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The map label for this gene is mtnP [H]

Identifier: 86751796

GI number: 86751796

Start: 5316808

End: 5317713

Strand: Reverse

Name: mtnP [H]

Synonym: RPB_4698

Alternate gene names: 86751796

Gene position: 5317713-5316808 (Counterclockwise)

Preceding gene: 86751802

Following gene: 86751795

Centisome position: 99.74

GC content: 67.33

Gene sequence:

>906_bases
ATGCGCTCGGAACGACGCGGGAGACAGGGCATGACCAGGGCGGTACTCGGCATCATCGGCGGATCCGGCATCTATGATTT
GCCGGGGCTGGAGGACGTCCGCGAGGAGGCGATCGCGAGCCCGTGGGGCGAGCCGTCCTCGGCGGTGCGGCGCGGCAACA
TCGCCGGCCTGCCGATCGTGTTCCTGCCGCGCCACGACAAGGGCCACCGGCTGTCGCCCTCCGACATCAACTACCGCGCC
AATATCGACGTGCTGAAACGCGCCGGTGTCACCGACCTGATCTCGCTGTCGGCCTGCGGCTCGTTCAAGGAAGAGCTGCC
GCCCGGCACCTTCGTGCTGGTCGACCAGTTCGTCGATCGCACCTACAAGCGCGAGAGTTCGTTCTTCGGCCGTGGCTGCG
TCGCCCACGTCTCGATGGCGCATCCGGTGAGCCCGCGGCTGCGCATCCATCTCGCCGCCGCCGCCGAGGCCGAAGGCATC
GCGTTCGCGCGCGGCGGCACCTACCTCTGCATGGAAGGCCCGCAATTCTCCAGCTACGCCGAGAGCGTCACCTACAAGCA
GCTCGGCTATTCGGTGATCGGCATGACCAACATGCCGGAGGCCAAGCTCGCCCGCGAGGCCGAGATCTGCTACGCCACCG
TGGCGATGGTGACCGATTTCGACTGCTGGCACCCCGACCACGACGCCGTCACGGTGCAGGACATCATCCGGGTGCTGACC
ACCAATGCCGAAAAGGCCAAGAGCCTGGTGGCGCGGCTGGCGCAGGACTTCCCGCGCGAGCACGAAGACTGCCCGATCGG
CTCCGACCGCGCGCTGGACACCGCTCTGATCACCCAGCCCGACGCGCGCGATCCGGAACTGCTGAAGAAGCTGGATGCGG
TGGCGGGGCGGATTTTGAAGGGTTAG

Upstream 100 bases:

>100_bases
GTCGCGCGTCGGGCCGCGGCTGGCGCGCGCCGTCGGTAAAATGAGACGTTTGTCGGATACGCCTGATATGGGGGTTGTCG
GGCCACCGCGCGCATGTTGA

Downstream 100 bases:

>100_bases
TCACCACCGCCGTCATTGCCGGGCTCGACCCGGCAATCCATCCTCTTCAATGATGGATGCCCGGGTCAAGCCCGGGCATG
ACGAGTTGAGAAGTTGCGGT

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MRSERRGRQGMTRAVLGIIGGSGIYDLPGLEDVREEAIASPWGEPSSAVRRGNIAGLPIVFLPRHDKGHRLSPSDINYRA
NIDVLKRAGVTDLISLSACGSFKEELPPGTFVLVDQFVDRTYKRESSFFGRGCVAHVSMAHPVSPRLRIHLAAAAEAEGI
AFARGGTYLCMEGPQFSSYAESVTYKQLGYSVIGMTNMPEAKLAREAEICYATVAMVTDFDCWHPDHDAVTVQDIIRVLT
TNAEKAKSLVARLAQDFPREHEDCPIGSDRALDTALITQPDARDPELLKKLDAVAGRILKG

Sequences:

>Translated_301_residues
MRSERRGRQGMTRAVLGIIGGSGIYDLPGLEDVREEAIASPWGEPSSAVRRGNIAGLPIVFLPRHDKGHRLSPSDINYRA
NIDVLKRAGVTDLISLSACGSFKEELPPGTFVLVDQFVDRTYKRESSFFGRGCVAHVSMAHPVSPRLRIHLAAAAEAEGI
AFARGGTYLCMEGPQFSSYAESVTYKQLGYSVIGMTNMPEAKLAREAEICYATVAMVTDFDCWHPDHDAVTVQDIIRVLT
TNAEKAKSLVARLAQDFPREHEDCPIGSDRALDTALITQPDARDPELLKKLDAVAGRILKG
>Mature_301_residues
MRSERRGRQGMTRAVLGIIGGSGIYDLPGLEDVREEAIASPWGEPSSAVRRGNIAGLPIVFLPRHDKGHRLSPSDINYRA
NIDVLKRAGVTDLISLSACGSFKEELPPGTFVLVDQFVDRTYKRESSFFGRGCVAHVSMAHPVSPRLRIHLAAAAEAEGI
AFARGGTYLCMEGPQFSSYAESVTYKQLGYSVIGMTNMPEAKLAREAEICYATVAMVTDFDCWHPDHDAVTVQDIIRVLT
TNAEKAKSLVARLAQDFPREHEDCPIGSDRALDTALITQPDARDPELLKKLDAVAGRILKG

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=245, Percent_Identity=44.4897959183673, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71980569, Length=240, Percent_Identity=42.0833333333333, Blast_Score=182, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6323045, Length=296, Percent_Identity=35.1351351351351, Blast_Score=167, Evalue=2e-42,
Organism=Drosophila melanogaster, GI20130079, Length=251, Percent_Identity=41.8326693227092, Blast_Score=190, Evalue=8e-49,
Organism=Drosophila melanogaster, GI221459247, Length=250, Percent_Identity=31.2, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 32867; Mature: 32867

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSERRGRQGMTRAVLGIIGGSGIYDLPGLEDVREEAIASPWGEPSSAVRRGNIAGLPIV
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCEE
FLPRHDKGHRLSPSDINYRANIDVLKRAGVTDLISLSACGSFKEELPPGTFVLVDQFVDR
EEECCCCCCCCCCCCCCEECCHHHHHHCCHHHHHHHHHCCCHHHHCCCCEEEHHHHHHHH
TYKRESSFFGRGCVAHVSMAHPVSPRLRIHLAAAAEAEGIAFARGGTYLCMEGPQFSSYA
HHHHHHHHHCCHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEECCCEEEEECCCCHHHHH
ESVTYKQLGYSVIGMTNMPEAKLAREAEICYATVAMVTDFDCWHPDHDAVTVQDIIRVLT
HHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHH
TNAEKAKSLVARLAQDFPREHEDCPIGSDRALDTALITQPDARDPELLKKLDAVAGRILK
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHEECCCCCCCHHHHHHHHHHHHHHCC
G
C
>Mature Secondary Structure
MRSERRGRQGMTRAVLGIIGGSGIYDLPGLEDVREEAIASPWGEPSSAVRRGNIAGLPIV
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCEE
FLPRHDKGHRLSPSDINYRANIDVLKRAGVTDLISLSACGSFKEELPPGTFVLVDQFVDR
EEECCCCCCCCCCCCCCEECCHHHHHHCCHHHHHHHHHCCCHHHHCCCCEEEHHHHHHHH
TYKRESSFFGRGCVAHVSMAHPVSPRLRIHLAAAAEAEGIAFARGGTYLCMEGPQFSSYA
HHHHHHHHHCCHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEECCCEEEEECCCCHHHHH
ESVTYKQLGYSVIGMTNMPEAKLAREAEICYATVAMVTDFDCWHPDHDAVTVQDIIRVLT
HHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHH
TNAEKAKSLVARLAQDFPREHEDCPIGSDRALDTALITQPDARDPELLKKLDAVAGRILK
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHEECCCCCCCHHHHHHHHHHHHHHCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA