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The map label for this gene is serS

Identifier: 87198872

GI number: 87198872

Start: 900738

End: 902018

Strand: Reverse

Name: serS

Synonym: Saro_0850

Alternate gene names: 87198872

Gene position: 902018-900738 (Counterclockwise)

Preceding gene: 87198873

Following gene: 87198871

Centisome position: 25.33

GC content: 66.74

Gene sequence:

>1281_bases
ATGCACGATATACGCCTGATCCGCGAAAATGCCGAAGCTTTCGATGCCGCCCTCGCCCGTCGCGGCGTAGGCCCGGTCGC
GCAATCGATCCTCTCGCTCGACAGCCGCCGGCGTGAAATCGCCACGCGGATGCAGGAAGTGCAGGCGCGCCGCAACGAAG
CATCAAAGGCCATCGGTGCGGCCATGGGCAAGGGCGACAAGGATACCGCAGAAGCCCTCAAGGCCGAAGTCGCCGCGCTC
AAGGTGGAATTACCCGCGCTCGAGGAAGAAGAGCGTCAGCTCACCGCGCAGCAGAACGCCGCGCTTGCCGCCTATCCCAA
CACGCCCGCCGCCGATGTGCCCGAGGGCGCCGACGAGGCCGACAATGTCGAGGTAAGCCGCTGGGGCACTCCGCGCGATT
TCGCATTCGCGCCGAAGGAACACGCCGATCTCGGCCCCGCCCTGGGCCTCGATTTCGAAACGGGCGCGCTCATCTCGGGC
GCGCGCTTCACTTTCCTCAAGGGCCAGATGGCCCGCCTCCACCGCGCGCTGGCGCAGTTCATGCTGGATCGCCAGACCGG
CGAGAACGGCTACATGGAATGCATCCCGCCGCTGCTGGTGAAGGACGAGGCCGTGTTCGGCACGGGCCAGCTCCCCAAGT
TCGCCGAGGACCTGTTCCGGACGACCGATGGCCGCTGGCTGATCCCCACCGCCGAAGTCAGCCTGACCAATGCGGTGCAG
GGCCAGATCCTGGGCGAGGCGCAACTTCCGCTGCGGATGACCGCGCTCACCCCGTGCTTCCGCTCGGAAGCGGGCGCGGC
CGGGCGCGATACGCGCGGCTTCATCCGCCAGCACCAGTTCGAGAAGGTCGAACTCGTCTCGATCACGCGCCCGGAAGATT
CGGAAAGCGAGCACGAGCGCATGACCCAGTGCGCCGAGGGCATTCTCCAGGCGCTCGGCCTGCCCTATCGCAAGGTCCTG
CTTTGCACCGGCGACATGGGTTTCACCGCGCGCAAGACCTATGACCTCGAGGTCTGGCTGCCGGGACAGGGCGCCTACCG
CGAGATTTCTTCGTGCTCCAATTGCGGCGATTTCCAGGCGCGCCGGATGAACGCGCGATATCGTCCCGAGGGTGCGAAGG
GCACCGAATTCGTCCACACTCTCAACGGTTCAGGCCTTGCCGTCGGGCGCACCCTCGTTGCGGTGCTGGAGAACTACCAG
CAGGAGGACGGCAGCGTGGCCGTTCCCGAAGTACTGCTCCCCTACATGGGCGGCCTCGCCCGCCTGACGCCGCAGGGCTG
A

Upstream 100 bases:

>100_bases
GCGGATATGTCCGCTTTACTCCCTCATTGGAGCCAATACCTGCCCCCGCAAGTAGCGGCCCGACTTGCCACCCGGGGATC
GAGGCGGCATAGCCGCGCCC

Downstream 100 bases:

>100_bases
TGAAGCGGCTCGCCGCCGCACTGCTTTTCGTGGCGGCGCCGCTTGCCGCACAGCAAGGCGCGCGCGGGCCGATCGTTGCC
TGGACCTATACGGTTCAGGC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MHDIRLIRENAEAFDAALARRGVGPVAQSILSLDSRRREIATRMQEVQARRNEASKAIGAAMGKGDKDTAEALKAEVAAL
KVELPALEEEERQLTAQQNAALAAYPNTPAADVPEGADEADNVEVSRWGTPRDFAFAPKEHADLGPALGLDFETGALISG
ARFTFLKGQMARLHRALAQFMLDRQTGENGYMECIPPLLVKDEAVFGTGQLPKFAEDLFRTTDGRWLIPTAEVSLTNAVQ
GQILGEAQLPLRMTALTPCFRSEAGAAGRDTRGFIRQHQFEKVELVSITRPEDSESEHERMTQCAEGILQALGLPYRKVL
LCTGDMGFTARKTYDLEVWLPGQGAYREISSCSNCGDFQARRMNARYRPEGAKGTEFVHTLNGSGLAVGRTLVAVLENYQ
QEDGSVAVPEVLLPYMGGLARLTPQG

Sequences:

>Translated_426_residues
MHDIRLIRENAEAFDAALARRGVGPVAQSILSLDSRRREIATRMQEVQARRNEASKAIGAAMGKGDKDTAEALKAEVAAL
KVELPALEEEERQLTAQQNAALAAYPNTPAADVPEGADEADNVEVSRWGTPRDFAFAPKEHADLGPALGLDFETGALISG
ARFTFLKGQMARLHRALAQFMLDRQTGENGYMECIPPLLVKDEAVFGTGQLPKFAEDLFRTTDGRWLIPTAEVSLTNAVQ
GQILGEAQLPLRMTALTPCFRSEAGAAGRDTRGFIRQHQFEKVELVSITRPEDSESEHERMTQCAEGILQALGLPYRKVL
LCTGDMGFTARKTYDLEVWLPGQGAYREISSCSNCGDFQARRMNARYRPEGAKGTEFVHTLNGSGLAVGRTLVAVLENYQ
QEDGSVAVPEVLLPYMGGLARLTPQG
>Mature_426_residues
MHDIRLIRENAEAFDAALARRGVGPVAQSILSLDSRRREIATRMQEVQARRNEASKAIGAAMGKGDKDTAEALKAEVAAL
KVELPALEEEERQLTAQQNAALAAYPNTPAADVPEGADEADNVEVSRWGTPRDFAFAPKEHADLGPALGLDFETGALISG
ARFTFLKGQMARLHRALAQFMLDRQTGENGYMECIPPLLVKDEAVFGTGQLPKFAEDLFRTTDGRWLIPTAEVSLTNAVQ
GQILGEAQLPLRMTALTPCFRSEAGAAGRDTRGFIRQHQFEKVELVSITRPEDSESEHERMTQCAEGILQALGLPYRKVL
LCTGDMGFTARKTYDLEVWLPGQGAYREISSCSNCGDFQARRMNARYRPEGAKGTEFVHTLNGSGLAVGRTLVAVLENYQ
QEDGSVAVPEVLLPYMGGLARLTPQG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=467, Percent_Identity=34.9036402569593, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI8923421, Length=403, Percent_Identity=30.0248138957816, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI225579074, Length=405, Percent_Identity=29.1358024691358, Blast_Score=168, Evalue=7e-42,
Organism=Escherichia coli, GI1787120, Length=428, Percent_Identity=56.0747663551402, Blast_Score=463, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17539260, Length=430, Percent_Identity=33.0232558139535, Blast_Score=210, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI17542084, Length=330, Percent_Identity=29.6969696969697, Blast_Score=148, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6321799, Length=391, Percent_Identity=31.9693094629156, Blast_Score=209, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6320226, Length=440, Percent_Identity=32.7272727272727, Blast_Score=206, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24581334, Length=458, Percent_Identity=32.0960698689956, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI17737985, Length=355, Percent_Identity=32.112676056338, Blast_Score=161, Evalue=9e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_NOVAD (Q2GA28)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496129.1
- ProteinModelPortal:   Q2GA28
- SMR:   Q2GA28
- STRING:   Q2GA28
- GeneID:   3915905
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_0850
- NMPDR:   fig|48935.1.peg.3433
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- PhylomeDB:   Q2GA28
- ProtClustDB:   PRK05431
- BioCyc:   NARO279238:SARO_0850-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 46491; Mature: 46491

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 284-284 BINDING 384-384

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDIRLIRENAEAFDAALARRGVGPVAQSILSLDSRRREIATRMQEVQARRNEASKAIGA
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMGKGDKDTAEALKAEVAALKVELPALEEEERQLTAQQNAALAAYPNTPAADVPEGADEA
HHCCCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCC
DNVEVSRWGTPRDFAFAPKEHADLGPALGLDFETGALISGARFTFLKGQMARLHRALAQF
CCEEEECCCCCCCCCCCCCHHCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHH
MLDRQTGENGYMECIPPLLVKDEAVFGTGQLPKFAEDLFRTTDGRWLIPTAEVSLTNAVQ
HHHHCCCCCCCHHHCCCHHCCCCCEECCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHH
GQILGEAQLPLRMTALTPCFRSEAGAAGRDTRGFIRQHQFEKVELVSITRPEDSESEHER
CCEECCCCCCEEHHHHCHHHHHCCCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHH
MTQCAEGILQALGLPYRKVLLCTGDMGFTARKTYDLEVWLPGQGAYREISSCSNCGDFQA
HHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEEEEEECCCCHHHHHHHCCCCCCHHH
RRMNARYRPEGAKGTEFVHTLNGSGLAVGRTLVAVLENYQQEDGSVAVPEVLLPYMGGLA
HHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCC
RLTPQG
CCCCCC
>Mature Secondary Structure
MHDIRLIRENAEAFDAALARRGVGPVAQSILSLDSRRREIATRMQEVQARRNEASKAIGA
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMGKGDKDTAEALKAEVAALKVELPALEEEERQLTAQQNAALAAYPNTPAADVPEGADEA
HHCCCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCC
DNVEVSRWGTPRDFAFAPKEHADLGPALGLDFETGALISGARFTFLKGQMARLHRALAQF
CCEEEECCCCCCCCCCCCCHHCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHH
MLDRQTGENGYMECIPPLLVKDEAVFGTGQLPKFAEDLFRTTDGRWLIPTAEVSLTNAVQ
HHHHCCCCCCCHHHCCCHHCCCCCEECCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHH
GQILGEAQLPLRMTALTPCFRSEAGAAGRDTRGFIRQHQFEKVELVSITRPEDSESEHER
CCEECCCCCCEEHHHHCHHHHHCCCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHH
MTQCAEGILQALGLPYRKVLLCTGDMGFTARKTYDLEVWLPGQGAYREISSCSNCGDFQA
HHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEEEEEECCCCHHHHHHHCCCCCCHHH
RRMNARYRPEGAKGTEFVHTLNGSGLAVGRTLVAVLENYQQEDGSVAVPEVLLPYMGGLA
HHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCC
RLTPQG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA