Click here to switch to the map view.

The map label for this gene is dxr [H]

Identifier: 87199396

GI number: 87199396

Start: 1421222

End: 1422379

Strand: Direct

Name: dxr [H]

Synonym: Saro_1375

Alternate gene names: 87199396

Gene position: 1421222-1422379 (Clockwise)

Preceding gene: 87199395

Following gene: 87199397

Centisome position: 39.9

GC content: 67.53

Gene sequence:

>1158_bases
ATGACGCGAACGATTTCCGTCCTTGGCGCGACCGGATCGATCGGAGCCTCGACGCTGGACCTGATCCGGCGCGAGCGCGA
CAAGTGGCGCGTAGTGGCGCTGACCGCGAACGGTAATGCGCGCGAACTGGCCGCGCTCGCCCGCGAGTTCGGGGCTGAGG
TCGCGGTTGTTGCCGACGAGAGCGCGCTGGCGGCCTTGCGGGATGCGCTGGCTGGATCGGGCATCGAGGCGGCGGCTGGA
CCAGGCGCGTTGATCGATGCGGCTGCGCTTGGTGCGGAAGTGACTGTCGCCGCGATCGTCGGATGCGCCGGGCTCGCGCC
GACCATGGCAGCCATCGAGCGCGGCGGGATCATCGCGCTGGCCAACAAGGAAGCGCTGGTTTCCGCTGGCGACGTCATGA
TGGCGGCGGTGGAGCGCCACGGCGCCACGCTGCTGCCGGTCGATTCGGAACACAACGCGATCTTCCAGTGCCTACAGGGT
AACGACATCGCCCACGTTCGCGCGATCACGCTCACGGCAAGCGGCGGTCCGTTCCGCGACTGGACGACCGAGCAGTTGCA
GCGCGCCACGCCCGCCGAGGCGGTCAGGCATCCGAACTGGTCGATGGGCGCGAAGATCAGCGTCGATTCCGCAACGATGA
TGAACAAGGGGCTCGAGTTCATCGAGGCCTTCCACCTGTTCCCCGTCGGCGTGGAACGGCTGCGCATCATCGTGCATCCC
CAGTCCATCGTGCATTCCATGGTCGAATACCGCGATGGTTCGACGCTGGCGCAACTCGGGCCTTCGGACATGCGCGTGCC
GATCGCGTCGGCGCTTGCCTGGCCGGCCCGGATGGACACGCCTTGCGATCCGCTTGATCTTGCGACCATTGGGCAGCTGA
CCTTCCGTGCACCGGACGAGCAGCGGTTTCCCGCGACGCGGCTGGCACGCGAAGCCGTGATTGCGGGCGGTGCGGCGCCA
GCCGTGCTGAACGCGGCGAACGAAATGGCGGTTGCGGCGTTCCTTGGCGGTCAGATTGGGTTCACCCGGATCGTGCAATG
TTGCGAGGACGTGCTTGCGCACGGTCTTGCGCCTGCCCCGCGCAGTCTGGCCGAGGTTATCGCGGTCGATGCAGAGGCGC
GGGCGCGGGCGCTCGAACTGATGGAGCCGGTGCGTTGA

Upstream 100 bases:

>100_bases
CCTGGCCACGGAGGCCTGTTCGACCGCGTTGACGGATTGCTCCCGGTTGCGATCATTGTCGGGACGTCATGGGCCGCCAC
GCAGGCTGGACTGTAAGCCG

Downstream 100 bases:

>100_bases
CGAGTGCTTTGCGATGCAGATGATGGAAAGCCCCGGAATCCTCACGACCTTGCTGGCTTTCGTGCTCGTGCTGGGGCCGC
TCGTCTTCATTCATGAGTTC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MTRTISVLGATGSIGASTLDLIRRERDKWRVVALTANGNARELAALAREFGAEVAVVADESALAALRDALAGSGIEAAAG
PGALIDAAALGAEVTVAAIVGCAGLAPTMAAIERGGIIALANKEALVSAGDVMMAAVERHGATLLPVDSEHNAIFQCLQG
NDIAHVRAITLTASGGPFRDWTTEQLQRATPAEAVRHPNWSMGAKISVDSATMMNKGLEFIEAFHLFPVGVERLRIIVHP
QSIVHSMVEYRDGSTLAQLGPSDMRVPIASALAWPARMDTPCDPLDLATIGQLTFRAPDEQRFPATRLAREAVIAGGAAP
AVLNAANEMAVAAFLGGQIGFTRIVQCCEDVLAHGLAPAPRSLAEVIAVDAEARARALELMEPVR

Sequences:

>Translated_385_residues
MTRTISVLGATGSIGASTLDLIRRERDKWRVVALTANGNARELAALAREFGAEVAVVADESALAALRDALAGSGIEAAAG
PGALIDAAALGAEVTVAAIVGCAGLAPTMAAIERGGIIALANKEALVSAGDVMMAAVERHGATLLPVDSEHNAIFQCLQG
NDIAHVRAITLTASGGPFRDWTTEQLQRATPAEAVRHPNWSMGAKISVDSATMMNKGLEFIEAFHLFPVGVERLRIIVHP
QSIVHSMVEYRDGSTLAQLGPSDMRVPIASALAWPARMDTPCDPLDLATIGQLTFRAPDEQRFPATRLAREAVIAGGAAP
AVLNAANEMAVAAFLGGQIGFTRIVQCCEDVLAHGLAPAPRSLAEVIAVDAEARARALELMEPVR
>Mature_384_residues
TRTISVLGATGSIGASTLDLIRRERDKWRVVALTANGNARELAALAREFGAEVAVVADESALAALRDALAGSGIEAAAGP
GALIDAAALGAEVTVAAIVGCAGLAPTMAAIERGGIIALANKEALVSAGDVMMAAVERHGATLLPVDSEHNAIFQCLQGN
DIAHVRAITLTASGGPFRDWTTEQLQRATPAEAVRHPNWSMGAKISVDSATMMNKGLEFIEAFHLFPVGVERLRIIVHPQ
SIVHSMVEYRDGSTLAQLGPSDMRVPIASALAWPARMDTPCDPLDLATIGQLTFRAPDEQRFPATRLAREAVIAGGAAPA
VLNAANEMAVAAFLGGQIGFTRIVQCCEDVLAHGLAPAPRSLAEVIAVDAEARARALELMEPVR

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=385, Percent_Identity=49.8701298701299, Blast_Score=329, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 40177; Mature: 40045

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRTISVLGATGSIGASTLDLIRRERDKWRVVALTANGNARELAALAREFGAEVAVVADE
CCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHCCCEEEEECH
SALAALRDALAGSGIEAAAGPGALIDAAALGAEVTVAAIVGCAGLAPTMAAIERGGIIAL
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHCCCEEEE
ANKEALVSAGDVMMAAVERHGATLLPVDSEHNAIFQCLQGNDIAHVRAITLTASGGPFRD
ECCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCEEEEEEEEEEECCCCCCC
WTTEQLQRATPAEAVRHPNWSMGAKISVDSATMMNKGLEFIEAFHLFPVGVERLRIIVHP
CCHHHHHHCCCHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCHHHEEEEECC
QSIVHSMVEYRDGSTLAQLGPSDMRVPIASALAWPARMDTPCDPLDLATIGQLTFRAPDE
HHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCEEECCCCC
QRFPATRLAREAVIAGGAAPAVLNAANEMAVAAFLGGQIGFTRIVQCCEDVLAHGLAPAP
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCH
RSLAEVIAVDAEARARALELMEPVR
HHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TRTISVLGATGSIGASTLDLIRRERDKWRVVALTANGNARELAALAREFGAEVAVVADE
CEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHCCCEEEEECH
SALAALRDALAGSGIEAAAGPGALIDAAALGAEVTVAAIVGCAGLAPTMAAIERGGIIAL
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHCCCEEEE
ANKEALVSAGDVMMAAVERHGATLLPVDSEHNAIFQCLQGNDIAHVRAITLTASGGPFRD
ECCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCEEEEEEEEEEECCCCCCC
WTTEQLQRATPAEAVRHPNWSMGAKISVDSATMMNKGLEFIEAFHLFPVGVERLRIIVHP
CCHHHHHHCCCHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCHHHEEEEECC
QSIVHSMVEYRDGSTLAQLGPSDMRVPIASALAWPARMDTPCDPLDLATIGQLTFRAPDE
HHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCEEECCCCC
QRFPATRLAREAVIAGGAAPAVLNAANEMAVAAFLGGQIGFTRIVQCCEDVLAHGLAPAP
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCH
RSLAEVIAVDAEARARALELMEPVR
HHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11004410 [H]