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The map label for this gene is yngI [H]

Identifier: 87199490

GI number: 87199490

Start: 1510080

End: 1511672

Strand: Direct

Name: yngI [H]

Synonym: Saro_1470

Alternate gene names: 87199490

Gene position: 1510080-1511672 (Clockwise)

Preceding gene: 87199487

Following gene: 87199492

Centisome position: 42.4

GC content: 61.08

Gene sequence:

>1593_bases
ATGCCGGTGACCGTCACAACCGAGGTAGCAACCGTTGGCGACCTGCTGCTCCGTGCGGCAGACTTGCACGCGGAACGTAC
GGCACTGGCGCTGCCCGGGGTGGCTGTATCCTACCGTGAACTGCGCGACGGAGCTTTTCGGGTTGCACGAGCACTGATTG
GGCTTGGCATTGCTCGAGGCGAGCATGTCGCATTGCTGATGCCAAACTCGGTCGAATTTGCAGAAGCCCTGTTCGGGATC
ATGTTGGCCGGCTGCGTCGCAGTGCCGCTTAATGCGCGGCATCGCGCCGCTGAAATCGGCTATATCATTGACAACTCCCA
GGCGCGCATACTGCTTACAAGTCGTCATGATAGCGATCCGGTAAACTTCATCGAGGTTATCGAACAGGCACTGCCGACAC
CGTCTGCCGCACCGGCTCTGCGCTATGTGGCGCTGTTGAGAGGCGAAGGCTCGGGTGACGTGCTTGGCCGCGAAGCTTTC
CTCTCGCAGGGCGTGCGGACAGATCCGGCGGAAGTCGAGCACACCCGCCGCAGCGTGCGGGTGCGCGATGCAGCATTGAT
CATCTACACCTCTGGCACCACTGCCAATCCCAAAGGCTGTGTGCTACCGCACGAGGCGGTGACGCGTGGCCCTGTGGAGC
GTGCTCGTTACCGCTTGTCTGCGAACGGGGTCGATGTCACCTGGGCAGGCGGGCCGCTGTTCCACATCGGCAGCCTGGCA
CCATTCATCGGCTCGGTTGGGGTGGCAGGCACGTTTCTGGCGGACAGTTATTTCGAGCCGGGCAGGGCGATCGCACTCAT
GGAAAAACACGCGGTGACGCTTGCGTGGCCGTGGTTTGCTGCAATCGTCCAGGGCATCATCGATCACCCCGAATTCAGCG
CTGAAAAGTTCGCGCACCTGAAATACCTATTCCTGATCGCTCCGCCAACTTTGGTAGAACGTGTCCAGGACCTGCTGCCC
CACACCGAGATCATCCAAGCCTGCGGCATGACCGAGACTTCGGGCGTTTTTGCCCTGTGTGACACTGACGAGGACCGCGA
ATCGCGCATTTTCACGCAGGGCAAGGCGTGCCCGGGTATCGAGATCCGGATCGTCGATCCCGAGACCGGCCAGGACCTGC
CCGACGGGACGATGGGTGAGATTCTCGTGCGCGGGTACAACGTGATGGACGGATACTGGGACGCGCCCGAAAAGACGAGC
GAGGCGCTGGTCGGCCATGGTTGGCTCAAGACGGGCGATCTCTACACCCGTCAGCCCAACGGTAGCCTAATCTTCGGCGG
GCGCTGCAAGGATATGCTCAAAGTTGGTGGCGAGAATGTCGCCGCGATTGAGGTCGAAGCGTTCCTGTGCACACATCCGG
CGGTAAAGACCGCCGAAGTCGTTGGTCGGCCTGATCCACGCCTCGACGAAGTGCCTGTGGCCTTCATCGAGCTCTATGAC
GGTGAGACGATCAATGAGGAGGAACTGATCGCGTTCTGTCGCGGTCGTATCGCAAGTTACAAGGTGCCTCGCGCGATCCG
TTTCATGTCGGCCGCCGATTGGCCGATGTCGGCGACCAAGATTGACAAGCGGGCACTGCGAGCGCAGCTGTGA

Upstream 100 bases:

>100_bases
ACCAGAATCGCCGACTCTGTCAACTACTGTGTTGACTAGACGGTCTGGTTTTTTCCATAAGCTGGCTCACGCCACAGATT
AGGCGGATTGGAGAGGAAAG

Downstream 100 bases:

>100_bases
TGTTGTCAGTTCCCCTTTTCGGGGTTCATACCGTCGATGAAAATCGACCAGAACGCTTCGGCTACTTGCGCGCCAGTCAT
CGGACCGCCAGGCGTAAACC

Product: AMP-dependent synthetase and ligase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MPVTVTTEVATVGDLLLRAADLHAERTALALPGVAVSYRELRDGAFRVARALIGLGIARGEHVALLMPNSVEFAEALFGI
MLAGCVAVPLNARHRAAEIGYIIDNSQARILLTSRHDSDPVNFIEVIEQALPTPSAAPALRYVALLRGEGSGDVLGREAF
LSQGVRTDPAEVEHTRRSVRVRDAALIIYTSGTTANPKGCVLPHEAVTRGPVERARYRLSANGVDVTWAGGPLFHIGSLA
PFIGSVGVAGTFLADSYFEPGRAIALMEKHAVTLAWPWFAAIVQGIIDHPEFSAEKFAHLKYLFLIAPPTLVERVQDLLP
HTEIIQACGMTETSGVFALCDTDEDRESRIFTQGKACPGIEIRIVDPETGQDLPDGTMGEILVRGYNVMDGYWDAPEKTS
EALVGHGWLKTGDLYTRQPNGSLIFGGRCKDMLKVGGENVAAIEVEAFLCTHPAVKTAEVVGRPDPRLDEVPVAFIELYD
GETINEEELIAFCRGRIASYKVPRAIRFMSAADWPMSATKIDKRALRAQL

Sequences:

>Translated_530_residues
MPVTVTTEVATVGDLLLRAADLHAERTALALPGVAVSYRELRDGAFRVARALIGLGIARGEHVALLMPNSVEFAEALFGI
MLAGCVAVPLNARHRAAEIGYIIDNSQARILLTSRHDSDPVNFIEVIEQALPTPSAAPALRYVALLRGEGSGDVLGREAF
LSQGVRTDPAEVEHTRRSVRVRDAALIIYTSGTTANPKGCVLPHEAVTRGPVERARYRLSANGVDVTWAGGPLFHIGSLA
PFIGSVGVAGTFLADSYFEPGRAIALMEKHAVTLAWPWFAAIVQGIIDHPEFSAEKFAHLKYLFLIAPPTLVERVQDLLP
HTEIIQACGMTETSGVFALCDTDEDRESRIFTQGKACPGIEIRIVDPETGQDLPDGTMGEILVRGYNVMDGYWDAPEKTS
EALVGHGWLKTGDLYTRQPNGSLIFGGRCKDMLKVGGENVAAIEVEAFLCTHPAVKTAEVVGRPDPRLDEVPVAFIELYD
GETINEEELIAFCRGRIASYKVPRAIRFMSAADWPMSATKIDKRALRAQL
>Mature_529_residues
PVTVTTEVATVGDLLLRAADLHAERTALALPGVAVSYRELRDGAFRVARALIGLGIARGEHVALLMPNSVEFAEALFGIM
LAGCVAVPLNARHRAAEIGYIIDNSQARILLTSRHDSDPVNFIEVIEQALPTPSAAPALRYVALLRGEGSGDVLGREAFL
SQGVRTDPAEVEHTRRSVRVRDAALIIYTSGTTANPKGCVLPHEAVTRGPVERARYRLSANGVDVTWAGGPLFHIGSLAP
FIGSVGVAGTFLADSYFEPGRAIALMEKHAVTLAWPWFAAIVQGIIDHPEFSAEKFAHLKYLFLIAPPTLVERVQDLLPH
TEIIQACGMTETSGVFALCDTDEDRESRIFTQGKACPGIEIRIVDPETGQDLPDGTMGEILVRGYNVMDGYWDAPEKTSE
ALVGHGWLKTGDLYTRQPNGSLIFGGRCKDMLKVGGENVAAIEVEAFLCTHPAVKTAEVVGRPDPRLDEVPVAFIELYDG
ETINEEELIAFCRGRIASYKVPRAIRFMSAADWPMSATKIDKRALRAQL

Specific function: Could Catalyze The Transfer Of CoA To Crotonobetaine Or Carnitine. [C]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=541, Percent_Identity=28.6506469500924, Blast_Score=205, Evalue=8e-53,
Organism=Homo sapiens, GI187761345, Length=532, Percent_Identity=26.3157894736842, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI187761343, Length=532, Percent_Identity=26.3157894736842, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI115511026, Length=516, Percent_Identity=27.3255813953488, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI58082049, Length=514, Percent_Identity=26.4591439688716, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI157311624, Length=515, Percent_Identity=26.2135922330097, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI157311622, Length=515, Percent_Identity=26.2135922330097, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI42544132, Length=489, Percent_Identity=24.7443762781186, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI38505220, Length=511, Percent_Identity=24.0704500978474, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI122937307, Length=515, Percent_Identity=25.0485436893204, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI83745141, Length=173, Percent_Identity=26.5895953757225, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI221142682, Length=522, Percent_Identity=29.3103448275862, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI145693145, Length=540, Percent_Identity=28.8888888888889, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1788107, Length=576, Percent_Identity=26.7361111111111, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI1786810, Length=524, Percent_Identity=27.2900763358779, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1790505, Length=544, Percent_Identity=23.5294117647059, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786529, Length=544, Percent_Identity=22.6102941176471, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71994703, Length=555, Percent_Identity=29.7297297297297, Blast_Score=209, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI71994690, Length=555, Percent_Identity=29.7297297297297, Blast_Score=209, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI71994694, Length=555, Percent_Identity=29.7297297297297, Blast_Score=209, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17560308, Length=515, Percent_Identity=26.7961165048544, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI32563687, Length=481, Percent_Identity=27.4428274428274, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17558820, Length=505, Percent_Identity=25.9405940594059, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17557194, Length=515, Percent_Identity=27.5728155339806, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17559526, Length=515, Percent_Identity=24.2718446601942, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17538037, Length=555, Percent_Identity=26.1261261261261, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17531443, Length=528, Percent_Identity=21.4015151515152, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17560140, Length=472, Percent_Identity=22.6694915254237, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=561, Percent_Identity=22.6381461675579, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17553312, Length=203, Percent_Identity=27.5862068965517, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319699, Length=525, Percent_Identity=25.7142857142857, Blast_Score=150, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24581924, Length=492, Percent_Identity=28.6585365853659, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21355181, Length=531, Percent_Identity=24.8587570621469, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI18859661, Length=478, Percent_Identity=27.4058577405858, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21358303, Length=504, Percent_Identity=21.4285714285714, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21356947, Length=475, Percent_Identity=22.9473684210526, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI20130357, Length=318, Percent_Identity=27.9874213836478, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI281365686, Length=483, Percent_Identity=22.360248447205, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24656500, Length=463, Percent_Identity=22.4622030237581, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356441, Length=504, Percent_Identity=21.8253968253968, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI19921316, Length=168, Percent_Identity=34.5238095238095, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24653035, Length=358, Percent_Identity=25.4189944134078, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24648260, Length=472, Percent_Identity=21.8220338983051, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648257, Length=467, Percent_Identity=25.4817987152034, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI161076582, Length=358, Percent_Identity=24.0223463687151, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17933690, Length=125, Percent_Identity=33.6, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 57455; Mature: 57323

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVTVTTEVATVGDLLLRAADLHAERTALALPGVAVSYRELRDGAFRVARALIGLGIARG
CCEEEEEHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
EHVALLMPNSVEFAEALFGIMLAGCVAVPLNARHRAAEIGYIIDNSQARILLTSRHDSDP
CEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCC
VNFIEVIEQALPTPSAAPALRYVALLRGEGSGDVLGREAFLSQGVRTDPAEVEHTRRSVR
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHEE
VRDAALIIYTSGTTANPKGCVLPHEAVTRGPVERARYRLSANGVDVTWAGGPLFHIGSLA
EEEEEEEEEECCCCCCCCCCCCCHHHHHCCCHHHHHEEEECCCEEEEECCCCHHHHHHHH
PFIGSVGVAGTFLADSYFEPGRAIALMEKHAVTLAWPWFAAIVQGIIDHPEFSAEKFAHL
HHHHCCCCHHHHHHHCCCCCCCEEEEEECCEEEEECHHHHHHHHHHHCCCCCCHHHHHHE
KYLFLIAPPTLVERVQDLLPHTEIIQACGMTETSGVFALCDTDEDRESRIFTQGKACPGI
EEEEEECCHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEECCCCCCHHHEEECCCCCCCE
EIRIVDPETGQDLPDGTMGEILVRGYNVMDGYWDAPEKTSEALVGHGWLKTGDLYTRQPN
EEEEECCCCCCCCCCCCHHHHHHHCCEECCCCCCCCCHHHHHHHCCCCEECCCEEEECCC
GSLIFGGRCKDMLKVGGENVAAIEVEAFLCTHPAVKTAEVVGRPDPRLDEVPVAFIELYD
CCEEECCCCHHHHHCCCCCEEEEEEEEEEECCCCCHHHHHHCCCCCCCCCCCEEEEEEEC
GETINEEELIAFCRGRIASYKVPRAIRFMSAADWPMSATKIDKRALRAQL
CCCCCHHHHHHHHHCCHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
PVTVTTEVATVGDLLLRAADLHAERTALALPGVAVSYRELRDGAFRVARALIGLGIARG
CEEEEEHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
EHVALLMPNSVEFAEALFGIMLAGCVAVPLNARHRAAEIGYIIDNSQARILLTSRHDSDP
CEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCC
VNFIEVIEQALPTPSAAPALRYVALLRGEGSGDVLGREAFLSQGVRTDPAEVEHTRRSVR
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHEE
VRDAALIIYTSGTTANPKGCVLPHEAVTRGPVERARYRLSANGVDVTWAGGPLFHIGSLA
EEEEEEEEEECCCCCCCCCCCCCHHHHHCCCHHHHHEEEECCCEEEEECCCCHHHHHHHH
PFIGSVGVAGTFLADSYFEPGRAIALMEKHAVTLAWPWFAAIVQGIIDHPEFSAEKFAHL
HHHHCCCCHHHHHHHCCCCCCCEEEEEECCEEEEECHHHHHHHHHHHCCCCCCHHHHHHE
KYLFLIAPPTLVERVQDLLPHTEIIQACGMTETSGVFALCDTDEDRESRIFTQGKACPGI
EEEEEECCHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEECCCCCCHHHEEECCCCCCCE
EIRIVDPETGQDLPDGTMGEILVRGYNVMDGYWDAPEKTSEALVGHGWLKTGDLYTRQPN
EEEEECCCCCCCCCCCCHHHHHHHCCEECCCCCCCCCHHHHHHHCCCCEECCCEEEECCC
GSLIFGGRCKDMLKVGGENVAAIEVEAFLCTHPAVKTAEVVGRPDPRLDEVPVAFIELYD
CCEEECCCCHHHHHCCCCCEEEEEEEEEEECCCCCHHHHHHCCCCCCCCCCCEEEEEEEC
GETINEEELIAFCRGRIASYKVPRAIRFMSAADWPMSATKIDKRALRAQL
CCCCCHHHHHHHHHCCHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]