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The map label for this gene is uppS [H]

Identifier: 87199394

GI number: 87199394

Start: 1419771

End: 1420481

Strand: Direct

Name: uppS [H]

Synonym: Saro_1373

Alternate gene names: 87199394

Gene position: 1419771-1420481 (Clockwise)

Preceding gene: 87199393

Following gene: 87199395

Centisome position: 39.86

GC content: 64.56

Gene sequence:

>711_bases
GTGACCGCAGTCCCCGCCTCGACCGGCGGCACCGCGCCGCATGGCGCGCGGCATGTTGCCATCATCATGGATGGCAATGG
TCGCTGGGCGAAGAAGCGCATGATGCCGCGGGCCTTCGGGCACAAGCGCGGGGTCGATACTGTGCGCGAGATTGCCCGCG
CTGCCCGCGACATGGGGCTCGAGGCGCTCACGCTCTACGCCTTCTCGTCGGAGAACTGGAAGCGGCCCGCCGACGAGATC
GCGGACCTGATGGGGCTCTTGCGCACCTTCATCCGCAATGATCTGGACGAGTTCGTCGCGAACAATACTCGGCTACGCAT
CATCGGTGATTATCAGGCACTTGCCCCTGATATTGTCCAGATGATCGAGGATGCCATGGCGCGTACGGCGGGCAATACGG
GCACGACCCTGGCCATTGCGCTCAATTATGGGTCGCAGCAGGAAATCGCCCGTGCCGCCGCTCGCGCGGCCGAGAAGGGT
GCGATCACGCCCGAGGCGATCGAGGCCGAACTCGATACGGCCTGCCTGCCGCCTCTGGACCTGCTGATCCGGACCTCGGG
AGAGATCCGCCTGTCGAACTTCCTGCTGTGGCAGGCGGCCTATGCCGAAATGTGGTTTACAGACGTGCTCTGGCCCGATT
TCACTGCGGCCCACCTGCGCGACGCGCTTGACCAGTTCACATCGCGAGAGAGGCGCTTCGGTGGACGTTGA

Upstream 100 bases:

>100_bases
AGCGCAAGCGCGCCGAGACCGATCTGCAGAAGCTGACCGACGATATCATCAAGCAGGCGGACGAAGCTGCCGCGGCCAAG
GAGAAGGAAATCCTCGGCAA

Downstream 100 bases:

>100_bases
GCCGACCCTGACACCGCCGGGACCCGCTCCCGTGAAGAAATCGGACCTGCCCGTCCGCATCGTTTCTGCCGTGATCATGC
TGGCGATCGCCGGAACCGCG

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTAVPASTGGTAPHGARHVAIIMDGNGRWAKKRMMPRAFGHKRGVDTVREIARAARDMGLEALTLYAFSSENWKRPADEI
ADLMGLLRTFIRNDLDEFVANNTRLRIIGDYQALAPDIVQMIEDAMARTAGNTGTTLAIALNYGSQQEIARAAARAAEKG
AITPEAIEAELDTACLPPLDLLIRTSGEIRLSNFLLWQAAYAEMWFTDVLWPDFTAAHLRDALDQFTSRERRFGGR

Sequences:

>Translated_236_residues
MTAVPASTGGTAPHGARHVAIIMDGNGRWAKKRMMPRAFGHKRGVDTVREIARAARDMGLEALTLYAFSSENWKRPADEI
ADLMGLLRTFIRNDLDEFVANNTRLRIIGDYQALAPDIVQMIEDAMARTAGNTGTTLAIALNYGSQQEIARAAARAAEKG
AITPEAIEAELDTACLPPLDLLIRTSGEIRLSNFLLWQAAYAEMWFTDVLWPDFTAAHLRDALDQFTSRERRFGGR
>Mature_235_residues
TAVPASTGGTAPHGARHVAIIMDGNGRWAKKRMMPRAFGHKRGVDTVREIARAARDMGLEALTLYAFSSENWKRPADEIA
DLMGLLRTFIRNDLDEFVANNTRLRIIGDYQALAPDIVQMIEDAMARTAGNTGTTLAIALNYGSQQEIARAAARAAEKGA
ITPEAIEAELDTACLPPLDLLIRTSGEIRLSNFLLWQAAYAEMWFTDVLWPDFTAAHLRDALDQFTSRERRFGGR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=221, Percent_Identity=37.5565610859729, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI45580742, Length=221, Percent_Identity=37.5565610859729, Blast_Score=147, Evalue=1e-35,
Organism=Escherichia coli, GI1786371, Length=230, Percent_Identity=52.6086956521739, Blast_Score=230, Evalue=7e-62,
Organism=Caenorhabditis elegans, GI71993029, Length=220, Percent_Identity=34.0909090909091, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6319474, Length=207, Percent_Identity=39.1304347826087, Blast_Score=125, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=219, Percent_Identity=31.5068493150685, Blast_Score=105, Evalue=5e-24,
Organism=Drosophila melanogaster, GI18857969, Length=220, Percent_Identity=35.4545454545455, Blast_Score=138, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 26077; Mature: 25946

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVPASTGGTAPHGARHVAIIMDGNGRWAKKRMMPRAFGHKRGVDTVREIARAARDMGL
CCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHCHHHHCCCCCHHHHHHHHHHHHHCCC
EALTLYAFSSENWKRPADEIADLMGLLRTFIRNDLDEFVANNTRLRIIGDYQALAPDIVQ
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHH
MIEDAMARTAGNTGTTLAIALNYGSQQEIARAAARAAEKGAITPEAIEAELDTACLPPLD
HHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHH
LLIRTSGEIRLSNFLLWQAAYAEMWFTDVLWPDFTAAHLRDALDQFTSRERRFGGR
HHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TAVPASTGGTAPHGARHVAIIMDGNGRWAKKRMMPRAFGHKRGVDTVREIARAARDMGL
CCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHCHHHHCCCCCHHHHHHHHHHHHHCCC
EALTLYAFSSENWKRPADEIADLMGLLRTFIRNDLDEFVANNTRLRIIGDYQALAPDIVQ
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHH
MIEDAMARTAGNTGTTLAIALNYGSQQEIARAAARAAEKGAITPEAIEAELDTACLPPLD
HHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHH
LLIRTSGEIRLSNFLLWQAAYAEMWFTDVLWPDFTAAHLRDALDQFTSRERRFGGR
HHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]