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The map label for this gene is pyrC [H]

Identifier: 87201074

GI number: 87201074

Start: 3280706

End: 3281935

Strand: Direct

Name: pyrC [H]

Synonym: Saro_3062

Alternate gene names: 87201074

Gene position: 3280706-3281935 (Clockwise)

Preceding gene: 87201073

Following gene: 87201078

Centisome position: 92.11

GC content: 71.38

Gene sequence:

>1230_bases
ATGATCGCGCAGCCTCTCACGATCATAGGCGGCCGGCTGGTGCCGGGCTCGGGCGAGCCGGTCGCCGGGAACCTGCGCTG
CGAGGGCGGACGCATCGTCGCGCTGGGCGATGTGGCGCCGCAGGACGGCGACACGGTGTTCGACGCCGGGGGCGCGCTGG
TCGCGCCGGGGCTGGTGGACCTCGGCGTCTTCGCGGTCGACAAGCCCGCGTTCCATTTCGGCGGGATCACGCGCGCGGCG
CTCATGCCCGACCAGGCGCCGCCGCTCGACCATCCGGCGCGGGTGCGCTTCGCCGCACAGTCGGGCAAGCCGGACATGTG
GGTCCACCCGCTGGCCGCCGCAACGCGCGGGCTGGAAGGAACGGAGTTGGCCGAACTGGCGCTGATGCGCGACGCGGGCG
CCAAGGCTGTCTCCACCGGACGGGCATGGATCGGCGATTCAGGCGTGATGCTGCGCCTGCTGCGCTACTGCGCGATGCTG
AGGCTGGTCGTGGTCACGCATGCAGAGGATGCGGCGATAACCGGATCGGCCGTCGCGACGGCAGGCGAGGTGGCGACGCG
ACTCGGCCTGCCGAGCGCGCCGGCCGAGGCCGAAGCGCTGGCCGTGGCTCGCGACATCGCGCTTGCCGAAATGTCGGGCT
GCCACGTCCATTTCCGGCAGGTGACGACGGCGCAGGCGCTGGATCTCGTGCGGACGGCCAAGGCGCGCGGCGTGCGCGTG
ACGGCAGGGGTCACGCCTGCGCACTTCGTCCTTTCCGATCTCGAACTCGTCGGCTTCCGCACCTTCTGCCGTCTCTCGCC
GCCGCTGCGCTCGGACGCGGATCGCAAGGCCGTGATCGCGGCGATTGCCGATGGCACCATCGACGTCATCGCATCGGGTC
ACGACCCGCGCGGGCCGGAAGACAAGCGCCTCCCCTTTGCCGACGCGGAGCCCGGCATGGCGGGCGCCGAAACGCTCCTG
CCGCTTACCTTGACGCTCGTGCGCGACGGCGTGATCGATCTGGCACGCGCGTTCGAGCTGCTCGCCGGAAACCCGGCGCG
GCTACTGGGGGTCGATGCCGGACGACTCGAGACAGGGGCCGAGGCCGACATCGCGATCGTCGATCCGGCGCGGCCGTGGA
TCGTCAATTCGGGCAAGATGGCCGCCAGCGCCGGAAACACCCCGTTCGACCGACGACCCGTCGAAGGCCGGGTCACCGCG
CTGTTCAAGGGCGGCAAGCAGGTCCACTGA

Upstream 100 bases:

>100_bases
GGCAGGTCGAAATGGGTGTTGCCATCCGCATGGCCTGCCTCGAGGTGCTGACGCGGCGGGCACGGCGCACCCCGGGCTGG
GAAGCGGAAGGAGCCTCGGC

Downstream 100 bases:

>100_bases
AACGGAAATGGGCGCGGGATTGCCAAGGCACCCGCGCCCGTCCGCCCCCGGAAGGAAAATCGGCGCCCTAGCGCTTGGCC
ATGCGCGTTTCAGCGGCGCG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MIAQPLTIIGGRLVPGSGEPVAGNLRCEGGRIVALGDVAPQDGDTVFDAGGALVAPGLVDLGVFAVDKPAFHFGGITRAA
LMPDQAPPLDHPARVRFAAQSGKPDMWVHPLAAATRGLEGTELAELALMRDAGAKAVSTGRAWIGDSGVMLRLLRYCAML
RLVVVTHAEDAAITGSAVATAGEVATRLGLPSAPAEAEALAVARDIALAEMSGCHVHFRQVTTAQALDLVRTAKARGVRV
TAGVTPAHFVLSDLELVGFRTFCRLSPPLRSDADRKAVIAAIADGTIDVIASGHDPRGPEDKRLPFADAEPGMAGAETLL
PLTLTLVRDGVIDLARAFELLAGNPARLLGVDAGRLETGAEADIAIVDPARPWIVNSGKMAASAGNTPFDRRPVEGRVTA
LFKGGKQVH

Sequences:

>Translated_409_residues
MIAQPLTIIGGRLVPGSGEPVAGNLRCEGGRIVALGDVAPQDGDTVFDAGGALVAPGLVDLGVFAVDKPAFHFGGITRAA
LMPDQAPPLDHPARVRFAAQSGKPDMWVHPLAAATRGLEGTELAELALMRDAGAKAVSTGRAWIGDSGVMLRLLRYCAML
RLVVVTHAEDAAITGSAVATAGEVATRLGLPSAPAEAEALAVARDIALAEMSGCHVHFRQVTTAQALDLVRTAKARGVRV
TAGVTPAHFVLSDLELVGFRTFCRLSPPLRSDADRKAVIAAIADGTIDVIASGHDPRGPEDKRLPFADAEPGMAGAETLL
PLTLTLVRDGVIDLARAFELLAGNPARLLGVDAGRLETGAEADIAIVDPARPWIVNSGKMAASAGNTPFDRRPVEGRVTA
LFKGGKQVH
>Mature_409_residues
MIAQPLTIIGGRLVPGSGEPVAGNLRCEGGRIVALGDVAPQDGDTVFDAGGALVAPGLVDLGVFAVDKPAFHFGGITRAA
LMPDQAPPLDHPARVRFAAQSGKPDMWVHPLAAATRGLEGTELAELALMRDAGAKAVSTGRAWIGDSGVMLRLLRYCAML
RLVVVTHAEDAAITGSAVATAGEVATRLGLPSAPAEAEALAVARDIALAEMSGCHVHFRQVTTAQALDLVRTAKARGVRV
TAGVTPAHFVLSDLELVGFRTFCRLSPPLRSDADRKAVIAAIADGTIDVIASGHDPRGPEDKRLPFADAEPGMAGAETLL
PLTLTLVRDGVIDLARAFELLAGNPARLLGVDAGRLETGAEADIAIVDPARPWIVNSGKMAASAGNTPFDRRPVEGRVTA
LFKGGKQVH

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=410, Percent_Identity=28.780487804878, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI19923821, Length=239, Percent_Identity=27.1966527196653, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786722, Length=412, Percent_Identity=25, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI87082175, Length=437, Percent_Identity=26.3157894736842, Blast_Score=92, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI193204318, Length=217, Percent_Identity=30.4147465437788, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24642586, Length=209, Percent_Identity=32.5358851674641, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 42371; Mature: 42371

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAQPLTIIGGRLVPGSGEPVAGNLRCEGGRIVALGDVAPQDGDTVFDAGGALVAPGLVD
CCCCCCCCCCCEECCCCCCCCCCCEEECCCEEEEECCCCCCCCCEEEECCCCEECCCHHH
LGVFAVDKPAFHFGGITRAALMPDQAPPLDHPARVRFAAQSGKPDMWVHPLAAATRGLEG
CCEEEECCCCHHHCCEEHHHCCCCCCCCCCCCCEEEEEECCCCCCEEEEHHHHHHCCCCC
TELAELALMRDAGAKAVSTGRAWIGDSGVMLRLLRYCAMLRLVVVTHAEDAAITGSAVAT
CHHHHHHHHHHCCCCEECCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEECCHHHHH
AGEVATRLGLPSAPAEAEALAVARDIALAEMSGCHVHFRQVTTAQALDLVRTAKARGVRV
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCEEE
TAGVTPAHFVLSDLELVGFRTFCRLSPPLRSDADRKAVIAAIADGTIDVIASGHDPRGPE
EECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCC
DKRLPFADAEPGMAGAETLLPLTLTLVRDGVIDLARAFELLAGNPARLLGVDAGRLETGA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCC
EADIAIVDPARPWIVNSGKMAASAGNTPFDRRPVEGRVTALFKGGKQVH
CCCEEEECCCCCEEEECCCEEECCCCCCCCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MIAQPLTIIGGRLVPGSGEPVAGNLRCEGGRIVALGDVAPQDGDTVFDAGGALVAPGLVD
CCCCCCCCCCCEECCCCCCCCCCCEEECCCEEEEECCCCCCCCCEEEECCCCEECCCHHH
LGVFAVDKPAFHFGGITRAALMPDQAPPLDHPARVRFAAQSGKPDMWVHPLAAATRGLEG
CCEEEECCCCHHHCCEEHHHCCCCCCCCCCCCCEEEEEECCCCCCEEEEHHHHHHCCCCC
TELAELALMRDAGAKAVSTGRAWIGDSGVMLRLLRYCAMLRLVVVTHAEDAAITGSAVAT
CHHHHHHHHHHCCCCEECCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEECCHHHHH
AGEVATRLGLPSAPAEAEALAVARDIALAEMSGCHVHFRQVTTAQALDLVRTAKARGVRV
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCEEE
TAGVTPAHFVLSDLELVGFRTFCRLSPPLRSDADRKAVIAAIADGTIDVIASGHDPRGPE
EECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCC
DKRLPFADAEPGMAGAETLLPLTLTLVRDGVIDLARAFELLAGNPARLLGVDAGRLETGA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCC
EADIAIVDPARPWIVNSGKMAASAGNTPFDRRPVEGRVTALFKGGKQVH
CCCEEEECCCCCEEEECCCEEECCCCCCCCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA