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The map label for this gene is ethA [H]

Identifier: 87198862

GI number: 87198862

Start: 889465

End: 890988

Strand: Reverse

Name: ethA [H]

Synonym: Saro_0840

Alternate gene names: 87198862

Gene position: 890988-889465 (Counterclockwise)

Preceding gene: 87198868

Following gene: 87198861

Centisome position: 25.02

GC content: 63.98

Gene sequence:

>1524_bases
TTGGGCGCTGAACAGAGCAGATTCGTCGCCGCCAACCCCGATGTGGACGTGCTGATCGTCGGCGCAGGCATCTCGGGCAT
CGGCATGGCCGCACACATGAAGATGCTGTGCCCCGACCGCAGCTTCGCCATTGTCGAGCGCCGCGCCCAGATCGGCGGCA
CCTGGGACCTGTTCCGCTATCCCGGCGTGCGTTCGGATTCAGACATGCATACCCTCGGCTTCGTGTTCGAACCGTGGAAG
CACGAAAAGTCGATCGCGGACGGCCCAGCCATCCTCGAATACCTCAACCGCATCGCCGACGAACGCGACATCCGCCGCCA
CATCCGCTTCGACAGCAAGGTGCTCAGCGCCGACTTCGACAGTGAGGCCGCCCACTGGGTCGTGACGGTCGAAGGCCCGG
ACGGCGAACGTCGTCGCCTGACCGCGCGCTGGCTCTATCTCGGCTCCGGCTACTATGACTACGACACACCGTACGAAGCG
CATTTCGAAGGCCGTGCGGATTTCCGGGGCCAAATCATCCACCCGCAGTTCTGGCCGGAAAACTTCGATTATTCGGGCAA
GCGCGTGGTCGTCATCGGCTCGGGCGCAACCGCTGTCACCATCGTCCCCTCGATGGCGGACACGGCGGCGCACGTCACGA
TGCTCCAGCGCACACCAACCTGGTACGGCATCCGCCCGGCGCGCGATGCCATCGCGAATTTCCTGCGCAAGATCCTGCCC
GAGGAGCTTGCCTACCGCATCACCCGCTTCAAGAACGTCCGCCTCCAGAACCTCGTGTTCAAGCGCGCGCGCACCCAGCC
GGAAAAGGTCAAGCAGTTCCTGACCAAGCGGATCAAGGCAGCGCTGGGCGACAAGTACGACGAGAAGGCCTTCACCCCGC
CCTACAACCCATGGGACCAGCGCCTCTGCCTGGTGCCCGATGCCGACCTGTTCGAGGCCATCAAGGCCGGCAAGGCCAGC
GTGGTGACCGACCACATCGACCGCTTCGACGCGACCGGCATCAAGCTCAAGTCGGGCCAGCACCTCGATGCGGACGTCAT
TGTCACCGCCACCGGGCTGAAGATGGTCATGGCCGGCAAGATCGCGATCAGCGTCGATGGCGTGCCGGTCGATTTCGCCG
AGAAGTACTACTACAAGGGCGCGATGTTCTCGAACGTGCCCAACCTTGCGGCGGTGTTCGGATATCTCAACGCCTCGTGG
ACCCTGCGCGCCGACATCAACGCGCGCTACATCTGCGACGTACTCAACGCGATGAAGGCCAAGGGCATGGAAGTGGCAGT
GCCGAAGCTGGCGCCCAACCATCCCCTCGACGATGACAACATCTACGATTTCTCGTCGGGCTACATCGAACGCGCGCGCC
ATCTCCTGCCGAAAAGCGCGCACGACATGCGCTGGCGCCTGAACCAGGACTACGTGCGCGACAGGGTGTGGATGCGCGAG
GACCCGATCGAGGACGGCGTGCTGCAGTTCGGCCATGCCCGGCCGGCCATGCAGGCCGACCCACAGATGGAAGCGGCGGA
ATAG

Upstream 100 bases:

>100_bases
TCAGCGTCATTGGCCATCAGTGGCAAAGACGGATCGGACTCGCAATCGCCCGCAGACGTGCTAACATCACTGTTAATACA
AAAAGGACGGGAGAGACCTC

Downstream 100 bases:

>100_bases
CGCTTTTGCGCGCCAGACGGTTCGGTTATCCCATGATCCGATGACCGACGAATCCCGCATATGGACCGCCGCCCTCGTCG
TCGTGGGCGACGAGATCCTT

Product: flavin-containing monooxygenase FMO

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MGAEQSRFVAANPDVDVLIVGAGISGIGMAAHMKMLCPDRSFAIVERRAQIGGTWDLFRYPGVRSDSDMHTLGFVFEPWK
HEKSIADGPAILEYLNRIADERDIRRHIRFDSKVLSADFDSEAAHWVVTVEGPDGERRRLTARWLYLGSGYYDYDTPYEA
HFEGRADFRGQIIHPQFWPENFDYSGKRVVVIGSGATAVTIVPSMADTAAHVTMLQRTPTWYGIRPARDAIANFLRKILP
EELAYRITRFKNVRLQNLVFKRARTQPEKVKQFLTKRIKAALGDKYDEKAFTPPYNPWDQRLCLVPDADLFEAIKAGKAS
VVTDHIDRFDATGIKLKSGQHLDADVIVTATGLKMVMAGKIAISVDGVPVDFAEKYYYKGAMFSNVPNLAAVFGYLNASW
TLRADINARYICDVLNAMKAKGMEVAVPKLAPNHPLDDDNIYDFSSGYIERARHLLPKSAHDMRWRLNQDYVRDRVWMRE
DPIEDGVLQFGHARPAMQADPQMEAAE

Sequences:

>Translated_507_residues
MGAEQSRFVAANPDVDVLIVGAGISGIGMAAHMKMLCPDRSFAIVERRAQIGGTWDLFRYPGVRSDSDMHTLGFVFEPWK
HEKSIADGPAILEYLNRIADERDIRRHIRFDSKVLSADFDSEAAHWVVTVEGPDGERRRLTARWLYLGSGYYDYDTPYEA
HFEGRADFRGQIIHPQFWPENFDYSGKRVVVIGSGATAVTIVPSMADTAAHVTMLQRTPTWYGIRPARDAIANFLRKILP
EELAYRITRFKNVRLQNLVFKRARTQPEKVKQFLTKRIKAALGDKYDEKAFTPPYNPWDQRLCLVPDADLFEAIKAGKAS
VVTDHIDRFDATGIKLKSGQHLDADVIVTATGLKMVMAGKIAISVDGVPVDFAEKYYYKGAMFSNVPNLAAVFGYLNASW
TLRADINARYICDVLNAMKAKGMEVAVPKLAPNHPLDDDNIYDFSSGYIERARHLLPKSAHDMRWRLNQDYVRDRVWMRE
DPIEDGVLQFGHARPAMQADPQMEAAE
>Mature_506_residues
GAEQSRFVAANPDVDVLIVGAGISGIGMAAHMKMLCPDRSFAIVERRAQIGGTWDLFRYPGVRSDSDMHTLGFVFEPWKH
EKSIADGPAILEYLNRIADERDIRRHIRFDSKVLSADFDSEAAHWVVTVEGPDGERRRLTARWLYLGSGYYDYDTPYEAH
FEGRADFRGQIIHPQFWPENFDYSGKRVVVIGSGATAVTIVPSMADTAAHVTMLQRTPTWYGIRPARDAIANFLRKILPE
ELAYRITRFKNVRLQNLVFKRARTQPEKVKQFLTKRIKAALGDKYDEKAFTPPYNPWDQRLCLVPDADLFEAIKAGKASV
VTDHIDRFDATGIKLKSGQHLDADVIVTATGLKMVMAGKIAISVDGVPVDFAEKYYYKGAMFSNVPNLAAVFGYLNASWT
LRADINARYICDVLNAMKAKGMEVAVPKLAPNHPLDDDNIYDFSSGYIERARHLLPKSAHDMRWRLNQDYVRDRVWMRED
PIEDGVLQFGHARPAMQADPQMEAAE

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503759, Length=291, Percent_Identity=28.5223367697594, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI50541965, Length=219, Percent_Identity=26.9406392694064, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI50541961, Length=219, Percent_Identity=26.9406392694064, Blast_Score=67, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI193202226, Length=322, Percent_Identity=23.6024844720497, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17555726, Length=270, Percent_Identity=22.2222222222222, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25150462, Length=365, Percent_Identity=22.7397260273973, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 57308; Mature: 57177

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAEQSRFVAANPDVDVLIVGAGISGIGMAAHMKMLCPDRSFAIVERRAQIGGTWDLFRY
CCCCCCCEEEECCCEEEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEHHCC
PGVRSDSDMHTLGFVFEPWKHEKSIADGPAILEYLNRIADERDIRRHIRFDSKVLSADFD
CCCCCCCCCEEECEEECCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHCCHHEECCCC
SEAAHWVVTVEGPDGERRRLTARWLYLGSGYYDYDTPYEAHFEGRADFRGQIIHPQFWPE
CCCCEEEEEEECCCCCCCEEEEEEEEEECCEECCCCCCCCCCCCCCCCCCEEECCCCCCC
NFDYSGKRVVVIGSGATAVTIVPSMADTAAHVTMLQRTPTWYGIRPARDAIANFLRKILP
CCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCH
EELAYRITRFKNVRLQNLVFKRARTQPEKVKQFLTKRIKAALGDKYDEKAFTPPYNPWDQ
HHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHC
RLCLVPDADLFEAIKAGKASVVTDHIDRFDATGIKLKSGQHLDADVIVTATGLKMVMAGK
EEEECCCHHHHHHHHCCCCHHHHHHHHHCCCCCEEECCCCCCCCEEEEEECCEEEEEECE
IAISVDGVPVDFAEKYYYKGAMFSNVPNLAAVFGYLNASWTLRADINARYICDVLNAMKA
EEEEECCCCCHHHHHHHHCCHHHCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHH
KGMEVAVPKLAPNHPLDDDNIYDFSSGYIERARHLLPKSAHDMRWRLNQDYVRDRVWMRE
CCCEEEECCCCCCCCCCCCCCEECCCHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHCCCC
DPIEDGVLQFGHARPAMQADPQMEAAE
CCCHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GAEQSRFVAANPDVDVLIVGAGISGIGMAAHMKMLCPDRSFAIVERRAQIGGTWDLFRY
CCCCCCEEEECCCEEEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEHHCC
PGVRSDSDMHTLGFVFEPWKHEKSIADGPAILEYLNRIADERDIRRHIRFDSKVLSADFD
CCCCCCCCCEEECEEECCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHCCHHEECCCC
SEAAHWVVTVEGPDGERRRLTARWLYLGSGYYDYDTPYEAHFEGRADFRGQIIHPQFWPE
CCCCEEEEEEECCCCCCCEEEEEEEEEECCEECCCCCCCCCCCCCCCCCCEEECCCCCCC
NFDYSGKRVVVIGSGATAVTIVPSMADTAAHVTMLQRTPTWYGIRPARDAIANFLRKILP
CCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCH
EELAYRITRFKNVRLQNLVFKRARTQPEKVKQFLTKRIKAALGDKYDEKAFTPPYNPWDQ
HHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHC
RLCLVPDADLFEAIKAGKASVVTDHIDRFDATGIKLKSGQHLDADVIVTATGLKMVMAGK
EEEECCCHHHHHHHHCCCCHHHHHHHHHCCCCCEEECCCCCCCCEEEEEECCEEEEEECE
IAISVDGVPVDFAEKYYYKGAMFSNVPNLAAVFGYLNASWTLRADINARYICDVLNAMKA
EEEEECCCCCHHHHHHHHCCHHHCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHH
KGMEVAVPKLAPNHPLDDDNIYDFSSGYIERARHLLPKSAHDMRWRLNQDYVRDRVWMRE
CCCEEEECCCCCCCCCCCCCCEECCCHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHCCCC
DPIEDGVLQFGHARPAMQADPQMEAAE
CCCHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA