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The map label for this gene is dnaX [H]

Identifier: 87199378

GI number: 87199378

Start: 1403928

End: 1405649

Strand: Direct

Name: dnaX [H]

Synonym: Saro_1357

Alternate gene names: 87199378

Gene position: 1403928-1405649 (Clockwise)

Preceding gene: 87199377

Following gene: 87199379

Centisome position: 39.42

GC content: 65.68

Gene sequence:

>1722_bases
GTGACCGGGCAGGTTGCCGTAGCAGTCGCTGCGCAGTCCGCTCCTGCGCCTTCCGCCGCTCCTCCGGCGCAGCCCTATCG
CGTGTTGGCGCGCAAGTACCGCTCGCAGACCTTTGCCGAACTGATCGGCCAGGATGCGATGGTCCAGACACTGGCCAACG
CGATCAAGCGCGACCGGCTGGCTCATGCCTTCCTCATGACCGGCGTGCGCGGGGTGGGCAAGACTTCGACCGCGCGGCTC
ATCGCCAAGGCGCTCAACTGCATCGGCCCGGACGGGCAGGGCGGTCCGACCATCGATCCCTGTGGCGTGTGCGAGCCATG
CCGCGCGATTGCCGAGGGTCGGCACATCGATGTGATCGAGATGGACGCCGCGTCCAACACTGGCGTGGACGACGTGCGCG
AAATCATCGAGGCGGTGCGTTATGCTGCGGTCTCGGCGCGCTACAAGATCTACATCGTCGACGAAGTCCACATGCTATCT
CGCAATGCTTTCAATGCGTTGCTGAAGACACTTGAGGAACCGCCGGCGCACGTGAAGTTTCTCTTCGCGACGACCGAGGT
AGACAAGCTGCCGGTCACGGTGCTGTCGCGCTGCCAGCGTTTCGACCTGAAGCGCATTCCCGCGCCGCTGCTTGCCAGCC
ATTTCGCAATGATCTGCGAGAAGGAAGGCGTCGAGGCCGAGGCAGAGGCGCTGGCGATGGTCGCCGCCGCCGCAGAAGGT
TCGGTTCGTGACGGCCTGTCGATCCTCGATCAGGCGATCAGCCACGCGGATCTCGTTGGCAGCGACGATGGCAAGACGCG
CGTGACGGCGGAGCAGGTCCGCCAGATGCTGGGCCTTGCCGACAAGACCATGCAGCGCCGCCTGCTGGATGCCGTGCTTT
CCGGGAATGGCTCCGCCGTGCTCGAGGAAGTGGCGCAACAATATGCGCTGGGCATCGAGCCGGTGGCGATGATGCGCGCG
CAGATGGACGTGGTCCACCGCGTTACCGTGGCCCAGATCGGCGGCGTCGGACCGGACGTGCGTTCGACTGAGGAGCGCGA
GGCACTGGAAGGCTGGGCCAAGGCAATTTCGGCGGGACAGCTTCACCGGCTTTGGCAGCTTCTGCTCAAGGGCTATGAAG
AAGTGAAGACTGCGCCCGACCCGCTGGTCGCCGCGCAGATGGCGCTGCTGCGCGTGATGCATGCGGCGGAAATGCCCGAT
CCGGGCGGACTGGTCAGGAAGCTCGAGGAACTTGCTTCGCGCCCAGCCGTCGCAGCGCCGACTGCGGGTGGTGACGGCGC
CGCTTCTGCACCTTCCGCGCAAGGTCAGGTCCACGCCGACGCAGGTCCGGCGGCAAGCGTCGATTGGGAATCGCTGGTCG
AGCAGGTCGAGCACGTCTCGCCACTCGTCGGATCGACGATGCGTCTCGCCGTAAGGCTTGTTGACCTGAAGCCCGGGCTT
CTGCGCTATCAGCTTGCGCCCGGCTTGCCCGGCGATCCTGCCCCCGATATTCGGCGTGCGCTCAACCATGTGACCGGCGA
GGCGTGGATCGTCGAGCGGGCGGAGGGCGTGGCGCAGCCAAGTCTCGAGGAAGTCAAGGCCGCCAAGGCCGTGGCCGCGG
ACGCGGCGATGAAGGAAGATCCGCTGGTCAAGGCCGCGCTGGAAGCCTTTCCGGGCGCTGTGATCATTGATGAGGAAAGC
TCGCGAGAGCACGAGAAGAGACCCTGGAGCAAACGCGCATGA

Upstream 100 bases:

>100_bases
GGAACTCGAGGCAGCAGGACAGGTATCGTTGTTCGGGGCTCCCGAACCTGCACCCGCTCCCGCACCGGAAATTGCCGTCG
TTCCGGCGCCCGCTCCCGAG

Downstream 100 bases:

>100_bases
AGTCGATGGAAGAGATGATCCAGGCCGCCCAGCAGGCGGCGCAGACCATCCAGAAGCAGATGGAGGACGCGCAGGCGACC
CTCGATGCGATCGAGGTCGA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 573; Mature: 572

Protein sequence:

>573_residues
MTGQVAVAVAAQSAPAPSAAPPAQPYRVLARKYRSQTFAELIGQDAMVQTLANAIKRDRLAHAFLMTGVRGVGKTSTARL
IAKALNCIGPDGQGGPTIDPCGVCEPCRAIAEGRHIDVIEMDAASNTGVDDVREIIEAVRYAAVSARYKIYIVDEVHMLS
RNAFNALLKTLEEPPAHVKFLFATTEVDKLPVTVLSRCQRFDLKRIPAPLLASHFAMICEKEGVEAEAEALAMVAAAAEG
SVRDGLSILDQAISHADLVGSDDGKTRVTAEQVRQMLGLADKTMQRRLLDAVLSGNGSAVLEEVAQQYALGIEPVAMMRA
QMDVVHRVTVAQIGGVGPDVRSTEEREALEGWAKAISAGQLHRLWQLLLKGYEEVKTAPDPLVAAQMALLRVMHAAEMPD
PGGLVRKLEELASRPAVAAPTAGGDGAASAPSAQGQVHADAGPAASVDWESLVEQVEHVSPLVGSTMRLAVRLVDLKPGL
LRYQLAPGLPGDPAPDIRRALNHVTGEAWIVERAEGVAQPSLEEVKAAKAVAADAAMKEDPLVKAALEAFPGAVIIDEES
SREHEKRPWSKRA

Sequences:

>Translated_573_residues
MTGQVAVAVAAQSAPAPSAAPPAQPYRVLARKYRSQTFAELIGQDAMVQTLANAIKRDRLAHAFLMTGVRGVGKTSTARL
IAKALNCIGPDGQGGPTIDPCGVCEPCRAIAEGRHIDVIEMDAASNTGVDDVREIIEAVRYAAVSARYKIYIVDEVHMLS
RNAFNALLKTLEEPPAHVKFLFATTEVDKLPVTVLSRCQRFDLKRIPAPLLASHFAMICEKEGVEAEAEALAMVAAAAEG
SVRDGLSILDQAISHADLVGSDDGKTRVTAEQVRQMLGLADKTMQRRLLDAVLSGNGSAVLEEVAQQYALGIEPVAMMRA
QMDVVHRVTVAQIGGVGPDVRSTEEREALEGWAKAISAGQLHRLWQLLLKGYEEVKTAPDPLVAAQMALLRVMHAAEMPD
PGGLVRKLEELASRPAVAAPTAGGDGAASAPSAQGQVHADAGPAASVDWESLVEQVEHVSPLVGSTMRLAVRLVDLKPGL
LRYQLAPGLPGDPAPDIRRALNHVTGEAWIVERAEGVAQPSLEEVKAAKAVAADAAMKEDPLVKAALEAFPGAVIIDEES
SREHEKRPWSKRA
>Mature_572_residues
TGQVAVAVAAQSAPAPSAAPPAQPYRVLARKYRSQTFAELIGQDAMVQTLANAIKRDRLAHAFLMTGVRGVGKTSTARLI
AKALNCIGPDGQGGPTIDPCGVCEPCRAIAEGRHIDVIEMDAASNTGVDDVREIIEAVRYAAVSARYKIYIVDEVHMLSR
NAFNALLKTLEEPPAHVKFLFATTEVDKLPVTVLSRCQRFDLKRIPAPLLASHFAMICEKEGVEAEAEALAMVAAAAEGS
VRDGLSILDQAISHADLVGSDDGKTRVTAEQVRQMLGLADKTMQRRLLDAVLSGNGSAVLEEVAQQYALGIEPVAMMRAQ
MDVVHRVTVAQIGGVGPDVRSTEEREALEGWAKAISAGQLHRLWQLLLKGYEEVKTAPDPLVAAQMALLRVMHAAEMPDP
GGLVRKLEELASRPAVAAPTAGGDGAASAPSAQGQVHADAGPAASVDWESLVEQVEHVSPLVGSTMRLAVRLVDLKPGLL
RYQLAPGLPGDPAPDIRRALNHVTGEAWIVERAEGVAQPSLEEVKAAKAVAADAAMKEDPLVKAALEAFPGAVIIDEESS
REHEKRPWSKRA

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=321, Percent_Identity=24.6105919003115, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI194306571, Length=303, Percent_Identity=24.0924092409241, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI194306567, Length=303, Percent_Identity=24.0924092409241, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4506491, Length=261, Percent_Identity=25.2873563218391, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI31881687, Length=261, Percent_Identity=25.2873563218391, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI31563534, Length=255, Percent_Identity=25.0980392156863, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786676, Length=379, Percent_Identity=44.0633245382586, Blast_Score=309, Evalue=3e-85,
Organism=Escherichia coli, GI1787341, Length=155, Percent_Identity=34.1935483870968, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17554730, Length=243, Percent_Identity=26.3374485596708, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322528, Length=293, Percent_Identity=26.2798634812287, Blast_Score=84, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6324478, Length=235, Percent_Identity=23.8297872340426, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI18859927, Length=327, Percent_Identity=24.1590214067278, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 60949; Mature: 60817

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGQVAVAVAAQSAPAPSAAPPAQPYRVLARKYRSQTFAELIGQDAMVQTLANAIKRDRL
CCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AHAFLMTGVRGVGKTSTARLIAKALNCIGPDGQGGPTIDPCGVCEPCRAIAEGRHIDVIE
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEE
MDAASNTGVDDVREIIEAVRYAAVSARYKIYIVDEVHMLSRNAFNALLKTLEEPPAHVKF
ECCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCEEE
LFATTEVDKLPVTVLSRCQRFDLKRIPAPLLASHFAMICEKEGVEAEAEALAMVAAAAEG
EEEECCCHHCCHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
SVRDGLSILDQAISHADLVGSDDGKTRVTAEQVRQMLGLADKTMQRRLLDAVLSGNGSAV
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LEEVAQQYALGIEPVAMMRAQMDVVHRVTVAQIGGVGPDVRSTEEREALEGWAKAISAGQ
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
LHRLWQLLLKGYEEVKTAPDPLVAAQMALLRVMHAAEMPDPGGLVRKLEELASRPAVAAP
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCC
TAGGDGAASAPSAQGQVHADAGPAASVDWESLVEQVEHVSPLVGSTMRLAVRLVDLKPGL
CCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LRYQLAPGLPGDPAPDIRRALNHVTGEAWIVERAEGVAQPSLEEVKAAKAVAADAAMKED
EEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
PLVKAALEAFPGAVIIDEESSREHEKRPWSKRA
HHHHHHHHHCCCEEEECCCCCCHHHCCCCCCCC
>Mature Secondary Structure 
TGQVAVAVAAQSAPAPSAAPPAQPYRVLARKYRSQTFAELIGQDAMVQTLANAIKRDRL
CCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AHAFLMTGVRGVGKTSTARLIAKALNCIGPDGQGGPTIDPCGVCEPCRAIAEGRHIDVIE
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEE
MDAASNTGVDDVREIIEAVRYAAVSARYKIYIVDEVHMLSRNAFNALLKTLEEPPAHVKF
ECCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCEEE
LFATTEVDKLPVTVLSRCQRFDLKRIPAPLLASHFAMICEKEGVEAEAEALAMVAAAAEG
EEEECCCHHCCHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
SVRDGLSILDQAISHADLVGSDDGKTRVTAEQVRQMLGLADKTMQRRLLDAVLSGNGSAV
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LEEVAQQYALGIEPVAMMRAQMDVVHRVTVAQIGGVGPDVRSTEEREALEGWAKAISAGQ
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
LHRLWQLLLKGYEEVKTAPDPLVAAQMALLRVMHAAEMPDPGGLVRKLEELASRPAVAAP
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCC
TAGGDGAASAPSAQGQVHADAGPAASVDWESLVEQVEHVSPLVGSTMRLAVRLVDLKPGL
CCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LRYQLAPGLPGDPAPDIRRALNHVTGEAWIVERAEGVAQPSLEEVKAAKAVAADAAMKED
EEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
PLVKAALEAFPGAVIIDEESSREHEKRPWSKRA
HHHHHHHHHCCCEEEECCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]