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The map label for this gene is purM

Identifier: 87198921

GI number: 87198921

Start: 955550

End: 956656

Strand: Reverse

Name: purM

Synonym: Saro_0899

Alternate gene names: 87198921

Gene position: 956656-955550 (Counterclockwise)

Preceding gene: 87198926

Following gene: 87198920

Centisome position: 26.86

GC content: 66.49

Gene sequence:

>1107_bases
ATGAGCGACGAGCAGAACAAGCCAGAGAGCTACAGCTACGCCAAAGCCGGCGTGAACATTGCTGCGGGCAACGCATTGGT
GAAGGCCATAGGCCCCCTTGCGAAGTCCACCGCCCGCCCCGGCGCGGACGCGGAACTCGGCGGCTTTGGCGGCTTCTTCG
ATCTCAAGGCCGCTGGCTACAACGACCCTCTGCTGGTCGCCGGCAACGACGGCGTGGGCACCAAGGTCAAGCTCGCCATC
GACCATGACCGGCACGACCAGATCGGCATCGATCTTGTCGCGATGTGCGTCAACGACCTCATCGTCCAGGGCGCGGAGCC
CCTGTTCTTCCTCGACTATTTCGCCACCGGACGTCTCGATAACGGCGTTGCCGAACGTGTCGTCGCGGGCATCGCCGATG
GCTGCAAGCTGGCCGGTTGCGCCCTCATCGGCGGCGAGACCGCCGAAATGCCCGGCATGTATGCCGACGGCGACTACGAC
CTTGCCGGCTTCTGCGTCGGTGCGGTCGAACGGGGCGAGCAACTGACCGGAGACCGCGTGGCCGAAGGCGACGTGCTGCT
CGGCCTCGCTTCCTCGGGCGTCCATTCCAACGGCTATTCCCTCGTCCGCCGCCTTGCCGCCGACAAGGGCTGGAAGCTCG
ATCGCCCGGCCCTGTTCGACAACGAGCGCCTGTTGATCGATTACCTGATCGAACCGACCCGCATCTATGTGAAGAGCCTG
CTGCCCTTCATCCGCAGCGGCCGGATCAACGCGCTGGCCCACATCACCGGCGGCGGCCTGCTTGAGAACGTCCCGCGCGT
CCTGCCGCGTGGCCTCCACGCCCGGATCGACGCCGACAGCTGGGAACAAAGCCGCCTGATGGCCTTCCTCCAGGCCCAGG
GCAACATCGAGCCCGAGGAAATGGCCCGCACCTTCAACTGCGGCATCGGCATGATCCTCGCGGTCAATCCGGCACAGGCG
GATGCGCTTGCCGCAGACCTCGCCGCCGCCGGCGAGACGGTCTACCGCGTCGGCACCATCGTGAAGGGCGAAAAGGGCTG
CACCGTCACCGGAAGCGCCGAGACCTGGTCCGCCCGCTCGGCCTGGGAAGCCACCCACATTGGCTGA

Upstream 100 bases:

>100_bases
CCATGCTAGCATCCGGAATTCGAATTTTCGGACCGGACAATCCCGCTTTTGCCCAAAGGCAAGTGGAAATCCAAGCGAGA
AAGCGCTAGGCGCGCTCGCC

Downstream 100 bases:

>100_bases
ACGCACGCCCGTCGCGGTCTTCATCTCCGGCAGCGGCACCAACATGGCCGCGCTGCTCTATGCCTCGCGCATGGCGGGCT
GCCCCTACGAGATCGCGCTC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSDEQNKPESYSYAKAGVNIAAGNALVKAIGPLAKSTARPGADAELGGFGGFFDLKAAGYNDPLLVAGNDGVGTKVKLAI
DHDRHDQIGIDLVAMCVNDLIVQGAEPLFFLDYFATGRLDNGVAERVVAGIADGCKLAGCALIGGETAEMPGMYADGDYD
LAGFCVGAVERGEQLTGDRVAEGDVLLGLASSGVHSNGYSLVRRLAADKGWKLDRPALFDNERLLIDYLIEPTRIYVKSL
LPFIRSGRINALAHITGGGLLENVPRVLPRGLHARIDADSWEQSRLMAFLQAQGNIEPEEMARTFNCGIGMILAVNPAQA
DALAADLAAAGETVYRVGTIVKGEKGCTVTGSAETWSARSAWEATHIG

Sequences:

>Translated_368_residues
MSDEQNKPESYSYAKAGVNIAAGNALVKAIGPLAKSTARPGADAELGGFGGFFDLKAAGYNDPLLVAGNDGVGTKVKLAI
DHDRHDQIGIDLVAMCVNDLIVQGAEPLFFLDYFATGRLDNGVAERVVAGIADGCKLAGCALIGGETAEMPGMYADGDYD
LAGFCVGAVERGEQLTGDRVAEGDVLLGLASSGVHSNGYSLVRRLAADKGWKLDRPALFDNERLLIDYLIEPTRIYVKSL
LPFIRSGRINALAHITGGGLLENVPRVLPRGLHARIDADSWEQSRLMAFLQAQGNIEPEEMARTFNCGIGMILAVNPAQA
DALAADLAAAGETVYRVGTIVKGEKGCTVTGSAETWSARSAWEATHIG
>Mature_367_residues
SDEQNKPESYSYAKAGVNIAAGNALVKAIGPLAKSTARPGADAELGGFGGFFDLKAAGYNDPLLVAGNDGVGTKVKLAID
HDRHDQIGIDLVAMCVNDLIVQGAEPLFFLDYFATGRLDNGVAERVVAGIADGCKLAGCALIGGETAEMPGMYADGDYDL
AGFCVGAVERGEQLTGDRVAEGDVLLGLASSGVHSNGYSLVRRLAADKGWKLDRPALFDNERLLIDYLIEPTRIYVKSLL
PFIRSGRINALAHITGGGLLENVPRVLPRGLHARIDADSWEQSRLMAFLQAQGNIEPEEMARTFNCGIGMILAVNPAQAD
ALAADLAAAGETVYRVGTIVKGEKGCTVTGSAETWSARSAWEATHIG

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=343, Percent_Identity=55.6851311953353, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI209869995, Length=343, Percent_Identity=55.6851311953353, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI209869993, Length=343, Percent_Identity=55.6851311953353, Blast_Score=392, Evalue=1e-109,
Organism=Escherichia coli, GI1788845, Length=331, Percent_Identity=54.9848942598187, Blast_Score=357, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17567511, Length=342, Percent_Identity=43.2748538011696, Blast_Score=278, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6321203, Length=363, Percent_Identity=48.2093663911846, Blast_Score=342, Evalue=8e-95,
Organism=Drosophila melanogaster, GI24582400, Length=286, Percent_Identity=44.4055944055944, Blast_Score=233, Evalue=2e-61,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_NOVAD (Q2G9X9)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496178.1
- ProteinModelPortal:   Q2G9X9
- SMR:   Q2G9X9
- STRING:   Q2G9X9
- GeneID:   3917985
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_0899
- NMPDR:   fig|48935.1.peg.1557
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- PhylomeDB:   Q2G9X9
- ProtClustDB:   PRK05385
- BioCyc:   NARO279238:SARO_0899-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 38765; Mature: 38634

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDEQNKPESYSYAKAGVNIAAGNALVKAIGPLAKSTARPGADAELGGFGGFFDLKAAGY
CCCCCCCCCCCHHHHCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCC
NDPLLVAGNDGVGTKVKLAIDHDRHDQIGIDLVAMCVNDLIVQGAEPLFFLDYFATGRLD
CCCEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCC
NGVAERVVAGIADGCKLAGCALIGGETAEMPGMYADGDYDLAGFCVGAVERGEQLTGDRV
CHHHHHHHHHHHCCCCEEEEEEECCCCHHCCCEECCCCCCHHHHHHHHHHCCCCCCCCCC
AEGDVLLGLASSGVHSNGYSLVRRLAADKGWKLDRPALFDNERLLIDYLIEPTRIYVKSL
CCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCEECCCEEEEEECCCHHHHHHHHH
LPFIRSGRINALAHITGGGLLENVPRVLPRGLHARIDADSWEQSRLMAFLQAQGNIEPEE
HHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCCHHH
MARTFNCGIGMILAVNPAQADALAADLAAAGETVYRVGTIVKGEKGCTVTGSAETWSARS
HHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCHHEEEEEEEECCCCCEEECCCCCCCCCC
AWEATHIG
CCCCCCCC
>Mature Secondary Structure 
SDEQNKPESYSYAKAGVNIAAGNALVKAIGPLAKSTARPGADAELGGFGGFFDLKAAGY
CCCCCCCCCCHHHHCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCC
NDPLLVAGNDGVGTKVKLAIDHDRHDQIGIDLVAMCVNDLIVQGAEPLFFLDYFATGRLD
CCCEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCC
NGVAERVVAGIADGCKLAGCALIGGETAEMPGMYADGDYDLAGFCVGAVERGEQLTGDRV
CHHHHHHHHHHHCCCCEEEEEEECCCCHHCCCEECCCCCCHHHHHHHHHHCCCCCCCCCC
AEGDVLLGLASSGVHSNGYSLVRRLAADKGWKLDRPALFDNERLLIDYLIEPTRIYVKSL
CCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCEECCCEEEEEECCCHHHHHHHHH
LPFIRSGRINALAHITGGGLLENVPRVLPRGLHARIDADSWEQSRLMAFLQAQGNIEPEE
HHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCCHHH
MARTFNCGIGMILAVNPAQADALAADLAAAGETVYRVGTIVKGEKGCTVTGSAETWSARS
HHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCHHEEEEEEEECCCCCEEECCCCCCCCCC
AWEATHIG
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA