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The map label for this gene is glmU

Identifier: 87199221

GI number: 87199221

Start: 1247448

End: 1248821

Strand: Direct

Name: glmU

Synonym: Saro_1199

Alternate gene names: 87199221

Gene position: 1247448-1248821 (Clockwise)

Preceding gene: 87199218

Following gene: 87199222

Centisome position: 35.03

GC content: 67.98

Gene sequence:

>1374_bases
ATGACCGACGCTTCTACCGTGGATAGCCCCCTTGCCATCATCGTCCTTGCCGCCGGCAAGGGCACCCGCATGAAGAGCGA
CCTGCACAAGGTGCTCCACCCGATCGCCGGGCGGCCGATGCTGATGCACCTGATGGCGAGCGCCGCCGAACTTTCCCCCG
CGCGCCAGGTCGTCGTGGCTGGCCACGGGCGCGAGCAGCTGGAGAAGGCGCTGGGCGGCAGCGCGGACATCGCGGTGCAG
GACCCGCAGCTTGGCACCGCCCACGCGGTGCAGCAGGCGCAAGGCGCGCTGTCGGGCTTCGAGGGCGATGTGCTGATCCT
CTATGGCGATGTGCCGTTCGTGCGTGCATCGACCATGCGCGCGATGATCGAACGCCTGCACGGCGCGGACGAGCCTGCCG
CTGTGGTGCTGGGCTTCGCGCCCGCCGACACGCTGCAATACGGCCGCGTGATCGCCGATGACGGCCGCATCGTGAAGATG
GTGGAGCACAAGGACGCGAGCGAGGCCGAACGCGCCTGCCGCGTGTGCAATTCGGGCCTTATGGCGGTGCGCAGCGCGGA
CCTGTTCGGGCTGCTGGCGCGCGTCGGCAACGACAACGCGCAGGGCGAATACTACCTGCCCGACGTGGTCAACATCGCCA
TTGCCGATGGCCGGACCTGCGCGGTGGTGGTGACGGACGATGCGGACGAGGTGGCCGGGATCAACAGTCGCGGCGAACTG
GCCGAGGCGGAAGGGCGCTGGCAGCAGCGCCGCCGCGCGGCCGCCATGGCCGACGGGGCCAGCCTGATCGCGCCCGAGAC
GGTCTGGTTCGCGTGGGACACGGTGCTGGGCCGCGACGTGACGATCGAGCCCAACGTGTTCTTCGGCCCCGGCGTGACGG
TGGGCGACAACGTGACGATCCACGCCTTCAGCCATCTCGAAGGGGCGAGCCTGGCGCAGGGCGTGGAAGTCGGGCCATAT
GCGCGACTGCGGCCGGGCGCGCGGCTGGAGGAGAAGGTCAAGGTCGGCAACTTCGTCGAGGTGAAGAACGCGGTGCTGCA
CAAGGGTGCCAAGGCCAACCACCTGACCTATCTGGGTGATGCCGACGTGGGTGCGGGCGCGAACATCGGGGCAGGCACCA
TCACCTGCAACTATGACGGTTACTTCAAGCACAGGACCGTGATCGGCGAGCGCGCGTTCATCGGATCGAACAGCGCGCTG
ATCGCGCCGGTGCGGATTGGCGCCGACGCCATCGTTGCCGCCGGAAGTGCCGTATCGCGCGATGTGGCGGACGGTGAATT
GCGCATGGTGCGCGCCGAACAGCTCGTCAAGCCGGGCTGGGCAGACCGTTTCCACGACGCGATGAAGAAGAAGAAGGCGG
AAAAGAAATCCTGA

Upstream 100 bases:

>100_bases
GAGGTCGAAGCCGACGATCGCATAAGGAAATTTGGCCATGGTGTGCGCAACTGGCGCGCCGTTCTGGAAAGCGCAAGGTT
TGTCTGGCAAGGGTGCGCGC

Downstream 100 bases:

>100_bases
AAGATCAGGCGCGGATGTGGCCTCGCGGAGGAAGATGCGGCTTGACGATATCACGATATGATATCATGATATCAACATGA
CTCGCATCCTTGCAGATCTG

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MTDASTVDSPLAIIVLAAGKGTRMKSDLHKVLHPIAGRPMLMHLMASAAELSPARQVVVAGHGREQLEKALGGSADIAVQ
DPQLGTAHAVQQAQGALSGFEGDVLILYGDVPFVRASTMRAMIERLHGADEPAAVVLGFAPADTLQYGRVIADDGRIVKM
VEHKDASEAERACRVCNSGLMAVRSADLFGLLARVGNDNAQGEYYLPDVVNIAIADGRTCAVVVTDDADEVAGINSRGEL
AEAEGRWQQRRRAAAMADGASLIAPETVWFAWDTVLGRDVTIEPNVFFGPGVTVGDNVTIHAFSHLEGASLAQGVEVGPY
ARLRPGARLEEKVKVGNFVEVKNAVLHKGAKANHLTYLGDADVGAGANIGAGTITCNYDGYFKHRTVIGERAFIGSNSAL
IAPVRIGADAIVAAGSAVSRDVADGELRMVRAEQLVKPGWADRFHDAMKKKKAEKKS

Sequences:

>Translated_457_residues
MTDASTVDSPLAIIVLAAGKGTRMKSDLHKVLHPIAGRPMLMHLMASAAELSPARQVVVAGHGREQLEKALGGSADIAVQ
DPQLGTAHAVQQAQGALSGFEGDVLILYGDVPFVRASTMRAMIERLHGADEPAAVVLGFAPADTLQYGRVIADDGRIVKM
VEHKDASEAERACRVCNSGLMAVRSADLFGLLARVGNDNAQGEYYLPDVVNIAIADGRTCAVVVTDDADEVAGINSRGEL
AEAEGRWQQRRRAAAMADGASLIAPETVWFAWDTVLGRDVTIEPNVFFGPGVTVGDNVTIHAFSHLEGASLAQGVEVGPY
ARLRPGARLEEKVKVGNFVEVKNAVLHKGAKANHLTYLGDADVGAGANIGAGTITCNYDGYFKHRTVIGERAFIGSNSAL
IAPVRIGADAIVAAGSAVSRDVADGELRMVRAEQLVKPGWADRFHDAMKKKKAEKKS
>Mature_456_residues
TDASTVDSPLAIIVLAAGKGTRMKSDLHKVLHPIAGRPMLMHLMASAAELSPARQVVVAGHGREQLEKALGGSADIAVQD
PQLGTAHAVQQAQGALSGFEGDVLILYGDVPFVRASTMRAMIERLHGADEPAAVVLGFAPADTLQYGRVIADDGRIVKMV
EHKDASEAERACRVCNSGLMAVRSADLFGLLARVGNDNAQGEYYLPDVVNIAIADGRTCAVVVTDDADEVAGINSRGELA
EAEGRWQQRRRAAAMADGASLIAPETVWFAWDTVLGRDVTIEPNVFFGPGVTVGDNVTIHAFSHLEGASLAQGVEVGPYA
RLRPGARLEEKVKVGNFVEVKNAVLHKGAKANHLTYLGDADVGAGANIGAGTITCNYDGYFKHRTVIGERAFIGSNSALI
APVRIGADAIVAAGSAVSRDVADGELRMVRAEQLVKPGWADRFHDAMKKKKAEKKS

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=453, Percent_Identity=40.6181015452539, Blast_Score=330, Evalue=1e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR001228
- InterPro:   IPR011004 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 48295; Mature: 48164

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDASTVDSPLAIIVLAAGKGTRMKSDLHKVLHPIAGRPMLMHLMASAAELSPARQVVVA
CCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEE
GHGREQLEKALGGSADIAVQDPQLGTAHAVQQAQGALSGFEGDVLILYGDVPFVRASTMR
CCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHH
AMIERLHGADEPAAVVLGFAPADTLQYGRVIADDGRIVKMVEHKDASEAERACRVCNSGL
HHHHHHCCCCCCCEEEEEECCCCHHHHCCEEECCCCEEEEEECCCHHHHHHHHHHHCCCH
MAVRSADLFGLLARVGNDNAQGEYYLPDVVNIAIADGRTCAVVVTDDADEVAGINSRGEL
HHHHHHHHHHHHHHHCCCCCCCCEECCCEEEEEEECCCEEEEEEECCCHHHCCCCCCCCC
AEAEGRWQQRRRAAAMADGASLIAPETVWFAWDTVLGRDVTIEPNVFFGPGVTVGDNVTI
HHHHHHHHHHHHHHHHCCCCCEECCCEEEEEEHHHCCCCEEECCCEEECCCEEECCCEEE
HAFSHLEGASLAQGVEVGPYARLRPGARLEEKVKVGNFVEVKNAVLHKGAKANHLTYLGD
EEECCCCCCHHHCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCCCEEEECC
ADVGAGANIGAGTITCNYDGYFKHRTVIGERAFIGSNSALIAPVRIGADAIVAAGSAVSR
CCCCCCCCCCCCEEEECCCCEEEEEEEECCEEEECCCCEEEEEEEECCCHHEECCCHHHC
DVADGELRMVRAEQLVKPGWADRFHDAMKKKKAEKKS
CCCCCHHEEEEHHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDASTVDSPLAIIVLAAGKGTRMKSDLHKVLHPIAGRPMLMHLMASAAELSPARQVVVA
CCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEE
GHGREQLEKALGGSADIAVQDPQLGTAHAVQQAQGALSGFEGDVLILYGDVPFVRASTMR
CCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHH
AMIERLHGADEPAAVVLGFAPADTLQYGRVIADDGRIVKMVEHKDASEAERACRVCNSGL
HHHHHHCCCCCCCEEEEEECCCCHHHHCCEEECCCCEEEEEECCCHHHHHHHHHHHCCCH
MAVRSADLFGLLARVGNDNAQGEYYLPDVVNIAIADGRTCAVVVTDDADEVAGINSRGEL
HHHHHHHHHHHHHHHCCCCCCCCEECCCEEEEEEECCCEEEEEEECCCHHHCCCCCCCCC
AEAEGRWQQRRRAAAMADGASLIAPETVWFAWDTVLGRDVTIEPNVFFGPGVTVGDNVTI
HHHHHHHHHHHHHHHHCCCCCEECCCEEEEEEHHHCCCCEEECCCEEECCCEEECCCEEE
HAFSHLEGASLAQGVEVGPYARLRPGARLEEKVKVGNFVEVKNAVLHKGAKANHLTYLGD
EEECCCCCCHHHCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCCCEEEECC
ADVGAGANIGAGTITCNYDGYFKHRTVIGERAFIGSNSALIAPVRIGADAIVAAGSAVSR
CCCCCCCCCCCCEEEECCCCEEEEEEEECCEEEECCCCEEEEEEEECCCHHEECCCHHHC
DVADGELRMVRAEQLVKPGWADRFHDAMKKKKAEKKS
CCCCCHHEEEEHHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA