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The map label for this gene is gmr [H]

Identifier: 86751736

GI number: 86751736

Start: 5242565

End: 5244391

Strand: Direct

Name: gmr [H]

Synonym: RPB_4638

Alternate gene names: 86751736

Gene position: 5242565-5244391 (Clockwise)

Preceding gene: 86751734

Following gene: 86751737

Centisome position: 98.33

GC content: 63.82

Gene sequence:

>1827_bases
ATGTCCAGTGCAGCCCCCCACGAAATGTCCGGCGACGCGACCGAATCGGAGCCCAGCGCCTCCGCAGGGACTGCGTCCGG
TGGGGATCTGCCGGCGTTTGCCGAAGACATCGACTTTCAGCTTCTGAAAGACATCGTCCGCGGGCTCCCATCCTTGGTCA
CGGTACAAGATCACCAGGGCGAGTTTCTGATCGTTAACGATGCCGCCGCCGCCCGCTTCAACCGGCCGGCCGGTCCAGGC
GCGACCGCCACGCCCTGCGTCGCGCTCGAACAGCGCCGTGCCGACGGCTTGGCTTTGCTCGCCACCGGCCGCGGCGCGAT
CTGCGAGGAACGCGCCGGCGACGGCGCGACGGCGCGCACGTTCCTGACCGCGCATCGGCCGATCGAGATCGGCGGGCGCC
GGCTGCTGCTGTCGAGCTCCCTCGACATGACCGAACAGAAGGCGATCGAGGACGACCTGTTTCGCCGCGCCTATTTCGAC
GAGTTGACGGGGCTGCCGAATCGCAGCGTGATCGAACATCGCGCCGACACCTTGCTGCGCGCCGGGGGAACGCCGAGCCG
GTTCGCGCTGGCGTTCCTCGACATCGATAATTTCAAGCACATCAACGATTATTACGGCCACGCGGTCGGCGATGCATTGT
TGGTCGGGGTCGCCAAACGGCTCGGCCTCGAACTGCGCGAGACCGACATGCTGTCGCGCATCAGCGGCGACGAATTCCTG
CTGTTGCTGAATCCGATCGAGAGCCCGGCCGAGGTCGCCGACCACATCGATTTCCTGCTGCAGCGACTGAAGGCGCCGTT
CTACATCGACGGGTCGGAATTGTTCGCTTCGGCTTCGACCGGCATCAGCCTGTATCCCGAGCACGGCCACACCTTCGACG
CCTTGCGCCAGAACGCCGACATTGCGATGTACCGGGTCAAGATCGCGACGAAGGGCGCGGCCGCGATGTTCGACGTCGCG
ATGGAGCGCGAGGCGCTGGAACGCATGCGCATCGAGCAGTCACTGCGCCAGGCGATCCTCGACAGGCGTTTCTGCTGCGC
ATTCCAGCCCAAGGTCGACATCCGGACCCGCGAGATCAAGGGGATCGAGGCACTGGTCCGGCTGCGCGATGACGACGGCG
TCATCCAGGCGCCAGGCACTTTCGTCGATCTGGCGGTCGAACTCGGGCTGATCGACGAACTCACCCACCTGGTCCTCGCC
GAGATCATGAAATCGATCGACCTGATCAATGACGCATTCGGCACCCACGCCAGCATCAGCATCAACGTCGCGGCCAAGCA
GGCCGGCAATTCCCATTTCATGCAGTCGTTTGCGGCAGCGCTCGCGGCGACCGAGTGCCCGTCGCGCTTCATCATCGAGG
TGACGGAAGACGCTTTCGTCACGAAAAGTCACTTCCAGAGCGAAATTCTGCCGATGCTGCGCGAGATCGGCGTCGGCATC
TCGATCGACGATTTCGGCATCGGCTACTCGTCACTGTCGGCGCTGGCGGACATCACCGCGGACGAAATCAAGATCGATCG
ATCCTTCATCACGGACATCCACAAGCGGCCGCGCAGCCAGGGCATCCTCAGGGCGATCGAGTCGCTGAGCGAGGCGCTCG
GCATGACGGTGATTGCCGAAGGCATCGAGACCTTCGAAGAACTCGCCTATCTGCAGACTATGACCCGGATCCGCTACGCA
CAGGGCTATTATTTCGCAAAGCCGGTGTTCCTCGAGGAGTTGAAGCCCTCGGCGCAAGGCTTCGAGGGCGGGCGTCCACG
CGAGTCAGGTCGCCAGATCGACCAGGCGCGACCGGTGATTTCGCGCACCAATGCCGGTCGCAGTTAG

Upstream 100 bases:

>100_bases
GCAGTGTCGCAATTCAAATCGAGTAGGGCGCAGATTTGCGGCAACCTTTGCGCGTGGAACTTAACATTTATTACAACCAA
GCTTGCCATGCTTCGCCGCG

Downstream 100 bases:

>100_bases
TCCGCGCAGAGCTATCTGCACGGGACGCAGAGCTCCCGCAGAGCCGGCCTCGTATTTCTCCCAAGCCGTTGATTGCCGAC
GACTTTGAGCCCCGCCCACG

Product: diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MSSAAPHEMSGDATESEPSASAGTASGGDLPAFAEDIDFQLLKDIVRGLPSLVTVQDHQGEFLIVNDAAAARFNRPAGPG
ATATPCVALEQRRADGLALLATGRGAICEERAGDGATARTFLTAHRPIEIGGRRLLLSSSLDMTEQKAIEDDLFRRAYFD
ELTGLPNRSVIEHRADTLLRAGGTPSRFALAFLDIDNFKHINDYYGHAVGDALLVGVAKRLGLELRETDMLSRISGDEFL
LLLNPIESPAEVADHIDFLLQRLKAPFYIDGSELFASASTGISLYPEHGHTFDALRQNADIAMYRVKIATKGAAAMFDVA
MEREALERMRIEQSLRQAILDRRFCCAFQPKVDIRTREIKGIEALVRLRDDDGVIQAPGTFVDLAVELGLIDELTHLVLA
EIMKSIDLINDAFGTHASISINVAAKQAGNSHFMQSFAAALAATECPSRFIIEVTEDAFVTKSHFQSEILPMLREIGVGI
SIDDFGIGYSSLSALADITADEIKIDRSFITDIHKRPRSQGILRAIESLSEALGMTVIAEGIETFEELAYLQTMTRIRYA
QGYYFAKPVFLEELKPSAQGFEGGRPRESGRQIDQARPVISRTNAGRS

Sequences:

>Translated_608_residues
MSSAAPHEMSGDATESEPSASAGTASGGDLPAFAEDIDFQLLKDIVRGLPSLVTVQDHQGEFLIVNDAAAARFNRPAGPG
ATATPCVALEQRRADGLALLATGRGAICEERAGDGATARTFLTAHRPIEIGGRRLLLSSSLDMTEQKAIEDDLFRRAYFD
ELTGLPNRSVIEHRADTLLRAGGTPSRFALAFLDIDNFKHINDYYGHAVGDALLVGVAKRLGLELRETDMLSRISGDEFL
LLLNPIESPAEVADHIDFLLQRLKAPFYIDGSELFASASTGISLYPEHGHTFDALRQNADIAMYRVKIATKGAAAMFDVA
MEREALERMRIEQSLRQAILDRRFCCAFQPKVDIRTREIKGIEALVRLRDDDGVIQAPGTFVDLAVELGLIDELTHLVLA
EIMKSIDLINDAFGTHASISINVAAKQAGNSHFMQSFAAALAATECPSRFIIEVTEDAFVTKSHFQSEILPMLREIGVGI
SIDDFGIGYSSLSALADITADEIKIDRSFITDIHKRPRSQGILRAIESLSEALGMTVIAEGIETFEELAYLQTMTRIRYA
QGYYFAKPVFLEELKPSAQGFEGGRPRESGRQIDQARPVISRTNAGRS
>Mature_607_residues
SSAAPHEMSGDATESEPSASAGTASGGDLPAFAEDIDFQLLKDIVRGLPSLVTVQDHQGEFLIVNDAAAARFNRPAGPGA
TATPCVALEQRRADGLALLATGRGAICEERAGDGATARTFLTAHRPIEIGGRRLLLSSSLDMTEQKAIEDDLFRRAYFDE
LTGLPNRSVIEHRADTLLRAGGTPSRFALAFLDIDNFKHINDYYGHAVGDALLVGVAKRLGLELRETDMLSRISGDEFLL
LLNPIESPAEVADHIDFLLQRLKAPFYIDGSELFASASTGISLYPEHGHTFDALRQNADIAMYRVKIATKGAAAMFDVAM
EREALERMRIEQSLRQAILDRRFCCAFQPKVDIRTREIKGIEALVRLRDDDGVIQAPGTFVDLAVELGLIDELTHLVLAE
IMKSIDLINDAFGTHASISINVAAKQAGNSHFMQSFAAALAATECPSRFIIEVTEDAFVTKSHFQSEILPMLREIGVGIS
IDDFGIGYSSLSALADITADEIKIDRSFITDIHKRPRSQGILRAIESLSEALGMTVIAEGIETFEELAYLQTMTRIRYAQ
GYYFAKPVFLEELKPSAQGFEGGRPRESGRQIDQARPVISRTNAGRS

Specific function: Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG, csgBAC/ymaD and adrA (yaic). Activity of this protein is antag

COG id: COG5001

COG function: function code T; Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=459, Percent_Identity=33.9869281045752, Blast_Score=249, Evalue=4e-67,
Organism=Escherichia coli, GI87081921, Length=419, Percent_Identity=29.8329355608592, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI1790496, Length=251, Percent_Identity=33.0677290836653, Blast_Score=135, Evalue=1e-32,
Organism=Escherichia coli, GI87081845, Length=239, Percent_Identity=33.8912133891213, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI226510982, Length=461, Percent_Identity=24.5119305856833, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1788502, Length=250, Percent_Identity=29.2, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI87081743, Length=260, Percent_Identity=30.7692307692308, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1787055, Length=260, Percent_Identity=32.6923076923077, Blast_Score=102, Evalue=9e-23,
Organism=Escherichia coli, GI87081881, Length=201, Percent_Identity=34.3283582089552, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1788849, Length=432, Percent_Identity=26.1574074074074, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI87081980, Length=264, Percent_Identity=27.2727272727273, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1788956, Length=166, Percent_Identity=36.7469879518072, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082096, Length=427, Percent_Identity=24.5901639344262, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788381, Length=180, Percent_Identity=36.1111111111111, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI87081977, Length=158, Percent_Identity=34.8101265822785, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1786507, Length=266, Percent_Identity=27.8195488721804, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1787410, Length=223, Percent_Identity=30.4932735426009, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786584, Length=160, Percent_Identity=31.875, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87082007, Length=174, Percent_Identity=31.0344827586207, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1787816, Length=88, Percent_Identity=39.7727272727273, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1787262, Length=89, Percent_Identity=34.8314606741573, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR000014
- InterPro:   IPR013767 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF00989 PAS [H]

EC number: =3.1.4.52 [H]

Molecular weight: Translated: 66376; Mature: 66245

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAAPHEMSGDATESEPSASAGTASGGDLPAFAEDIDFQLLKDIVRGLPSLVTVQDHQG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCEEEEECCCC
EFLIVNDAAAARFNRPAGPGATATPCVALEQRRADGLALLATGRGAICEERAGDGATART
CEEEEECHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHH
FLTAHRPIEIGGRRLLLSSSLDMTEQKAIEDDLFRRAYFDELTGLPNRSVIEHRADTLLR
HEEECCCEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AGGTPSRFALAFLDIDNFKHINDYYGHAVGDALLVGVAKRLGLELRETDMLSRISGDEFL
CCCCCHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEE
LLLNPIESPAEVADHIDFLLQRLKAPFYIDGSELFASASTGISLYPEHGHTFDALRQNAD
EEECCCCCHHHHHHHHHHHHHHHCCCEEECHHHHHHHCCCCCEEECCCCCHHHHHHCCCC
IAMYRVKIATKGAAAMFDVAMEREALERMRIEQSLRQAILDRRFCCAFQPKVDIRTREIK
EEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCCCCCHHHHH
GIEALVRLRDDDGVIQAPGTFVDLAVELGLIDELTHLVLAEIMKSIDLINDAFGTHASIS
HHHHHHEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
INVAAKQAGNSHFMQSFAAALAATECPSRFIIEVTEDAFVTKSHFQSEILPMLREIGVGI
EEEEHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCC
SIDDFGIGYSSLSALADITADEIKIDRSFITDIHKRPRSQGILRAIESLSEALGMTVIAE
EECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GIETFEELAYLQTMTRIRYAQGYYFAKPVFLEELKPSAQGFEGGRPRESGRQIDQARPVI
HHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHCCCCCCCCCCCCCCHHHCHHHHHCCHH
SRTNAGRS
HCCCCCCC
>Mature Secondary Structure 
SSAAPHEMSGDATESEPSASAGTASGGDLPAFAEDIDFQLLKDIVRGLPSLVTVQDHQG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCEEEEECCCC
EFLIVNDAAAARFNRPAGPGATATPCVALEQRRADGLALLATGRGAICEERAGDGATART
CEEEEECHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHH
FLTAHRPIEIGGRRLLLSSSLDMTEQKAIEDDLFRRAYFDELTGLPNRSVIEHRADTLLR
HEEECCCEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AGGTPSRFALAFLDIDNFKHINDYYGHAVGDALLVGVAKRLGLELRETDMLSRISGDEFL
CCCCCHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEE
LLLNPIESPAEVADHIDFLLQRLKAPFYIDGSELFASASTGISLYPEHGHTFDALRQNAD
EEECCCCCHHHHHHHHHHHHHHHCCCEEECHHHHHHHCCCCCEEECCCCCHHHHHHCCCC
IAMYRVKIATKGAAAMFDVAMEREALERMRIEQSLRQAILDRRFCCAFQPKVDIRTREIK
EEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCCCCCHHHHH
GIEALVRLRDDDGVIQAPGTFVDLAVELGLIDELTHLVLAEIMKSIDLINDAFGTHASIS
HHHHHHEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
INVAAKQAGNSHFMQSFAAALAATECPSRFIIEVTEDAFVTKSHFQSEILPMLREIGVGI
EEEEHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCC
SIDDFGIGYSSLSALADITADEIKIDRSFITDIHKRPRSQGILRAIESLSEALGMTVIAE
EECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GIETFEELAYLQTMTRIRYAQGYYFAKPVFLEELKPSAQGFEGGRPRESGRQIDQARPVI
HHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHCCCCCCCCCCCCCCHHHCHHHHHCCHH
SRTNAGRS
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]