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The map label for this gene is gmk

Identifier: 87199025

GI number: 87199025

Start: 1047044

End: 1047709

Strand: Reverse

Name: gmk

Synonym: Saro_1003

Alternate gene names: 87199025

Gene position: 1047709-1047044 (Counterclockwise)

Preceding gene: 87199026

Following gene: 87199020

Centisome position: 29.42

GC content: 65.77

Gene sequence:

>666_bases
ATGGCTGGCAATCCCGCAAACACCGAGTCCCATGACGACGACGCCCTGCACCGCCGGGGCCTGATGTTCATCCTGTCCTC
GCCCTCGGGCGCGGGCAAGACCACCATCGCGCGCAAGCTTCTGTCGGAAGACAGCGAGATTGCCATGTCGGTTTCGGTAA
CGACGCGCCCGATGCGGCCCGGCGAAGTTGACGGCAAGGACTACTTCTTCGTCGAACCGGCCGAGTTCGAGCGGATGGTG
GAAGCCAACGAATTCTACGAATGGGCCACGGTCTTCGGCAATTGCTACGGCACGCCCAAGGCCCACATCCGCGAGCGATT
GAAGACCGGCGGCGACGTACTGTTCGACATCGACTGGCAGGGAACGCAGCAGCTCTACCAGAAGGCGCAGGCCGACGTGG
TCCGCGTGTTCATCCTGCCCCCCAGCCTCGACGAACTGCGCCGCCGCCTGACCGGGCGCGGAACGGACAGCGCGGAAGTG
ATCGCCGCGCGCATGGACCGCGCGCAGGCGGAGATCAGCCACTGGGACGGCTACGATTACGTCGTGGTCAACGACGATGT
CGACGGCTGCTTCGGCAAGGTCCGGGAAATCCTGGCGGCCGAGCGCATGCGCCGCACGCGCCAGACAGGGCTGATCGACT
TCGTGCGCGGGCTGATGCGGGGCTGA

Upstream 100 bases:

>100_bases
GAAAAGCAGGTCGAGCGCGGCAAGAAGGGCTGAGGCCGCCACCTGCGCCGGGTCCTCTTCCGCACTTGACCGGCCGGGAA
CCGATGCGCCACTAGCGGGC

Downstream 100 bases:

>100_bases
GCAGGCGTCAGGGACGCCCGGCGCGGGAGACCTCGACTTCGGTCACCAGAATCGCGCCCGTGGGGAGAACCCCGGCGTCG
GGTTCCACCGTATCGGCCAC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MAGNPANTESHDDDALHRRGLMFILSSPSGAGKTTIARKLLSEDSEIAMSVSVTTRPMRPGEVDGKDYFFVEPAEFERMV
EANEFYEWATVFGNCYGTPKAHIRERLKTGGDVLFDIDWQGTQQLYQKAQADVVRVFILPPSLDELRRRLTGRGTDSAEV
IAARMDRAQAEISHWDGYDYVVVNDDVDGCFGKVREILAAERMRRTRQTGLIDFVRGLMRG

Sequences:

>Translated_221_residues
MAGNPANTESHDDDALHRRGLMFILSSPSGAGKTTIARKLLSEDSEIAMSVSVTTRPMRPGEVDGKDYFFVEPAEFERMV
EANEFYEWATVFGNCYGTPKAHIRERLKTGGDVLFDIDWQGTQQLYQKAQADVVRVFILPPSLDELRRRLTGRGTDSAEV
IAARMDRAQAEISHWDGYDYVVVNDDVDGCFGKVREILAAERMRRTRQTGLIDFVRGLMRG
>Mature_220_residues
AGNPANTESHDDDALHRRGLMFILSSPSGAGKTTIARKLLSEDSEIAMSVSVTTRPMRPGEVDGKDYFFVEPAEFERMVE
ANEFYEWATVFGNCYGTPKAHIRERLKTGGDVLFDIDWQGTQQLYQKAQADVVRVFILPPSLDELRRRLTGRGTDSAEVI
AARMDRAQAEISHWDGYDYVVVNDDVDGCFGKVREILAAERMRRTRQTGLIDFVRGLMRG

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=191, Percent_Identity=37.696335078534, Blast_Score=120, Evalue=7e-28,
Organism=Homo sapiens, GI4504221, Length=191, Percent_Identity=37.696335078534, Blast_Score=120, Evalue=7e-28,
Organism=Homo sapiens, GI226874831, Length=191, Percent_Identity=37.696335078534, Blast_Score=120, Evalue=7e-28,
Organism=Homo sapiens, GI4505237, Length=183, Percent_Identity=30.6010928961749, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI262118259, Length=183, Percent_Identity=30.6010928961749, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI262118255, Length=183, Percent_Identity=30.6010928961749, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI262118263, Length=183, Percent_Identity=30.6010928961749, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=27.5280898876405, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI21361598, Length=207, Percent_Identity=27.536231884058, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI119943108, Length=174, Percent_Identity=28.735632183908, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI111154074, Length=179, Percent_Identity=26.8156424581006, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI119943106, Length=174, Percent_Identity=28.735632183908, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI261862237, Length=174, Percent_Identity=28.735632183908, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1790080, Length=192, Percent_Identity=51.0416666666667, Blast_Score=189, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI193203132, Length=181, Percent_Identity=35.3591160220994, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17508835, Length=181, Percent_Identity=35.3591160220994, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71984092, Length=145, Percent_Identity=30.3448275862069, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71988041, Length=183, Percent_Identity=26.775956284153, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71988048, Length=183, Percent_Identity=26.775956284153, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=41.2087912087912, Blast_Score=152, Evalue=3e-38,
Organism=Drosophila melanogaster, GI21356141, Length=190, Percent_Identity=34.2105263157895, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45554813, Length=174, Percent_Identity=32.7586206896552, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161077752, Length=174, Percent_Identity=32.7586206896552, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161077754, Length=174, Percent_Identity=32.7586206896552, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281360700, Length=174, Percent_Identity=32.7586206896552, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641282, Length=174, Percent_Identity=32.7586206896552, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45554818, Length=174, Percent_Identity=32.7586206896552, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45554804, Length=174, Percent_Identity=32.7586206896552, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45554791, Length=174, Percent_Identity=32.7586206896552, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641280, Length=174, Percent_Identity=32.7586206896552, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116007136, Length=194, Percent_Identity=27.319587628866, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45554481, Length=194, Percent_Identity=27.319587628866, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI85724806, Length=194, Percent_Identity=27.319587628866, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI45554489, Length=194, Percent_Identity=27.319587628866, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24640542, Length=194, Percent_Identity=27.319587628866, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI161077626, Length=194, Percent_Identity=27.319587628866, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221330164, Length=126, Percent_Identity=31.7460317460317, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221330166, Length=126, Percent_Identity=31.7460317460317, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221330162, Length=126, Percent_Identity=31.7460317460317, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_NOVAD (Q2G9M5)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496282.1
- ProteinModelPortal:   Q2G9M5
- SMR:   Q2G9M5
- STRING:   Q2G9M5
- GeneID:   3915785
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_1003
- NMPDR:   fig|48935.1.peg.3107
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- PhylomeDB:   Q2G9M5
- ProtClustDB:   PRK00300
- BioCyc:   NARO279238:SARO_1003-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 24883; Mature: 24752

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGNPANTESHDDDALHRRGLMFILSSPSGAGKTTIARKLLSEDSEIAMSVSVTTRPMRP
CCCCCCCCCCCCHHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCC
GEVDGKDYFFVEPAEFERMVEANEFYEWATVFGNCYGTPKAHIRERLKTGGDVLFDIDWQ
CCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCC
GTQQLYQKAQADVVRVFILPPSLDELRRRLTGRGTDSAEVIAARMDRAQAEISHWDGYDY
CHHHHHHHHHCCEEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
VVVNDDVDGCFGKVREILAAERMRRTRQTGLIDFVRGLMRG
EEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure 
AGNPANTESHDDDALHRRGLMFILSSPSGAGKTTIARKLLSEDSEIAMSVSVTTRPMRP
CCCCCCCCCCCHHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCC
GEVDGKDYFFVEPAEFERMVEANEFYEWATVFGNCYGTPKAHIRERLKTGGDVLFDIDWQ
CCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCC
GTQQLYQKAQADVVRVFILPPSLDELRRRLTGRGTDSAEVIAARMDRAQAEISHWDGYDY
CHHHHHHHHHCCEEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
VVVNDDVDGCFGKVREILAAERMRRTRQTGLIDFVRGLMRG
EEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA