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The map label for this gene is hlgA [H]

Identifier: 88195648

GI number: 88195648

Start: 1859995

End: 1860900

Strand: Reverse

Name: hlgA [H]

Synonym: SAOUHSC_01955

Alternate gene names: 88195648

Gene position: 1860900-1859995 (Counterclockwise)

Preceding gene: 88195651

Following gene: 88195647

Centisome position: 65.96

GC content: 32.89

Gene sequence:

>906_bases
TTGTCAGTAGGACTGATTGCACCTTTAGCATCTCCGATTCAAGAATCTAGAGCAAATACTAATATTGAAAATATTGGTGA
TGGTGCTGAAGTAATCAAACGTACGGAGGATGTAAGTAGTAAGAAATGGGGCGTTACTCAAAATGTCCAATTCGACTTTG
TAAAAGATAAAAAATATAACAAAGACGCTTTAATTGTTAAAATGCAAGGTTTTATTAATTCCAGAACTTCATTTTCAGAT
GTGAAGGGTAGTGGATATGAATTAACTAAACGAATGATTTGGCCATTCCAATATAATATAGGACTGACGACTAAAGATCC
AAATGTTAGCTTAATCAATTACCTTCCTAAAAACAAAATAGAAACTACTGATGTTGGTCAAACATTAGGATATAACATTG
GAGGTAATTTCCAGTCAGCACCATCTATAGGTGGCAATGGCTCATTTAATTATTCTAAAACAATTAGTTATACCCAAAAG
AGTTATGTCAGTGAAGTAGACAAGCAAAACTCAAAATCTGTTAAATGGGGTGTTAAAGCAAACGAATTTGTTACGCCTGA
TGGAAAAAAATCTGCGCATGATAGATATTTATTCGTACAAAGTCCAAATGGTCCAACAGGTTCAGCAAGAGAATATTTTG
CTCCTGATAATCAATTGCCACCTTTAGTTCAAAGTGGCTTTAATCCATCGTTTATCACTACACTATCACATGAAAAAGGT
TCAAGTGATACGAGTGAATTTGAAATTTCATATGGTAGAAACTTAGATATTACATATGCGACTTTATTCCCTAGAACTGG
TATTTACGCAGAAAGAAAGCATAATGCATTTGTAAATAGAAACTTTGTAGTTAGATATGAAGTTAATTGGAAAACACACG
AAATTAAAGTGAAAGGACATAATTAA

Upstream 100 bases:

>100_bases
ATTTTATAAATAAGTGAAATAATCTAGAATAAATTTGTATTAAAAATTTATATAGAAAGAAAGTGAAACTTATGTTTAAG
AAAAAATGTTAGCTGCAACT

Downstream 100 bases:

>100_bases
TATGAAAATGAAAAAATTAGTCAAATCATCAGTTGCTTCATCAATTGCACTGCTTTTGCTATCGAATACAGTTGATGCAG
CTCAACATATCACACCTGTA

Product: leukotoxin, LukE

Products: NA

Alternate protein names: H-gamma-2; H-gamma-II [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSVGLIAPLASPIQESRANTNIENIGDGAEVIKRTEDVSSKKWGVTQNVQFDFVKDKKYNKDALIVKMQGFINSRTSFSD
VKGSGYELTKRMIWPFQYNIGLTTKDPNVSLINYLPKNKIETTDVGQTLGYNIGGNFQSAPSIGGNGSFNYSKTISYTQK
SYVSEVDKQNSKSVKWGVKANEFVTPDGKKSAHDRYLFVQSPNGPTGSAREYFAPDNQLPPLVQSGFNPSFITTLSHEKG
SSDTSEFEISYGRNLDITYATLFPRTGIYAERKHNAFVNRNFVVRYEVNWKTHEIKVKGHN

Sequences:

>Translated_301_residues
MSVGLIAPLASPIQESRANTNIENIGDGAEVIKRTEDVSSKKWGVTQNVQFDFVKDKKYNKDALIVKMQGFINSRTSFSD
VKGSGYELTKRMIWPFQYNIGLTTKDPNVSLINYLPKNKIETTDVGQTLGYNIGGNFQSAPSIGGNGSFNYSKTISYTQK
SYVSEVDKQNSKSVKWGVKANEFVTPDGKKSAHDRYLFVQSPNGPTGSAREYFAPDNQLPPLVQSGFNPSFITTLSHEKG
SSDTSEFEISYGRNLDITYATLFPRTGIYAERKHNAFVNRNFVVRYEVNWKTHEIKVKGHN
>Mature_300_residues
SVGLIAPLASPIQESRANTNIENIGDGAEVIKRTEDVSSKKWGVTQNVQFDFVKDKKYNKDALIVKMQGFINSRTSFSDV
KGSGYELTKRMIWPFQYNIGLTTKDPNVSLINYLPKNKIETTDVGQTLGYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS
YVSEVDKQNSKSVKWGVKANEFVTPDGKKSAHDRYLFVQSPNGPTGSAREYFAPDNQLPPLVQSGFNPSFITTLSHEKGS
SDTSEFEISYGRNLDITYATLFPRTGIYAERKHNAFVNRNFVVRYEVNWKTHEIKVKGHN

Specific function: Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerolysin family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003963
- InterPro:   IPR001340
- InterPro:   IPR016183 [H]

Pfam domain/function: PF07968 Leukocidin [H]

EC number: NA

Molecular weight: Translated: 33687; Mature: 33556

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVGLIAPLASPIQESRANTNIENIGDGAEVIKRTEDVSSKKWGVTQNVQFDFVKDKKYN
CCCCCCCHHHHHHHHHHCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCC
KDALIVKMQGFINSRTSFSDVKGSGYELTKRMIWPFQYNIGLTTKDPNVSLINYLPKNKI
CCEEEEEEECCCCCCCCCCCCCCCCCEEHHEEECEEEEEEEEECCCCCEEEEECCCCCCC
ETTDVGQTLGYNIGGNFQSAPSIGGNGSFNYSKTISYTQKSYVSEVDKQNSKSVKWGVKA
CCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCEEECCCC
NEFVTPDGKKSAHDRYLFVQSPNGPTGSAREYFAPDNQLPPLVQSGFNPSFITTLSHEKG
CCEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEECCCCC
SSDTSEFEISYGRNLDITYATLFPRTGIYAERKHNAFVNRNFVVRYEVNWKTHEIKVKGH
CCCCCEEEEECCCCCEEEEEEECCCCCCEECCCCCEEECCCEEEEEEECCEEEEEEEECC
N
C
>Mature Secondary Structure 
SVGLIAPLASPIQESRANTNIENIGDGAEVIKRTEDVSSKKWGVTQNVQFDFVKDKKYN
CCCCCCHHHHHHHHHHCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCC
KDALIVKMQGFINSRTSFSDVKGSGYELTKRMIWPFQYNIGLTTKDPNVSLINYLPKNKI
CCEEEEEEECCCCCCCCCCCCCCCCCEEHHEEECEEEEEEEEECCCCCEEEEECCCCCCC
ETTDVGQTLGYNIGGNFQSAPSIGGNGSFNYSKTISYTQKSYVSEVDKQNSKSVKWGVKA
CCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCEEECCCC
NEFVTPDGKKSAHDRYLFVQSPNGPTGSAREYFAPDNQLPPLVQSGFNPSFITTLSHEKG
CCEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEECCCCC
SSDTSEFEISYGRNLDITYATLFPRTGIYAERKHNAFVNRNFVVRYEVNWKTHEIKVKGH
CCCCCEEEEECCCCCEEEEEEECCCCCCEECCCCCEEECCCEEEEEEECCEEEEEEEECC
N
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA