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The map label for this gene is cysG [H]

Identifier: 87200569

GI number: 87200569

Start: 2759238

End: 2760008

Strand: Direct

Name: cysG [H]

Synonym: Saro_2556

Alternate gene names: 87200569

Gene position: 2759238-2760008 (Clockwise)

Preceding gene: 87200568

Following gene: 87200570

Centisome position: 77.47

GC content: 67.19

Gene sequence:

>771_bases
ATGAGCAATTCTTCTTCGAGAATCGGGACAGTCCATCTCGTGGGCGCGGGTCCGGGCGATGCCGACCTCCTCACGCTGCG
CGCGGCGCGGCTGGTGATGAATGCCCGCGTGCTGGTGCACGACGGGCTGGTGGATCCTTCGATCCTGGCGATGGCGCCCA
AGGGTTGCCGGATGATCTCCGTCGCCAAGAGCCGGTCGCGCCACACCATGAAGCAGGGCGAGATCAACGCCCTGCTGGTG
CGCGAGGCGCTGGCGGGCAACGACGTGGTACGTCTCAAGGGCGGCGATCCGTTCGTGTTCGGGCGCGGCGGAGAGGAAGC
GGAAGACTGCCTTGCGGCGGGCGTTCCGGTTCAGGTCGTGCCCGGAGTGAGCGCCGCAATGGGCGCGGCGGCAGCGGCGA
TGATCCCTCTCACCCACCGCGAGAGCGCGAGCATCGTGAGCTTCGTCGCGGGCCAGTGCAAGGGCCTGACCGACCAGAAC
TGGGCCGGCCTTGCAGGGGTTGGCAGGACGCTGGTGATCTATATGGGCGTCGCCACTTCGGAAGCGATTGCCGAAAAGCT
GATGGCGGACGGGCTGGCGCCCGAGATGCCGGTGGCCGTGGTGGAAAATGCCGCACGGCCGCAGATGCGCGTGCTGCGCG
GGACGCTGGCGGGCCTCGGGTGCCTGGTGGCGGACAACAAGGTCAGGAGCCCTGCCCTCATCGTGATCGGTGAAGTGGCA
GGCCGGGGAGACATGATGGAATTGAGACAAGTTTTGGAGGCCGCGCGATGA

Upstream 100 bases:

>100_bases
GTGACTTTCGGATTGAGCGCCCCTGCCGCTAAAGATCATCTAGGCGGGGGGAAAAGCATTCTCGCTGGTGACTTGATGGC
TCTGCGCCCATCTGCGCCGG

Downstream 100 bases:

>100_bases
AGATCATCACCGGGAACGACCTGCGCACCGGAGACGTGATCTGGTGGACCGGCGAAGGCTGGTCGCGCCACGTCAACGAT
GCGGTGGAGGCGGGCGAGCA

Product: uroporphyrinogen-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MSNSSSRIGTVHLVGAGPGDADLLTLRAARLVMNARVLVHDGLVDPSILAMAPKGCRMISVAKSRSRHTMKQGEINALLV
REALAGNDVVRLKGGDPFVFGRGGEEAEDCLAAGVPVQVVPGVSAAMGAAAAAMIPLTHRESASIVSFVAGQCKGLTDQN
WAGLAGVGRTLVIYMGVATSEAIAEKLMADGLAPEMPVAVVENAARPQMRVLRGTLAGLGCLVADNKVRSPALIVIGEVA
GRGDMMELRQVLEAAR

Sequences:

>Translated_256_residues
MSNSSSRIGTVHLVGAGPGDADLLTLRAARLVMNARVLVHDGLVDPSILAMAPKGCRMISVAKSRSRHTMKQGEINALLV
REALAGNDVVRLKGGDPFVFGRGGEEAEDCLAAGVPVQVVPGVSAAMGAAAAAMIPLTHRESASIVSFVAGQCKGLTDQN
WAGLAGVGRTLVIYMGVATSEAIAEKLMADGLAPEMPVAVVENAARPQMRVLRGTLAGLGCLVADNKVRSPALIVIGEVA
GRGDMMELRQVLEAAR
>Mature_255_residues
SNSSSRIGTVHLVGAGPGDADLLTLRAARLVMNARVLVHDGLVDPSILAMAPKGCRMISVAKSRSRHTMKQGEINALLVR
EALAGNDVVRLKGGDPFVFGRGGEEAEDCLAAGVPVQVVPGVSAAMGAAAAAMIPLTHRESASIVSFVAGQCKGLTDQNW
AGLAGVGRTLVIYMGVATSEAIAEKLMADGLAPEMPVAVVENAARPQMRVLRGTLAGLGCLVADNKVRSPALIVIGEVAG
RGDMMELRQVLEAAR

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=238, Percent_Identity=46.6386554621849, Blast_Score=204, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6322922, Length=242, Percent_Identity=29.7520661157025, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 26423; Mature: 26292

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSSSRIGTVHLVGAGPGDADLLTLRAARLVMNARVLVHDGLVDPSILAMAPKGCRMIS
CCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCEEEEECCCCCCHHEEECCCCCEEEH
VAKSRSRHTMKQGEINALLVREALAGNDVVRLKGGDPFVFGRGGEEAEDCLAAGVPVQVV
HHHHHHHHHHHCCCCHHEEEHHHHCCCCEEEEECCCEEEECCCCCHHHHHHHCCCCEEEE
PGVSAAMGAAAAAMIPLTHRESASIVSFVAGQCKGLTDQNWAGLAGVGRTLVIYMGVATS
CCCHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCEEEEEEECCCH
EAIAEKLMADGLAPEMPVAVVENAARPQMRVLRGTLAGLGCLVADNKVRSPALIVIGEVA
HHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCCCCEEEEEECCC
GRGDMMELRQVLEAAR
CCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SNSSSRIGTVHLVGAGPGDADLLTLRAARLVMNARVLVHDGLVDPSILAMAPKGCRMIS
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCEEEEECCCCCCHHEEECCCCCEEEH
VAKSRSRHTMKQGEINALLVREALAGNDVVRLKGGDPFVFGRGGEEAEDCLAAGVPVQVV
HHHHHHHHHHHCCCCHHEEEHHHHCCCCEEEEECCCEEEECCCCCHHHHHHHCCCCEEEE
PGVSAAMGAAAAAMIPLTHRESASIVSFVAGQCKGLTDQNWAGLAGVGRTLVIYMGVATS
CCCHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCEEEEEEECCCH
EAIAEKLMADGLAPEMPVAVVENAARPQMRVLRGTLAGLGCLVADNKVRSPALIVIGEVA
HHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCCCCEEEEEECCC
GRGDMMELRQVLEAAR
CCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA