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The map label for this gene is pleC [H]

Identifier: 88606773

GI number: 88606773

Start: 1007568

End: 1008980

Strand: Reverse

Name: pleC [H]

Synonym: APH_0944

Alternate gene names: 88606773

Gene position: 1008980-1007568 (Counterclockwise)

Preceding gene: 88606760

Following gene: 88607477

Centisome position: 68.58

GC content: 39.56

Gene sequence:

>1413_bases
ATGCTTAGATGGGTCTTCAGATTTCTGATAAGGGCGACATTGGTTGTGCTGTTTGTTGGGTCAATGTGGTTTACTTATGC
ATATGTATCTGACAGAACGCTAAGCAAAGCAGCTATAACAATAAACACAGAGCTGAATAATGTATTTGAGCATTCGATTT
TAAGAAAATACATAGTCTTGTTGCGTGGAGCGCCTGTACATGTTGGTACTAACCCTTATCATATCAATCTCATAATTAAA
ATGCAGGCAGAGTTCATGCATGCCCTCCATATGCTTAAAGACGTTGAGTTGGTTTTATATAACGCTAACGGGAATGTCAT
GTTCACTGTAAGCGATGATATGGATACGGAAGTCAGTGATGCAAGTATTGTGCTATCTCCTGAAGAGCTTTCTCTTCTTT
CCAAGGGGGAAATCGTGCATGGAACAAGTGCGTACGGCATATACTCTTCCGTATTCCCCCTTATGGATGAATCAGGAGAG
CCTATAGTATTTTTGCGAGTCACAAGGGACTGCAGCGAGATGGCGGTTTTCTTCTCTAACTCGAATTTTGTATTTGTAAT
ACTGGTCGGTATTGCTGCAGCAATATGTATAGTGTTGACCCTTGTCATATACAGAAAAAATGTAAAGTTGCTTAATAGCC
AATACGATGCAAACCTTGAGTTACAAGAAAAGAAGGAAAACGCAGAAAAAGAGAGCGTAAGTAAGTCACAATTTCTTGCT
AATGTCAGTCATGAGTTACGCACTCCTCTAAACTCCATTATAGGTTTTTCAGAAATAGTTCAGAGAGAGTCTTTGGGACC
ACTTGGAAATGCGCAGTACAAGGAGTATATCAAGGAGATAAACCATGCTGGGGTACACTTATTAAGTCTGATAAATGACA
TATTGGATTTTTCTAAGGCAGAAGCAAATAAACTCAGTGTAGAGCTCGTAAAATGCGATCTACGTAAGATAGTGGATTCC
TGTTTTAACATGATGTTACCCAAGGCTCAGGAAGCCAAGGTCGAATTAAAGCGTGATATGCCAGAATCACAAATAGTGCT
GATGGTTGATGCCAGAAGAATGAAGCAGGTTATACTCAACATACTAACTAATTCTATGAAATTCACACCAGAGAAAGGGT
TTGTAAGGTTGTCTGTTGAGAAAAAGCAGGAAGAGGTTGTAATAGAAATATGTGACAATGGCATAGGTATTGCACAACAG
GATCTGTACAAAGTAATGTCAGTATTTGGGCAGGCAGATAGTACACATTCTCGCAAATATGAAGGAACAGGATTGGGTTT
GCCTCTGAGTAAAAAGTTGGTAGAGCTGATGAATGGTACTTTCAGTATTAAAGGTGAAGCAAATCTTGGAACAGTTGTAA
CTCTCTCATTTCCATGCGTTGAAGAAAGCCCTGAGAGCGAAAAGGCCTTTTAA

Upstream 100 bases:

>100_bases
AGGTCAACAGAAAAGTACCTTGGAAGCCAAATGATCATTAAGGATTGATGCTCTCAGAGTATGCTATATATTTTTAGGAC
AGTTCGAGAGCGGTGTATCT

Downstream 100 bases:

>100_bases
TTTTTGCTATACGGTAATTCACAGCCTATAAGCCGATAAGGAAAATAGACACATCAGTGCCCAAATATGAGTAGTATTCT
CCTGCTTTGCTTCCAGATAG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MLRWVFRFLIRATLVVLFVGSMWFTYAYVSDRTLSKAAITINTELNNVFEHSILRKYIVLLRGAPVHVGTNPYHINLIIK
MQAEFMHALHMLKDVELVLYNANGNVMFTVSDDMDTEVSDASIVLSPEELSLLSKGEIVHGTSAYGIYSSVFPLMDESGE
PIVFLRVTRDCSEMAVFFSNSNFVFVILVGIAAAICIVLTLVIYRKNVKLLNSQYDANLELQEKKENAEKESVSKSQFLA
NVSHELRTPLNSIIGFSEIVQRESLGPLGNAQYKEYIKEINHAGVHLLSLINDILDFSKAEANKLSVELVKCDLRKIVDS
CFNMMLPKAQEAKVELKRDMPESQIVLMVDARRMKQVILNILTNSMKFTPEKGFVRLSVEKKQEEVVIEICDNGIGIAQQ
DLYKVMSVFGQADSTHSRKYEGTGLGLPLSKKLVELMNGTFSIKGEANLGTVVTLSFPCVEESPESEKAF

Sequences:

>Translated_470_residues
MLRWVFRFLIRATLVVLFVGSMWFTYAYVSDRTLSKAAITINTELNNVFEHSILRKYIVLLRGAPVHVGTNPYHINLIIK
MQAEFMHALHMLKDVELVLYNANGNVMFTVSDDMDTEVSDASIVLSPEELSLLSKGEIVHGTSAYGIYSSVFPLMDESGE
PIVFLRVTRDCSEMAVFFSNSNFVFVILVGIAAAICIVLTLVIYRKNVKLLNSQYDANLELQEKKENAEKESVSKSQFLA
NVSHELRTPLNSIIGFSEIVQRESLGPLGNAQYKEYIKEINHAGVHLLSLINDILDFSKAEANKLSVELVKCDLRKIVDS
CFNMMLPKAQEAKVELKRDMPESQIVLMVDARRMKQVILNILTNSMKFTPEKGFVRLSVEKKQEEVVIEICDNGIGIAQQ
DLYKVMSVFGQADSTHSRKYEGTGLGLPLSKKLVELMNGTFSIKGEANLGTVVTLSFPCVEESPESEKAF
>Mature_470_residues
MLRWVFRFLIRATLVVLFVGSMWFTYAYVSDRTLSKAAITINTELNNVFEHSILRKYIVLLRGAPVHVGTNPYHINLIIK
MQAEFMHALHMLKDVELVLYNANGNVMFTVSDDMDTEVSDASIVLSPEELSLLSKGEIVHGTSAYGIYSSVFPLMDESGE
PIVFLRVTRDCSEMAVFFSNSNFVFVILVGIAAAICIVLTLVIYRKNVKLLNSQYDANLELQEKKENAEKESVSKSQFLA
NVSHELRTPLNSIIGFSEIVQRESLGPLGNAQYKEYIKEINHAGVHLLSLINDILDFSKAEANKLSVELVKCDLRKIVDS
CFNMMLPKAQEAKVELKRDMPESQIVLMVDARRMKQVILNILTNSMKFTPEKGFVRLSVEKKQEEVVIEICDNGIGIAQQ
DLYKVMSVFGQADSTHSRKYEGTGLGLPLSKKLVELMNGTFSIKGEANLGTVVTLSFPCVEESPESEKAF

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=244, Percent_Identity=36.8852459016393, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI145693157, Length=266, Percent_Identity=34.9624060150376, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI87081816, Length=323, Percent_Identity=31.2693498452012, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI48994928, Length=246, Percent_Identity=31.3008130081301, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788713, Length=245, Percent_Identity=31.4285714285714, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1788549, Length=248, Percent_Identity=25.8064516129032, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788393, Length=231, Percent_Identity=24.6753246753247, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786783, Length=240, Percent_Identity=25.4166666666667, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1786912, Length=247, Percent_Identity=22.2672064777328, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790436, Length=300, Percent_Identity=23.6666666666667, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87082128, Length=230, Percent_Identity=26.5217391304348, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786600, Length=228, Percent_Identity=24.5614035087719, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790861, Length=221, Percent_Identity=25.7918552036199, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790346, Length=236, Percent_Identity=23.728813559322, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1788279, Length=208, Percent_Identity=25.9615384615385, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52717; Mature: 52717

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRWVFRFLIRATLVVLFVGSMWFTYAYVSDRTLSKAAITINTELNNVFEHSILRKYIVL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHH
LRGAPVHVGTNPYHINLIIKMQAEFMHALHMLKDVELVLYNANGNVMFTVSDDMDTEVSD
HCCCCEEECCCCEEEEEEEEEHHHHHHHHHHHCCEEEEEEECCCCEEEEECCCCCCCCCC
ASIVLSPEELSLLSKGEIVHGTSAYGIYSSVFPLMDESGEPIVFLRVTRDCSEMAVFFSN
CEEEECHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEC
SNFVFVILVGIAAAICIVLTLVIYRKNVKLLNSQYDANLELQEKKENAEKESVSKSQFLA
CCEEEEHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEHHHHCCHHHHHHHHHHHHH
NVSHELRTPLNSIIGFSEIVQRESLGPLGNAQYKEYIKEINHAGVHLLSLINDILDFSKA
HHHHHHHCCHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EANKLSVELVKCDLRKIVDSCFNMMLPKAQEAKVELKRDMPESQIVLMVDARRMKQVILN
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHH
ILTNSMKFTPEKGFVRLSVEKKQEEVVIEICDNGIGIAQQDLYKVMSVFGQADSTHSRKY
HHHCCCEECCCCCEEEEEECCCCHHEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
EGTGLGLPLSKKLVELMNGTFSIKGEANLGTVVTLSFPCVEESPESEKAF
CCCCCCCCHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MLRWVFRFLIRATLVVLFVGSMWFTYAYVSDRTLSKAAITINTELNNVFEHSILRKYIVL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHH
LRGAPVHVGTNPYHINLIIKMQAEFMHALHMLKDVELVLYNANGNVMFTVSDDMDTEVSD
HCCCCEEECCCCEEEEEEEEEHHHHHHHHHHHCCEEEEEEECCCCEEEEECCCCCCCCCC
ASIVLSPEELSLLSKGEIVHGTSAYGIYSSVFPLMDESGEPIVFLRVTRDCSEMAVFFSN
CEEEECHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEC
SNFVFVILVGIAAAICIVLTLVIYRKNVKLLNSQYDANLELQEKKENAEKESVSKSQFLA
CCEEEEHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEHHHHCCHHHHHHHHHHHHH
NVSHELRTPLNSIIGFSEIVQRESLGPLGNAQYKEYIKEINHAGVHLLSLINDILDFSKA
HHHHHHHCCHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EANKLSVELVKCDLRKIVDSCFNMMLPKAQEAKVELKRDMPESQIVLMVDARRMKQVILN
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHH
ILTNSMKFTPEKGFVRLSVEKKQEEVVIEICDNGIGIAQQDLYKVMSVFGQADSTHSRKY
HHHCCCEECCCCCEEEEEECCCCHHEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
EGTGLGLPLSKKLVELMNGTFSIKGEANLGTVVTLSFPCVEESPESEKAF
CCCCCCCCHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]