 100 bases:

>100_bases
GTGAAGTGTGAATTCTGGGTAGAATAATTCACTATTGGTTGGCGGGAGCTACTTGGAGTGTGTTTTATGTGGCCTGTAGT
TTTGAAATCTTAGTATAGGC

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MSPLEQFKVVRLLEIPMPFGMDISFTNCALFMILASLVSAVLLCCALRKRTDGSSSMSHTAVELIYNFVVGAIESNAGVG
GLRYIPFVLSIFLFVLACNIIGILPLGFTATSHVSVTLALSVVVCASVTVLGFNHQGLHFLRIFLPEGTPLWLAPMMVFI
KLFAYLARPVSLAIRLAANMIAGHTIIAVIAEFVLKMHPVLAPLPFAFIMVLIAFEIFVAILQAYIFTVLTTVYLSDAVA
GH

Sequences:

>Translated_242_residues
MSPLEQFKVVRLLEIPMPFGMDISFTNCALFMILASLVSAVLLCCALRKRTDGSSSMSHTAVELIYNFVVGAIESNAGVG
GLRYIPFVLSIFLFVLACNIIGILPLGFTATSHVSVTLALSVVVCASVTVLGFNHQGLHFLRIFLPEGTPLWLAPMMVFI
KLFAYLARPVSLAIRLAANMIAGHTIIAVIAEFVLKMHPVLAPLPFAFIMVLIAFEIFVAILQAYIFTVLTTVYLSDAVA
GH
>Mature_241_residues
SPLEQFKVVRLLEIPMPFGMDISFTNCALFMILASLVSAVLLCCALRKRTDGSSSMSHTAVELIYNFVVGAIESNAGVGG
LRYIPFVLSIFLFVLACNIIGILPLGFTATSHVSVTLALSVVVCASVTVLGFNHQGLHFLRIFLPEGTPLWLAPMMVFIK
LFAYLARPVSLAIRLAANMIAGHTIIAVIAEFVLKMHPVLAPLPFAFIMVLIAFEIFVAILQAYIFTVLTTVYLSDAVAG
H

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Homo sapiens, GI251831112, Length=163, Percent_Identity=35.5828220858896, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1790176, Length=213, Percent_Identity=29.1079812206573, Blast_Score=67, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6226527, Length=254, Percent_Identity=29.5275590551181, Blast_Score=121, Evalue=8e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_ANAPZ (Q2GIS5)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_505726.1
- ProteinModelPortal:   Q2GIS5
- SMR:   Q2GIS5
- STRING:   Q2GIS5
- GeneID:   3930426
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_1192
- NMPDR:   fig|212042.5.peg.1142
- TIGR:   APH_1192
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   TSHFLIT
- PhylomeDB:   Q2GIS5
- ProtClustDB:   PRK05815
- BioCyc:   APHA212042:APH_1192-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 26235; Mature: 26104

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x19c12438)-; HASH(0x17970368)-; HASH(0x198b03b4)-; HASH(0x19e552ac)-; HASH(0x19dae730)-; HASH(0x95ae158)-; HASH(0x19d506e0)-;

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CH
>Mature Secondary Structure 
SPLEQFKVVRLLEIPMPFGMDISFTNCALFMILASLVSAVLLCCALRKRTDGSSSMSHT
CHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
AVELIYNFVVGAIESNAGVGGLRYIPFVLSIFLFVLACNIIGILPLGFTATSHVSVTLAL
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
SVVVCASVTVLGFNHQGLHFLRIFLPEGTPLWLAPMMVFIKLFAYLARPVSLAIRLAANM
HHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAGHTIIAVIAEFVLKMHPVLAPLPFAFIMVLIAFEIFVAILQAYIFTVLTTVYLSDAVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GH
CH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA