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The map label for this gene is mleN [H]

Identifier: 88196243

GI number: 88196243

Start: 2390182

End: 2391393

Strand: Reverse

Name: mleN [H]

Synonym: SAOUHSC_02601

Alternate gene names: 88196243

Gene position: 2391393-2390182 (Counterclockwise)

Preceding gene: 88196245

Following gene: 88196242

Centisome position: 84.76

GC content: 35.4

Gene sequence:

>1212_bases
ATGCCATTAAATGTTGCAATTACGATAACGGTAATTGTGGCGTTATTAATGAATCGAAAAGAATCATTTGCTAAAAAAGT
TGAGGTCTTCACGAAAGGTGCAGGCCATTCAAACATTGTTTTAATGATGTTGATTTTTATTTTAGCAGGTGCATTTTCAA
ATACAGCTGAAAAAATGGGTGGCGTAAAGTCGACAGTTAATTTAGGACTATCATTAATCCCAGAAAATTTAATTATTGTA
GGATTGTTTGTGATTTGTATGTTTGTTTCTATATCTATGGGGACGTCTGTAGGAACTGTTGCTGCAATAGCACCTGTTGG
TTACGGATTTGCACAAGCGACAGATGTACCAACTGCGCTAGCAATGGCTACAGTTGTTGGAGGTGCAATGTTCGGCGATA
ATCTATCAATGATTTCAGATACAACAATTGCTGCGGTTAGAACACAACATACGAAAATGAAAGATAAATTCAGAGTAAAC
TTTAAAATTGTATTGCCAGGTGCTATTTTAACGATTATTATTCTGTATTTCTTAACGAATGGCATTTCTTTAAATCATGC
TAAAAACTATGATTATAATCTAATTAAAGTTGTACCGTATATCTTAGTATTGGTATTAGCATTATTAGGTGTAAATGTCA
TTATCGTATTGATTGGCGGAACATTATTAGCCGGAATCATTGGTCTCATAGATGGTTCATTCGGTTGGATGGGGCTACTA
GATGCAGTGTCCAAAGGTATTATAAGCATGGAAGATATTGCTATGATTGCGTTGCTAATTGGTGGTTTAGTCGGTATTAT
TCAACACAATGGTGGTATTGAATGGTTGTTGCAATTTGTTCGCTCTAAAGTGAAATCAAAGCGTGGCGCAGAATTAGGAA
TTGCTAGTTTGGTAAGTGTCGCAGATATTGCCACGGCAAACAACACCATCTCTATTATTATGTCAGGTCCTTTAGCTAAA
AATATTGCAGATGAATATGATGTAGATTCAAGGAAATCAGCAAGTATTCTTGATATATTTGGAGGCTGCTTCCAAGGTTT
ATTACCATATAGCCCGCAAGTCATTTCAGCGGCTGGTGTAGCTGGTATTTCACCGTTAATGTTATTCCCATACAGCATTT
ATCCTATATTATTAGGTGTATGCGGACTTATTGCGATTTTATTTAATTTTCCAAAGCTAAAAAAGAACACTAGTCAAGAA
ATGAAACATTAA

Upstream 100 bases:

>100_bases
GGAAGTACATAAAAAGAGCAATGCTTGGGCATTATTCCCCTTGTTATTATTTGTGGCGTTGTTTTTAGGCGTAGGTATTA
TCACAGGTGATTTTACTTCA

Downstream 100 bases:

>100_bases
TGCTTAACAATATATCGATGTAGCCAAGTAAGGTGGCTTGTTATATTAACAGATCATGTTGTACTCACCGTATAACGCTA
ATCTTTTAAAAATGATGATC

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MPLNVAITITVIVALLMNRKESFAKKVEVFTKGAGHSNIVLMMLIFILAGAFSNTAEKMGGVKSTVNLGLSLIPENLIIV
GLFVICMFVSISMGTSVGTVAAIAPVGYGFAQATDVPTALAMATVVGGAMFGDNLSMISDTTIAAVRTQHTKMKDKFRVN
FKIVLPGAILTIIILYFLTNGISLNHAKNYDYNLIKVVPYILVLVLALLGVNVIIVLIGGTLLAGIIGLIDGSFGWMGLL
DAVSKGIISMEDIAMIALLIGGLVGIIQHNGGIEWLLQFVRSKVKSKRGAELGIASLVSVADIATANNTISIIMSGPLAK
NIADEYDVDSRKSASILDIFGGCFQGLLPYSPQVISAAGVAGISPLMLFPYSIYPILLGVCGLIAILFNFPKLKKNTSQE
MKH

Sequences:

>Translated_403_residues
MPLNVAITITVIVALLMNRKESFAKKVEVFTKGAGHSNIVLMMLIFILAGAFSNTAEKMGGVKSTVNLGLSLIPENLIIV
GLFVICMFVSISMGTSVGTVAAIAPVGYGFAQATDVPTALAMATVVGGAMFGDNLSMISDTTIAAVRTQHTKMKDKFRVN
FKIVLPGAILTIIILYFLTNGISLNHAKNYDYNLIKVVPYILVLVLALLGVNVIIVLIGGTLLAGIIGLIDGSFGWMGLL
DAVSKGIISMEDIAMIALLIGGLVGIIQHNGGIEWLLQFVRSKVKSKRGAELGIASLVSVADIATANNTISIIMSGPLAK
NIADEYDVDSRKSASILDIFGGCFQGLLPYSPQVISAAGVAGISPLMLFPYSIYPILLGVCGLIAILFNFPKLKKNTSQE
MKH
>Mature_402_residues
PLNVAITITVIVALLMNRKESFAKKVEVFTKGAGHSNIVLMMLIFILAGAFSNTAEKMGGVKSTVNLGLSLIPENLIIVG
LFVICMFVSISMGTSVGTVAAIAPVGYGFAQATDVPTALAMATVVGGAMFGDNLSMISDTTIAAVRTQHTKMKDKFRVNF
KIVLPGAILTIIILYFLTNGISLNHAKNYDYNLIKVVPYILVLVLALLGVNVIIVLIGGTLLAGIIGLIDGSFGWMGLLD
AVSKGIISMEDIAMIALLIGGLVGIIQHNGGIEWLLQFVRSKVKSKRGAELGIASLVSVADIATANNTISIIMSGPLAKN
IADEYDVDSRKSASILDIFGGCFQGLLPYSPQVISAAGVAGISPLMLFPYSIYPILLGVCGLIAILFNFPKLKKNTSQEM
KH

Specific function: Couples proton uptake and Na(+) efflux to the substrate- product malate/lactate antiport, in an electroneutral malate- 2H(+)/Na(+)-lactate exchange. Plays a role in supporting growth to high density on malate at reduced protonmotive force [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 42607; Mature: 42475

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLNVAITITVIVALLMNRKESFAKKVEVFTKGAGHSNIVLMMLIFILAGAFSNTAEKMG
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHC
GVKSTVNLGLSLIPENLIIVGLFVICMFVSISMGTSVGTVAAIAPVGYGFAQATDVPTAL
CHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCHHHH
AMATVVGGAMFGDNLSMISDTTIAAVRTQHTKMKDKFRVNFKIVLPGAILTIIILYFLTN
HHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHEEEEEEEEECHHHHHHHHHHHHHC
GISLNHAKNYDYNLIKVVPYILVLVLALLGVNVIIVLIGGTLLAGIIGLIDGSFGWMGLL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
DAVSKGIISMEDIAMIALLIGGLVGIIQHNGGIEWLLQFVRSKVKSKRGAELGIASLVSV
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ADIATANNTISIIMSGPLAKNIADEYDVDSRKSASILDIFGGCFQGLLPYSPQVISAAGV
HHHHCCCCEEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHCCC
AGISPLMLFPYSIYPILLGVCGLIAILFNFPKLKKNTSQEMKH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHCCC
>Mature Secondary Structure 
PLNVAITITVIVALLMNRKESFAKKVEVFTKGAGHSNIVLMMLIFILAGAFSNTAEKMG
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHC
GVKSTVNLGLSLIPENLIIVGLFVICMFVSISMGTSVGTVAAIAPVGYGFAQATDVPTAL
CHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCHHHH
AMATVVGGAMFGDNLSMISDTTIAAVRTQHTKMKDKFRVNFKIVLPGAILTIIILYFLTN
HHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHEEEEEEEEECHHHHHHHHHHHHHC
GISLNHAKNYDYNLIKVVPYILVLVLALLGVNVIIVLIGGTLLAGIIGLIDGSFGWMGLL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
DAVSKGIISMEDIAMIALLIGGLVGIIQHNGGIEWLLQFVRSKVKSKRGAELGIASLVSV
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ADIATANNTISIIMSGPLAKNIADEYDVDSRKSASILDIFGGCFQGLLPYSPQVISAAGV
HHHHCCCCEEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHCCC
AGISPLMLFPYSIYPILLGVCGLIAILFNFPKLKKNTSQEMKH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10903309 [H]