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The map label for this gene is hisD [H]

Identifier: 86751452

GI number: 86751452

Start: 4933854

End: 4935197

Strand: Reverse

Name: hisD [H]

Synonym: RPB_4350

Alternate gene names: 86751452

Gene position: 4935197-4933854 (Counterclockwise)

Preceding gene: 86751453

Following gene: 86751451

Centisome position: 92.56

GC content: 69.79

Gene sequence:

>1344_bases
TTGAGCATTCGCGGCCTTGTGGGCCTTTGTGACTCCGGAAGCTTCCAAATGCCAGTTCGCCTCGACGCCGCCAGTACCGA
TTTTCCTCAGCAGTTCAAGGCCTTCCTGGCCATGAAGCGCGAGGTCGCGGCGGATATCGAGGCCGCCACGAGGGCCATCG
TCGACGACGTCGCGGCGCGCGGCGACGCCGCGCTGCTGGACGCCACTGCGAAGTTCGACCGGCTGACGCTGGACGCGGCC
GGCCTGCGCGTCACCGCGGCCGACATCGATGCCGCGGTGCAGGCCTGCGACCCTGATACCGTCGACGCGCTGAAATTCGC
CCGCGACCGCATCGAGTTCTTCCACCGCCGGCAATTGCCCAAGGACGACCGCTTCACCGATGCGCTGGGCGTCGAACTCG
GCTGGCGCTGGAGCTCGATCGAGGCGGTGGGTCTGTACGTGCCCGGCGGCACCGCGGCCTACCCGTCCTCGGTGCTGATG
AACGCGATCCCGGCCAAAGTCGCCGGCGTCGACCGCGTCGTGATGGTGGTGCCGTCGCCGGACGGCAAGCTCAACCCGCT
GGTGCTGGCCGCCGCTTCGCTCGGCGGCGTCACCGAGATCTACCGCGTCGGCGGCGCCCAGGCGGTGGCGGCGCTGGCTT
ACGGCACCGCGACGATCGCGCCGGTGTCGAAGATCGTCGGCCCCGGCAACGCCTATGTGGCGGCCGCCAAGCGGCAGGTG
TTCGGCCGCGTCGGCATCGACATGATCGCCGGCCCGTCCGAGGTGGTGGTGGTCGCCGACAGCACCGGCAATCCGGACTG
GATCGCCGCGGACCTGCTGGCGCAGGCCGAGCACGACGCCAATGCGCAGTCGATCCTGATCACCGACGACGCCGAACTCG
CCGACGCCGTCGAACGCGCCGTAACGGCGCAACTCACGACGCTGCCGCGCGCCGAGATCGCCCGCGCCTCGTGGGAGGCC
TATGGCGCCATCATCAAGGTCGCGCGTCTCGACGATGCGGTGGCGCTGGCGGACGCGATCGCGGCCGAGCATCTCGAGAT
CATCACCGCCGATCCGGAAGCCTTCGCCGCGAAGATCCGCAATGCGGGCGCGATCTTCCTGGGCGCGCATACGCCGGAGG
CGATCGGTGACTATGTCGGCGGCTCCAACCACGTGCTGCCGACGGCGCGCTCGGCGCGGTTCTCGTCTGGGCTCGGCGTG
CTCGACTTCATGAAGCGCACCTCGATCCTGAAATGCGGCCCCGAGCAGCTCGCCGCGCTGGGCCCGGCTGCGATGACGCT
CGGCCATGCCGAGGGTCTGGAGGCTCACGCGCGCTCGGTGGGACTGCGTCTGAATCGGCGATGA

Upstream 100 bases:

>100_bases
GGTCTGGACTGAGTCGGTCTCGCCGGCCGATCGAAGCCGTTCGACAGGTCCGGCAAGACCCTGCGGGCATAAGGGTTGAC
GGCGGTAGGGCGGCGCGCCA

Downstream 100 bases:

>100_bases
GCAACCCGCAACCAGACGATTCCAACAATCGCATCGTCGCGGTGACGCTCGACGAGGAATCGATCGGGCGCTCCGGGCCG
GACATCGAGCACGAGCGCGC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSIRGLVGLCDSGSFQMPVRLDAASTDFPQQFKAFLAMKREVAADIEAATRAIVDDVAARGDAALLDATAKFDRLTLDAA
GLRVTAADIDAAVQACDPDTVDALKFARDRIEFFHRRQLPKDDRFTDALGVELGWRWSSIEAVGLYVPGGTAAYPSSVLM
NAIPAKVAGVDRVVMVVPSPDGKLNPLVLAAASLGGVTEIYRVGGAQAVAALAYGTATIAPVSKIVGPGNAYVAAAKRQV
FGRVGIDMIAGPSEVVVVADSTGNPDWIAADLLAQAEHDANAQSILITDDAELADAVERAVTAQLTTLPRAEIARASWEA
YGAIIKVARLDDAVALADAIAAEHLEIITADPEAFAAKIRNAGAIFLGAHTPEAIGDYVGGSNHVLPTARSARFSSGLGV
LDFMKRTSILKCGPEQLAALGPAAMTLGHAEGLEAHARSVGLRLNRR

Sequences:

>Translated_447_residues
MSIRGLVGLCDSGSFQMPVRLDAASTDFPQQFKAFLAMKREVAADIEAATRAIVDDVAARGDAALLDATAKFDRLTLDAA
GLRVTAADIDAAVQACDPDTVDALKFARDRIEFFHRRQLPKDDRFTDALGVELGWRWSSIEAVGLYVPGGTAAYPSSVLM
NAIPAKVAGVDRVVMVVPSPDGKLNPLVLAAASLGGVTEIYRVGGAQAVAALAYGTATIAPVSKIVGPGNAYVAAAKRQV
FGRVGIDMIAGPSEVVVVADSTGNPDWIAADLLAQAEHDANAQSILITDDAELADAVERAVTAQLTTLPRAEIARASWEA
YGAIIKVARLDDAVALADAIAAEHLEIITADPEAFAAKIRNAGAIFLGAHTPEAIGDYVGGSNHVLPTARSARFSSGLGV
LDFMKRTSILKCGPEQLAALGPAAMTLGHAEGLEAHARSVGLRLNRR
>Mature_446_residues
SIRGLVGLCDSGSFQMPVRLDAASTDFPQQFKAFLAMKREVAADIEAATRAIVDDVAARGDAALLDATAKFDRLTLDAAG
LRVTAADIDAAVQACDPDTVDALKFARDRIEFFHRRQLPKDDRFTDALGVELGWRWSSIEAVGLYVPGGTAAYPSSVLMN
AIPAKVAGVDRVVMVVPSPDGKLNPLVLAAASLGGVTEIYRVGGAQAVAALAYGTATIAPVSKIVGPGNAYVAAAKRQVF
GRVGIDMIAGPSEVVVVADSTGNPDWIAADLLAQAEHDANAQSILITDDAELADAVERAVTAQLTTLPRAEIARASWEAY
GAIIKVARLDDAVALADAIAAEHLEIITADPEAFAAKIRNAGAIFLGAHTPEAIGDYVGGSNHVLPTARSARFSSGLGVL
DFMKRTSILKCGPEQLAALGPAAMTLGHAEGLEAHARSVGLRLNRR

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=417, Percent_Identity=43.8848920863309, Blast_Score=291, Evalue=7e-80,
Organism=Saccharomyces cerevisiae, GI6319819, Length=426, Percent_Identity=37.5586854460094, Blast_Score=254, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46638; Mature: 46506

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIRGLVGLCDSGSFQMPVRLDAASTDFPQQFKAFLAMKREVAADIEAATRAIVDDVAAR
CCCCCEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GDAALLDATAKFDRLTLDAAGLRVTAADIDAAVQACDPDTVDALKFARDRIEFFHRRQLP
CCHHEEECHHHHCEEEEECCCCEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
KDDRFTDALGVELGWRWSSIEAVGLYVPGGTAAYPSSVLMNAIPAKVAGVDRVVMVVPSP
CCCCCHHHHCCEECCEECCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECC
DGKLNPLVLAAASLGGVTEIYRVGGAQAVAALAYGTATIAPVSKIVGPGNAYVAAAKRQV
CCCCCCEEEEEHHCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCEEHHHHHHH
FGRVGIDMIAGPSEVVVVADSTGNPDWIAADLLAQAEHDANAQSILITDDAELADAVERA
HHHCCCCEECCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHH
VTAQLTTLPRAEIARASWEAYGAIIKVARLDDAVALADAIAAEHLEIITADPEAFAAKIR
HHHHHHCCCHHHHHHHHHHHHHHHEEEEHHCHHHHHHHHHHHHCEEEEECCHHHHHHHHC
NAGAIFLGAHTPEAIGDYVGGSNHVLPTARSARFSSGLGVLDFMKRTSILKCGPEQLAAL
CCCEEEEECCCCHHHHHHCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHCCCHHHHHHC
GPAAMTLGHAEGLEAHARSVGLRLNRR
CHHHHHHCCCCCHHHHHHHHCEEECCC
>Mature Secondary Structure 
SIRGLVGLCDSGSFQMPVRLDAASTDFPQQFKAFLAMKREVAADIEAATRAIVDDVAAR
CCCCEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GDAALLDATAKFDRLTLDAAGLRVTAADIDAAVQACDPDTVDALKFARDRIEFFHRRQLP
CCHHEEECHHHHCEEEEECCCCEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
KDDRFTDALGVELGWRWSSIEAVGLYVPGGTAAYPSSVLMNAIPAKVAGVDRVVMVVPSP
CCCCCHHHHCCEECCEECCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECC
DGKLNPLVLAAASLGGVTEIYRVGGAQAVAALAYGTATIAPVSKIVGPGNAYVAAAKRQV
CCCCCCEEEEEHHCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCEEHHHHHHH
FGRVGIDMIAGPSEVVVVADSTGNPDWIAADLLAQAEHDANAQSILITDDAELADAVERA
HHHCCCCEECCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHH
VTAQLTTLPRAEIARASWEAYGAIIKVARLDDAVALADAIAAEHLEIITADPEAFAAKIR
HHHHHHCCCHHHHHHHHHHHHHHHEEEEHHCHHHHHHHHHHHHCEEEEECCHHHHHHHHC
NAGAIFLGAHTPEAIGDYVGGSNHVLPTARSARFSSGLGVLDFMKRTSILKCGPEQLAAL
CCCEEEEECCCCHHHHHHCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHCCCHHHHHHC
GPAAMTLGHAEGLEAHARSVGLRLNRR
CHHHHHHCCCCCHHHHHHHHCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA