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The map label for this gene is cah [H]

Identifier: 86751723

GI number: 86751723

Start: 5225798

End: 5226589

Strand: Direct

Name: cah [H]

Synonym: RPB_4625

Alternate gene names: 86751723

Gene position: 5225798-5226589 (Clockwise)

Preceding gene: 86751722

Following gene: 86751725

Centisome position: 98.01

GC content: 63.76

Gene sequence:

>792_bases
ATGGAACCCATCCTCATCCCGGAGCACAGACCGATGGACCGTCGCGCTATCCTCAAGGCCTTCGCGGGCCTCGCCCTTTG
TCCGCTTTGCGCCAGCGCCGGCGTTGCCGGGGAAGGCGGGCATCATTGGGGCTATGAAGGCGACGGCGGACCGGCGAAGT
GGGGCGAGCTCGATCCGGCCAACCAGTTCTGCAGTGTCGGCGTGCAGCAATCGCCGATCGATATCGGCACGACGATCGGA
GCCAATCTGTACCCGATCGAGATCCGTTGGGCGGACACGGCCGACACCATCGTCAACAACGGCCACACCATCCAGCTCAA
CGTCGCCGAAGGCAGTCACCTGAAGCTCGGCGGCGTGACCTTCAAGCTGGTTCAGTTCCATTTCCATCATCCGAGCGAGC
ATCTGATCGACGGCAAGAACTTCCCGATGGAAGTGCACTTCGTTCATCGCGCGGATTCCGGCACGCTCGGCGTGGTCGGC
GTTCTGATGCAGCCCGGCAAGGCCAACGCCGCCTTCAGCAAGATCGTCGCGACAATGCCGCAGAGCGAGGGACCGGCGAA
AAAGGCCGACCCGGCGATCGATCCGAACGCGCTGCTGCCGGAGACCCGCAACTATTACCGCTACGAAGGCTCGCTGACGA
CGCCGCCATGCTCCGAGATCGTCGACTGGATGGTGCTGGCGAGTCCGATCACCGTGGCGGCCGACGACATCGCCGCCTTC
GCCAAGCTGTATCCGATGAATGCGCGGCCGGTGCAGAAGGACAACCGCCGCTTCGTGCTGCAGTCGAACTGA

Upstream 100 bases:

>100_bases
GACGTCGAGTGGATCGCACGCATCGTCTGGGCCAGCCAGTAACCAACTGTAAGTCCTAGCTGTTCGTCGGGACTTCACAA
AGTTCCCGGGGTGACGGATG

Downstream 100 bases:

>100_bases
GCGACCGCAACGCGCATCGCAGATACAAAAAGACCCGAGCCGCTGTCCGGCTCGGGTCTTTTCGCTGAACTCTGAACGTG
GTTGCTGCTGTGGTCAGCCG

Product: carbonate dehydratase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MEPILIPEHRPMDRRAILKAFAGLALCPLCASAGVAGEGGHHWGYEGDGGPAKWGELDPANQFCSVGVQQSPIDIGTTIG
ANLYPIEIRWADTADTIVNNGHTIQLNVAEGSHLKLGGVTFKLVQFHFHHPSEHLIDGKNFPMEVHFVHRADSGTLGVVG
VLMQPGKANAAFSKIVATMPQSEGPAKKADPAIDPNALLPETRNYYRYEGSLTTPPCSEIVDWMVLASPITVAADDIAAF
AKLYPMNARPVQKDNRRFVLQSN

Sequences:

>Translated_263_residues
MEPILIPEHRPMDRRAILKAFAGLALCPLCASAGVAGEGGHHWGYEGDGGPAKWGELDPANQFCSVGVQQSPIDIGTTIG
ANLYPIEIRWADTADTIVNNGHTIQLNVAEGSHLKLGGVTFKLVQFHFHHPSEHLIDGKNFPMEVHFVHRADSGTLGVVG
VLMQPGKANAAFSKIVATMPQSEGPAKKADPAIDPNALLPETRNYYRYEGSLTTPPCSEIVDWMVLASPITVAADDIAAF
AKLYPMNARPVQKDNRRFVLQSN
>Mature_263_residues
MEPILIPEHRPMDRRAILKAFAGLALCPLCASAGVAGEGGHHWGYEGDGGPAKWGELDPANQFCSVGVQQSPIDIGTTIG
ANLYPIEIRWADTADTIVNNGHTIQLNVAEGSHLKLGGVTFKLVQFHFHHPSEHLIDGKNFPMEVHFVHRADSGTLGVVG
VLMQPGKANAAFSKIVATMPQSEGPAKKADPAIDPNALLPETRNYYRYEGSLTTPPCSEIVDWMVLASPITVAADDIAAF
AKLYPMNARPVQKDNRRFVLQSN

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI4557395, Length=230, Percent_Identity=34.7826086956522, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI4885101, Length=234, Percent_Identity=35.8974358974359, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI258679498, Length=248, Percent_Identity=33.8709677419355, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI192447434, Length=248, Percent_Identity=33.8709677419355, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI192447432, Length=248, Percent_Identity=33.8709677419355, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI192447430, Length=248, Percent_Identity=33.8709677419355, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI4502517, Length=248, Percent_Identity=33.8709677419355, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI45935383, Length=292, Percent_Identity=30.8219178082192, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI4502515, Length=292, Percent_Identity=30.8219178082192, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI4885099, Length=258, Percent_Identity=31.0077519379845, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI38348436, Length=229, Percent_Identity=32.7510917030568, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI169636420, Length=233, Percent_Identity=31.7596566523605, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI62240989, Length=173, Percent_Identity=35.2601156069364, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI4502521, Length=235, Percent_Identity=30.2127659574468, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI4502519, Length=272, Percent_Identity=30.8823529411765, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI6912284, Length=271, Percent_Identity=31.7343173431734, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI22027500, Length=226, Percent_Identity=30.5309734513274, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI6005723, Length=205, Percent_Identity=32.1951219512195, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI91208428, Length=237, Percent_Identity=29.535864978903, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI194097398, Length=269, Percent_Identity=27.1375464684015, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI70167127, Length=249, Percent_Identity=27.3092369477912, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17568715, Length=246, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71995280, Length=257, Percent_Identity=30.7392996108949, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17569163, Length=227, Percent_Identity=29.5154185022026, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17569165, Length=227, Percent_Identity=29.5154185022026, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI32564019, Length=227, Percent_Identity=27.3127753303965, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17553578, Length=202, Percent_Identity=28.7128712871287, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17737413, Length=244, Percent_Identity=33.1967213114754, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24645604, Length=279, Percent_Identity=29.3906810035842, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221329761, Length=281, Percent_Identity=26.6903914590747, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI18858185, Length=239, Percent_Identity=27.1966527196653, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21358169, Length=294, Percent_Identity=27.5510204081633, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI161079350, Length=266, Percent_Identity=27.0676691729323, Blast_Score=81, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 28424; Mature: 28424

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00162 ALPHA_CA_1 ; PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPILIPEHRPMDRRAILKAFAGLALCPLCASAGVAGEGGHHWGYEGDGGPAKWGELDPA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH
NQFCSVGVQQSPIDIGTTIGANLYPIEIRWADTADTIVNNGHTIQLNVAEGSHLKLGGVT
HHHHHCCCCCCCCEECCCCCCEEEEEEEEECCCHHHHHCCCCEEEEEECCCCEEEECCEE
FKLVQFHFHHPSEHLIDGKNFPMEVHFVHRADSGTLGVVGVLMQPGKANAAFSKIVATMP
EEEEEEEECCCHHHCCCCCCCCEEEEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHCC
QSEGPAKKADPAIDPNALLPETRNYYRYEGSLTTPPCSEIVDWMVLASPITVAADDIAAF
CCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEHHHHHHH
AKLYPMNARPVQKDNRRFVLQSN
HHHCCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MEPILIPEHRPMDRRAILKAFAGLALCPLCASAGVAGEGGHHWGYEGDGGPAKWGELDPA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH
NQFCSVGVQQSPIDIGTTIGANLYPIEIRWADTADTIVNNGHTIQLNVAEGSHLKLGGVT
HHHHHCCCCCCCCEECCCCCCEEEEEEEEECCCHHHHHCCCCEEEEEECCCCEEEECCEE
FKLVQFHFHHPSEHLIDGKNFPMEVHFVHRADSGTLGVVGVLMQPGKANAAFSKIVATMP
EEEEEEEECCCHHHCCCCCCCCEEEEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHCC
QSEGPAKKADPAIDPNALLPETRNYYRYEGSLTTPPCSEIVDWMVLASPITVAADDIAAF
CCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEHHHHHHH
AKLYPMNARPVQKDNRRFVLQSN
HHHCCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9811652 [H]