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The map label for this gene is folK [H]

Identifier: 87201104

GI number: 87201104

Start: 3312771

End: 3313274

Strand: Reverse

Name: folK [H]

Synonym: Saro_3092

Alternate gene names: 87201104

Gene position: 3313274-3312771 (Counterclockwise)

Preceding gene: 87201105

Following gene: 87201103

Centisome position: 93.03

GC content: 68.65

Gene sequence:

>504_bases
GTGAACCGATATCTCATCGCGCTGGGATCAAATCAGCGCCACCCCCGTCATGGCCTGCCGTCCATGATCCTGCGGGCAGC
GGTGGACGAACTGCGCGGTGAAGGGGTCCTTGTCGAGGCGGTCAGCCCGACGCTGCGCAGCCGCCCTCTCGGGCCGTCGC
TGCGCGAGTATGCGAACGGTGCGGCCGTGATTTCCACGCATCTCGACCCGCCCGAACTTCTCGAACTCCTGCAACAGGTC
GAACGTCGCTTCGGCCGGCGACGGCAAGGCCAGCGCTGGCGCTCGCGCACGCTCGACCTTGACGTGGTGCTGTGGTCGGG
CGGCTTTTGGGCGGACGAGGCGCTGGTCATTCCCCACCGCGAATTCCGCAAGCGCGATTTCGTCCTCGCGCCGGCCGCGA
AAATTGCCCCCGACTGGCGCGATCCCCTGACGGGTCTGACCATCCGCCATCTCGCCGCCCGCCTTGCCCGCCCCTTGACC
CGCCGCCCCCCGCACCCTAGGTGA

Upstream 100 bases:

>100_bases
CCGCCACGATCGACCTGGCGCGTGCGGCAAGGCACCGTGCCGGCATGGGCTTCTTCCGCGACCGCCGGCCGCAGCTCTAT
GCGCGCCTCGCCGAGGACAA

Downstream 100 bases:

>100_bases
CGCGCCACGCCGCGCGCACCAGCGCGAACTCGGGCGGGCCCTTAGCTCAGTCGGTAGAGCAACTGACTTTTAATCAGTAG
GTCGCTGGTTCGAACCCAGC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
MNRYLIALGSNQRHPRHGLPSMILRAAVDELRGEGVLVEAVSPTLRSRPLGPSLREYANGAAVISTHLDPPELLELLQQV
ERRFGRRRQGQRWRSRTLDLDVVLWSGGFWADEALVIPHREFRKRDFVLAPAAKIAPDWRDPLTGLTIRHLAARLARPLT
RRPPHPR

Sequences:

>Translated_167_residues
MNRYLIALGSNQRHPRHGLPSMILRAAVDELRGEGVLVEAVSPTLRSRPLGPSLREYANGAAVISTHLDPPELLELLQQV
ERRFGRRRQGQRWRSRTLDLDVVLWSGGFWADEALVIPHREFRKRDFVLAPAAKIAPDWRDPLTGLTIRHLAARLARPLT
RRPPHPR
>Mature_167_residues
MNRYLIALGSNQRHPRHGLPSMILRAAVDELRGEGVLVEAVSPTLRSRPLGPSLREYANGAAVISTHLDPPELLELLQQV
ERRFGRRRQGQRWRSRTLDLDVVLWSGGFWADEALVIPHREFRKRDFVLAPAAKIAPDWRDPLTGLTIRHLAARLARPLT
RRPPHPR

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=139, Percent_Identity=35.9712230215827, Blast_Score=80, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19057; Mature: 19057

Theoretical pI: Translated: 11.99; Mature: 11.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRYLIALGSNQRHPRHGLPSMILRAAVDELRGEGVLVEAVSPTLRSRPLGPSLREYANG
CCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCHHHHHHCCC
AAVISTHLDPPELLELLQQVERRFGRRRQGQRWRSRTLDLDVVLWSGGFWADEALVIPHR
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEECCCCCCCCEEECCCH
EFRKRDFVLAPAAKIAPDWRDPLTGLTIRHLAARLARPLTRRPPHPR
HHHCCCEEECCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNRYLIALGSNQRHPRHGLPSMILRAAVDELRGEGVLVEAVSPTLRSRPLGPSLREYANG
CCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCHHHHHHCCC
AAVISTHLDPPELLELLQQVERRFGRRRQGQRWRSRTLDLDVVLWSGGFWADEALVIPHR
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEECCCCCCCCEEECCCH
EFRKRDFVLAPAAKIAPDWRDPLTGLTIRHLAARLARPLTRRPPHPR
HHHCCCEEECCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]