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The map label for this gene is uvrB [H]

Identifier: 87200793

GI number: 87200793

Start: 2999521

End: 3001764

Strand: Direct

Name: uvrB [H]

Synonym: Saro_2780

Alternate gene names: 87200793

Gene position: 2999521-3001764 (Clockwise)

Preceding gene: 87200790

Following gene: 87200794

Centisome position: 84.22

GC content: 65.24

Gene sequence:

>2244_bases
ATGGCGTGGATCACTTCGGTTGCGCGGACGCTGTTTGTTCCCCATATCCGGCGCATGGCCGAACTCGTTATCCGCAGGGG
ACTCGAAGAGCCCGACACCTCCGGCACCTTCGTGCCCCACCGCCCCGCAAGGCCGGACAAGGTGGAAGGCGGCAAGCGCT
TCAGGATCGTGTCCGACTACCAGCCGGCGGGCGACCAGCCGACCGCCATCGCCGATCTCGTCGAAGGCATCCGCGCGGAT
GACAAGACGCAGGTCCTGCTTGGCGTCACCGGTTCGGGCAAGACCTTCACGATGGCGCAGGTCATCGAGGCGACCCAGCG
GCCCGCGCTGATCCTTGCCCCCAACAAGATCCTCGCCGCCCAGCTCTATGGCGAGATGAAGAGCTTCTTCCCCGAAAACG
CGGTCGAATATTTCGTCTCCTACTACGACTACTACCAGCCGGAGGCCTACGTGCCCCGGTCGGACACCTACATCGAGAAG
GAAAGCTCGGTGAACGAGGCGATCGACCGGATGCGCCACTCGGCCACCCGCGCCCTGCTGGAGCGCGACGACGTGATCAT
CGTCGCCTCGGTCTCGTGCCTCTATGGCATCGGCTCGGTCGAAACCTACTCGGCCATGATCTTCGACCTCAAGGTCGGCA
CCACGGTCGACAGCGGCGAGATCATCCGCAAGCTGGTGGCCCTGCAGTACAAGCGCAACGATGCCGCCTTCAGTCGCGGC
AACTTCCGCGTACGCGGCGACAATCTCGAGATCTTCCCCTCGCACTACGAAGACGTTGCCTGGCGCATCTCGTTCTTCGG
CGACGAGATCGAGCAGATCGTCGAGTTCGATCCGCTGACCGGCAAGGCGGGCACGAAGCTCACCGCGATCCGCGTCTACG
CCAATTCGCACTACGTGACGCCCGGCCCGACGATGAAGCAGGCCGCAGACGCGATCCGCTTCGAACTGACCGAGCGGCTC
AAGGAACTGGTCGCGGAAGGAAAGCTGCTCGAAGCGCAACGGCTGGAACAGCGCACCAACTTCGACCTGGAAATGATCGC
CGCGACCGGTTCATGCGCCGGGATCGAGAACTACAGCCGTTTCCTGACCGGCCGCCTCCCCGGCGAACCGCCCCCCACGC
TGTTCGAATACCTGCCGGACAATGCCCTGCTCTTCGTCGACGAGAGCCACCAGACGGTGCCGCAGATCGGCGCGATGGCG
CGAGGCGACCATCGCCGCAAGCTTACGCTCGCCGAATACGGCTTCCGCCTGCCGAGCTGCATCGACAACCGACCGCTGCG
CTTCAACGAATGGGACGCGATGCGCCCCCAGACGGTCGCGGTCTCGGCCACCCCGGGCGGCTGGGAAATGGAGCAGGCCG
GCGGCGTCTTTGCCGAACAGGTCATCCGCCCGACCGGCCTGATCGACCCGCCGGTGCTGATCCGCCCGGTCGAGGACCAG
GTGCAGGACTGCATCAACGAGTGCCGCGAGACCGCCGCCAAGGGCTATCGCACGCTCGTCACCACCCTGACCAAGCGCAT
GGCGGAAGACCTGACCGAGTTCATGCACGAAGCGGGCCTGCGCGTACGCTACATGCACTCCGACGTCGAGACGCTGGAGC
GCATCGAGCTGATCCGCGACCTGCGGCTTGGCGTCTATGACGTTCTCGTCGGCATCAACCTGCTGCGCGAAGGTCTCGAC
ATTCCCGAGTGCGGCCTCGTCTGCATCCTCGATGCCGACAAGGAGGGCTTCCTGCGCTCCGAGACCTCGCTGATCCAGAC
CATCGGCCGCGCCGCGCGCAACGTCGATGGCCGCGTCATCCTCTATGCCGATCGCATGACCGGCTCGATGGAACGCGCCA
TCGCCGAAACCGACCGCCGCCGCGCAAAGCAGCAGGCCTACAACGAAGAACACGGCATCACGCCGCAAACGATCAAGCGC
AACATCCACGACATCGTCGCGGATACCGCCAGCCGCGACGGCGTGGTCGTCGACACCGGCGACGACGAGCGCAACAACCT
CGTCGGCCACAACCTGCGCGCCTATATCGAGGACCTCGAAAAGCGCATGCGCGCGGCCGCAGCGGACCTCGAATTCGAGG
AAGCCGGCCGCCTGCGCGACGAGATCAGGCGGCTCGAGGCCACCGAACTCGGCCTGCCTGAAGGCGAGCGGAAAGCGCCG
ATCGTGGGACGCAGCAACGAAGGCAAGCCGGGTACGCGCAAGACGCGCTACGGGAAGTCACAGAAGACGAAGTGGGGGAA
GTAG

Upstream 100 bases:

>100_bases
GCGGCAAGCATGAGCGGCAGGACCAGCACGAATGCAGCGCGCATGAACATCTCCCTCGTTCTTCCACCCGCGAGGCTATC
ACCATGGCGCAGAACCTCAA

Downstream 100 bases:

>100_bases
TGCGTTCAATCCTGGCAGCATCAATCGTCGCCCTCTCCCTCACCGCCTGCTCGAAATCACCGACCCCGCCCCCGCGCGAG
GGGGCGCCGGAGAATGCCGT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 747; Mature: 746

Protein sequence:

>747_residues
MAWITSVARTLFVPHIRRMAELVIRRGLEEPDTSGTFVPHRPARPDKVEGGKRFRIVSDYQPAGDQPTAIADLVEGIRAD
DKTQVLLGVTGSGKTFTMAQVIEATQRPALILAPNKILAAQLYGEMKSFFPENAVEYFVSYYDYYQPEAYVPRSDTYIEK
ESSVNEAIDRMRHSATRALLERDDVIIVASVSCLYGIGSVETYSAMIFDLKVGTTVDSGEIIRKLVALQYKRNDAAFSRG
NFRVRGDNLEIFPSHYEDVAWRISFFGDEIEQIVEFDPLTGKAGTKLTAIRVYANSHYVTPGPTMKQAADAIRFELTERL
KELVAEGKLLEAQRLEQRTNFDLEMIAATGSCAGIENYSRFLTGRLPGEPPPTLFEYLPDNALLFVDESHQTVPQIGAMA
RGDHRRKLTLAEYGFRLPSCIDNRPLRFNEWDAMRPQTVAVSATPGGWEMEQAGGVFAEQVIRPTGLIDPPVLIRPVEDQ
VQDCINECRETAAKGYRTLVTTLTKRMAEDLTEFMHEAGLRVRYMHSDVETLERIELIRDLRLGVYDVLVGINLLREGLD
IPECGLVCILDADKEGFLRSETSLIQTIGRAARNVDGRVILYADRMTGSMERAIAETDRRRAKQQAYNEEHGITPQTIKR
NIHDIVADTASRDGVVVDTGDDERNNLVGHNLRAYIEDLEKRMRAAAADLEFEEAGRLRDEIRRLEATELGLPEGERKAP
IVGRSNEGKPGTRKTRYGKSQKTKWGK

Sequences:

>Translated_747_residues
MAWITSVARTLFVPHIRRMAELVIRRGLEEPDTSGTFVPHRPARPDKVEGGKRFRIVSDYQPAGDQPTAIADLVEGIRAD
DKTQVLLGVTGSGKTFTMAQVIEATQRPALILAPNKILAAQLYGEMKSFFPENAVEYFVSYYDYYQPEAYVPRSDTYIEK
ESSVNEAIDRMRHSATRALLERDDVIIVASVSCLYGIGSVETYSAMIFDLKVGTTVDSGEIIRKLVALQYKRNDAAFSRG
NFRVRGDNLEIFPSHYEDVAWRISFFGDEIEQIVEFDPLTGKAGTKLTAIRVYANSHYVTPGPTMKQAADAIRFELTERL
KELVAEGKLLEAQRLEQRTNFDLEMIAATGSCAGIENYSRFLTGRLPGEPPPTLFEYLPDNALLFVDESHQTVPQIGAMA
RGDHRRKLTLAEYGFRLPSCIDNRPLRFNEWDAMRPQTVAVSATPGGWEMEQAGGVFAEQVIRPTGLIDPPVLIRPVEDQ
VQDCINECRETAAKGYRTLVTTLTKRMAEDLTEFMHEAGLRVRYMHSDVETLERIELIRDLRLGVYDVLVGINLLREGLD
IPECGLVCILDADKEGFLRSETSLIQTIGRAARNVDGRVILYADRMTGSMERAIAETDRRRAKQQAYNEEHGITPQTIKR
NIHDIVADTASRDGVVVDTGDDERNNLVGHNLRAYIEDLEKRMRAAAADLEFEEAGRLRDEIRRLEATELGLPEGERKAP
IVGRSNEGKPGTRKTRYGKSQKTKWGK
>Mature_746_residues
AWITSVARTLFVPHIRRMAELVIRRGLEEPDTSGTFVPHRPARPDKVEGGKRFRIVSDYQPAGDQPTAIADLVEGIRADD
KTQVLLGVTGSGKTFTMAQVIEATQRPALILAPNKILAAQLYGEMKSFFPENAVEYFVSYYDYYQPEAYVPRSDTYIEKE
SSVNEAIDRMRHSATRALLERDDVIIVASVSCLYGIGSVETYSAMIFDLKVGTTVDSGEIIRKLVALQYKRNDAAFSRGN
FRVRGDNLEIFPSHYEDVAWRISFFGDEIEQIVEFDPLTGKAGTKLTAIRVYANSHYVTPGPTMKQAADAIRFELTERLK
ELVAEGKLLEAQRLEQRTNFDLEMIAATGSCAGIENYSRFLTGRLPGEPPPTLFEYLPDNALLFVDESHQTVPQIGAMAR
GDHRRKLTLAEYGFRLPSCIDNRPLRFNEWDAMRPQTVAVSATPGGWEMEQAGGVFAEQVIRPTGLIDPPVLIRPVEDQV
QDCINECRETAAKGYRTLVTTLTKRMAEDLTEFMHEAGLRVRYMHSDVETLERIELIRDLRLGVYDVLVGINLLREGLDI
PECGLVCILDADKEGFLRSETSLIQTIGRAARNVDGRVILYADRMTGSMERAIAETDRRRAKQQAYNEEHGITPQTIKRN
IHDIVADTASRDGVVVDTGDDERNNLVGHNLRAYIEDLEKRMRAAAADLEFEEAGRLRDEIRRLEATELGLPEGERKAPI
VGRSNEGKPGTRKTRYGKSQKTKWGK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=664, Percent_Identity=58.7349397590361, Blast_Score=778, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 83930; Mature: 83799

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWITSVARTLFVPHIRRMAELVIRRGLEEPDTSGTFVPHRPARPDKVEGGKRFRIVSDY
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECC
QPAGDQPTAIADLVEGIRADDKTQVLLGVTGSGKTFTMAQVIEATQRPALILAPNKILAA
CCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCEEHHHHHHHHHCCCEEEECCCHHHHH
QLYGEMKSFFPENAVEYFVSYYDYYQPEAYVPRSDTYIEKESSVNEAIDRMRHSATRALL
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ERDDVIIVASVSCLYGIGSVETYSAMIFDLKVGTTVDSGEIIRKLVALQYKRNDAAFSRG
CCCCEEEEEEHHHHHCCCCCHHHEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCC
NFRVRGDNLEIFPSHYEDVAWRISFFGDEIEQIVEFDPLTGKAGTKLTAIRVYANSHYVT
CEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCEEEC
PGPTMKQAADAIRFELTERLKELVAEGKLLEAQRLEQRTNFDLEMIAATGSCAGIENYSR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
FLTGRLPGEPPPTLFEYLPDNALLFVDESHQTVPQIGAMARGDHRRKLTLAEYGFRLPSC
HHHCCCCCCCCCHHHHHCCCCEEEEEECCCCCHHHHHHHCCCCCCCEEEHHHHCCCCCHH
IDNRPLRFNEWDAMRPQTVAVSATPGGWEMEQAGGVFAEQVIRPTGLIDPPVLIRPVEDQ
HCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHCCHHHHHHHCCCCCCCCCEEEECHHHH
VQDCINECRETAAKGYRTLVTTLTKRMAEDLTEFMHEAGLRVRYMHSDVETLERIELIRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHH
LRLGVYDVLVGINLLREGLDIPECGLVCILDADKEGFLRSETSLIQTIGRAARNVDGRVI
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEE
LYADRMTGSMERAIAETDRRRAKQQAYNEEHGITPQTIKRNIHDIVADTASRDGVVVDTG
EEECCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECC
DDERNNLVGHNLRAYIEDLEKRMRAAAADLEFEEAGRLRDEIRRLEATELGLPEGERKAP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
IVGRSNEGKPGTRKTRYGKSQKTKWGK
EECCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AWITSVARTLFVPHIRRMAELVIRRGLEEPDTSGTFVPHRPARPDKVEGGKRFRIVSDY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECC
QPAGDQPTAIADLVEGIRADDKTQVLLGVTGSGKTFTMAQVIEATQRPALILAPNKILAA
CCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCEEHHHHHHHHHCCCEEEECCCHHHHH
QLYGEMKSFFPENAVEYFVSYYDYYQPEAYVPRSDTYIEKESSVNEAIDRMRHSATRALL
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ERDDVIIVASVSCLYGIGSVETYSAMIFDLKVGTTVDSGEIIRKLVALQYKRNDAAFSRG
CCCCEEEEEEHHHHHCCCCCHHHEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCC
NFRVRGDNLEIFPSHYEDVAWRISFFGDEIEQIVEFDPLTGKAGTKLTAIRVYANSHYVT
CEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCEEEC
PGPTMKQAADAIRFELTERLKELVAEGKLLEAQRLEQRTNFDLEMIAATGSCAGIENYSR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
FLTGRLPGEPPPTLFEYLPDNALLFVDESHQTVPQIGAMARGDHRRKLTLAEYGFRLPSC
HHHCCCCCCCCCHHHHHCCCCEEEEEECCCCCHHHHHHHCCCCCCCEEEHHHHCCCCCHH
IDNRPLRFNEWDAMRPQTVAVSATPGGWEMEQAGGVFAEQVIRPTGLIDPPVLIRPVEDQ
HCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHCCHHHHHHHCCCCCCCCCEEEECHHHH
VQDCINECRETAAKGYRTLVTTLTKRMAEDLTEFMHEAGLRVRYMHSDVETLERIELIRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHH
LRLGVYDVLVGINLLREGLDIPECGLVCILDADKEGFLRSETSLIQTIGRAARNVDGRVI
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEE
LYADRMTGSMERAIAETDRRRAKQQAYNEEHGITPQTIKRNIHDIVADTASRDGVVVDTG
EEECCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECC
DDERNNLVGHNLRAYIEDLEKRMRAAAADLEFEEAGRLRDEIRRLEATELGLPEGERKAP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
IVGRSNEGKPGTRKTRYGKSQKTKWGK
EECCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA