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The map label for this gene is fhs [H]

Identifier: 88195544

GI number: 88195544

Start: 1750440

End: 1752107

Strand: Reverse

Name: fhs [H]

Synonym: SAOUHSC_01845

Alternate gene names: 88195544

Gene position: 1752107-1750440 (Counterclockwise)

Preceding gene: 88195545

Following gene: 88195542

Centisome position: 62.1

GC content: 36.51

Gene sequence:

>1668_bases
TTGACTCATTTATCAGATTTAGATATTGCGAATCAATCAACACTACAACCAATTAAGGATATTGCTGCATCAGTAGGTAT
TTCAGAGGATGCATTAGAACCTTATGGTCATTACAAAGCTAAAATCGACATTAATAAAATTACGCCAAGAGAAAACAAAG
GGAAAGTTGTTTTAGTAACTGCGATGAGCCCAACACCAGCTGGTGAAGGTAAATCAACGGTTACAGTTGGTTTAGCTGAT
GCATTCCATGAGTTAAATAAAAACGTTATGGTTGCATTAAGAGAGCCTGCTTTAGGACCAACATTTGGTATCAAAGGTGG
TGCGACTGGTGGTGGTTATGCGCAAGTCTTACCTATGGAAGATATCAACTTACATTTCAACGGAGATTTCCATGCGATTA
CAACTGCAAATAATGCATTGTCTGCGTTTATCGATAATCATATTCACCAAGGTAACGAATTAGGAATCGATCAAAGACGT
ATTGAGTGGAAACGTGTATTAGATATGAATGATCGTGCACTTAGACATGTAAACGTTGGGTTAGGTGGACCTACAAATGG
TGTACCACGTGAAGATGGCTTTAATATTACAGTAGCGTCTGAAATTATGGCGATTTTATGTTTAAGTAGAAGTATTAAAG
ACTTAAAAGATAAAATTAGTCGTATTACTATTGGTTACACTAGAGATCGCAAGCCAGTTACAGTTGCAGATTTAAAAGTG
GAAGGTGCACTTGCAATGATTTTAAAAGATGCAATAAAACCAAACTTAGTACAATCAATTGAAGGGACACCTGCATTAGT
TCATGGTGGACCATTTGCGAATATCGCACACGGTTGTAACTCAATTTTAGCAACTGAAACAGCACGTGATTTAGCTGATA
TCGTTGTAACGGAAGCTGGATTTGGTTCAGACTTAGGCGCTGAAAAATTCATGGACATTAAAGCGCGTGAAGCAGGATTT
GATCCGGCAGCTGTCGTTGTTGTTGCGACAATTCGTGCGTTAAAAATGCATGGTGGTGTAGCGAAAGATAATTTAAAAGA
AGAAAATGTAGAAGCAGTAAAAGCAGGAATTGTTAATTTAGAGCGTCATGTTAATAATATTAAAAAATTCGGTGTAGAAC
CGGTTGTTGCAATTAATGCATTTATACATGATACCGATGCAGAAGTAGAATATGTAAAATCTTGGGCTAAAGAAAATAAC
GTACGAATTGCCTTAACTGAAGTTTGGGAAAAAGGTGGTAAAGGTGGCGTTGACTTAGCAAATGAAGTATTAGAAGTCAT
TGATCAACCTAATTCATTTAAACCTTTATATGAATTAGAATTACCATTAGAGCAAAAGATTGAAAAGATTGTGACTGAAA
TCTATGGCGGTTCAAAAGTAACGTTTAGCAGTAAAGCGCAAAAACAATTAAAACAATTTAAAGAAAATGGTTGGGATAAT
TACCCAGTATGTATGGCGAAAACACAATATTCATTCTCAGATGATCAAACGTTGTTAGGTGCACCATCAGGATTTGAAAT
TACAATTCGTGAATTAGAAGCGAAAACAGGTGCAGGATTTATCGTAGCGTTGACAGGTGCAATCATGACTATGCCTGGTT
TACCTAAAAAACCAGCAGCATTAAACATGGATGTTACTGATGATGGTCATGCAATTGGGTTATTCTAA

Upstream 100 bases:

>100_bases
GTTTTTAACAGTTCGTTATTATATGAATGTAAGTAAAAATTTCTTAGCTACAACTTACATATTATAAATGCATAAATTAA
ACAAAAAGGGGCGAAAAAAG

Downstream 100 bases:

>100_bases
TAAATCATGTCAATTGTTTAATAAAGATAAGTAAATAGTTTAATAGACCGGACTGTTGGAGATGCATTATTTCAGCAGTT
CGGTTTTTTGCTGTGCTAAA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MTHLSDLDIANQSTLQPIKDIAASVGISEDALEPYGHYKAKIDINKITPRENKGKVVLVTAMSPTPAGEGKSTVTVGLAD
AFHELNKNVMVALREPALGPTFGIKGGATGGGYAQVLPMEDINLHFNGDFHAITTANNALSAFIDNHIHQGNELGIDQRR
IEWKRVLDMNDRALRHVNVGLGGPTNGVPREDGFNITVASEIMAILCLSRSIKDLKDKISRITIGYTRDRKPVTVADLKV
EGALAMILKDAIKPNLVQSIEGTPALVHGGPFANIAHGCNSILATETARDLADIVVTEAGFGSDLGAEKFMDIKAREAGF
DPAAVVVVATIRALKMHGGVAKDNLKEENVEAVKAGIVNLERHVNNIKKFGVEPVVAINAFIHDTDAEVEYVKSWAKENN
VRIALTEVWEKGGKGGVDLANEVLEVIDQPNSFKPLYELELPLEQKIEKIVTEIYGGSKVTFSSKAQKQLKQFKENGWDN
YPVCMAKTQYSFSDDQTLLGAPSGFEITIRELEAKTGAGFIVALTGAIMTMPGLPKKPAALNMDVTDDGHAIGLF

Sequences:

>Translated_555_residues
MTHLSDLDIANQSTLQPIKDIAASVGISEDALEPYGHYKAKIDINKITPRENKGKVVLVTAMSPTPAGEGKSTVTVGLAD
AFHELNKNVMVALREPALGPTFGIKGGATGGGYAQVLPMEDINLHFNGDFHAITTANNALSAFIDNHIHQGNELGIDQRR
IEWKRVLDMNDRALRHVNVGLGGPTNGVPREDGFNITVASEIMAILCLSRSIKDLKDKISRITIGYTRDRKPVTVADLKV
EGALAMILKDAIKPNLVQSIEGTPALVHGGPFANIAHGCNSILATETARDLADIVVTEAGFGSDLGAEKFMDIKAREAGF
DPAAVVVVATIRALKMHGGVAKDNLKEENVEAVKAGIVNLERHVNNIKKFGVEPVVAINAFIHDTDAEVEYVKSWAKENN
VRIALTEVWEKGGKGGVDLANEVLEVIDQPNSFKPLYELELPLEQKIEKIVTEIYGGSKVTFSSKAQKQLKQFKENGWDN
YPVCMAKTQYSFSDDQTLLGAPSGFEITIRELEAKTGAGFIVALTGAIMTMPGLPKKPAALNMDVTDDGHAIGLF
>Mature_554_residues
THLSDLDIANQSTLQPIKDIAASVGISEDALEPYGHYKAKIDINKITPRENKGKVVLVTAMSPTPAGEGKSTVTVGLADA
FHELNKNVMVALREPALGPTFGIKGGATGGGYAQVLPMEDINLHFNGDFHAITTANNALSAFIDNHIHQGNELGIDQRRI
EWKRVLDMNDRALRHVNVGLGGPTNGVPREDGFNITVASEIMAILCLSRSIKDLKDKISRITIGYTRDRKPVTVADLKVE
GALAMILKDAIKPNLVQSIEGTPALVHGGPFANIAHGCNSILATETARDLADIVVTEAGFGSDLGAEKFMDIKAREAGFD
PAAVVVVATIRALKMHGGVAKDNLKEENVEAVKAGIVNLERHVNNIKKFGVEPVVAINAFIHDTDAEVEYVKSWAKENNV
RIALTEVWEKGGKGGVDLANEVLEVIDQPNSFKPLYELELPLEQKIEKIVTEIYGGSKVTFSSKAQKQLKQFKENGWDNY
PVCMAKTQYSFSDDQTLLGAPSGFEITIRELEAKTGAGFIVALTGAIMTMPGLPKKPAALNMDVTDDGHAIGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=619, Percent_Identity=40.5492730210016, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI36796743, Length=618, Percent_Identity=41.747572815534, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI310124614, Length=86, Percent_Identity=37.2093023255814, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17568737, Length=612, Percent_Identity=42.9738562091503, Blast_Score=444, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17568739, Length=612, Percent_Identity=42.9738562091503, Blast_Score=444, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6319558, Length=631, Percent_Identity=42.3137876386688, Blast_Score=451, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=41.85303514377, Blast_Score=443, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24645718, Length=619, Percent_Identity=43.6187399030695, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI17137370, Length=619, Percent_Identity=43.6187399030695, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI62472483, Length=619, Percent_Identity=43.6187399030695, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45551871, Length=619, Percent_Identity=43.6187399030695, Blast_Score=468, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 59857; Mature: 59726

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHLSDLDIANQSTLQPIKDIAASVGISEDALEPYGHYKAKIDINKITPRENKGKVVLVT
CCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCEEEEEEEEECCCCCCCCCEEEEE
AMSPTPAGEGKSTVTVGLADAFHELNKNVMVALREPALGPTFGIKGGATGGGYAQVLPME
ECCCCCCCCCCCEEEEEHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEC
DINLHFNGDFHAITTANNALSAFIDNHIHQGNELGIDQRRIEWKRVLDMNDRALRHVNVG
CCEEEECCCEEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEC
LGGPTNGVPREDGFNITVASEIMAILCLSRSIKDLKDKISRITIGYTRDRKPVTVADLKV
CCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEEEEEE
EGALAMILKDAIKPNLVQSIEGTPALVHGGPFANIAHGCNSILATETARDLADIVVTEAG
CHHHHHHHHHHCCCHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHEECCC
FGSDLGAEKFMDIKAREAGFDPAAVVVVATIRALKMHGGVAKDNLKEENVEAVKAGIVNL
CCCCCCHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
ERHVNNIKKFGVEPVVAINAFIHDTDAEVEYVKSWAKENNVRIALTEVWEKGGKGGVDLA
HHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEHHHHCCCCCCHHHH
NEVLEVIDQPNSFKPLYELELPLEQKIEKIVTEIYGGSKVTFSSKAQKQLKQFKENGWDN
HHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCC
YPVCMAKTQYSFSDDQTLLGAPSGFEITIRELEAKTGAGFIVALTGAIMTMPGLPKKPAA
CCEEEEEEECCCCCCCEEEECCCCCEEEEEEECCCCCCCEEEEEHHHHHHCCCCCCCCCE
LNMDVTDDGHAIGLF
EEEEECCCCCEEECC
>Mature Secondary Structure 
THLSDLDIANQSTLQPIKDIAASVGISEDALEPYGHYKAKIDINKITPRENKGKVVLVT
CCCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCEEEEEEEEECCCCCCCCCEEEEE
AMSPTPAGEGKSTVTVGLADAFHELNKNVMVALREPALGPTFGIKGGATGGGYAQVLPME
ECCCCCCCCCCCEEEEEHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEC
DINLHFNGDFHAITTANNALSAFIDNHIHQGNELGIDQRRIEWKRVLDMNDRALRHVNVG
CCEEEECCCEEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEC
LGGPTNGVPREDGFNITVASEIMAILCLSRSIKDLKDKISRITIGYTRDRKPVTVADLKV
CCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEEEEEE
EGALAMILKDAIKPNLVQSIEGTPALVHGGPFANIAHGCNSILATETARDLADIVVTEAG
CHHHHHHHHHHCCCHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHEECCC
FGSDLGAEKFMDIKAREAGFDPAAVVVVATIRALKMHGGVAKDNLKEENVEAVKAGIVNL
CCCCCCHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
ERHVNNIKKFGVEPVVAINAFIHDTDAEVEYVKSWAKENNVRIALTEVWEKGGKGGVDLA
HHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEHHHHCCCCCCHHHH
NEVLEVIDQPNSFKPLYELELPLEQKIEKIVTEIYGGSKVTFSSKAQKQLKQFKENGWDN
HHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCC
YPVCMAKTQYSFSDDQTLLGAPSGFEITIRELEAKTGAGFIVALTGAIMTMPGLPKKPAA
CCEEEEEEECCCCCCCEEEECCCCCEEEEEEECCCCCCCEEEEEHHHHHHCCCCCCCCCE
LNMDVTDDGHAIGLF
EEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA