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The map label for this gene is nuoH

Identifier: 87200307

GI number: 87200307

Start: 2434564

End: 2435607

Strand: Reverse

Name: nuoH

Synonym: Saro_2293

Alternate gene names: 87200307

Gene position: 2435607-2434564 (Counterclockwise)

Preceding gene: 87200308

Following gene: 87200306

Centisome position: 68.39

GC content: 60.63

Gene sequence:

>1044_bases
ATGACCGAATTCTTCATGGGTCTTGGCCTCTCGTACGAGTGGGCCTGGGGCATATCGACCATTGCCGGCATCCTGCTGAT
CGCGCTGCCGTTGATGCTCGGTGTTGCCATGATCATCTATGCCGACCGCAAGATCTGGGCGGCGATGGCGCTGCGTCGCG
GGCCGAACGTGGTGGGCCCGCTGGGCCTGCTGCAGTCGTTCGCGGACGGCTTGAAGGTGTTCCTGCAGGAAACCATCATC
CCGACGGCTGCGAACAAGGGCCTGTTCCTGATCGCGCCGATCATCACCTTTACTGTCGCGCTGATGGCCTGGGCGGTGAT
CCCGTTCAATTCGGGCGCGGTTCTGGCCAACATCAACGTCGGCCTGCTCTACGTGCTCGCGATCTCGTCGCTCGGCGTTT
ACGGCGTGGTGATCGCGGGTTGGTCGTCCAACTCGAAGTATCCGTTCTTCTCGGCGATGCGCGCTTCGGCGCAGATGATT
TCCTATGAAGTCTCGATCGGCTTCATCCTGATCTGCGTGGTCCTGTGGGCGGGGACGTTCAACCTGAACGACATCGTGAA
GGCGCAGCAGAGCCACGTCTGGATCATCAACGGCTTCGTCGCGAACCCGCTACTGTTCCCGATGTGGGTGATGTTCCTGA
TCTCGGGCATGGCCGAAACCGCGCGCGCGCCGTTCGACCTGACCGAGGCGGAATCGGAACTCGTCGCCGGTTACCAGACC
GAATACTCGTCGATGGCTTTCGCGCTCTACTGGCTTGGCGAATATGCCAACGTGCTGCTGATGTGTGCGCTGAACGCCGT
GCTGTTCTGGGGTGGATACCTGCCGCCGCTCGACATTCCGGTGCTCTATCTGGTGCCGGGCTTCGTGTGGCTGCTTCTCA
AGATCCTGTTCTTCTTCTTCATCTTCAGTTGGGTGAAGGCGACGGTCCCGCGCTATCGCTATGACCAGCTGATGCGCCTG
GGCTGGAAGGTCTTCCTGCCCGTATCGCTGCTGTTCGTGTTCCTCGTCAGCGGCTACCTCATGGCTACCGGACACTTCGC
ATGA

Upstream 100 bases:

>100_bases
ACTTGTTTCAGGGTCCATGGTGCCCCACAGCACGAACCGTGCAGGTTGAGGGATGGATGCTGGAACAAGGTCAGCATGAC
GAAACTGGAGGTCAGGGGGC

Downstream 100 bases:

>100_bases
CCGTTGGACAGCTCATCAAGAGCTTCACCCTGTGGGAGTTCGTGAAGGCGCACTGGCTGACCTTGAAGTATTTCTTCAAG
CCCAAGGCGACGATCAACTA

Product: respiratory-chain NADH dehydrogenase subunit 1

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTEFFMGLGLSYEWAWGISTIAGILLIALPLMLGVAMIIYADRKIWAAMALRRGPNVVGPLGLLQSFADGLKVFLQETII
PTAANKGLFLIAPIITFTVALMAWAVIPFNSGAVLANINVGLLYVLAISSLGVYGVVIAGWSSNSKYPFFSAMRASAQMI
SYEVSIGFILICVVLWAGTFNLNDIVKAQQSHVWIINGFVANPLLFPMWVMFLISGMAETARAPFDLTEAESELVAGYQT
EYSSMAFALYWLGEYANVLLMCALNAVLFWGGYLPPLDIPVLYLVPGFVWLLLKILFFFFIFSWVKATVPRYRYDQLMRL
GWKVFLPVSLLFVFLVSGYLMATGHFA

Sequences:

>Translated_347_residues
MTEFFMGLGLSYEWAWGISTIAGILLIALPLMLGVAMIIYADRKIWAAMALRRGPNVVGPLGLLQSFADGLKVFLQETII
PTAANKGLFLIAPIITFTVALMAWAVIPFNSGAVLANINVGLLYVLAISSLGVYGVVIAGWSSNSKYPFFSAMRASAQMI
SYEVSIGFILICVVLWAGTFNLNDIVKAQQSHVWIINGFVANPLLFPMWVMFLISGMAETARAPFDLTEAESELVAGYQT
EYSSMAFALYWLGEYANVLLMCALNAVLFWGGYLPPLDIPVLYLVPGFVWLLLKILFFFFIFSWVKATVPRYRYDQLMRL
GWKVFLPVSLLFVFLVSGYLMATGHFA
>Mature_346_residues
TEFFMGLGLSYEWAWGISTIAGILLIALPLMLGVAMIIYADRKIWAAMALRRGPNVVGPLGLLQSFADGLKVFLQETIIP
TAANKGLFLIAPIITFTVALMAWAVIPFNSGAVLANINVGLLYVLAISSLGVYGVVIAGWSSNSKYPFFSAMRASAQMIS
YEVSIGFILICVVLWAGTFNLNDIVKAQQSHVWIINGFVANPLLFPMWVMFLISGMAETARAPFDLTEAESELVAGYQTE
YSSMAFALYWLGEYANVLLMCALNAVLFWGGYLPPLDIPVLYLVPGFVWLLLKILFFFFIFSWVKATVPRYRYDQLMRLG
WKVFLPVSLLFVFLVSGYLMATGHFA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=297, Percent_Identity=41.4141414141414, Blast_Score=228, Evalue=5e-60,
Organism=Escherichia coli, GI1788618, Length=313, Percent_Identity=42.4920127795527, Blast_Score=239, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_NOVAD (Q2G5Z3)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_497564.1
- STRING:   Q2G5Z3
- GeneID:   3916611
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_2293
- NMPDR:   fig|48935.1.peg.207
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   FMVEYGS
- PhylomeDB:   Q2G5Z3
- ProtClustDB:   CLSK843948
- BioCyc:   NARO279238:SARO_2293-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 38455; Mature: 38324

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x167a75b0)-; HASH(0x16f67df4)-; HASH(0x173ec910)-; HASH(0x16ded414)-; HASH(0x17341c30)-; HASH(0x173ec8bc)-; HASH(0x17491d14)-; HASH(0x17430834)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFFMGLGLSYEWAWGISTIAGILLIALPLMLGVAMIIYADRKIWAAMALRRGPNVVGP
CCCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCH
LGLLQSFADGLKVFLQETIIPTAANKGLFLIAPIITFTVALMAWAVIPFNSGAVLANINV
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHEECCCCCEEEECCH
GLLYVLAISSLGVYGVVIAGWSSNSKYPFFSAMRASAQMISYEVSIGFILICVVLWAGTF
HHHHHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NLNDIVKAQQSHVWIINGFVANPLLFPMWVMFLISGMAETARAPFDLTEAESELVAGYQT
CHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
EYSSMAFALYWLGEYANVLLMCALNAVLFWGGYLPPLDIPVLYLVPGFVWLLLKILFFFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IFSWVKATVPRYRYDQLMRLGWKVFLPVSLLFVFLVSGYLMATGHFA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure 
TEFFMGLGLSYEWAWGISTIAGILLIALPLMLGVAMIIYADRKIWAAMALRRGPNVVGP
CCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCH
LGLLQSFADGLKVFLQETIIPTAANKGLFLIAPIITFTVALMAWAVIPFNSGAVLANINV
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHEECCCCCEEEECCH
GLLYVLAISSLGVYGVVIAGWSSNSKYPFFSAMRASAQMISYEVSIGFILICVVLWAGTF
HHHHHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NLNDIVKAQQSHVWIINGFVANPLLFPMWVMFLISGMAETARAPFDLTEAESELVAGYQT
CHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
EYSSMAFALYWLGEYANVLLMCALNAVLFWGGYLPPLDIPVLYLVPGFVWLLLKILFFFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IFSWVKATVPRYRYDQLMRLGWKVFLPVSLLFVFLVSGYLMATGHFA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA