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The map label for this gene is atpB

Identifier: 87199337

GI number: 87199337

Start: 1361358

End: 1362140

Strand: Direct

Name: atpB

Synonym: Saro_1316

Alternate gene names: 87199337

Gene position: 1361358-1362140 (Clockwise)

Preceding gene: 87199336

Following gene: 87199338

Centisome position: 38.22

GC content: 60.54

Gene sequence:

>783_bases
GTGGCCGAAGGCAAGGTCGATCCGGTTCACCAGTTCACGATCGAGACCCTTTTCGGGACCGATCACTGGTCGATTGGCGG
TTACAACATCGCTTTCACCAACTCTGCGCTGTGGATGGCTATCACCACTGCCGTCCTGATCGTGTTCGTTGCCGGCGGCG
CCAAGCGCGAACTGGTTCCGGGCCGTTGGCAGATGGCGGTCGAGGGGCTGACCGGCTTCGTCGACAACCTGCTTCAGGCG
AACATCGGCAAGGCTGGTCGCAAGTACCTGCCTTACGTGTTCTCGCTGTTCGCGTTCATCCTTTTCGCCAACATGCTCGG
CCTGCTGCCGCTGGCTCTCGTTGGCGTGCATCCGTTCACGGCGACCAGCCATTTCACCGTCACCGGTGTGCTCGCGATCA
TGAGCTTCGCCATCGTGCTCGGCGTCGGCTTTGCCAAGCACGGCCTGCACTTCTTCTCGCTTTTCGTGCCGCACGGTACG
CCCGTCCCGATGATCCCGATCATTTTCCCGATCGAGCTGATCTCGTTCATGGTGCGTCCGTTCAGCCTTGGCCTTCGTCT
CTTCGTGGCGATGATGGCCGGGCACGTGCTGCTCGAAGTGCTCTCGGGCTTCGTCATCTCCGGCACCAATGCCGGTGTGG
GCACCTTCTTCCTCGCCGCCGTTCCCAGCTTCCTGCTGATGATCGGTATCTGCGCGCTGGAACTTCTGGTGGCAGGCATC
CAGGCTTACGTCTTTGCCCTGCTCACCTGCGTCTATCTGAATGACGCCGAGAACCTTCACTAA

Upstream 100 bases:

>100_bases
ATGGGGGTCGTCGTGGCGTTCCGGAACATCATCCGAATTTCGAGCCGGCGCCCCGAATAAGGGCGCTGTTGTTGTATTCG
AGTGATACGGGGTTAAGCGC

Downstream 100 bases:

>100_bases
TACCTGCAACATTTTTCCTTACGGATTTGAGAAAAGGGAGTTTTTGACATGGACGCAGAAAGCGCAAAGCTGCTCGGTGC
TGGTCTCGCCGCTGTCGGCG

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MAEGKVDPVHQFTIETLFGTDHWSIGGYNIAFTNSALWMAITTAVLIVFVAGGAKRELVPGRWQMAVEGLTGFVDNLLQA
NIGKAGRKYLPYVFSLFAFILFANMLGLLPLALVGVHPFTATSHFTVTGVLAIMSFAIVLGVGFAKHGLHFFSLFVPHGT
PVPMIPIIFPIELISFMVRPFSLGLRLFVAMMAGHVLLEVLSGFVISGTNAGVGTFFLAAVPSFLLMIGICALELLVAGI
QAYVFALLTCVYLNDAENLH

Sequences:

>Translated_260_residues
MAEGKVDPVHQFTIETLFGTDHWSIGGYNIAFTNSALWMAITTAVLIVFVAGGAKRELVPGRWQMAVEGLTGFVDNLLQA
NIGKAGRKYLPYVFSLFAFILFANMLGLLPLALVGVHPFTATSHFTVTGVLAIMSFAIVLGVGFAKHGLHFFSLFVPHGT
PVPMIPIIFPIELISFMVRPFSLGLRLFVAMMAGHVLLEVLSGFVISGTNAGVGTFFLAAVPSFLLMIGICALELLVAGI
QAYVFALLTCVYLNDAENLH
>Mature_259_residues
AEGKVDPVHQFTIETLFGTDHWSIGGYNIAFTNSALWMAITTAVLIVFVAGGAKRELVPGRWQMAVEGLTGFVDNLLQAN
IGKAGRKYLPYVFSLFAFILFANMLGLLPLALVGVHPFTATSHFTVTGVLAIMSFAIVLGVGFAKHGLHFFSLFVPHGTP
VPMIPIIFPIELISFMVRPFSLGLRLFVAMMAGHVLLEVLSGFVISGTNAGVGTFFLAAVPSFLLMIGICALELLVAGIQ
AYVFALLTCVYLNDAENLH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Homo sapiens, GI251831112, Length=202, Percent_Identity=29.7029702970297, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1790176, Length=217, Percent_Identity=25.3456221198157, Blast_Score=61, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6226527, Length=261, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_NOVAD (Q2G8R3)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496594.1
- ProteinModelPortal:   Q2G8R3
- SMR:   Q2G8R3
- STRING:   Q2G8R3
- GeneID:   3917948
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_1316
- NMPDR:   fig|48935.1.peg.1897
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   RFANTVE
- PhylomeDB:   Q2G8R3
- ProtClustDB:   PRK05815
- BioCyc:   NARO279238:SARO_1316-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 27995; Mature: 27864

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x136d8690)-; HASH(0x12c47404)-; HASH(0x153aa2ec)-; HASH(0x153520dc)-; HASH(0x127b5b18)-; HASH(0x157d41d4)-; HASH(0x14bcd1a0)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure 
AEGKVDPVHQFTIETLFGTDHWSIGGYNIAFTNSALWMAITTAVLIVFVAGGAKRELVP
CCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCC
GRWQMAVEGLTGFVDNLLQANIGKAGRKYLPYVFSLFAFILFANMLGLLPLALVGVHPFT
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ATSHFTVTGVLAIMSFAIVLGVGFAKHGLHFFSLFVPHGTPVPMIPIIFPIELISFMVRP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
FSLGLRLFVAMMAGHVLLEVLSGFVISGTNAGVGTFFLAAVPSFLLMIGICALELLVAGI
HHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAYVFALLTCVYLNDAENLH
HHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA