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The map label for this gene is ltrA [H]

Identifier: 87200211

GI number: 87200211

Start: 2334380

End: 2336281

Strand: Reverse

Name: ltrA [H]

Synonym: Saro_2196

Alternate gene names: 87200211

Gene position: 2336281-2334380 (Counterclockwise)

Preceding gene: 87200213

Following gene: 87200210

Centisome position: 65.6

GC content: 58.94

Gene sequence:

>1902_bases
ATGCTGCCAGATACCATTGAGAGGGCCGTCAGATCACTCCCGACCGTCATCAGGTCGGGTCGGAAGGTCAATGGCCTCTA
TCGCCTGCTGAAAAGCCCGCTCCTCTGGGAGCATGCCTACCAGCGGATCGCCCCGAATAAAGGGGCGATGACGCCCGGAG
TTGATGGTCAGACATTCGACGGCTTCTCGCCCGACAAGGTCAGGTCCATCATCGAACGGCTTGCGAACGGGACCTATCGA
CCTCAACCGGCAAGACGGGTGTATATCCCGAAAGCCAATGGCCAGAAACGGCCACTTGGCGTGCCGACCACGGAAGACAA
GTTGGTCCAGGAAGTGGTGCGGACGATCCTCGAGCAAATCTATGAGCCGCTGTTTTCCAGACACTCTCATGGGTTCCGCC
CGAAACGTTCATGCCACACGGCGTTGGAATCGATCCGCGCCATCTGGACCGGGGTGAAATGGCTGATCGACGTCGATGTT
GTCGGGTTCTTCGACAACATCGATCATGATGTCCTCGTATCCCTGCTCGAAAAACGGATTGCGGATCGTCGCTTCGTGCG
GCTCATCCGGGGTCTACTCAAGGCCGGGTATGTCGAAGACTGGGTCTTTCACAAGACCTACAGCGGAACGCCCCAAGGCG
GGGTCGTCTCCCCGATGCTGGCGAACATCTACCTGCATGAACTGGATATGTTCATGCAGGCCAAGATGGCTGGCTTCGAC
AAAGGGAAGCAGCGATCACCATCCCCTGATGCCCGGCGCATCAGGAACCGCCTGTCCTATGTCCGCCGCACAGTGGATCA
ACTTCGCGCCAAAGGGCGCGGCGACGATCCCAGAGTCACTTCCTTCTTGGAAGAGATCGGTCGGCTCAAGGCGGAACGGC
TTGCCGTTCCGGCCAGCGACGCCTTTGATCCGAACTACAGGAGACTGCGCTACTGCCGATACGCCGACGACTTCATCATC
GGCGTCACTGGTAGCAAATCGGAAGCACGACAAATCATGGAGGAGGTCAGGACCTACCTGTCCGATCACCTGAAGTTGGC
CGTGTCCGCCGAGAAAAGCGGAATCCACAAGGCTTCGGATGGGGCACGGTTCCTCGGATACGAAGTCCGGACCATGACCA
ATCCCAATCCGCACAAGGCGATCTTCGATGGTCGTCCGGCAGTGCGGCGAGGCTTGGCCGACCGGATGAAACTTCTGGTG
CCAAGGGACCGCGTCGTGCGGTTCGTCAACTCAAAGGAATGGGGCGACTACGACAGCTTCAGACCTGTTGGGAGGGCGGC
CTTGCGCTTCGCAAGCGATGTGGAAATCGTCCTAGCCTATAACGCCGAATGGCGCGGCTTTGCGAACTATTATGCCATTG
CTGACGACGTGAAACGCAAGCTGAACAAGGCAGGTTACTTCGCCTTGCTCTCATGCGTGAAAACCATCGCCGGAAAGCAC
AGGACATCGGCTCGCAGAGTCTTCGCCAAACTGCGTCGCGGTACGGACTTCTATATCAGCTACGAGGTGGGAGACACCAC
CCGGACAATAAAACTGTGGCAGTTGAAGGACCTCCAGCGACACACGCGCACCTGGGGCGGGATCGATATCCCTTCCTCAG
CAAAGTTCGTGTTCAGCAGGACAGAGCTGGTCGAGCGGCTCAACGCCCGCGAATGCGAGCGTTGCGGTAGCAATGACCAA
CCTTGTGAGGTTCATCACGTCCGCAGGATCGGCGAATTGCAGCATGCCGGGTTCAGTCGCCATATGGCGGCCGCCCGTCA
GCGTAAACGCATGGTCTTGTGCTCCCGCTGCCACAACGATGTCCATGCCGGACAGCCGACCGACCGCCAACGGCGGACAG
CACGCAGTCGTGGAGAGCCGAATGCGCTGAAAGGTGCACGTTCGGTTCGGAGGGGGGCCTAG

Upstream 100 bases:

>100_bases
GTCGGCAGTATAAGCTCGGGGTGACCCGGGCGAAAGCCTAACCGACCGGGGGAAGGGCGGCAGCGACTGCGATCAGACGA
CCTCAAAAGGAGGTGTGCTA

Downstream 100 bases:

>100_bases
CGATGTTCTCTCCGAGACATTGCGGGCCTACCCTACCCGATCAGGTCGACGGTCTGCCCGAGCGCTTCCATCCGGCTGCA
ACGCTGGAGCTCGTCGAGCC

Product: RNA-directed DNA polymerase

Products: NA

Alternate protein names: Reverse-transcriptase; RNA maturase; DNA endonuclease [H]

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MLPDTIERAVRSLPTVIRSGRKVNGLYRLLKSPLLWEHAYQRIAPNKGAMTPGVDGQTFDGFSPDKVRSIIERLANGTYR
PQPARRVYIPKANGQKRPLGVPTTEDKLVQEVVRTILEQIYEPLFSRHSHGFRPKRSCHTALESIRAIWTGVKWLIDVDV
VGFFDNIDHDVLVSLLEKRIADRRFVRLIRGLLKAGYVEDWVFHKTYSGTPQGGVVSPMLANIYLHELDMFMQAKMAGFD
KGKQRSPSPDARRIRNRLSYVRRTVDQLRAKGRGDDPRVTSFLEEIGRLKAERLAVPASDAFDPNYRRLRYCRYADDFII
GVTGSKSEARQIMEEVRTYLSDHLKLAVSAEKSGIHKASDGARFLGYEVRTMTNPNPHKAIFDGRPAVRRGLADRMKLLV
PRDRVVRFVNSKEWGDYDSFRPVGRAALRFASDVEIVLAYNAEWRGFANYYAIADDVKRKLNKAGYFALLSCVKTIAGKH
RTSARRVFAKLRRGTDFYISYEVGDTTRTIKLWQLKDLQRHTRTWGGIDIPSSAKFVFSRTELVERLNARECERCGSNDQ
PCEVHHVRRIGELQHAGFSRHMAAARQRKRMVLCSRCHNDVHAGQPTDRQRRTARSRGEPNALKGARSVRRGA

Sequences:

>Translated_633_residues
MLPDTIERAVRSLPTVIRSGRKVNGLYRLLKSPLLWEHAYQRIAPNKGAMTPGVDGQTFDGFSPDKVRSIIERLANGTYR
PQPARRVYIPKANGQKRPLGVPTTEDKLVQEVVRTILEQIYEPLFSRHSHGFRPKRSCHTALESIRAIWTGVKWLIDVDV
VGFFDNIDHDVLVSLLEKRIADRRFVRLIRGLLKAGYVEDWVFHKTYSGTPQGGVVSPMLANIYLHELDMFMQAKMAGFD
KGKQRSPSPDARRIRNRLSYVRRTVDQLRAKGRGDDPRVTSFLEEIGRLKAERLAVPASDAFDPNYRRLRYCRYADDFII
GVTGSKSEARQIMEEVRTYLSDHLKLAVSAEKSGIHKASDGARFLGYEVRTMTNPNPHKAIFDGRPAVRRGLADRMKLLV
PRDRVVRFVNSKEWGDYDSFRPVGRAALRFASDVEIVLAYNAEWRGFANYYAIADDVKRKLNKAGYFALLSCVKTIAGKH
RTSARRVFAKLRRGTDFYISYEVGDTTRTIKLWQLKDLQRHTRTWGGIDIPSSAKFVFSRTELVERLNARECERCGSNDQ
PCEVHHVRRIGELQHAGFSRHMAAARQRKRMVLCSRCHNDVHAGQPTDRQRRTARSRGEPNALKGARSVRRGA
>Mature_633_residues
MLPDTIERAVRSLPTVIRSGRKVNGLYRLLKSPLLWEHAYQRIAPNKGAMTPGVDGQTFDGFSPDKVRSIIERLANGTYR
PQPARRVYIPKANGQKRPLGVPTTEDKLVQEVVRTILEQIYEPLFSRHSHGFRPKRSCHTALESIRAIWTGVKWLIDVDV
VGFFDNIDHDVLVSLLEKRIADRRFVRLIRGLLKAGYVEDWVFHKTYSGTPQGGVVSPMLANIYLHELDMFMQAKMAGFD
KGKQRSPSPDARRIRNRLSYVRRTVDQLRAKGRGDDPRVTSFLEEIGRLKAERLAVPASDAFDPNYRRLRYCRYADDFII
GVTGSKSEARQIMEEVRTYLSDHLKLAVSAEKSGIHKASDGARFLGYEVRTMTNPNPHKAIFDGRPAVRRGLADRMKLLV
PRDRVVRFVNSKEWGDYDSFRPVGRAALRFASDVEIVLAYNAEWRGFANYYAIADDVKRKLNKAGYFALLSCVKTIAGKH
RTSARRVFAKLRRGTDFYISYEVGDTTRTIKLWQLKDLQRHTRTWGGIDIPSSAKFVFSRTELVERLNARECERCGSNDQ
PCEVHHVRRIGELQHAGFSRHMAAARQRKRMVLCSRCHNDVHAGQPTDRQRRTARSRGEPNALKGARSVRRGA

Specific function: Multifunctional protein that promotes group II intron splicing and mobility by acting both on RNA and DNA. It has three activities:reverse transcriptase (RT) for intron duplication, maturase to promote splicing, and DNA endonuclease for site- specific cle

COG id: COG3344

COG function: function code L; Retron-type reverse transcriptase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 reverse transcriptase domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6226521, Length=588, Percent_Identity=29.2517006802721, Blast_Score=248, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6226520, Length=608, Percent_Identity=29.1118421052632, Blast_Score=247, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003615
- InterPro:   IPR002866
- InterPro:   IPR000477 [H]

Pfam domain/function: PF01348 Intron_maturas2; PF00078 RVT_1 [H]

EC number: =2.7.7.49 [H]

Molecular weight: Translated: 72327; Mature: 72327

Theoretical pI: Translated: 10.85; Mature: 10.85

Prosite motif: PS50878 RT_POL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPDTIERAVRSLPTVIRSGRKVNGLYRLLKSPLLWEHAYQRIAPNKGAMTPGVDGQTFD
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
GFSPDKVRSIIERLANGTYRPQPARRVYIPKANGQKRPLGVPTTEDKLVQEVVRTILEQI
CCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
YEPLFSRHSHGFRPKRSCHTALESIRAIWTGVKWLIDVDVVGFFDNIDHDVLVSLLEKRI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHCCCHHHHHHHHHHHH
ADRRFVRLIRGLLKAGYVEDWVFHKTYSGTPQGGVVSPMLANIYLHELDMFMQAKMAGFD
HHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
KGKQRSPSPDARRIRNRLSYVRRTVDQLRAKGRGDDPRVTSFLEEIGRLKAERLAVPASD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
AFDPNYRRLRYCRYADDFIIGVTGSKSEARQIMEEVRTYLSDHLKLAVSAEKSGIHKASD
CCCCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
GARFLGYEVRTMTNPNPHKAIFDGRPAVRRGLADRMKLLVPRDRVVRFVNSKEWGDYDSF
CCHHHCEEEEECCCCCCCCCEECCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCC
RPVGRAALRFASDVEIVLAYNAEWRGFANYYAIADDVKRKLNKAGYFALLSCVKTIAGKH
CHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RTSARRVFAKLRRGTDFYISYEVGDTTRTIKLWQLKDLQRHTRTWGGIDIPSSAKFVFSR
HHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEHHHHHHHHHHCCCCCCCCCCCCHHHHHH
TELVERLNARECERCGSNDQPCEVHHVRRIGELQHAGFSRHMAAARQRKRMVLCSRCHND
HHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC
VHAGQPTDRQRRTARSRGEPNALKGARSVRRGA
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MLPDTIERAVRSLPTVIRSGRKVNGLYRLLKSPLLWEHAYQRIAPNKGAMTPGVDGQTFD
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
GFSPDKVRSIIERLANGTYRPQPARRVYIPKANGQKRPLGVPTTEDKLVQEVVRTILEQI
CCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
YEPLFSRHSHGFRPKRSCHTALESIRAIWTGVKWLIDVDVVGFFDNIDHDVLVSLLEKRI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHCCCHHHHHHHHHHHH
ADRRFVRLIRGLLKAGYVEDWVFHKTYSGTPQGGVVSPMLANIYLHELDMFMQAKMAGFD
HHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
KGKQRSPSPDARRIRNRLSYVRRTVDQLRAKGRGDDPRVTSFLEEIGRLKAERLAVPASD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
AFDPNYRRLRYCRYADDFIIGVTGSKSEARQIMEEVRTYLSDHLKLAVSAEKSGIHKASD
CCCCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
GARFLGYEVRTMTNPNPHKAIFDGRPAVRRGLADRMKLLVPRDRVVRFVNSKEWGDYDSF
CCHHHCEEEEECCCCCCCCCEECCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCC
RPVGRAALRFASDVEIVLAYNAEWRGFANYYAIADDVKRKLNKAGYFALLSCVKTIAGKH
CHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RTSARRVFAKLRRGTDFYISYEVGDTTRTIKLWQLKDLQRHTRTWGGIDIPSSAKFVFSR
HHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEHHHHHHHHHHCCCCCCCCCCCCHHHHHH
TELVERLNARECERCGSNDQPCEVHHVRRIGELQHAGFSRHMAAARQRKRMVLCSRCHND
HHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC
VHAGQPTDRQRRTARSRGEPNALKGARSVRRGA
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655550; 11157264; 10488339; 9353259; 10413481; 11731786 [H]