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The map label for this gene is fabZ

Identifier: 87199400

GI number: 87199400

Start: 1427166

End: 1427642

Strand: Direct

Name: fabZ

Synonym: Saro_1379

Alternate gene names: 87199400

Gene position: 1427166-1427642 (Clockwise)

Preceding gene: 87199399

Following gene: 87199401

Centisome position: 40.07

GC content: 64.15

Gene sequence:

>477_bases
ATGAGCGAAGAACAGGGCGCCGCGACCGACGGCGTGATCCTCGACTACGACGTGCGCAAGGTAATGGCGGCGCTTCCGCA
CCGCTATCCCCTGCTGCTGGTCGATCGCGTGGCGTCGCTGACGCTGAACGAGCGCATCCATGCGGTGAAGGCCGTGTCGA
TGAACGAGCAGTTCTTCCAGGGCCATTTCCCCGGCCGTCCGATCATGCCGGGCGTTCTCCAGATCGAGGCGCTGGCGCAG
GCCGCCGGCGTTCTCGCCGTGGAATCGCTTGGCCTCGCCGGTTCGGGCAAGCTCGTCTACTTCATGGCGATCGAGGACGC
GAAGTTCCGCAATCCCGTGGAACCGGGCGTGCTGCTCGACCTGCACGTCGAGTTCACCCAGAAGCGCTCGCGCGTCTGCA
AGTTTTCCGGCAAGGCGATGATCGGCGACAAGGTGACCTGCGAGGTCAACTTTACCGCGATGATCGCGGATAGCTGA

Upstream 100 bases:

>100_bases
GAGCAACAGGCTCAGGCCGCTCAGCAGCAGCAGCCCGCCGGCGCCCAGCCCGCCAAGAAGCAGCCGGAAGGCCGCTAAGG
CAATCGCGGGGGCAGGGGAA

Downstream 100 bases:

>100_bases
GGACCGCACGCGCTGGACATCCGCGCGGCTTTCCGCTAGGCGCGCGCCCTTACAGATTCTAGCGGCCGGTCGGAACCGGC
TGCGCACCGGAGCAAGACCC

Product: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase

Products: trans-Delta2-enoyl-acyl-ACP; H2O [C]

Alternate protein names: (3R)-hydroxymyristoyl ACP dehydrase

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MSEEQGAATDGVILDYDVRKVMAALPHRYPLLLVDRVASLTLNERIHAVKAVSMNEQFFQGHFPGRPIMPGVLQIEALAQ
AAGVLAVESLGLAGSGKLVYFMAIEDAKFRNPVEPGVLLDLHVEFTQKRSRVCKFSGKAMIGDKVTCEVNFTAMIADS

Sequences:

>Translated_158_residues
MSEEQGAATDGVILDYDVRKVMAALPHRYPLLLVDRVASLTLNERIHAVKAVSMNEQFFQGHFPGRPIMPGVLQIEALAQ
AAGVLAVESLGLAGSGKLVYFMAIEDAKFRNPVEPGVLLDLHVEFTQKRSRVCKFSGKAMIGDKVTCEVNFTAMIADS
>Mature_157_residues
SEEQGAATDGVILDYDVRKVMAALPHRYPLLLVDRVASLTLNERIHAVKAVSMNEQFFQGHFPGRPIMPGVLQIEALAQA
AGVLAVESLGLAGSGKLVYFMAIEDAKFRNPVEPGVLLDLHVEFTQKRSRVCKFSGKAMIGDKVTCEVNFTAMIADS

Specific function: Involved in saturated fatty acids biosynthesis

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabZ subfamily

Homologues:

Organism=Escherichia coli, GI1786377, Length=142, Percent_Identity=47.1830985915493, Blast_Score=136, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABZ_NOVAD (Q2G8K0)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496657.1
- ProteinModelPortal:   Q2G8K0
- SMR:   Q2G8K0
- STRING:   Q2G8K0
- GeneID:   3917833
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_1379
- eggNOG:   COG0764
- HOGENOM:   HBG433282
- OMA:   EFTQKRS
- PhylomeDB:   Q2G8K0
- ProtClustDB:   CLSK835358
- BioCyc:   NARO279238:SARO_1379-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00406
- InterPro:   IPR013114
- InterPro:   IPR010084
- TIGRFAMs:   TIGR01750

Pfam domain/function: PF07977 FabA

EC number: 4.2.1.- [C]

Molecular weight: Translated: 17204; Mature: 17073

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: ACT_SITE 62-62

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEQGAATDGVILDYDVRKVMAALPHRYPLLLVDRVASLTLNERIHAVKAVSMNEQFFQ
CCCCCCCCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCHHHHC
GHFPGRPIMPGVLQIEALAQAAGVLAVESLGLAGSGKLVYFMAIEDAKFRNPVEPGVLLD
CCCCCCCCCCHHHHHHHHHHHHCCCEEHHCCCCCCCCEEEEEEECCCCCCCCCCCCEEEE
LHVEFTQKRSRVCKFSGKAMIGDKVTCEVNFTAMIADS
EEEHHHHHHHHHHHCCCCEEECCEEEEEEEEEEEEECC
>Mature Secondary Structure 
SEEQGAATDGVILDYDVRKVMAALPHRYPLLLVDRVASLTLNERIHAVKAVSMNEQFFQ
CCCCCCCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCHHHHC
GHFPGRPIMPGVLQIEALAQAAGVLAVESLGLAGSGKLVYFMAIEDAKFRNPVEPGVLLD
CCCCCCCCCCHHHHHHHHHHHHCCCEEHHCCCCCCCCEEEEEEECCCCCCCCCCCCEEEE
LHVEFTQKRSRVCKFSGKAMIGDKVTCEVNFTAMIADS
EEEHHHHHHHHHHHCCCCEEECCEEEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-3-hydroxy-acyl-ACP [C]

Specific reaction: D-3-hydroxy-acyl-ACP = trans-Delta2-enoyl-acyl-ACP + H2O [C]

General reaction: Carbon-Oxygen Lyases; Hydro-Lyases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA