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The map label for this gene is dut [H]

Identifier: 88195741

GI number: 88195741

Start: 1952084

End: 1952620

Strand: Reverse

Name: dut [H]

Synonym: SAOUHSC_02057

Alternate gene names: 88195741

Gene position: 1952620-1952084 (Counterclockwise)

Preceding gene: 88195742

Following gene: 88195740

Centisome position: 69.21

GC content: 40.78

Gene sequence:

>537_bases
TTGCTACAGCTAGGGAGGAGCAGGAAAATGACTAACACATTACAAGTAAGGCTATTATCAGAAAATGCTAGAATGCCCGA
ACGAAATCATAAGACGGATGCAGGTTATGACATATTCTCAGCTGAAACTGTCGTACTTGAGCCACAAGAAAAGGCAGTGA
TTAAAACAGATGTAGCTGTAAGCATACCAGAGGGCTATGTCGGACTATTAACTAGCCGTAGTGGTGTAAGTAGTAAAACG
CATTTAGTGATTGAAACAGGCAAGATAGACGCGGGATATCACGGCAATTTAGGGATTAATATCAAGAATGACGCTATTGC
ATCGAATGGTTATATCACACCAGGTGTTTTTGATATTAAAGGAGAAATCGATTTGAGTGACGCCATAAGACAATACGGAA
CTTATCAAATCAACGAAGGAGACAAACTAGCTCAATTGGTTATCGTGCCTATATGGACACCTGAACTAAAGCAAGTGGAG
GAATTCGAAAGTGTTTCAGAACGTGGAGAAAAAGGCTTCGGAAGTAGCGGAGTGTAA

Upstream 100 bases:

>100_bases
GAAATACTTGATTTTATAGATGAGAACATTGAAGAATTTGAAATATTCCTCAATACCGCACTAATTCATATTGTTGAAAG
ATTGAAATTGAGAATAGCGT

Downstream 100 bases:

>100_bases
AGACATCTTAGATCGAGTCAAGGAGGTTTTGGGGAAGTGAGTTACATCATTACATTAGTTCCAATACTTGTATTCATAGT
AATATTTAACAATTTACTTA

Product: dUTP pyrophosphatase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MLQLGRSRKMTNTLQVRLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGLLTSRSGVSSKT
HLVIETGKIDAGYHGNLGINIKNDAIASNGYITPGVFDIKGEIDLSDAIRQYGTYQINEGDKLAQLVIVPIWTPELKQVE
EFESVSERGEKGFGSSGV

Sequences:

>Translated_178_residues
MLQLGRSRKMTNTLQVRLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGLLTSRSGVSSKT
HLVIETGKIDAGYHGNLGINIKNDAIASNGYITPGVFDIKGEIDLSDAIRQYGTYQINEGDKLAQLVIVPIWTPELKQVE
EFESVSERGEKGFGSSGV
>Mature_178_residues
MLQLGRSRKMTNTLQVRLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGLLTSRSGVSSKT
HLVIETGKIDAGYHGNLGINIKNDAIASNGYITPGVFDIKGEIDLSDAIRQYGTYQINEGDKLAQLVIVPIWTPELKQVE
EFESVSERGEKGFGSSGV

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=166, Percent_Identity=33.1325301204819, Blast_Score=98, Evalue=3e-21,
Organism=Homo sapiens, GI4503423, Length=166, Percent_Identity=33.1325301204819, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI70906441, Length=166, Percent_Identity=33.1325301204819, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71988561, Length=165, Percent_Identity=30.9090909090909, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19921126, Length=175, Percent_Identity=33.7142857142857, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24583610, Length=168, Percent_Identity=33.9285714285714, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 19439; Mature: 19439

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQLGRSRKMTNTLQVRLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAV
CCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEECCCEEEECCCCCEEEEECEEE
SIPEGYVGLLTSRSGVSSKTHLVIETGKIDAGYHGNLGINIKNDAIASNGYITPGVFDIK
ECCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCEECCCCCCCCCEEEEE
GEIDLSDAIRQYGTYQINEGDKLAQLVIVPIWTPELKQVEEFESVSERGEKGFGSSGV
CCCCHHHHHHHHCCEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MLQLGRSRKMTNTLQVRLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAV
CCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEECCCEEEECCCCCEEEEECEEE
SIPEGYVGLLTSRSGVSSKTHLVIETGKIDAGYHGNLGINIKNDAIASNGYITPGVFDIK
ECCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCEECCCCCCCCCEEEEE
GEIDLSDAIRQYGTYQINEGDKLAQLVIVPIWTPELKQVEEFESVSERGEKGFGSSGV
CCCCHHHHHHHHCCEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12606174 [H]