Click here to switch to the map view.

The map label for this gene is ribA [H]

Identifier: 87201203

GI number: 87201203

Start: 3410715

End: 3411779

Strand: Direct

Name: ribA [H]

Synonym: Saro_3191

Alternate gene names: 87201203

Gene position: 3410715-3411779 (Clockwise)

Preceding gene: 87201202

Following gene: 87201210

Centisome position: 95.76

GC content: 68.45

Gene sequence:

>1065_bases
GTGAGCGAATCGCGCAACGTTGCAAGGGCGCTCGACGCGCTGCGCCACGGCTGGGCGATCCGTGTGACCGGCCCGGAGGG
GGCGCTCGACCTGCTCCCCGCCGAAACCGCCTTCGTGCAGCCCGGCATCTACGCGGCCCGACTGCTCATCTCCGCCGCCC
GGGCCGCCACGTTGAAGCTTGCCAACCAGCGCGACGCCGCGGTGCCCGAAGCGCCGGTGATGATCCACGGCGCGGAGCCG
TTCAGCCTGTCCGCCGCGCGCAACCTTGCCGATCCGGCGCAGGACCTTGGCTCTCCCTTGCGCGGCCCGTTCAAGGCCGA
TGCCATCGAAGCACATGAGGCCGCCGTCGCCGCGATGGACATGGCGCGCCTTGCCGGCATCCTTCCGGCGTTCCTGATCT
CGACAGGCGTGGAAATCGCGGCGGAAGTCTCCACCGCCGATCTTGCCGCGTTCAAGGACCCGCTGAACCTTTCGATACAG
GCCCGCGCGCGCCTGCCGGTCCACGCCTGCGAGCATGCGGAAATCATCGCCTTCCGTGCCCGCGACGACCTGCGCGAACA
TGTCGCGCTCGTGCTAGGCACCCAGACCAGCGAACGCGAGCCGCTGGTGCGCCTGCACAGCGAATGCCTGACGGGCGACG
TGCTGGGCAGCCTGAAGTGCGATTGCGGCCCGCAGCTCGACGCAGCGTTGGCGCGCATGGCCGAGGAGGCCAATGCGGGC
GGCTGGGGCATACTGCTCTATCTCAGGCAGGAAGGGCGGGGAATCGGCCTGATCAACAAGCTGCGCGCCTACGAATTGCA
GGACCAGGGGTTCGACACGGTCGATGCCAACGAGCGACTGGGACTGCCGAGCGAGGCGCGCGACTTCCCGGTCGCGGCGC
GCATGCTTGACCTGCTGGGCGTGCGCAGCCTGCGCCTGTTGACCAACAATCCGCAGAAAGTGGCGACATTGCAGGCGCTT
GGGCTGGAGGTGACGGAGCGCGTGGCGCACCAGTTGCCGTCCAATCCGCACAACCAGCGCTATCTCGACACCAAGCGAGA
CCGGACCGGCCACCTCTTGCGATAG

Upstream 100 bases:

>100_bases
CCGAAGCAGCCGCACAGACCCGCGGGCACCGCTTCGTCGAGGAGACGCGCAAGTGGGACCAGCCTTCGGACCACATACCG
CTGATCACCGAGCTGGATCT

Downstream 100 bases:

>100_bases
GCCCCGAACCGGACGATCCCCTGCATTGCGCGAGGATCGCCCGAAACGGGGTTGACCGCCCCTGCCGCCGGTGGAGCGGC
AAGATGCAGGGTCGAGGCTT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MSESRNVARALDALRHGWAIRVTGPEGALDLLPAETAFVQPGIYAARLLISAARAATLKLANQRDAAVPEAPVMIHGAEP
FSLSAARNLADPAQDLGSPLRGPFKADAIEAHEAAVAAMDMARLAGILPAFLISTGVEIAAEVSTADLAAFKDPLNLSIQ
ARARLPVHACEHAEIIAFRARDDLREHVALVLGTQTSEREPLVRLHSECLTGDVLGSLKCDCGPQLDAALARMAEEANAG
GWGILLYLRQEGRGIGLINKLRAYELQDQGFDTVDANERLGLPSEARDFPVAARMLDLLGVRSLRLLTNNPQKVATLQAL
GLEVTERVAHQLPSNPHNQRYLDTKRDRTGHLLR

Sequences:

>Translated_354_residues
MSESRNVARALDALRHGWAIRVTGPEGALDLLPAETAFVQPGIYAARLLISAARAATLKLANQRDAAVPEAPVMIHGAEP
FSLSAARNLADPAQDLGSPLRGPFKADAIEAHEAAVAAMDMARLAGILPAFLISTGVEIAAEVSTADLAAFKDPLNLSIQ
ARARLPVHACEHAEIIAFRARDDLREHVALVLGTQTSEREPLVRLHSECLTGDVLGSLKCDCGPQLDAALARMAEEANAG
GWGILLYLRQEGRGIGLINKLRAYELQDQGFDTVDANERLGLPSEARDFPVAARMLDLLGVRSLRLLTNNPQKVATLQAL
GLEVTERVAHQLPSNPHNQRYLDTKRDRTGHLLR
>Mature_353_residues
SESRNVARALDALRHGWAIRVTGPEGALDLLPAETAFVQPGIYAARLLISAARAATLKLANQRDAAVPEAPVMIHGAEPF
SLSAARNLADPAQDLGSPLRGPFKADAIEAHEAAVAAMDMARLAGILPAFLISTGVEIAAEVSTADLAAFKDPLNLSIQA
RARLPVHACEHAEIIAFRARDDLREHVALVLGTQTSEREPLVRLHSECLTGDVLGSLKCDCGPQLDAALARMAEEANAGG
WGILLYLRQEGRGIGLINKLRAYELQDQGFDTVDANERLGLPSEARDFPVAARMLDLLGVRSLRLLTNNPQKVATLQALG
LEVTERVAHQLPSNPHNQRYLDTKRDRTGHLLR

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=179, Percent_Identity=54.7486033519553, Blast_Score=194, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6319438, Length=196, Percent_Identity=41.8367346938776, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 38136; Mature: 38005

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESRNVARALDALRHGWAIRVTGPEGALDLLPAETAFVQPGIYAARLLISAARAATLKL
CCCCHHHHHHHHHHHCCCEEEEECCCCCEECCCCCHHHCCCCHHHHHHHHHHHHHHHHHC
ANQRDAAVPEAPVMIHGAEPFSLSAARNLADPAQDLGSPLRGPFKADAIEAHEAAVAAMD
CCCCCCCCCCCCEEEECCCCCCHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
MARLAGILPAFLISTGVEIAAEVSTADLAAFKDPLNLSIQARARLPVHACEHAEIIAFRA
HHHHHHHHHHHHHHCCCHHEECCCHHHHHHHCCCCCEEEEEECCCCHHHCCCCEEEEEHH
RDDLREHVALVLGTQTSEREPLVRLHSECLTGDVLGSLKCDCGPQLDAALARMAEEANAG
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
GWGILLYLRQEGRGIGLINKLRAYELQDQGFDTVDANERLGLPSEARDFPVAARMLDLLG
CEEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
VRSLRLLTNNPQKVATLQALGLEVTERVAHQLPSNPHNQRYLDTKRDRTGHLLR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SESRNVARALDALRHGWAIRVTGPEGALDLLPAETAFVQPGIYAARLLISAARAATLKL
CCCHHHHHHHHHHHCCCEEEEECCCCCEECCCCCHHHCCCCHHHHHHHHHHHHHHHHHC
ANQRDAAVPEAPVMIHGAEPFSLSAARNLADPAQDLGSPLRGPFKADAIEAHEAAVAAMD
CCCCCCCCCCCCEEEECCCCCCHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
MARLAGILPAFLISTGVEIAAEVSTADLAAFKDPLNLSIQARARLPVHACEHAEIIAFRA
HHHHHHHHHHHHHHCCCHHEECCCHHHHHHHCCCCCEEEEEECCCCHHHCCCCEEEEEHH
RDDLREHVALVLGTQTSEREPLVRLHSECLTGDVLGSLKCDCGPQLDAALARMAEEANAG
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
GWGILLYLRQEGRGIGLINKLRAYELQDQGFDTVDANERLGLPSEARDFPVAARMLDLLG
CEEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
VRSLRLLTNNPQKVATLQALGLEVTERVAHQLPSNPHNQRYLDTKRDRTGHLLR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7883178 [H]