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The map label for this gene is pyrH

Identifier: 87199392

GI number: 87199392

Start: 1418481

End: 1419215

Strand: Direct

Name: pyrH

Synonym: Saro_1371

Alternate gene names: 87199392

Gene position: 1418481-1419215 (Clockwise)

Preceding gene: 87199391

Following gene: 87199393

Centisome position: 39.83

GC content: 62.99

Gene sequence:

>735_bases
ATGAGCCTCCCTTCCTGCGTTCCCGGTTACAGGCGCATCCTCCTGAAGCTTTCGGGCGAAGTGCTGATGGGGGAACAGCA
GTTCGGGATAGACACCGACTACGTCGCGCGGGTGGCCCAGGAAGTTAAGGATGCGCGCGATAGCGGGCTGGAAATCTGCC
TCGTCATCGGCGGCGGCAACATCTTTCGCGGCATGGCGGGTGCGGCAAAGGGCATGGACCGTGCTCAGGCCGACTACATG
GGCATGCTTGCCACGGTCATGAATGCGCTGGCGATGCAATCCGCTCTCGAGCAGCTTGGCGTCCCGACGCGGGTCCAGTC
CGCGATCGAGATGGACAAGGTCTGCGAGCCGGTAATCCGCCGCCGTGCAGAGCGTCACCTCGAGAAGGGACGCATCGTGA
TCTTCGCCGCGGGCGTCGGCGCTCCCTATTTCACCACCGATTCCGGTGCCGCGCTGCGCGCCGCCGAGATGAAGTGCGAC
GCGCTGCTCAAGGGCACCAGCGTCGACGGGGTGTACAATGCCGACCCCAAGAAGGACCCGGCGGCAAAGCGTTACGAAAC
AGTCGATTACGACACTGTCCTGGCCGACAATCTGAAGGTCATGGATGCCAGCGCAGTTGCGCTGTGCCGTGACAACAACA
TTCCCATCGTCGTCTTCTCGATCCGCGAACGGGGCAATCTGGCCCGCGTACTTGCGGGTGAGGGGACGCAGACCACCGTG
AAGAAGGAAGCCTGA

Upstream 100 bases:

>100_bases
GCCCGTCGGTGCGGGGATAGTTACGTCTGCGCCCTTGGCACCGCCCCTTACAGGGGTATAAGGGCGGCCAATTCCCTTCG
GTCACGAGTACGTTCTTCCC

Downstream 100 bases:

>100_bases
CATGGCCAAGTATGACAAGGCGGACCTCGAGCGCCGCATGAAGGGCGCCGTGGAATCGCTGAGGGGCGATCTTTCGGGCC
TGCGCACCGGCCGCGCCAAC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MSLPSCVPGYRRILLKLSGEVLMGEQQFGIDTDYVARVAQEVKDARDSGLEICLVIGGGNIFRGMAGAAKGMDRAQADYM
GMLATVMNALAMQSALEQLGVPTRVQSAIEMDKVCEPVIRRRAERHLEKGRIVIFAAGVGAPYFTTDSGAALRAAEMKCD
ALLKGTSVDGVYNADPKKDPAAKRYETVDYDTVLADNLKVMDASAVALCRDNNIPIVVFSIRERGNLARVLAGEGTQTTV
KKEA

Sequences:

>Translated_244_residues
MSLPSCVPGYRRILLKLSGEVLMGEQQFGIDTDYVARVAQEVKDARDSGLEICLVIGGGNIFRGMAGAAKGMDRAQADYM
GMLATVMNALAMQSALEQLGVPTRVQSAIEMDKVCEPVIRRRAERHLEKGRIVIFAAGVGAPYFTTDSGAALRAAEMKCD
ALLKGTSVDGVYNADPKKDPAAKRYETVDYDTVLADNLKVMDASAVALCRDNNIPIVVFSIRERGNLARVLAGEGTQTTV
KKEA
>Mature_243_residues
SLPSCVPGYRRILLKLSGEVLMGEQQFGIDTDYVARVAQEVKDARDSGLEICLVIGGGNIFRGMAGAAKGMDRAQADYMG
MLATVMNALAMQSALEQLGVPTRVQSAIEMDKVCEPVIRRRAERHLEKGRIVIFAAGVGAPYFTTDSGAALRAAEMKCDA
LLKGTSVDGVYNADPKKDPAAKRYETVDYDTVLADNLKVMDASAVALCRDNNIPIVVFSIRERGNLARVLAGEGTQTTVK
KEA

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=235, Percent_Identity=49.3617021276596, Blast_Score=227, Evalue=5e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_NOVAD (Q2G8K8)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496649.1
- ProteinModelPortal:   Q2G8K8
- SMR:   Q2G8K8
- STRING:   Q2G8K8
- GeneID:   3917825
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_1371
- NMPDR:   fig|48935.1.peg.1228
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q2G8K8
- ProtClustDB:   PRK00358
- BioCyc:   NARO279238:SARO_1371-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26249; Mature: 26117

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: BINDING 58-58 BINDING 59-59 BINDING 63-63 BINDING 78-78 BINDING 166-166 BINDING 172-172 BINDING 175-175

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPSCVPGYRRILLKLSGEVLMGEQQFGIDTDYVARVAQEVKDARDSGLEICLVIGGGN
CCCCCCCHHHHHHHHHHCCCEEECCHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCH
IFRGMAGAAKGMDRAQADYMGMLATVMNALAMQSALEQLGVPTRVQSAIEMDKVCEPVIR
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RRAERHLEKGRIVIFAAGVGAPYFTTDSGAALRAAEMKCDALLKGTSVDGVYNADPKKDP
HHHHHHHHCCCEEEEEECCCCCEEECCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCC
AAKRYETVDYDTVLADNLKVMDASAVALCRDNNIPIVVFSIRERGNLARVLAGEGTQTTV
CHHHHCCCCHHHHHHCCEEEECCCEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCCCC
KKEA
CCCC
>Mature Secondary Structure 
SLPSCVPGYRRILLKLSGEVLMGEQQFGIDTDYVARVAQEVKDARDSGLEICLVIGGGN
CCCCCCHHHHHHHHHHCCCEEECCHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCH
IFRGMAGAAKGMDRAQADYMGMLATVMNALAMQSALEQLGVPTRVQSAIEMDKVCEPVIR
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RRAERHLEKGRIVIFAAGVGAPYFTTDSGAALRAAEMKCDALLKGTSVDGVYNADPKKDP
HHHHHHHHCCCEEEEEECCCCCEEECCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCC
AAKRYETVDYDTVLADNLKVMDASAVALCRDNNIPIVVFSIRERGNLARVLAGEGTQTTV
CHHHHCCCCHHHHHHCCEEEECCCEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCCCC
KKEA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA