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The map label for this gene is ldc [H]

Identifier: 86751645

GI number: 86751645

Start: 5142669

End: 5143811

Strand: Direct

Name: ldc [H]

Synonym: RPB_4547

Alternate gene names: 86751645

Gene position: 5142669-5143811 (Clockwise)

Preceding gene: 86751644

Following gene: 86751646

Centisome position: 96.46

GC content: 66.23

Gene sequence:

>1143_bases
ATGACCGAACGTATCCAGGAATTCCTCCGCGCCCGCCGCAACGAAGGTCAGGATCTCGAGCCCTGCCTGGTCGTCGACCT
CGACGTCGTGCGCGACAACTTCGCCAGCTTCGCCAAGGCGTTGCCGGACAGCCGCGTGTTCTACGCGGTGAAGGCCAACC
CGGCGCCGGAAGTGCTGTCGCTGCTGGCCTCGCTCGGCTCGTGCTTCGACTGCGCCTCGGTGCAGGAGATCCAGATGGCG
CTGGCCGCCGGCGCGACGCCGGACCGCATCTCGTTCGGCAACACCATCAAGAAGGAACGCGACATCGCGCGCGCCTTCGC
GCTCGGCATTCGCCTGTTCTCGGTCGACTGCAGCGCCGAGGTGGAGAAGATCGCGCGTTCGGCGCCGGGTTCGAAGGTGT
TCTGCCGCATCCTGTACGATTGCGCCGGCGCCGAGTGGCCGCTGTCGCGCAAGTTCGGCTGCGATCCGGAGATGGCGGTC
GACGTGCTCGACGCCGCCAAGCGCCTCGGCCTGGAGCCCTATGGAATCTCGTTCCATGTCGGCTCGCAGCAGCGCAAGGT
GAAGGCGTGGGACCGTGCGCTGGCGATGGCCGCGACCGTGTTCCGCGACTGCGCCGAGCGCGGCATCAACCTGTCGATGG
TCAACATGGGTGGCGGCTTCCCGACCAAGTATCTGAAGGAAGTGCCGGCCGTGGTGCAGTACGGGCGTTCGATCTTCCGG
GCGCTGCGCAAGCACTTCGGCAACCAGATCCCGGAGACCATCATCGAGCCGGGCCGCGGCATGGTCGGCAACGCCGGCAT
CATCGAGACCGAGGTCGTTCTGATCTCCAAGAAGAGCGACGAGGACGAGATGCGCTGGGTCTATCTCGACATCGGCAAGT
TCGGCGGTCTCGCCGAGACGATGGACGAGTCGATCCGCTACGCGATCAAGTCGCGCCATGACGGCGCGGAGATGGCGCCC
TGCGTGCTCGCCGGCCCGACCTGCGATTCGGCCGACGTGATGTACGAGAAGTTGCCGTACCCGCTGCCGGTGACGCTCGA
GATCGGCGACAAGCTGCTGATCGAAGGCACCGGCGCCTACACGTCGACCTACTCGGCGGTAGCCTTCAACGGCTTCCCGC
CGCTGCGGACCTACCACATCTGA

Upstream 100 bases:

>100_bases
TTTTTGGCTCGTCGCGCCTCCATCGCGCGCCGACGTCGAAGGCTCGGATCGGACGTCGTTTTTGAACGGTACCCATCGCT
GGGCCGTTTGGGAGAGTGCT

Downstream 100 bases:

>100_bases
GGTTGTTCACCTCCCCCGCTTGCGGGGGAGAGCCTGCCCTCGGGCTTGACCCGAGGGTCGGATCGCGAAGCGATCCGGGT
GGGGGAAAGAGCGACTCGCC

Product: ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MTERIQEFLRARRNEGQDLEPCLVVDLDVVRDNFASFAKALPDSRVFYAVKANPAPEVLSLLASLGSCFDCASVQEIQMA
LAAGATPDRISFGNTIKKERDIARAFALGIRLFSVDCSAEVEKIARSAPGSKVFCRILYDCAGAEWPLSRKFGCDPEMAV
DVLDAAKRLGLEPYGISFHVGSQQRKVKAWDRALAMAATVFRDCAERGINLSMVNMGGGFPTKYLKEVPAVVQYGRSIFR
ALRKHFGNQIPETIIEPGRGMVGNAGIIETEVVLISKKSDEDEMRWVYLDIGKFGGLAETMDESIRYAIKSRHDGAEMAP
CVLAGPTCDSADVMYEKLPYPLPVTLEIGDKLLIEGTGAYTSTYSAVAFNGFPPLRTYHI

Sequences:

>Translated_380_residues
MTERIQEFLRARRNEGQDLEPCLVVDLDVVRDNFASFAKALPDSRVFYAVKANPAPEVLSLLASLGSCFDCASVQEIQMA
LAAGATPDRISFGNTIKKERDIARAFALGIRLFSVDCSAEVEKIARSAPGSKVFCRILYDCAGAEWPLSRKFGCDPEMAV
DVLDAAKRLGLEPYGISFHVGSQQRKVKAWDRALAMAATVFRDCAERGINLSMVNMGGGFPTKYLKEVPAVVQYGRSIFR
ALRKHFGNQIPETIIEPGRGMVGNAGIIETEVVLISKKSDEDEMRWVYLDIGKFGGLAETMDESIRYAIKSRHDGAEMAP
CVLAGPTCDSADVMYEKLPYPLPVTLEIGDKLLIEGTGAYTSTYSAVAFNGFPPLRTYHI
>Mature_379_residues
TERIQEFLRARRNEGQDLEPCLVVDLDVVRDNFASFAKALPDSRVFYAVKANPAPEVLSLLASLGSCFDCASVQEIQMAL
AAGATPDRISFGNTIKKERDIARAFALGIRLFSVDCSAEVEKIARSAPGSKVFCRILYDCAGAEWPLSRKFGCDPEMAVD
VLDAAKRLGLEPYGISFHVGSQQRKVKAWDRALAMAATVFRDCAERGINLSMVNMGGGFPTKYLKEVPAVVQYGRSIFRA
LRKHFGNQIPETIIEPGRGMVGNAGIIETEVVLISKKSDEDEMRWVYLDIGKFGGLAETMDESIRYAIKSRHDGAEMAPC
VLAGPTCDSADVMYEKLPYPLPVTLEIGDKLLIEGTGAYTSTYSAVAFNGFPPLRTYHI

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=398, Percent_Identity=31.4070351758794, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI22538418, Length=376, Percent_Identity=30.0531914893617, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI21361583, Length=376, Percent_Identity=30.0531914893617, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI16506287, Length=374, Percent_Identity=30.7486631016043, Blast_Score=127, Evalue=3e-29,
Organism=Escherichia coli, GI1789203, Length=381, Percent_Identity=25.4593175853018, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562780, Length=364, Percent_Identity=31.5934065934066, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322664, Length=377, Percent_Identity=33.42175066313, Blast_Score=160, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24586472, Length=364, Percent_Identity=31.5934065934066, Blast_Score=161, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24586474, Length=357, Percent_Identity=31.3725490196078, Blast_Score=131, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 41703; Mature: 41572

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERIQEFLRARRNEGQDLEPCLVVDLDVVRDNFASFAKALPDSRVFYAVKANPAPEVLS
CCHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHH
LLASLGSCFDCASVQEIQMALAAGATPDRISFGNTIKKERDIARAFALGIRLFSVDCSAE
HHHHHCCHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCHHH
VEKIARSAPGSKVFCRILYDCAGAEWPLSRKFGCDPEMAVDVLDAAKRLGLEPYGISFHV
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEE
GSQQRKVKAWDRALAMAATVFRDCAERGINLSMVNMGGGFPTKYLKEVPAVVQYGRSIFR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
ALRKHFGNQIPETIIEPGRGMVGNAGIIETEVVLISKKSDEDEMRWVYLDIGKFGGLAET
HHHHHHCCCCCHHHHCCCCCCCCCCCEEEEEEEEEECCCCCCCEEEEEEECCCCCCHHHH
MDESIRYAIKSRHDGAEMAPCVLAGPTCDSADVMYEKLPYPLPVTLEIGDKLLIEGTGAY
HHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCEEEEECCCEEEEEECCCC
TSTYSAVAFNGFPPLRTYHI
CCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure 
TERIQEFLRARRNEGQDLEPCLVVDLDVVRDNFASFAKALPDSRVFYAVKANPAPEVLS
CHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHH
LLASLGSCFDCASVQEIQMALAAGATPDRISFGNTIKKERDIARAFALGIRLFSVDCSAE
HHHHHCCHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCHHH
VEKIARSAPGSKVFCRILYDCAGAEWPLSRKFGCDPEMAVDVLDAAKRLGLEPYGISFHV
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEE
GSQQRKVKAWDRALAMAATVFRDCAERGINLSMVNMGGGFPTKYLKEVPAVVQYGRSIFR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
ALRKHFGNQIPETIIEPGRGMVGNAGIIETEVVLISKKSDEDEMRWVYLDIGKFGGLAET
HHHHHHCCCCCHHHHCCCCCCCCCCCEEEEEEEEEECCCCCCCEEEEEEECCCCCCHHHH
MDESIRYAIKSRHDGAEMAPCVLAGPTCDSADVMYEKLPYPLPVTLEIGDKLLIEGTGAY
HHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCEEEEECCCEEEEEECCCC
TSTYSAVAFNGFPPLRTYHI
CCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]